Research graph
References from The Spatiotemporal Coupling Imbalance of Senescent Grey Hair: Remodelling of the HFSC – MeSC –Niche Network and a New Paradigm of Stem Cell Senescence. Local targets link to admitted publications; unresolved targets remain external evidence.
Hair Aging in Different Races and Ethnicities
2021 · External reference
Genotoxic Stress Abrogates Renewal of Melanocyte Stem Cells by Triggering Their Differentiation
10.1016/j.cell.2009.03.037 · 2009 · External reference
Human Hair Graying Revisited: Principles, Misconceptions, and Key Research Frontiers
10.1016/j.jid.2023.09.276 · 2024 · External reference
mTORC1 Activity Negatively Regulates Human Hair Follicle Growth and Pigmentation
10.15252/embr.202256574 · 2023 · External reference
Oxidative Stress in Ageing of Hair
10.4103/0974-7753.51923 · 2009 · External reference
Senile Hair Graying: H2O2‐Mediated Oxidative Stress Affects Human Hair Color by Blunting Methionine Sulfoxide Repair
10.1096/fj.08-125435 · 2009 · External reference
Mechanisms of Hair Graying: Incomplete Melanocyte Stem Cell Maintenance in the Niche
10.1126/science.1099593 · 2005 · External reference
Graying: Gerontobiology of the Hair Follicle Pigmentary Unit
10.1016/s0531-5565(00)00210-2 · 2001 · External reference
A Guide to Studying Human Hair Follicle Cycling In Vivo
10.1038/jid.2015.354 · 2016 · External reference
Three Streams for the Mechanism of Hair Graying
10.5021/ad.2018.30.4.397 · 2018 · External reference
Dominant Role of the Niche in Melanocyte Stem‐Cell Fate Determination
10.1038/416854a · 2002 · External reference
Dedifferentiation Maintains Melanocyte Stem Cells in a Dynamic Niche
10.1038/s41586-023-05960-6 · 2023 · External reference
Quantitative Mapping of Human Hair Greying and Reversal in Relation to Life Stress
10.7554/elife.67437 · 2021 · External reference
Melanocyte Stem Cells in the Skin: Origin, Biological Characteristics, Homeostatic Maintenance and Therapeutic Potential
10.1002/ctm2.1720 · 2024 · External reference
Single‐Cell Transcriptomics Reveals Lineage Trajectory of Human Scalp Hair Follicle and Informs Mechanisms of Hair Graying
10.1038/s41421-022-00394-2 · 2022 · External reference
Deciphering the Molecular Mechanisms of Stem Cell Dynamics in Hair Follicle Regeneration
10.1038/s12276-023-01151-5 · 2024 · External reference
Reversing Gray Hair: Inspiring the Development of New Therapies Through Research on Hair Pigmentation and Repigmentation Progress
10.7150/ijbs.86911 · 2023 · External reference
Hair Follicle Stem Cells as a Skin‐Organizing Signaling Center During Adult Homeostasis
2021 · External reference
Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells
10.1016/j.stem.2010.11.029 · 2011 · External reference
Mouse Models for Human Hair Loss Disorders
10.1046/j.1469-7580.2003.00140.x · 2003 · External reference
Ageing of Hair Follicle Stem Cells and Their Niches
10.5483/bmbrep.2022-0183 · 2023 · External reference
Functional Hair Follicle Regeneration: An Updated Review
10.1038/s41392-020-00441-y · 2021 · External reference
Melanin Pigmentation in Mammalian Skin and Its Hormonal Regulation
10.1152/physrev.00044.2003 · 2004 · External reference
Hair Follicle Pigmentation
10.1111/j.0022-202x.2004.23528.x · 2005 · External reference
Immune Niches for Hair Follicle Development and Homeostasis
10.3389/fphys.2024.1397067 · 2024 · External reference
Regulation of Melanocyte Stem Cell Behavior by the Niche Microenvironment
10.1111/pcmr.12701 · 2018 · External reference
Neuroimmunoendocrine Circuitry of the ‘Brain‐Skin Connection'
10.1016/j.it.2005.10.002 · 2006 · External reference
Controls of Hair Follicle Cycling
10.1152/physrev.2001.81.1.449 · 2001 · External reference
A Two‐Step Mechanism for Stem Cell Activation During Hair Regeneration
10.1016/j.stem.2008.12.009 · 2009 · External reference
Transit‐Amplifying Cells Orchestrate Stem Cell Activity and Tissue Regeneration
10.1016/j.cell.2014.02.057 · 2014 · External reference
The Biology of Hair Follicles
10.1056/nejm199908123410706 · 1999 · External reference
SCF/c‐Kit Signaling Is Required for Cyclic Regeneration of the Hair Pigmentation Unit
10.1096/fj.00-0368com · 2001 · External reference
Endothelins Secreted From Human Keratinocytes Are Intrinsic Mitogens for Human Melanocytes
10.1016/s0021-9258(18)35817-4 · 1992 · External reference
Coordinated Activation of Wnt in Epithelial and Melanocyte Stem Cells Initiates Pigmented Hair Regeneration
10.1016/j.cell.2011.05.004 · 2011 · External reference
melanocytes and Their Diseases
10.1101/cshperspect.a017046 · 2014 · External reference
Human Hair Greying Is Linked to a Specific Depletion of Hair Follicle Melanocytes Affecting Both the Bulb and the Outer Root Sheath
10.1046/j.1365-2133.2004.05787.x · 2004 · External reference
Beyond the Epidermal‐Melanin‐Unit: The Human Scalp Anagen Hair Bulb Is Home to Multiple Melanocyte Subpopulations of Variable Melanogenic Capacity
10.3390/ijms241612809 · 2023 · External reference
Ageing of the Hair Follicle Pigmentation System
10.4103/0974-7753.58550 · 2009 · External reference
The Fate of Hair Follicle Melanocytes During the Hair Growth Cycle
10.1038/sj.jidsp.5640239 · 1999 · External reference
Changes in Different Melanocyte Populations During Hair Follicle Involution (Catagen)
10.1111/j.0022-202x.2005.23959.x · 2005 · External reference
Unresolved reference
2008 · External reference
Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles
10.3389/fcell.2022.899095 · 2022 · External reference
Paracrine TGF‐β Signaling Counterbalances BMP‐Mediated Repression in Hair Follicle Stem Cell Activation
10.1016/j.stem.2011.11.005 · 2012 · External reference
Live Imaging of Stem Cell and Progeny Behaviour in Physiological Hair‐Follicle Regeneration
10.1038/nature11218 · 2012 · External reference
Toward Elucidating Epigenetic and Metabolic Regulation of Stem Cell Lineage Plasticity in Skin Aging
10.3389/fcell.2022.903904 · 2022 · External reference
Self‐Organizing and Stochastic Behaviors During the Regeneration of Hair Stem Cells
10.1126/science.1201647 · 2011 · External reference
Functional Characterization of Melanocyte Stem Cells in Hair Follicles
10.1038/jid.2011.195 · 2011 · External reference
Interaction Between Stem Cell Factor and Endothelin‐1: Effects on Melanogenesis in Human Skin Xenografts
10.1038/labinvest.3700469 · 2006 · External reference
SASH1 S519N Variant Links Skin Hyperpigmentation and Premature Hair Graying to Dysfunction of Melanocyte Lineage
10.1016/j.jid.2024.04.027 · 2025 · External reference
The Molecular Anatomy of Mouse Skin During Hair Growth and Rest
10.1016/j.stem.2020.01.012 · 2020 · External reference
Single‐Cell Transcriptomes of the Human Skin Reveal Age‐Related Loss of Fibroblast Priming
10.1038/s42003-020-0922-4 · 2020 · External reference
Multiscale Spatial Mapping of Cell Populations Across Anatomical Sites in Healthy Human Skin and Basal Cell Carcinoma
10.1073/pnas.2313326120 · 2024 · External reference
Regenerative Hair Pigmentation via Skin Organoids: Adaptive Patterning Mediated by Collagen VI and Semaphorin 3C
10.1002/advs.202502436 · 2025 · External reference
The Melanocyte Lineage in Development and Disease
10.1242/dev.106567 · 2015 · External reference
Neuropilin 1 Signaling Guides Neural Crest Cells to Coordinate Pathway Choice With Cell Specification
10.1073/pnas.0811521106 · 2009 · External reference
Skin Aging From the Perspective of Dermal Fibroblasts: The Interplay Between the Adaptation to the Extracellular Matrix Microenvironment and Cell Autonomous Processes
10.1007/s12079-023-00743-0 · 2023 · External reference
Extracellular Matrix Regulation of Fibroblast Function: Redefining Our Perspective on Skin Aging
10.1007/s12079-018-0459-1 · 2018 · External reference
Photoageing: UV Radiation‐Induced Inflammation and Immunosuppression Accelerate the Aging Process in the Skin
10.1007/s00011-022-01598-8 · 2022 · External reference
Niche Stiffening Compromises Hair Follicle Stem Cell Potential During Ageing by Reducing Bivalent Promoter Accessibility
10.1038/s41556-021-00705-x · 2021 · External reference
Ageing of the Somatosensory System at the Periphery: Age‐Related Changes in Cutaneous Mechanoreceptors
10.1111/joa.12983 · 2019 · External reference
Influence of Aging on Peripheral Nerve Function and Regeneration
10.1111/j.1529-8027.2000.00026.x · 2000 · External reference
Contribution of Semaphorins to the Formation of the Peripheral Nervous System in Higher Vertebrates
10.1080/19336918.2016.1243644 · 2016 · External reference
Antagonistic Stem Cell Fates Under Stress Govern Decisions Between Hair Greying and Melanoma
10.1038/s41556-025-01769-9 · 2025 · External reference
Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells
10.1038/s41586-020-1935-3 · 2020 · External reference
Exosomes Released by Keratinocytes Modulate Melanocyte Pigmentation
10.1038/ncomms8506 · 2015 · External reference
Extracellular Vesicles Released by Keratinocytes Regulate Melanosome Maturation, Melanocyte Dendricity, and Pigment Transfer
10.1073/pnas.2321323121 · 2024 · External reference
IL‐17 and TNF Synergistically Modulate Cytokine Expression While Suppressing Melanogenesis: Potential Relevance to Psoriasis
10.1038/jid.2013.237 · 2013 · External reference
Roles of Inflammation Factors in Melanogenesis (Review)
2020 · External reference
Inflammageing and the Skin
10.1016/j.jid.2020.11.006 · 2021 · External reference
MITF‐The First 25 Years
10.1101/gad.324657.119 · 2019 · External reference
Human Sensory Neurons Modulate Melanocytes Through Secretion of RGMB
10.1016/j.celrep.2022.111366 · 2022 · External reference
Hallmarks of Aging: An Expanding Universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
Regulation of Stem Cell Aging by Metabolism and Epigenetics
10.1016/j.cmet.2017.07.019 · 2017 · External reference
Quiescence and Aging of Melanocyte Stem Cells and a Novel Association With Programmed Death‐Ligand 1
10.1016/j.isci.2024.110908 · 2024 · External reference
Melanocyte Stem Cell Maintenance and Hair Graying
10.1016/j.cell.2005.03.021 · 2005 · External reference
DNA Methylation Age of Human Tissues and Cell Types
10.1186/gb-2013-14-10-r115 · 2013 · External reference
Regulation of Melanocyte Stem Cells in the Pigmentation of Skin and Its Appendages: Biological Patterning and Therapeutic Potentials
10.1111/exd.13856 · 2019 · External reference
RNA Velocity of Single Cells
10.1038/s41586-018-0414-6 · 2018 · External reference
The Dynamics and Regulators of Cell Fate Decisions Are Revealed by Pseudotemporal Ordering of Single Cells
10.1038/nbt.2859 · 2014 · External reference
A Single‐Cell Transcriptomic Atlas of Human Skin Aging
10.1016/j.devcel.2020.11.002 · 2021 · External reference
Lineage Tracing
10.1016/j.cell.2012.01.002 · 2012 · External reference
Quantitative Nanohistology of Aging Dermal Collagen
10.3389/fragi.2023.1178566 · 2023 · External reference
Alterations in Extracellular Matrix Composition During Aging and Photoageing of the Skin
10.1016/j.mbplus.2020.100041 · 2020 · External reference
Four‐Dimensional Molecular Mapping From a Spatial Snapshot Reveals the Dynamics of Hair Follicle Organogenesis
10.1016/j.cell.2026.06.014 · 2026 · External reference
Single‐Cell Spatial Transcriptomic Analysis of Human Skin Anatomy
10.1038/s41588-026-02552-8 · 2026 · External reference
Regulatory T Cells in Skin Facilitate Epithelial Stem Cell Differentiation
10.1016/j.cell.2017.05.002 · 2017 · External reference
A Subset of TREM2+ Dermal Macrophages Secretes Oncostatin M to Maintain Hair Follicle Stem Cell Quiescence and Inhibit Hair Growth
10.1016/j.stem.2019.01.011 · 2019 · External reference
Immune Modulation of Hair Follicle Regeneration
10.1038/s41536-020-0095-2 · 2020 · External reference
Sympathetic Nerves Are Dispensable for the Responses of Melanocyte Stem Cells to Ultraviolet B Exposure
10.1111/exd.70151 · 2025 · External reference
The Hallmarks of Aging
10.1016/j.cell.2013.05.039 · 2013 · External reference
Hair Graying Regulators Beyond Hair Follicle
10.3389/fphys.2022.839859 · 2022 · External reference
Melanocyte Stem Cells and Hair Graying
10.1111/jocd.15652 · 2023 · External reference
Stem Cell Aging: The Upcoming Era of Proteins and Metabolites
10.1016/j.mad.2020.111288 · 2020 · External reference
Skin Pressing: An Easy and Reliable Method to Induce Acute Hair Greying in Mice and Useful for Studying Canities
10.1111/exd.70126 · 2025 · External reference
The Intestinal Crypt, a Prototype Stem Cell Compartment
10.1016/j.cell.2013.07.004 · 2013 · External reference
The Blood Brain Barrier: Insights From Development and Ageing
10.1080/21688370.2017.1373897 · 2017 · External reference
Gut Stem Cell Aging Is Driven by mTORC1 via a p38 MAPK‐p53 Pathway
10.1038/s41467-019-13911-x · 2020 · External reference
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion During Premature or Physiological Aging
10.1016/j.stem.2019.06.007 · 2019 · External reference
Blood Vessels as Regulators of Neural Stem Cell Properties
10.3389/fnmol.2019.00085 · 2019 · External reference
Adrenergic Nerve Degeneration in Bone Marrow Drives Aging of the Hematopoietic Stem Cell Niche
10.1038/s41591-018-0030-x · 2018 · External reference
Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells
10.1016/j.celrep.2017.02.056 · 2017 · External reference
Ageing and Rejuvenation of Neural Stem Cells and Their Niches
10.1016/j.stem.2020.07.002 · 2020 · External reference
Importance of Circadian Timing for Aging and Longevity
10.1038/s41467-021-22922-6 · 2021 · External reference
Circadian Regulation of Adult Stem Cell Homeostasis and Aging
10.1016/j.stem.2020.05.002 · 2020 · External reference
Circadian System and Aging: Where Both Times Interact
10.3389/fragi.2025.1646794 · 2025 · External reference
Ageing and Rejuvenation of Tissue Stem Cells and Their Niches
10.1038/s41580-022-00510-w · 2023 · External reference
The Aging Hematopoietic Stem Cell Niche: Phenotypic and Functional Changes and Mechanisms That Contribute to Hematopoietic Aging
10.1053/j.seminhematol.2016.10.001 · 2017 · External reference
Niche Regulation of Hematopoiesis: The Environment Is "Micro," but the Influence Is Large
10.1161/atvbaha.121.316235 · 2022 · External reference
Progress in Understanding How Clock Genes Regulate Aging and Associated Metabolic Processes
10.3389/fphys.2025.1654369 · 2025 · External reference
Gray Hair: From Preventive to Treatment
10.2147/ccid.s526263 · 2025 · External reference
Manifestations and Mechanisms of Stem Cell Aging
10.1083/jcb.201010131 · 2011 · External reference
