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References from Dimerization of human PARP15 is required for NAD + binding and automodification. Local targets link to admitted publications; unresolved targets remain external evidence.
ADP‐ribosyltransferases, an update on function and nomenclature
10.1111/febs.16142 · 2022 · External reference
Family‐wide analysis of poly(ADP‐ribose) polymerase activity
10.1038/ncomms5426 · 2014 · External reference
ADP‐ribosylation of RNA and DNA: from in vitro characterization to in vivo function
10.1093/nar/gkab136 · 2021 · External reference
Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP‐ribose)
10.1038/ncomms9088 · 2015 · External reference
Serine is a new target residue for endogenous ADP‐ribosylation on histones
10.1038/nchembio.2180 · 2016 · External reference
Histone ADP‐ribosylation in DNA repair, replication and transcription
10.1016/j.tcb.2011.06.001 · 2011 · External reference
FTO suppresses DNA repair by inhibiting PARP1
10.1038/s41467-025-58309-0 · 2025 · External reference
Mono‐ADP‐ribosylation by PARP10 inhibits chikungunya virus nsP2 proteolytic activity and viral replication
10.1007/s00018-023-04717-8 · 2023 · External reference
Intracellular mono‐ADP‐ribosyltransferases at the host–virus interphase
10.1007/s00018-022-04290-6 · 2022 · External reference
PARP14 is a PARP with both ADP‐ribosyl transferase and hydrolase activities
10.1126/sciadv.adi2687 · 2023 · External reference
Recognition of mono‐ADP‐Ribosylated ARTD10 substrates by ARTD8 macrodomains
10.1016/j.str.2012.12.019 · 2013 · External reference
A family of macrodomain proteins reverses cellular mono‐ADP‐ribosylation
10.1038/nsmb.2523 · 2013 · External reference
Macrodomain‐containing proteins are new mono‐ADP‐ribosylhydrolases
10.1038/nsmb.2521 · 2013 · External reference
Ubiquitin is directly linked via an ester to protein‐conjugated mono‐ADP‐ribose
10.1038/s44318-025-00391-7 · 2025 · External reference
The emergence of MARUbe – a hybrid ADP‐ribose–ubiquitin modification
10.1038/s41580-025-00903-7 · 2025 · External reference
Deltex and RING‐UIM E3 ligases cooperate to create a ubiquitin‐ADP‐ribose hybrid mark on tankyrase, promoting its stabilization
10.1126/sciadv.adx7172 · 2025 · External reference
Updated protein domain annotation of the PARP protein family sheds new light on biological function
10.1093/nar/gkad514 · 2023 · External reference
B‐aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP‐ribose) polymerase activity
10.1074/jbc.m505408200 · 2005 · External reference
Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals
10.1038/31275 · 1998 · External reference
The macro domain protein family: structure, functions, and their potential therapeutic implications
10.1016/j.mrrev.2011.03.001 · 2011 · External reference
Macrodomains: structure, function, evolution, and catalytic activities
10.1146/annurev-biochem-060815-014935 · 2016 · External reference
The macro domain is an ADP‐ribose binding module
10.1038/sj.emboj.7600664 · 2005 · External reference
Family‐wide analysis of human macrodomains reveals novel activities and identifies PARG as most efficient ADPr‐RNA hydrolase
10.1038/s42003-025-07901-7 · 2025 · External reference
The SARS‐CoV‐2 conserved macrodomain is a mono‐ADP‐Ribosylhydrolase
10.1128/jvi.01969-20 · 2021 · External reference
The conserved macrodomains of the non‐structural proteins of chikungunya virus and other pathogenic positive strand RNA viruses function as mono‐ADP‐ribosylhydrolases
10.1038/srep41746 · 2017 · External reference
Viral macro domains reverse protein ADP‐ribosylation
10.1128/jvi.00705-16 · 2016 · External reference
ADP‐ribosylhydrolase activity of chikungunya virus macrodomain is critical for virus replication and virulence
10.1073/pnas.1621485114 · 2017 · External reference
The controversial roles of ADP‐ribosyl hydrolases MACROD1, MACROD2 and TARG1 in carcinogenesis
10.3390/cancers12030604 · 2020 · External reference
ADP‐ribosylation signalling and human disease
10.1098/rsob.190041 · 2019 · External reference
BAL is a novel risk‐related gene in diffuse large B‐cell lymphomas that enhances cellular migration
10.1182/blood.v96.13.4328 · 2000 · External reference
Rapid evolution of PARP genes suggests a broad role for ADP‐ribosylation in host‐virus conflicts
10.1371/journal.pgen.1004403 · 2014 · External reference
Recurrent loss of macrodomain activity in host immunity and viral proteins
10.3390/pathogens12050674 · 2023 · External reference
A study into the ADP‐Ribosylome of IFN‐γ‐stimulated THP‐1 human macrophage‐like cells identifies ARTD8/PARP14 and ARTD9/PARP9 ADP‐ribosylation
10.1021/acs.jproteome.8b00895 · 2019 · External reference
PARP9 and PARP14 cross‐regulate macrophage activation via STAT1 ADP‐ribosylation
10.1038/ncomms12849 · 2016 · External reference
Identification of poly(ADP‐ribose) polymerase 9 (PARP9) as a potent suppressor for mycobacterium tuberculosis infection
10.1007/s43657-023-00112-2 · 2024 · External reference
PARP15 is a susceptibility locus for Clarkson disease (monoclonal gammopathy–associated systemic capillary leak syndrome)
10.1161/atvbaha.124.321522 · 2024 · External reference
Poly(ADP‐ribose) regulates stress responses and MicroRNA activity in the cytoplasm
10.1016/j.molcel.2011.04.015 · 2011 · External reference
RACK1 MARylation regulates translation and stress granules in ovarian cancer cells
10.1083/jcb.202401101 · 2025 · External reference
PARP10 is critical for stress granule initiation
10.26508/lsa.202403026 · 2025 · External reference
Reversible ADP‐ribosylation of RNA
10.1093/nar/gkz305 · 2019 · External reference
ADP‐ribosylation of RNA in mammalian cells is mediated by TRPT1 and multiple PARPs
10.1093/nar/gkac711 · 2022 · External reference
Fundamental properties of the mammalian innate immune system revealed by multispecies comparison of type I interferon responses
10.1371/journal.pbio.2004086 · 2017 · External reference
An enzymatic assay for poly(ADP‐ribose) polymerase‐1 (PARP‐1) via the chemical quantitation of NAD+: application to the high‐throughput screening of small molecules as potential inhibitors
10.1016/j.ab.2003.11.015 · 2004 · External reference
Activity‐based assay for human mono‐ADP‐ribosyltransferases ARTD7/PARP15 and ARTD10/PARP10 aimed at screening and profiling inhibitors
10.1016/j.ejps.2013.02.012 · 2013 · External reference
Engineering Af1521 improves ADP‐ribose binding and identification of ADP‐ribosylated proteins
10.1038/s41467-020-18981-w · 2020 · External reference
A molecular toolbox for ADP‐ribosyl binding proteins
10.1016/j.crmeth.2021.100121 · 2021 · External reference
MacroD1 is a promiscuous ADP‐ribosyl hydrolase localized to mitochondria
10.3389/fmicb.2018.00020 · 2018 · External reference
Differential activities of cellular and viral macro domain proteins in binding of ADP‐ribose metabolites
10.1016/j.jmb.2008.10.045 · 2009 · External reference
Proteomic analyses identify ARH3 as a serine mono‐ADP‐ribosylhydrolase
10.1038/s41467-017-02253-1 · 2017 · External reference
Serine ADP‐ribosylation reversal by the hydrolase ARH3
10.7554/elife.28533 · 2017 · External reference
Reversibility of arginine‐specific mono(ADP‐ribosyl)ation: identification in erythrocytes of an ADP‐ribose‐L‐arginine cleavage enzyme
10.1073/pnas.82.17.5603 · 1985 · External reference
Identification and characterization of a mammalian 39‐kDa poly(ADP‐ribose) Glycohydrolase
10.1074/jbc.m510290200 · 2006 · External reference
Mono‐ADP‐ribosylation of peptides: an overview of synthetic and chemoenzymatic methodologies
10.1002/cbic.202400440 · 2024 · External reference
Rapid analysis of ADP‐ribosylation dynamics and site‐specificity using TLC‐MALDI
10.1021/acschembio.1c00542 · 2021 · External reference
Development of an inhibitor screening assay for mono‐ADP‐ribosyl hydrolyzing macrodomains using AlphaScreen technology
10.1177/2472555217737006 · 2018 · External reference
Deficiency of terminal ADP‐ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease
10.1038/emboj.2013.51 · 2013 · External reference
Characterization of TCDD‐inducible poly‐ADP‐ribose polymerase (TIPARP/ARTD14) catalytic activity
10.1042/bcj20180347 · 2018 · External reference
Site‐specific characterization of the asp‐ and Glu‐ADP‐ribosylated proteome
10.1038/nmeth.2603 · 2013 · External reference
Regulation of ADP‐ribosyltransferase activity by ART domain dimerization in PARP15
10.1038/s41467-025-65315-9 · 2025 · External reference
Screening assay to monitor mono‐ADP‐ribosylhydrolase activity of viral macrodomains in cells
10.1038/s42003-026-09832-3 · 2026 · External reference
Structural basis for Lack of ADP‐ribosyltransferase activity in poly(ADP‐ribose) Polymerase‐13/zinc finger antiviral protein
10.1074/jbc.m114.630160 · 2015 · External reference
The power of two: protein dimerization in biology
10.1016/j.tibs.2004.09.006 · 2004 · External reference
Regulation of glucose metabolism by NAD+ and ADP‐ribosylation
10.3390/cells8080890 · 2019 · External reference
Metabolic regulation of transcription through compartmentalized NAD+ biosynthesis
10.1126/science.aan5780 · 2018 · External reference
Zika virus subverts stress granules to promote and restrict viral gene expression
10.1128/jvi.00520-19 · 2019 · External reference
Stress granule formation, disassembly, and composition are regulated by alphavirus ADP‐ribosylhydrolase activity
10.1073/pnas.2021719118 · 2021 · External reference
Phosphorylation of the arginine/serine dipeptide‐rich motif of the severe acute respiratory syndrome coronavirus nucleocapsid protein modulates its multimerization, translation inhibitory activity and cellular localization
10.1111/j.1742-4658.2008.06564.x · 2008 · External reference
Phosphoproteomic approach to characterize protein mono‐ and poly(ADP‐ribosyl)ation sites from cells
10.1021/pr401032q · 2014 · External reference
Deciphering cytokine‐driven ADP‐ribosylation signaling networks via Af1521‐based mass spectrometry analysis of labile Glu/asp‐linkages
10.1038/s41467-026-73677-x · 2026 · External reference
Comparative analysis of MACROD1, MACROD2 and TARG1 expression, localisation and interactome
10.1038/s41598-020-64623-y · 2020 · External reference
Regulation of PARP1/2 and the tankyrases: emerging parallels
10.1042/bcj20230230 · 2024 · External reference
One‐step sequence‐ and ligation‐independent cloning as a rapid and versatile cloning method for functional genomics studies
10.1128/aem.00844-12 · 2012 · External reference
Small‐molecule chemical probe rescues cells from mono‐ADP‐Ribosyltransferase ARTD10/PARP10‐induced apoptosis and sensitizes cancer cells to DNA damage
10.1016/j.chembiol.2016.08.012 · 2016 · External reference
Activity‐based screening assay for mono‐ADP‐Ribosylhydrolases
10.1177/2472555220928911 · 2021 · External reference
[1,2,4]triazolo[3,4‐b ]benzothiazole scaffold as versatile nicotinamide mimic allowing nanomolar inhibition of different PARP enzymes
10.1021/acs.jmedchem.2c01460 · 2023 · External reference
NanoLuc luciferase – a multifunctional tool for high throughput antibody screening
10.3389/fphar.2016.00027 · 2016 · External reference
ID30B – a versatile beamline for macromolecular crystallography experiments at the ESRF
10.1107/s1600577518007166 · 2018 · External reference
XDS
10.1107/s0907444909047337 · 2010 · External reference
Phaser crystallographic software
10.1107/s0021889807021206 · 2007 · External reference
Evaluation of 3‐ and 4‐Phenoxybenzamides as selective inhibitors of the mono‐ADP‐Ribosyltransferase PARP10
10.1002/open.202100087 · 2021 · External reference
PRODRG: a tool for high‐throughput crystallography of protein–ligand complexes
10.1107/s0907444904011679 · 2004 · External reference
REFMAC 5 for the refinement of macromolecular crystal structures
10.1107/s0907444911001314 · 2011 · External reference
CCP 4 i 2: the new graphical user interface to the CCP 4 program suite
10.1107/s2059798317016035 · 2018 · External reference
Overview of the CCP 4 suite and current developments
10.1107/s0907444910045749 · 2011 · External reference
Features and development of Coot
10.1107/s0907444910007493 · 2010 · External reference
Accurate structure prediction of biomolecular interactions with AlphaFold 3
10.1038/s41586-024-07487-w · 2024 · External reference