Research graph
References from Building an Interleukin‐10‐Producing Identity: How B Cells Acquire Interleukin‐10 Competence and How Plasma Cell Differentiation Consolidates This Program. Local targets link to admitted publications; unresolved targets remain external evidence.
B Cells Regulate Autoimmunity by Provision of IL‐10
10.1038/ni833 · 2002 · External reference
IL‐35‐Producing B Cells Are Critical Regulators of Immunity During Autoimmune and Infectious Diseases
10.1038/nature12979 · 2014 · External reference
LAG‐3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells
10.1016/j.immuni.2018.06.007 · 2018 · External reference
Intracellular Demonstration of Active TGFbeta1 in B Cells and Plasma Cells of Autoimmune Mice. IgG‐Bound TGFbeta1 Suppresses Neutrophil Function and Host Defense Against Staphylococcus aureus Infection
10.1172/jci119068 · 1996 · External reference
Lipopolysaccharide‐Activated B Cells Down‐Regulate Th1 Immunity and Prevent Autoimmune Diabetes in Nonobese Diabetic Mice
10.4049/jimmunol.167.2.1081 · 2001 · External reference
A Novel IL‐10‐Independent Regulatory Role for B Cells in Suppressing Autoimmunity by Maintenance of Regulatory T Cells via GITR Ligand
10.4049/jimmunol.1103354 · 2012 · External reference
Adenosine Production by Human B Cells and B Cell‐Mediated Suppression of Activated T Cells
10.1182/blood-2013-02-482406 · 2013 · External reference
Signaling via the MyD88 Adaptor Protein in B Cells Suppresses Protective Immunity During Salmonella typhimurium Infection
10.1016/j.immuni.2010.10.016 · 2010 · External reference
Regulatory B Cells Prevent and Reverse Allergic Airway Inflammation via FoxP3‐Positive T Regulatory Cells in a Murine Model
10.1016/j.jaci.2010.01.018 · 2010 · External reference
Inhibitory Effects of B Cells on Antitumor Immunity
10.1158/0008-5472.can-05-3766 · 2006 · External reference
Distinct Effector Cytokine Profiles of Memory and Naive Human B Cell Subsets and Implication in Multiple Sclerosis
10.4049/jimmunol.178.10.6092 · 2007 · External reference
Helminth Infections Associated With Multiple Sclerosis Induce Regulatory B Cells
10.1002/ana.21438 · 2008 · External reference
B Cells as a Therapeutic Target for IFN‐Beta in Relapsing‐Remitting Multiple Sclerosis
10.4049/jimmunol.1000271 · 2011 · External reference
The Effect of Glatiramer Acetate Therapy on Functional Properties of B Cells From Patients With Relapsing‐Remitting Multiple Sclerosis
10.1001/jamaneurol.2014.1472 · 2014 · External reference
B Cells From Glatiramer Acetate‐Treated Mice Suppress Experimental Autoimmune Encephalomyelitis
10.1016/j.expneurol.2009.10.015 · 2010 · External reference
Glucocorticoids Inhibit Human Antigen‐Specific and Enhance Total IgE and IgG4 Production due to Differential Effects on T and B Cells In Vitro
10.1002/eji.1830270933 · 1997 · External reference
A Regulatory B Cell Subset With a Unique CD1dhiCD5+ Phenotype Controls T Cell‐Dependent Inflammatory Responses
10.1016/j.immuni.2008.03.017 · 2008 · External reference
TLR‐9 Activation of Marginal Zone B Cells in Lupus Mice Regulates Immunity Through Increased IL‐10 Production
10.1007/s10875-005-0355-6 · 2005 · External reference
In‐Depth Characterization of CD24(High)CD38(High) Transitional Human B Cells Reveals Different Regulatory Profiles
10.1016/j.jaci.2015.09.014 · 2016 · External reference
IL‐10 Produced by Activated Human B Cells Regulates CD4(+) T‐Cell Activation In Vitro
10.1002/eji.201040673 · 2010 · External reference
CD19(+)CD24(hi)CD38(hi) B Cells Exhibit Regulatory Capacity in Healthy Individuals but Are Functionally Impaired in Systemic Lupus Erythematosus Patients
10.1016/j.immuni.2009.11.009 · 2010 · External reference
Diversity of Regulatory B Cells: Markers and Functions
10.1002/eji.202350496 · 2024 · External reference
TLR‐Activated B Cells Suppress T Cell‐Mediated Autoimmunity
10.4049/jimmunol.180.7.4763 · 2008 · External reference
TLR‐Mediated STAT3 and ERK Activation Controls IL‐10 Secretion by Human B Cells
10.1002/eji.201344341 · 2014 · External reference
Interleukin‐10‐Producing Plasmablasts Exert Regulatory Function in Autoimmune Inflammation
10.1016/j.immuni.2014.10.016 · 2014 · External reference
IFN‐Alpha Induces the Human IL‐10 Gene by Recruiting Both IFN Regulatory Factor 1 and Stat3
10.4049/jimmunol.171.1.285 · 2003 · External reference
Type I Interferons Protect Neonates From Acute Inflammation Through Interleukin 10‐Producing B Cells
10.1084/jem.20062013 · 2007 · External reference
Inflammatory Signal Induced IL‐10 Production of Marginal Zone B‐Cells Depends on CREB
10.1016/j.imlet.2019.06.004 · 2019 · External reference
Low‐Dose IL‐2 Enhances the Generation of IL‐10‐Producing Immunoregulatory B Cells
10.1038/s41467-023-37424-w · 2023 · External reference
IL‐10‐Producing Regulatory B Cells Induced by IL‐33 (Breg(IL‐33)) Effectively Attenuate Mucosal Inflammatory Responses in the Gut
10.1016/j.jaut.2014.01.032 · 2014 · External reference
Regulatory B Cells Are Induced by Gut Microbiota‐Driven Interleukin‐1beta and Interleukin‐6 Production
10.1038/nm.3680 · 2014 · External reference
Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL‐10‐Producing Regulatory B Cells
10.1016/j.celrep.2019.10.018 · 2019 · External reference
Hypoxia‐Inducible Factor‐1alpha Is a Critical Transcription Factor for IL‐10‐Producing B Cells in Autoimmune Disease
10.1038/s41467-017-02683-x · 2018 · External reference
NFATc1 Affects Mouse Splenic B Cell Function by Controlling the Calcineurin—NFAT Signaling Network
10.1084/jem.20100945 · 2011 · External reference
A Splenic IgM Memory Subset With Antibacterial Specificities Is Sustained From Persistent Mucosal Responses
10.1084/jem.20180977 · 2018 · External reference
Resolution of Three Nonproliferative Immature Splenic B Cell Subsets Reveals Multiple Selection Points During Peripheral B Cell Maturation
10.4049/jimmunol.167.12.6834 · 2001 · External reference
Novel Suppressive Function of Transitional 2 B Cells in Experimental Arthritis
10.4049/jimmunol.178.12.7868 · 2007 · External reference
Characterization of Marginal Zone B Cell Precursors
10.1084/jem.20051038 · 2005 · External reference
Interleukin‐10 From Marginal Zone Precursor B‐Cell Subset Is Required for Costimulatory Blockade‐Induced Transplantation Tolerance
10.1097/tp.0000000000000718 · 2015 · External reference
TLR‐Mediated Stimulation of APC: Distinct Cytokine Responses of B Cells and Dendritic Cells
10.1002/eji.200636483 · 2007 · External reference
A Tolerogenic Role for Toll‐Like Receptor 9 Is Revealed by B‐Cell Interaction With DNA Complexes Expressed on Apoptotic Cells
10.1073/pnas.1109173109 · 2012 · External reference
IL‐10‐Dependent Crosstalk Between Murine Marginal Zone B Cells, Macrophages, and CD8alpha(+) Dendritic Cells Promotes Listeria monocytogenes Infection
10.1016/j.immuni.2019.05.011 · 2019 · External reference
Chronic Intestinal Inflammatory Condition Generates IL‐10‐Producing Regulatory B Cell Subset Characterized by CD1d Upregulation
10.1016/s1074-7613(02)00274-1 · 2002 · External reference
Ly‐1 B (B‐1) Cells Are the Main Source of B Cell‐Derived Interleukin 10
10.1002/eji.1830220314 · 1992 · External reference
Immune Tolerance to Apoptotic Self Is Mediated Primarily by Regulatory B1a Cells
10.3389/fimmu.2017.01952 · 2017 · External reference
Regulatory Role of B‐1 B Cells in Chronic Colitis
10.1093/intimm/dxn031 · 2008 · External reference
Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies
10.1126/science.286.5447.2156 · 1999 · External reference
IGM Is Required for Efficient Complement Mediated Phagocytosis of Apoptotic Cells In Vivo
10.1080/08916930500124452 · 2005 · External reference
The Role of IgM Antibodies in the Recognition and Clearance of Apoptotic Cells
10.1016/j.molimm.2004.07.045 · 2005 · External reference
Predominant Autoantibody Production by Early Human B Cell Precursors
10.1126/science.1086907 · 2003 · External reference
B‐Cell Tolerance Checkpoints in Health and Autoimmunity
10.1016/j.coi.2008.09.001 · 2008 · External reference
B Cell Antigen Receptor Specificity and Surface Density Together Determine B‐1 Versus B‐2 Cell Development
10.1084/jem.190.4.471 · 1999 · External reference
Positive Selection of Natural Autoreactive B Cells
10.1126/science.285.5424.113 · 1999 · External reference
Evidence of Marginal‐Zone B Cell‐Positive Selection in Spleen
10.1016/j.immuni.2005.08.007 · 2005 · External reference
Pten Inactivation Alters Peripheral B Lymphocyte Fate and Reconstitutes CD19 Function
10.1038/ni892 · 2003 · External reference
Qualitative Regulation of B Cell Antigen Receptor Signaling by CD19: Selective Requirement for PI3‐Kinase Activation, Inositol‐1,4,5‐Trisphosphate Production and Ca2+ Mobilization
10.1084/jem.186.11.1897 · 1997 · External reference
Cd19‐Dependent Activation of Akt Kinase in B‐Lymphocytes
10.1074/jbc.m003918200 · 2001 · External reference
AKT Activity Orchestrates Marginal Zone B Cell Development in Mice and Humans
10.1016/j.celrep.2023.112378 · 2023 · External reference
Homeostasis of Peripheral B Cells in the Absence of B Cell Influx From the Bone Marrow
10.1084/jem.194.8.1151 · 2001 · External reference
In Vivo Ablation of Surface Immunoglobulin on Mature B Cells by Inducible Gene Targeting Results in Rapid Cell Death
10.1016/s0092-8674(00)80373-6 · 1997 · External reference
Antigen Receptor Signaling Gives Lymphocytes a Long Life
10.1016/s0092-8674(00)80362-1 · 1997 · External reference
The B‐Cell Antigen Receptor Integrates Adaptive and Innate Immune Signals
10.1073/pnas.1516428112 · 2015 · External reference
Stromal Notch Ligands Foster Lymphopenia‐Driven Functional Plasticity and Homeostatic Proliferation of Naive B Cells
10.1172/jci158885 · 2022 · External reference
BCR‐Dependent Lineage Plasticity in Mature B Cells
10.1126/science.aau8475 · 2019 · External reference
Prevention of Arthritis by Interleukin 10‐Producing B Cells
10.1084/jem.20021293 · 2003 · External reference
Deficient Expression of a B Cell Cytoplasmic Tyrosine Kinase in Human X‐Linked Agammaglobulinemia
10.1016/0092-8674(93)90667-f · 1993 · External reference
The Gene Involved in X‐Linked Agammaglobulinaemia Is a Member of the Src Family of Protein‐Tyrosine Kinases
10.1038/361226a0 · 1993 · External reference
Mutations in Igalpha (CD79a) Result in a Complete Block in B‐Cell Development
10.1172/jci7696 · 1999 · External reference
CD40 Ligand Gene Defects Responsible for X‐Linked Hyper‐IgM Syndrome
10.1126/science.7679801 · 1993 · External reference
Defective Expression of T‐Cell CD40 Ligand Causes X‐Linked Immunodeficiency With Hyper‐IgM
10.1038/361539a0 · 1993 · External reference
Anti‐Interleukin‐6 Signalling Therapy Rebalances the Disrupted Cytokine Production of B Cells From Patients With Active Rheumatoid Arthritis
10.1002/eji.201747191 · 2018 · External reference
Distinct Profiles of Human B Cell Effector Cytokines: A Role in Immune Regulation?
10.4049/jimmunol.172.6.3422 · 2004 · External reference
Characterization of a Rare IL‐10‐Competent B‐Cell Subset in Humans That Parallels Mouse Regulatory B10 Cells
10.1182/blood-2010-07-294249 · 2011 · External reference
Suppressive Functions of Activated B Cells in Autoimmune Diseases Reveal the Dual Roles of Toll‐Like Receptors in Immunity
10.1111/j.0105-2896.2009.00855.x · 2010 · External reference
The Calcium Sensors STIM1 and STIM2 Control B Cell Regulatory Function Through Interleukin‐10 Production
10.1016/j.immuni.2011.03.016 · 2011 · External reference
Human IL‐10‐Producing B Cells Have Diverse States That Are Induced From Multiple B Cell Subsets
10.1016/j.celrep.2022.110728 · 2022 · External reference
In Vitro‐Induced Human IL‐10(+) B Cells Do Not Show a Subset‐Defining Marker Signature and Plastically co‐Express IL‐10 With Pro‐Inflammatory Cytokines
10.3389/fimmu.2018.01913 · 2018 · External reference
Targeting Cytokine Pathways: The Role of Biologics in Autoinflammatory Disorders
10.1080/1744666x.2026.2625277 · 2026 · External reference
A Great Disturbance in the Force: IL‐2 Receptor Defects Disrupt Immune Homeostasis
10.1097/mop.0000000000001181 · 2022 · External reference
Human Immune Disorder Arising From Mutation of the Alpha Chain of the Interleukin‐2 Receptor
10.1073/pnas.94.7.3168 · 1997 · External reference
The Discovery of Regulatory T Cells: A Paradigm Shift in Immunology
10.1016/j.cellimm.2025.105049 · 2026 · External reference
Molecular Basis of Deficient IL‐2 Production in T Cells From Patients With Systemic Lupus Erythematosus
10.4049/jimmunol.166.6.4216 · 2001 · External reference
Systemic Lupus Erythematosus Serum IgG Increases CREM Binding to the IL‐2 Promoter and Suppresses IL‐2 Production Through CaMKIV
10.1172/jci22854 · 2005 · External reference
Decreased Peripheral Blood T Cell Cytokine Gene Expression in Rheumatoid Arthritis
10.1080/03009749950155625 · 1999 · External reference
Diminished Production of Type‐I Interferons and Interleukin‐2 in Patients With Multiple Sclerosis
10.1016/s0022-510x(97)05383-5 · 1997 · External reference
Dynamic Foxp3‐Chromatin Interaction Controls Tunable Treg Cell Function
10.1084/jem.20232068 · 2024 · External reference
Commitment to the B‐Lymphoid Lineage Depends on the Transcription Factor Pax5
10.1038/44076 · 1999 · External reference
The Transcription Factor Pax5 Regulates Its Target Genes by Recruiting Chromatin‐Modifying Proteins in Committed B Cells
10.1038/emboj.2011.140 · 2011 · External reference
The Transcription Repressors Bach2 and Bach1 Promote B Cell Development by Repressing the Myeloid Program
10.1038/ni.3024 · 2014 · External reference
The Transcription Repressor Bach2 Is Required for Maintaining the B‐1 Cell Population by Regulating Self‐Renewal
10.3389/fimmu.2025.1553089 · 2025 · External reference
The Transcriptional Programme of Antibody Class Switching Involves the Repressor Bach2
10.1038/nature02596 · 2004 · External reference
Accelerated Plasma‐Cell Differentiation in Bach2‐Deficient Mouse B Cells Is Caused by Altered IRF4 Functions
10.1038/s44318-024-00077-6 · 2024 · External reference
Blimp‐1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program
10.1016/s1074-7613(02)00335-7 · 2002 · External reference
Bach2 Represses Plasma Cell Gene Regulatory Network in B Cells to Promote Antibody Class Switch
10.1038/emboj.2010.257 · 2010 · External reference
Bach2 Maintains T Cells in a Naive State by Suppressing Effector Memory‐Related Genes
10.1073/pnas.1306691110 · 2013 · External reference
The Menin‐Bach2 Axis Is Critical for Regulating CD4 T‐Cell Senescence and Cytokine Homeostasis
10.1038/ncomms4555 · 2014 · External reference
Bach2 Regulates Homeostasis of Foxp3+ Regulatory T Cells and Protects Against Fatal Lung Disease in Mice
10.4049/jimmunol.1302378 · 2014 · External reference
Attenuation of TCR‐Induced Transcription by Bach2 Controls Regulatory T Cell Differentiation and Homeostasis
10.1038/s41467-019-14112-2 · 2020 · External reference
The Generation of Antibody‐Secreting Plasma Cells
10.1038/nri3795 · 2015 · External reference
Transcription Factor IRF4 Controls Plasma Cell Differentiation and Class‐Switch Recombination
10.1038/ni1357 · 2006 · External reference
IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis
10.1016/j.celrep.2019.10.097 · 2019 · External reference
A Distal Cis‐Regulatory Element, CNS‐9, Controls NFAT1 and IRF4‐Mediated IL‐10 Gene Activation in T Helper Cells
10.1016/j.molimm.2008.07.037 · 2009 · External reference
A Monoclonal Antibody (MUM1p) Detects Expression of the MUM1/IRF4 Protein in a Subset of Germinal Center B Cells, Plasma Cells, and Activated T Cells
10.1182/blood.v95.6.2084 · 2000 · External reference
Stages of Germinal Center Transit Are Defined by B Cell Transcription Factor Coexpression and Relative Abundance
10.4049/jimmunol.177.10.6930 · 2006 · External reference
Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function
10.1126/science.275.5299.540 · 1997 · External reference
Transcriptional Regulation of Germinal Center B and Plasma Cell Fates by Dynamical Control of IRF4
10.1016/j.immuni.2013.04.009 · 2013 · External reference
IRF4 Controls the Positioning of Mature B Cells in the Lymphoid Microenvironments by Regulating NOTCH2 Expression and Activity
10.1084/jem.20131026 · 2013 · External reference
Induced Regulatory B Cells Stably Expressing Interleukin‐10 Cure Central Nervous System Autoimmunity by Targeting Myeloid Cells
2026 · External reference
Blimp‐1 Is Required for the Formation of Immunoglobulin Secreting Plasma Cells and Pre‐Plasma Memory B Cells
10.1016/s1074-7613(03)00267-x · 2003 · External reference
Blimp‐1 Controls Plasma Cell Function Through the Regulation of Immunoglobulin Secretion and the Unfolded Protein Response
10.1038/ni.3348 · 2016 · External reference
Checkpoint Receptor TIGIT Expressed on Tim‐1(+) B Cells Regulates Tissue Inflammation
10.1016/j.celrep.2020.107892 · 2020 · External reference
Defective Toll‐Like Receptors Driven B Cell Response in Hyper IgE Syndrome Patients With STAT3 Mutations
10.3389/fped.2021.738799 · 2021 · External reference
The Regulation of IL‐10 Production by Immune Cells
10.1038/nri2711 · 2010 · External reference
STAT3 Deficiency in B Cells Exacerbates Uveitis by Promoting Expansion of Pathogenic Lymphocytes and Suppressing Regulatory B Cells (Bregs) and Tregs
10.1038/s41598-020-73093-1 · 2020 · External reference
STAT3‐Mediated Up‐Regulation of BLIMP1 Is Coordinated With BCL6 Down‐Regulation to Control Human Plasma Cell Differentiation
10.4049/jimmunol.180.7.4805 · 2008 · External reference
Analysis of Interleukin‐21‐Induced Prdm1 Gene Regulation Reveals Functional Cooperation of STAT3 and IRF4 Transcription Factors
10.1016/j.immuni.2009.10.008 · 2009 · External reference
STAT3 Signaling in B Cells Is Critical for Germinal Center Maintenance and Contributes to the Pathogenesis of Murine Models of Lupus
10.4049/jimmunol.1502043 · 2016 · External reference
Critical Role for Stat3 in T‐Dependent Terminal Differentiation of IgG B Cells
10.1182/blood-2005-07-2871 · 2006 · External reference
STAT3 Mutations in the Hyper‐IgE Syndrome
10.1056/nejmoa073687 · 2007 · External reference
Dominant‐Negative Mutations in the DNA‐Binding Domain of STAT3 Cause Hyper‐IgE Syndrome
10.1038/nature06096 · 2007 · External reference
NFATc1/alphaA: The Other Face of NFAT Factors in Lymphocytes
10.1186/1478-811x-10-16 · 2012 · External reference
NFATc1 Induction in Peripheral T and B Lymphocytes
10.4049/jimmunol.1201591 · 2013 · External reference
NFATc1 Supports Imiquimod‐Induced Skin Inflammation by Suppressing IL‐10 Synthesis in B Cells
10.1038/ncomms11724 · 2016 · External reference
NFATc1 Deficiency in B Cells Ameliorates Atopic Dermatitis
10.1038/s41598-025-11247-9 · 2025 · External reference
Ca(2+) ‐Related Signaling Events Influence TLR9‐Induced IL‐10 Secretion in Human B Cells
10.1002/eji.201343994 · 2014 · External reference
Induction of Short NFATc1/alphaA Isoform Interferes With Peripheral B Cell Differentiation
10.3389/fimmu.2018.00032 · 2018 · External reference
Per‐ARNT‐Sim (PAS) Domains in Basic Helix‐Loop‐Helix (bHLH)‐PAS Transcription Factors and Coactivators: Structures and Mechanisms
10.1016/j.jmb.2023.168370 · 2024 · External reference
The Aryl Hydrocarbon Receptor: Multitasking in the Immune System
10.1146/annurev-immunol-032713-120245 · 2014 · External reference
Identification of the Ah Receptor Nuclear Translocator Protein (Arnt) as a Component of the DNA Binding Form of the Ah Receptor
10.1126/science.256.5060.1193 · 1992 · External reference
Microbiota‐Derived Metabolites Suppress Arthritis by Amplifying Aryl‐Hydrocarbon Receptor Activation in Regulatory B Cells
10.1016/j.cmet.2020.03.003 · 2020 · External reference
Control of T(Reg) and T(H)17 Cell Differentiation by the Aryl Hydrocarbon Receptor
10.1038/nature06880 · 2008 · External reference
Gut Microbes Promote Colonic Serotonin Production Through an Effect of Short‐Chain Fatty Acids on Enterochromaffin Cells
10.1096/fj.14-259598 · 2015 · External reference
The Aryl Hydrocarbon Receptor Controls Cell‐Fate Decisions in B Cells
10.1084/jem.20160789 · 2017 · External reference
HIF1alpha and Metabolic Reprogramming in Inflammation
10.1172/jci84431 · 2016 · External reference
The Role of HIF in Immunity and Inflammation
10.1016/j.cmet.2020.08.002 · 2020 · External reference
The Special Unfolded Protein Response in Plasma Cells
10.1111/imr.13012 · 2021 · External reference
Lifetime of Plasma Cells in the Bone Marrow
10.1038/40540 · 1997 · External reference
