Research graph
References from Beta Cell Stress to Epitope Diversification: Post‐Translationally Modified Antigens in Type 1 Diabetes. Local targets link to admitted publications; unresolved targets remain external evidence.
Epitope Spreading in Immune‐Mediated Diseases: Implications for Immunotherapy
10.1038/nri724 · 2002 · External reference
Inducing Immune Tolerance: A Focus on Type 1 Diabetes Mellitus
10.2217/dmt.13.36 · 2013 · External reference
Prediction and Pathogenesis in Type 1 Diabetes
10.1016/j.immuni.2010.03.018 · 2010 · External reference
Type 1 Diabetes Pathogenesis and the Role of Inhibitory Receptors in Islet Tolerance
10.1111/nyas.14106 · 2020 · External reference
Genetics, Pathogenesis and Clinical Interventions in Type 1 Diabetes
10.1038/nature08933 · 2010 · External reference
Decoding the Immune Dance: Unraveling the Interplay Between Beta Cells and Type 1 Diabetes
10.1016/j.molmet.2024.101998 · 2024 · External reference
Epitope spreading
10.1016/s0952-7915(96)80012-4 · 1996 · External reference
Spreading of T‐Cell Autoimmunity to Cryptic Determinants of an Autoantigen
10.1038/358155a0 · 1992 · External reference
Persistent Infection With Theiler's Virus Leads to CNS Autoimmunity via Epitope Spreading
10.1038/nm1097-1133 · 1997 · External reference
The Functional Significance of Epitope Spreading and Its Regulation by Co‐Stimulatory Molecules
10.1111/j.1600-065x.1998.tb01208.x · 1998 · External reference
Regulation of Adaptive Immunity by the Innate Immune System
10.1126/science.1183021 · 2010 · External reference
Neoepitopes in Type 1 Diabetes: Etiological Insights, Biomarkers and Therapeutic Targets
10.3389/fimmu.2021.667989 · 2021 · External reference
The Role of Beta Cell Stress and Neo‐Epitopes in the Immunopathology of Type 1 Diabetes
10.3389/fendo.2020.624590 · 2020 · External reference
Beta Cell and Immune Cell Interactions in Autoimmune Type 1 Diabetes: How They Meet and Talk to Each Other
10.1016/j.molmet.2022.101565 · 2022 · External reference
T Cell Epitopes and Post‐Translationally Modified Epitopes in Type 1 Diabetes
10.1007/s11892-015-0657-7 · 2015 · External reference
Immunogenic Self‐Peptides ‐ The Great Unknowns in Autoimmunity: Identifying T‐Cell Epitopes Driving the Autoimmune Response in Autoimmune Diseases
10.3389/fimmu.2022.1097871 · 2022 · External reference
Identification of Hybrid Insulin Peptides (HIPs) in Mouse and Human Islets by Mass Spectrometry
10.1021/acs.jproteome.8b00875 · 2019 · External reference
An Insulin‐IAPP Hybrid Peptide Is an Endogenous Antigen for CD4 T Cells in the Non‐Obese Diabetic Mouse
10.1016/j.jaut.2016.10.007 · 2017 · External reference
Pathogenic CD4 T Cells in Type 1 Diabetes Recognize Epitopes Formed by Peptide Fusion
10.1126/science.aad2791 · 2016 · External reference
Hybrid Insulin Peptides Are Neo‐Epitopes for CD4 T Cells in Autoimmune Diabetes
10.1097/med.0000000000000490 · 2019 · External reference
Diabetogenic T Cells Recognize Insulin Bound to IAg7 in an Unexpected, Weakly Binding Register
10.1073/pnas.1006545107 · 2010 · External reference
Autoimmune Susceptible HLA Class II Motifs Facilitate the Presentation of Modified Neoepitopes to Potentially Autoreactive T Cells
10.1016/j.cellimm.2023.104729 · 2023 · External reference
Structural Basis of Peptide Binding and Presentation by the Type I Diabetes‐Associated MHC Class II Molecule of NOD Mice
10.1016/s1074-7613(00)80220-4 · 2000 · External reference
The Diabetogenic Mouse MHC Class II Molecule I‐Ag7 Is Endowed With a Switch That Modulates TCR Affinity
10.1172/jci41502 · 2010 · External reference
Register Shifting of an Insulin Peptide‐MHC Complex Allows Diabetogenic T Cells to Escape Thymic Deletion
10.1084/jem.20111502 · 2011 · External reference
Natural Peptides Selected by Diabetogenic DQ8 and Murine I‐A(g7) Molecules Show Common Sequence Specificity
10.1172/jci25350 · 2005 · External reference
Autoimmunity Against a Defective Ribosomal Insulin Gene Product in Type 1 Diabetes
10.1038/nm.4289 · 2017 · External reference
IAPP and Type 1 Diabetes: Implications for Immunity, Metabolism and Islet Transplants
10.1530/jme-17-0138 · 2018 · External reference
Beta Cell ER Stress and the Implications for Immunogenicity in Type 1 Diabetes
10.3389/fcell.2015.00067 · 2015 · External reference
Chromogranin A as a Crucial Factor in the Sorting of Peptide Hormones to Secretory Granules
10.1007/s10571-010-9595-8 · 2010 · External reference
Chromogranin A and Derived Peptides in Health and Disease
10.1007/s12031-012-9728-2 · 2012 · External reference
Environmental Factors Contribute to Beta Cell Endoplasmic Reticulum Stress and Neo‐Antigen Formation in Type 1 Diabetes
10.3389/fendo.2017.00262 · 2017 · External reference
The Prevalence of Enteroviral Capsid Protein vp1 Immunostaining in Pancreatic Islets in Human Type 1 Diabetes
10.1007/s00125-009-1276-0 · 2009 · External reference
Detection of a Low‐Grade Enteroviral Infection in the Islets of Langerhans of Living Patients Newly Diagnosed With Type 1 Diabetes
10.2337/db14-1370 · 2015 · External reference
Interferon‐Alpha Mediates Human Beta Cell HLA Class I Overexpression, Endoplasmic Reticulum Stress and Apoptosis, Three Hallmarks of Early Human Type 1 Diabetes
10.1007/s00125-016-4201-3 · 2017 · External reference
An Integrated Multi‐Omics Approach Identifies the Landscape of Interferon‐Alpha‐Mediated Responses of Human Pancreatic Beta Cells
10.1038/s41467-020-16327-0 · 2020 · External reference
Carbonyl Posttranslational Modification Associated With Early‐Onset Type 1 Diabetes Autoimmunity
10.2337/db21-0989 · 2022 · External reference
The Role of Oxidative Post‐Translational Modifications in Type 1 Diabetes Pathogenesis
10.3389/fimmu.2025.1537405 · 2025 · External reference
Inherent ER Stress in Pancreatic Islet Beta Cells Causes Self‐Recognition by Autoreactive T Cells in Type 1 Diabetes
10.1016/j.jaut.2016.04.009 · 2016 · External reference
Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4(+) T Cells in Patients With Type 1 Diabetes
10.2337/db17-1166 · 2018 · External reference
In CD4+ T‐Cell‐Induced Diabetes, Macrophages Are the Final Effector Cells That Mediate Islet Beta‐Cell Killing: Studies From an Acute Model
10.2353/ajpath.2006.060539 · 2006 · External reference
Inflammation‐Induced Citrullinated Glucose‐Regulated Protein 78 Elicits Immune Responses in Human Type 1 Diabetes
10.2337/db18-0295 · 2018 · External reference
Diabetogenic T‐Cell Clones Recognize an Altered Peptide of Chromogranin A
10.2337/db12-0112 · 2012 · External reference
Chromogranin A Is an Autoantigen in Type 1 Diabetes
10.1038/ni.1844 · 2010 · External reference
Antibodies to Oxidized Insulin Improve Prediction of Type 1 Diabetes in Children With Positive Standard Islet Autoantibodies
10.1002/dmrr.3132 · 2019 · External reference
Posttranslational Modification of HLA‐DQ Binding Islet Autoantigens in Type 1 Diabetes
10.2337/db12-1214 · 2014 · External reference
Human Islets and Dendritic Cells Generate Post‐Translationally Modified Islet Autoantigens
10.1111/cei.12775 · 2016 · External reference
Glutamine Deamidation Does Not Increase the Immunogenicity of C‐Peptide in People With Type 1 Diabetes
10.1016/j.jtauto.2022.100180 · 2023 · External reference
Citrullination of Glucokinase Is Linked to Autoimmune Diabetes
10.1038/s41467-022-29512-0 · 2022 · External reference
Analysis of Self‐Antigen Specificity of Islet‐Infiltrating T Cells From Human Donors With Type 1 Diabetes
10.1038/nm.4203 · 2016 · External reference
Cathepsin D Drives the Formation of Hybrid Insulin Peptides Relevant to the Pathogenesis of Type 1 Diabetes
10.2337/db22-0303 · 2022 · External reference
Hybrid Insulin Peptide Isomers Spontaneously Form in Pancreatic Beta‐Cells From an Aspartic Anhydride Intermediate
10.1016/j.jbc.2023.105264 · 2023 · External reference
Insulin B‐Chain Hybrid Peptides Are Agonists for T Cells Reactive to Insulin B:9‐23 in Autoimmune Diabetes
10.3389/fimmu.2022.926650 · 2022 · External reference
HLA‐DQ8‐Associated T Cell Responses to the Diabetes Autoantigen Phogrin (IA‐2 Beta) in Human Prediabetes
10.4049/jimmunol.172.6.3955 · 2004 · External reference
Recognition of Multiple Hybrid Insulin Peptides by a Single Highly Diabetogenic T‐Cell Receptor
10.3389/fimmu.2021.737428 · 2021 · External reference
T Cell Receptor Recognition of Hybrid Insulin Peptides Bound to HLA‐DQ8
10.1038/s41467-021-25404-x · 2021 · External reference
A Novel Region of the Insulin B9‐23 Sequence Is Targeted by a HIP‐Reactive Diabetogenic T Cell Clone
10.3389/fimmu.2026.1837267 · 2026 · External reference
Why Must T Cells Be Cross‐Reactive?
10.1038/nri3279 · 2012 · External reference
Expression of Two T Cell Receptor Alpha Chains: Dual Receptor T Cells
10.1126/science.8211163 · 1993 · External reference
Expression of Two Alpha Chains on the Surface of T Cells in T Cell Receptor Transgenic Mice
10.1084/jem.178.5.1807 · 1993 · External reference
Bystander Activation and Autoimmunity
10.1016/j.jaut.2019.06.012 · 2019 · External reference
Peptide‐MHC Class I Tetramers Can Fail to Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen‐Reactive T Cell Populations
10.4049/jimmunol.1700242 · 2018 · External reference
T‐Cell Responses to Hybrid Insulin Peptides Prior to Type 1 Diabetes Development
2021 · External reference
Restoration of the Unfolded Protein Response in Pancreatic Beta Cells Protects Mice Against Type 1 Diabetes
10.1126/scitranslmed.3006534 · 2013 · External reference
