Research graph
References from GLP-1 receptor agonist attenuates endoplasmic reticulum stress-mediated β-cell damage in Akita mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Endoplasmic reticulum stress-mediated apoptosis in pancreatic β-cells
10.1023/a:1016175429877 · 2002 · External reference
Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls
10.1101/gad.13.10.1211 · 1999 · External reference
Tripartite management of unfolded proteins in the endoplasmic reticulum
10.1016/s0092-8674(00)80855-7 · 2000 · External reference
The unfolded protein response in nutrient sensing and differentiation
10.1038/nrm829 · 2002 · External reference
Stimulation of pancreatic β-cell replication by incretins involves transcriptional induction of cyclin D1 via multiple signalling pathways
10.1677/joe.1.06160 · 2006 · External reference
EGF receptor in pancreatic β-cell mass regulation
10.1042/bst0360280 · 2008 · External reference
The Wnt signaling pathway effector TCF7L2 and type 2 diabetes mellitus
10.1210/me.2008-0135 · 2008 · External reference
Exendin-4 differentiation of a human pancreatic duct cell line into endocrine cells: involvement of PDX-1 and HNF3β transcription factors
10.1002/jcp.10143 · 2002 · External reference
Glucagon-like peptide-1 treatment delays the onset of diabetes in 8 week-old db/db mice
10.1007/s00125-002-0828-3 · 2002 · External reference
Glucagon-like peptide 1 inhibits cell apoptosis and improves glucose responsiveness of freshly isolated human islets
10.1210/en.2003-0323 · 2003 · External reference
cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2
10.1101/gad.1097103 · 2003 · External reference
Glucagon-like peptide-1 receptor signaling modulates β cell apoptosis
10.1074/jbc.m209423200 · 2003 · External reference
Glucagon-like peptide-1 prevents beta cell glucolipotoxicity
10.1007/s00125-004-1379-6 · 2004 · External reference
The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits β-cell apoptosis in vitro
10.1016/j.bbrc.2005.03.013 · 2005 · External reference
Exendin-4 uses Irs2 signaling to mediate pancreatic β cell growth and function
10.1074/jbc.m508307200 · 2006 · External reference
GLP-1 receptor signaling protects pancreatic beta cells in intraportal islet transplant by inhibiting apoptosis
10.1016/j.bbrc.2008.01.046 · 2008 · External reference
A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice
10.2337/diabetes.46.5.887 · 1997 · External reference
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
10.1172/jci0214550 · 2002 · External reference
A novel GIP receptor splice variant influences GIP sensitivity of pancreatic β-cells in obese mice
10.1152/ajpendo.00358.2007 · 2008 · External reference
GLP-1 receptor activation improves β cell function and survival following induction of endoplasmic reticulum stress
10.1016/j.cmet.2006.10.001 · 2006 · External reference
A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse
10.1172/jci4431 · 1999 · External reference
Insulin gene mutations as a cause of permanent neonatal diabetes
10.1073/pnas.0707291104 · 2007 · External reference
Protection of pancreatic β-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress; in vivo and in vitro studies
10.1677/joe-06-0148 · 2007 · External reference
Glucagon-like peptide-1 agonists protect pancreatic β-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB
10.2337/db09-0685 · 2009 · External reference
β-cell deficit and increased β-cell apoptosis in humans with type 2 diabetes
10.2337/diabetes.52.1.102 · 2003 · External reference
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
10.2337/diacare.28.5.1083 · 2005 · External reference
