Research graph
References from 2-Methoxyestradiol ameliorates glucose tolerance with the increase in β-cell mass in db/db mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
10.2337/diacare.27.5.1047 · 2004 · External reference
Effect of oestrogen plus progestin on the incidence of diabetes in postmenopausal women: results from the Women’s Health Initiative Hormone Trial
10.1007/s00125-004-1448-x · 2004 · External reference
Glycemic effects of postmenopausal hormone therapy: the Heart and Estrogen/progestin Replacement Study. A randomized, double-blind, placebo-controlled trial
10.7326/0003-4819-138-1-200301070-00005 · 2003 · External reference
Minireview: estrogenic protection of beta-cell failure in metabolic diseases
10.1210/en.2009-1107 · 2010 · External reference
Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. Heart and Estrogen/progestin Replacement Study (HERS) Research Group
10.1001/jama.280.7.605 · 1998 · External reference
Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial
10.1001/jama.288.3.321 · 2002 · External reference
Cardiovascular pharmacology of estradiol metabolites
10.1124/jpet.103.058057 · 2004 · External reference
2-Methoxyestradiol - biology and mechanism of action
10.1016/j.steroids.2010.02.016 · 2010 · External reference
Novel therapy with 2-methoxyestradiol for the treatment of relapsed and plateau phase multiple myeloma
10.1158/1078-0432.ccr-07-0807 · 2007 · External reference
Activity of 2 methoxyestradiol (Panzem NCD) in advanced, platinum-resistant ovarian cancer and primary peritoneal carcinomatosis: a Hoosier Oncology Group trial
10.1016/j.ygyno.2009.05.042 · 2009 · External reference
Phase I safety, pharmacokinetic and pharmacodynamic studies of 2-methoxyestradiol alone or in combination with docetaxel in patients with locally recurrent or metastatic breast cancer
10.1007/s10637-006-9008-5 · 2007 · External reference
Phase I trial of 2-methoxyestradiol NanoCrystal dispersion in advanced solid malignancies
10.1158/1078-0432.ccr-08-1599 · 2009 · External reference
A phase II multicenter, randomized, double-blind, safety trial assessing the pharmacokinetics, pharmacodynamics, and efficacy of oral 2-methoxyestradiol capsules in hormone-refractory prostate cancer
10.1158/1078-0432.ccr-05-0440 · 2005 · External reference
Dose-response effects of 2-methoxyestradiol on estrogen target tissues in the ovariectomized rat
10.1210/en.2002-220632 · 2003 · External reference
Increased 2-methoxyestradiol production in human coronary versus aortic vascular cells
10.1161/01.hyp.37.2.658 · 2001 · External reference
2-Methoxyestradiol reduces monocyte adhesion to aortic endothelial cells in ovariectomized rats
10.1507/endocrj.k07e-034 · 2007 · External reference
2-Methoxyestradiol, an endogenous metabolite of estrogen, enhances apoptosis and beta-galactosidase expression in vascular endothelial cells
10.1006/bbrc.1998.8902 · 1998 · External reference
OB protein: a peripheral signal linking adiposity and central neural networks
10.1006/appe.1996.0024 · 1996 · External reference
Protein kinase Cdelta plays a non-redundant role in insulin secretion in pancreatic beta cells
10.1074/jbc.m610482200 · 2007 · External reference
Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
10.1016/j.cmet.2008.08.009 · 2008 · External reference
2-Methoxyestradiol and 2-ethoxyestradiol retard the progression of renal disease in aged, obese, diabetic ZSF1 rats
10.1097/fjc.0b013e31802cb88e · 2007 · External reference
The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth
10.1038/368237a0 · 1994 · External reference
Anti-proliferative effect of 2-methoxyestradiol on cultured smooth muscle cells from rabbit aorta
10.1016/0021-9150(94)05442-l · 1995 · External reference
17Beta-estradiol, its metabolites, and progesterone inhibit cardiac fibroblast growth
10.1161/01.hyp.31.1.522 · 1998 · External reference
Effect of 2-methoxyestradiol on the growth of methyl-nitroso-urea (MNU)-induced rat mammary carcinoma
10.1016/s0960-0760(02)00268-6 · 2003 · External reference
2-methoxyestradiol up-regulates death receptor 5 and induces apoptosis through activation of the extrinsic pathway
2003 · External reference
2-Methoxyestradiol, an endogenous estrogen metabolite, induces apoptosis in endothelial cells and inhibits angiogenesis: possible role for stress-activated protein kinase signaling pathway and Fas expression
10.1124/mol.51.6.951 · 1997 · External reference
Mechanisms for 2-methoxyestradiol-induced apoptosis of prostate cancer cells
10.1016/s0014-5793(02)03478-6 · 2002 · External reference
Roles of p38- and c-jun NH2-terminal kinase-mediated pathways in 2-methoxyestradiol-induced p53 induction and apoptosis
10.1093/carcin/bgg058 · 2003 · External reference
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
10.1016/s1535-6108(03)00077-1 · 2003 · External reference
The inhibitory effect of endogenous estrogen metabolites on copper-mediated in vitro oxidation of LDL
1998 · External reference
