Research graph
References from β-Cell failure in type 2 diabetes. Local targets link to admitted publications; unresolved targets remain external evidence.
Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficiencies
10.1016/s0140-6736(74)90140-8 · 1974 · External reference
High carbohydrate diets and insulin efficiency
10.1136/bmj.2.3836.57 · 1934 · External reference
Diabetes mellitus. Its differentiation into insulin-sensitive and insulin-insensitive types
10.1016/s0140-6736(01)36134-2 · 1936 · External reference
The molecular and physiological basis of insulin resistance: emerging implications for metabolic and cardiovascular disease
10.1172/jci10533 · 2000 · External reference
Plasma insulin response to sustained hyperglycaemia induced by glucose infusion in human subjects
10.1016/s0140-6736(63)90740-2 · 1963 · External reference
The plasma insulin response to glucose infusion in healthy subjects and in diabetes mellitus
10.1530/acta.0.0550278 · 1967 · External reference
Glucose tolerance and serum insulin in unaffected identical twins of diabetics
10.1136/bmj.4.5570.21 · 1967 · External reference
Insulin secretion in response to glycemic stimulus: relation of delayed initial release to carbohydrate intolerance in mild diabetes mellitus
10.1172/jci105534 · 1967 · External reference
Diminished serum insulin response to glucose in genetic prediabetic males with normal glucose tolerance
10.2337/diab.17.1.17 · 1968 · External reference
Insulin deficiency and insulin resistance in the pathogenesis of type 2 diabetes: is a divorce possible?
10.1007/bf00400591 · 1995 · External reference
Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes
10.1016/s0092-8674(00)80546-2 · 1999 · External reference
Interactions between insulin resistance and insulin secretion in the development of glucose intolerance
10.1172/jci10761 · 2000 · External reference
Effect of 6-month gliclazide treatment on insulin release and sensitivity to endogenous insulin in NIDDM: role of initial continuous subcutaneous insulin infusion-induced normoglycemia
10.1016/0002-9343(91)90416-u · 1991 · External reference
Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment
10.2337/diacare.20.9.1353 · 1997 · External reference
The response to short-term intensive insulin therapy in type 2 diabetes
10.1111/j.1463-1326.2009.01129.x · 2010 · External reference
Effect of intensive insulin therapy on ß-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: A multicentre randomised parallel-group trial
10.1016/s0140-6736(08)60762-x · 2008 · External reference
Studies on low insulin responders
10.1530/acta.0.090s005 · 1979 · External reference
Relationship between the plasma insulin response to oral glucose and insulin-stimulated glucose utilization in normal subjects
10.2337/diabetes.33.5.460 · 1984 · External reference
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians
10.1056/nejm199312303292703 · 1993 · External reference
Insulin resistance and hypersecretion in obesity
10.1172/jci119628 · 1997 · External reference
Dose-response relationship of plasma insulin and blood glucose levels during oral glucose loads in prediabetic and diabetic subjects
10.1016/s0140-6736(73)90599-0 · 1973 · External reference
The pathogenesis of NIDDM
10.1007/bf00400840 · 1994 · External reference
β-cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis
10.1210/jc.2004-1133 · 2005 · External reference
Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests
10.1210/jcem-42-2-222 · 1976 · External reference
Pulsatile insulin secretion: detection, regulation, and role in diabetes
10.2337/diabetes.51.2007.s245 · 2002 · External reference
10.1111/j.2040-1124.2010.00022.x · 2010 · Admitted local publication
K-value and low insulin secretion in a non-obese white population predicted glucose tolerance after 25 years
10.1007/s00125-005-1929-6 · 2005 · External reference
Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels
10.2337/dc08-1478 · 2009 · External reference
Primary defects in β-cell function further exacerbated by worsening of insulin resistance mark the development of impaired glucose tolerance in obese adolescents
10.2337/dc08-1274 · 2009 · External reference
Insulin response to glucose infusion in diabetic and non-diabetic monozygotic twin pairs. Genetic control of insulin response?
10.1530/acta.0.0550330 · 1967 · External reference
Glucose tolerance and serum insulin in identical twins of diabetics
10.1136/bmj.4.5736.649 · 1970 · External reference
Genetic regulation of the kinetics of glucose-induced insulin release in man - studies in families with diabetic and non-diabetic probands
10.1111/j.1399-0004.1985.tb01210.x · 1985 · External reference
Genetic influences on the insulin response of the beta cell to different secretagogues
10.1007/s00125-009-1532-3 · 2009 · External reference
Pathomechanisms of type 2 diabetes genes
10.1210/er.2009-0017 · 2009 · External reference
Beta cell glucose sensitivity is decreased by 39% in non-diabetic subjects carrying multiple diabetes-risk alleles compared with those with no risk alleles
10.1007/s00125-008-1124-7 · 2008 · External reference
Combined risk allele score of eight type 2 diabetes genes is associated with reduced first-phase glucose-stimulated insulin secretion during hyperglycaemic clamps
10.2337/db09-0736 · 2010 · External reference
Type 2 diabetes susceptibility gene TCF7L2 and its role in β-cell function
10.2337/db09-0099 · 2009 · External reference
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
10.2337/db08-1187 · 2009 · External reference
Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP and GLP-1 receptors and impaired beta-cell function
10.1093/hmg/ddp178 · 2009 · External reference
Genotype and tissue-specific effects on alternative splicing of the transcription factor 7-like 2 gene in humans
10.1210/jc.2009-2064 · 2010 · External reference
Breakthroughs in monogenic diabetes genetics: from pediatric forms to young adulthood diabetes
2009 · External reference
The diagnosis and management of monogenic diabetes in children and adolescents
10.1111/j.1399-5448.2009.00571.x · 2009 · External reference
Clinical and molecular genetics of neonatal diabetes due to mutations in the insulin gene
10.1007/s11154-010-9151-3 · 2010 · External reference
Long-term efficacy of sulfonylureas: a United Kingdom Prospective Diabetes Study perspective
10.1016/j.metabol.2006.02.006 · 2006 · External reference
Quantitative estimation of the pancreatic islet tissue in diabetic subjects
10.2337/diab.4.5.367 · 1955 · External reference
Die histopathologischen Veränderungen der Langerhansschen Inseln und ihre Bedeutung in der Frage des Pathogenese des menschlichen Diabetes
1958 · External reference
Islet morphometry in the diabetic pancreas of man
10.1620/tjem.125.185 · 1978 · External reference
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes
10.2337/diabetes.52.1.102 · 2003 · External reference
Decreased insulin secretion in type 2 diabetes: a problem of cellular mass or function?
10.2337/diabetes.50.2007.s169 · 2001 · External reference
Reduced beta-cell mass and expression of oxidative stress-related DNA damage in the islet of Japanese type II diabetic patients
10.1007/s125-002-8248-z · 2002 · External reference
Selective β-cell loss and α-cell expansion in patients with type 2 diabetes mellitus in Korea
10.1210/jc.2002-020735 · 2003 · External reference
Pancreatic beta-cell mass in European subjects with type 2 diabetes
10.1111/j.1463-1326.2008.00969.x · 2008 · External reference
Adaptive changes in pancreatic beta cell fractional area and beta cell turnover in human pregnancy
10.1007/s00125-010-1809-6 · 2010 · External reference
Imaging of beta-cell mass and function
10.2967/jnumed.109.068999 · 2010 · External reference
Dynamic changes in beta-cell mass and pancreatic insulin during the evolution of nutrition-dependent diabetes in Psammomys obesus. Impact of glycemic control
10.2337/diabetes.54.1.138 · 2005 · External reference
Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes
10.1016/j.cell.2005.05.027 · 2005 · External reference
Gene expression profiles of beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes
10.1371/journal.pone.0011499 · 2010 · External reference
Islet beta cell failure in type 2 diabetes
10.1172/jci29103 · 2006 · External reference
Failure of beta-cell adaptation in type 2 diabetes: lessons from animal models
10.2741/3296 · 2009 · External reference
The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation
10.1007/s00125-009-1562-x · 2010 · External reference
Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets
10.1172/jci200215318 · 2002 · External reference
Interleukin-1-receptor antagonist in type 2 diabetes mellitus
10.1056/nejmoa065213 · 2007 · External reference
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes
10.1172/jci34587 · 2008 · External reference
Glucose amplifies fatty acid-induced endoplasmic reticulum stress in pancreatic beta-cells via activation of mTORC1
10.1371/journal.pone.0004954 · 2009 · External reference
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes
10.2337/db07-0197 · 2007 · External reference
Protective unfolded protein response in human pancreatic beta cells transplanted into mice
10.1371/journal.pone.0011211 · 2010 · External reference
Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues
10.1016/0891-5849(96)02051-5 · 1996 · External reference
Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells
10.2337/diabetes.46.11.1733 · 1997 · External reference
Diabetic beta-cells can achieve self-protection against oxidative stress through an adaptive up-regulation of their antioxidant defenses
10.1371/journal.pone.0006500 · 2009 · External reference
Glucose suppresses superoxide generation in metabolically responsive pancreatic beta cells
10.1074/jbc.m411869200 · 2005 · External reference
Antioxidant function of thioredoxin and glutaredoxin systems
10.1089/ars.2000.2.4-811 · 2000 · External reference
Redox control of exocytosis: regulatory role of NADPH, thioredoxin, and glutaredoxin
10.2337/diabetes.54.7.2132 · 2005 · External reference
Role of thioredoxin in cell growth through interactions with signaling molecules
10.1089/ars.2006.8.2143 · 2006 · External reference
The interaction of thioredoxin with Txnip. Evidence for formation of a mixed disulfide by disulfide exchange
10.1074/jbc.m600427200 · 2006 · External reference
Intracellular shuttling and mitochondrial function of thioredoxin-interacting protein
10.1074/jbc.m109.034421 · 2010 · External reference
Thioredoxin-interacting protein is stimulated by glucose through a carbohydrate response element and induces beta-cell apoptosis
10.1210/en.2004-1378 · 2005 · External reference
Hyperglycemia promotes oxidative stress through inhibition of thioredoxin function by thioredoxin-interacting protein
10.1074/jbc.m400549200 · 2004 · External reference
High glucose-induced thioredoxin-interacting protein in renal proximal tubule cells is independent of transforming growth factor-beta1
10.2353/ajpath.2007.060813 · 2007 · External reference
Hyperglycemia regulates thioredoxin-ROS activity through induction of thioredoxin-interacting protein (TXNIP) in metastatic breast cancer-derived cells MDA-MB-231
10.1186/1471-2407-7-96 · 2007 · External reference
Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis
10.2337/db07-0715 · 2008 · External reference
Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes
10.1096/fj.08-111690 · 2008 · External reference
Insulin counteracts glucotoxic effects by suppressing thioredoxin-interacting protein production in INS-1E beta cells and in Psammomys obesus pancreatic islets
10.1007/s00125-009-1274-2 · 2009 · External reference
Thioredoxin-interacting protein links oxidative stress to inflammasome activation
10.1038/ni.1831 · 2010 · External reference
“What is inherited - what is added” hypothesis for the pathogenesis of diabetes mellitus
10.2337/diab.16.9.615 · 1967 · External reference
