Research graph
References from Traditional Chinese Medicine Formulas in Delaying Aging: From Theoretical Foundations to Molecular Mechanisms and Translational Perspectives. Local targets link to admitted publications; unresolved targets remain external evidence.
Biomarkers of Female Reproductive Aging in Gerotherapeutic Clinical Trials
10.1016/j.arr.2025.102901 · 2025 · External reference
Addressing Healthy Aging in China: Practices and Prospects
10.5582/bst.2024.01180 · 2024 · External reference
60 Years of Healthy Aging: On Definitions, Biomarkers, Scores and Challenges
10.1016/j.arr.2023.101934 · 2023 · External reference
Predicting 1‐, 3‐, 5‐, and 8‐Year All‐Cause Mortality in a Community‐Dwelling Older Adult Cohort: Relevance for Predictive, Preventive, and Personalized Medicine
10.1007/s13167-023-00342-4 · 2023 · External reference
From Geroscience to Precision Geromedicine: Understanding and Managing Aging
10.1016/j.cell.2025.03.011 · 2025 · External reference
On the Wake of Metformin: Do Anti‐Diabetic SGLT2 Inhibitors Exert Anti‐Aging Effects?
10.1016/j.arr.2023.102131 · 2023 · External reference
Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age‐Related Disease
10.14336/ad.2021.1213 · 2022 · External reference
Compound Combinations Targeting Longevity: Challenges and Perspectives
10.1016/j.arr.2023.101851 · 2023 · External reference
The Scientific Basis of Synergy in Traditional Chinese Medicine: Physicochemical, Pharmacokinetic, and Pharmacodynamic Perspectives
10.1186/s13020-025-01291-y · 2026 · External reference
Advances in the Pharmacology and Mechanism of Anti‐Skin Aging in Tonifying Traditional Chinese Medicines
10.1016/j.jep.2026.121233 · 2026 · External reference
Plasma Protein‐Based Organ‐Specific Aging and Mortality Models Unveil Diseases as Accelerated Aging of Organismal Systems
10.1016/j.cmet.2024.10.005 · 2025 · External reference
Mechanism Study on the Regulation of Autophagy and Oxidative Stress Through SIRT1/PI3K/AKT Pathway by Liuwei Dihuang Pill to Improve Ovarian Function
10.1186/s13048-025-01689-0 · 2025 · External reference
Liuwei Dihuang Pills Attenuate Ovariectomy‐Induced Bone Loss by Alleviating Bone Marrow Mesenchymal Stem Cell (BMSC) Senescence via the Yes‐Associated Protein (YAP)‐Autophagy Axis
10.1080/13880209.2023.2291675 · 2024 · External reference
Effect of Liuwei Dihuang Pill on Memory Function of SAMP8 Mice by Regulating Autophagy Through PI3K/Akt/FoxO3a Pathway
2022 · External reference
Bazi Bushen Maintains Intestinal Homeostasis Through Inhibiting TLR4/NFκB Signaling Pathway and Regulating Gut Microbiota in SAMP6 Mice
10.1002/jsfa.12812 · 2023 · External reference
The Efficacy and Safety of Bazi Bushen Capsule in Treating Premature Aging: A Randomized, Double Blind, Multicenter, Placebo‐Controlled Clinical Trial
10.1016/j.phymed.2024.155742 · 2024 · External reference
Bazi Bushen Alleviates Reproductive Aging in Aged Male Mice
10.1016/s1875-5364(24)60639-4 · 2024 · External reference
Bazi Bushen Mitigates Epigenetic Aging and Extends Healthspan in Naturally Aging Mice
10.1016/j.biopha.2023.114384 · 2023 · External reference
SIRT3 Suppresses Vascular Endothelial Senescence via DHRS2 and Contributes to the Anti‐Vascular Aging Effect of Bazi Bushen Capsule
10.1016/j.phymed.2025.156571 · 2025 · External reference
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Putative Identification of CASTOR1 as One of the Targets of Ganoderic Acid a via Thermal Proteome Profiling and Molecular Docking
10.3389/fphar.2026.1666269 · 2026 · External reference
A Real‐World Data Analysis‐Based Study of Chinese Medicine Treatment Patterns After Breast Cancer Surgery
10.1097/md.0000000000036642 · 2023 · External reference
Effect of Hong Huang Tang on Memory Enhancement and Mitigation of Microgravity‐Induced Oxidative Stress in C. elegans
10.1007/s10522-025-10361-5 · 2025 · External reference
Determination via an Integration Strategy of the Potential Dermal ECM Reconstruction Mechanism by Which the WAW Formula Alleviates Skin Aging
10.1111/jocd.70124 · 2025 · External reference
Prevalence of Traditional East Asian Medicine Patterns Among Older Adults With Frailty: A Systematic Review of Observational Studies
10.3831/kpi.2026.29.1.1 · 2026 · External reference
Immunosenescence, Gut Dysbiosis, and Chronic Kidney Disease: Interplay and Implications for Clinical Management
10.1016/j.bj.2023.100638 · 2024 · External reference
Biomarkers of Kidney Health and Dual Trajectories of Cognitive and Physical Function in Older Adults: Health Aging and Body Composition Study Findings
10.34067/kid.0000001084 · 2025 · External reference
Kidney‐Tonifying, Phlegm‐Resolving, and Blood Stasis‐Removing Therapy for Multiple Myeloma: Protocol for a Randomized Controlled Trial on Epigenetic and Immune Modulation
10.2196/86322 · 2026 · External reference
Kidney Aging and Chronic Kidney Disease
10.3390/ijms25126585 · 2024 · External reference
Therapeutic Effects of Buzhong Yiqi Decoction in Patients With Spleen and Stomach Qi Deficiency After Routine Surgery and Chemotherapy for Colorectal Cancer
10.4240/wjgs.v16.i7.2183 · 2024 · External reference
Organ Crosstalk: The Role of Spleen
10.1007/s43657-023-00147-5 · 2025 · External reference
The Pan‐Liver Network Theory: From Traditional Chinese Medicine to Western Medicine
10.4103/cjop.cjop-d-22-00131 · 2023 · External reference
Hallmarks of Aging: An Expanding Universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
Aging, Cellular Senescence and Parkinson's Disease
10.1177/1877718x251316552 · 2025 · External reference
Targeting Innovative Therapeutic Approaches to the Hallmarks of Aging to Combat Alzheimer's Disease
10.4103/nrr.nrr-d-25-00966 · 2025 · External reference
Aging and the Emerging Role of Cellular Senescence in Osteoarthritis
10.1016/j.joca.2023.11.018 · 2024 · External reference
Exercise and the Hallmarks of Cardiovascular Aging
10.1016/j.arr.2026.103030 · 2026 · External reference
Hallmarks of Ovarian Aging
10.1016/j.tem.2025.01.005 · 2025 · External reference
Comprehensive Human Proteome Profiles Across a 50‐Year Lifespan Reveal Aging Trajectories and Signatures
10.1016/j.cell.2025.06.047 · 2025 · External reference
NAD(+) Precursor Supplementation Prevents mtRNA/RIG‐I‐Dependent Inflammation During Kidney Injury
10.1038/s42255-023-00761-7 · 2023 · External reference
Effects of Klotho on Fibrosis and Cancer: A Renal Focus on Mechanisms and Therapeutic Strategies
10.1016/j.addr.2017.07.009 · 2017 · External reference
The Controversy of Klotho as a Potential Biomarker in Chronic Kidney Disease
10.3389/fphar.2022.931746 · 2022 · External reference
High Phosphate Induces and Klotho Attenuates Kidney Epithelial Senescence and Fibrosis
10.3389/fphar.2020.01273 · 2020 · External reference
The NAD+/PARP1/SIRT1 Axis in Aging
10.1089/rej.2017.1980 · 2017 · External reference
Effect of NAD+ Boosting on Kidney Ischemia‐Reperfusion Injury
10.1371/journal.pone.0252554 · 2021 · External reference
PARP1 Associates With R‐Loops to Promote Their Resolution and Genome Stability
10.1093/nar/gkad066 · 2023 · External reference
RETRACTED: A Subset of PARP Inhibitors Induces Lethal Telomere Fusion in ALT‐Dependent Tumor Cells
10.1126/scitranslmed.abc7211 · 2021 · External reference
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Study on the Relationship Between Kidney Deficiency Aging and Mitochondrial DNA Oxidative Damage
2002 · External reference
Interactions Among mTORC, AMPK and SIRT: A Computational Model for Cell Energy Balance and Metabolism
10.1186/s12964-021-00706-1 · 2021 · External reference
Effect of Kidney‐Tonifying and Spleen‐Strengthening Method on ULK1/FUNDC1‐Mediated Mitophagy in Muscle and Bone of OP Rats
2024 · External reference
Correlation Between Mitochondrial Quality Control and Kidney‐Yang Deficiency Pattern
2022 · External reference
Regulatory Effect of Shenqi Pill on Wnt/β‐Catenin Signaling Pathway in Intestinal Stem Cells and Their Microenvironment of Aged Rats
2017 · External reference
Association Between Soluble Klotho and Change in Kidney Function: The Health Aging and Body Composition Study
10.1681/asn.2016080828 · 2017 · External reference
Klotho Gene‐Modified BMSCs Showed Elevated Antifibrotic Effects by Inhibiting the Wnt/beta‐Catenin Pathway in Kidneys After Acute Injury
10.1002/cbin.11068 · 2018 · External reference
Adverse Reaction Types, Causes and Countermeasures of Glycyrrhiza and Its Preparations
2012 · External reference
Hypoxia Inducible Factor 1 Subunit Alpha Mediates Autophagy Disorder of Oral Lichen Planus by Regulating Lysosomal Pathway
10.3389/fimmu.2026.1789261 · 2026 · External reference
Hypoxia Promotes EV Secretion by Impairing Lysosomal Homeostasis in HNSCC Through Negative Regulation of ATP6V1A by HIF‐1alpha
10.1002/jev2.12310 · 2023 · External reference
Discussion on the Correlation Between the Pathogenesis Concept of “Kidney Deficiency and Collateral Stasis” and Insufficient Cellular Autophagy in Elderly Chronic Kidney Disease Based on Collateral Disease Theory
2024 · External reference
Dual Inhibition of Pyruvate Dehydrogenase Complex and Respiratory Chain Complex Induces Apoptosis by a Mitochondria‐Targeted Fluorescent Organic Arsenical In Vitro and In Vivo
10.1002/cmdc.201900686 · 2020 · External reference
The Role of the ATPase Inhibitor Factor 1 (IF(1)) in Cancer Cells Adaptation to Hypoxia and Anoxia
10.1016/j.bbabio.2017.10.007 · 2018 · External reference
Chronic Intermittent Hypoxia Induces the Pyroptosis of Renal Tubular Epithelial Cells by Activating the NLRP3 Inflammasome
10.1080/21655979.2022.2047394 · 2022 · External reference
Multifactorial Functions of the Inflammasome Component NLRP3 in Pathogenesis of Chronic Kidney Diseases
10.1016/j.kint.2019.01.014 · 2019 · External reference
Effect of Bushen Huoxue Granules on Nrf2/NLRP3 Inflammasome Axis in the Substantia Nigra of Parkinson's Disease Model Mice
2025 · External reference
Hypoxia‐Inducible Factor‐1alpha Activates the Transforming Growth Factor‐Beta/SMAD3 Pathway in Kidney Tubular Epithelial Cells
10.1159/000449323 · 2016 · External reference
Therapeutic Potential for Renal Fibrosis by Targeting Smad3‐Dependent Noncoding RNAs
10.1016/j.ymthe.2023.12.009 · 2024 · External reference
Morphometry and Immunoexpression of Metalloproteinase 2 and Its Inhibitor in the Fibrotic and Non‐Fibrotic Grafted Kidney‐Digital Analysis
2026 · External reference
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Failure to Sense Energy Depletion May Be a Novel Therapeutic Target in Chronic Kidney Disease
10.1016/j.kint.2018.08.030 · 2019 · External reference
AMPK at the Interface of Nutrient Sensing, Metabolic Flux and Energy Homeostasis
10.1038/s42255-025-01442-3 · 2026 · External reference
A Double Negative Feedback Loop Between mTORC1 and AMPK Kinases Guarantees Precise Autophagy Induction Upon Cellular Stress
10.3390/ijms20225543 · 2019 · External reference
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The Relationship Between Resting Cerebral Blood Flow, Neurometabolites, Cardio‐Respiratory Fitness and Aging‐Related Cognitive Decline
10.3389/fpsyt.2022.923076 · 2022 · External reference
Alzheimer's Disease: A Decreased Cerebral Blood Flow to Critical Intraneuronal Elements Is the Cause
10.3233/jad-215479 · 2022 · External reference
Exploring the Mechanism of TCM Formulae in the Treatment of Different Types of Coronary Heart Disease by Network Pharmacology and Machining Learning
10.1016/j.phrs.2020.105034 · 2020 · External reference
p16INK4A Participates in a G1 Arrest Checkpoint in Response to DNA Damage
10.1128/mcb.18.1.378 · 1998 · External reference
Transfusion Increased Skin Blood Flow When Initially Low in Volume‐Resuscitated Patients Without Acute Bleeding
10.3389/fmed.2023.1218462 · 2023 · External reference
The Role of Dissolved Oxygen Levels on Human Mesenchymal Stem Cell Culture Success, Regulatory Compliance, and Therapeutic Potential
10.1089/scd.2017.0291 · 2018 · External reference
Insights Into the Release Mechanism of Astrocytic Glutamate Evoking in Neurons NMDA Receptor‐Mediated Slow Depolarizing Inward Currents
10.1002/glia.23473 · 2018 · External reference
A 3D‐1D‐0D Multiscale Model of the Neuro‐Glial‐Vascular Unit for Synaptic and Vascular Dynamics in the Dorsal Vagal Complex
10.1007/s00285-025-02317-7 · 2025 · External reference
Explanation of Opening and Closing of Brain Xuanfu From Astrocytes Regulating Neurovascular Unit
2023 · External reference
Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
10.1210/er.2017-00211 · 2018 · External reference
Emerging Roles of Brain Metabolism in Cognitive Impairment and Neuropsychiatric Disorders
10.1016/j.neubiorev.2022.104892 · 2022 · External reference
Social Isolation Improves the Performance of Rodents in a Novel Cognitive Flexibility Task
10.1186/s12983-019-0339-4 · 2019 · External reference
Distribution of Traditional Chinese Medicine Patterns in Multidimensional Frailty of Elderly Diabetic Foot and Its Relationship With Social Isolation
2026 · External reference
Effect and Molecular Mechanism Research of Astragalus Membranaceus on Inhibiting Intestinal Absorption of Six Alkaloids of Aconitum carmichaelii in Spleen Deficiency Rats
10.1016/j.chmed.2021.07.001 · 2022 · External reference
Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions
10.3389/fimmu.2020.594150 · 2020 · External reference
Changes of Serum Free Amino Acids in Patients With Spleen Deficiency
1994 · External reference
Effect of Spleen‐Strengthening Method on Intestinal Sweet Taste Signal Molecule mRNA Expression
2015 · External reference
Effects of Single Amino Acid Deficiency on mRNA Translation Are Markedly Different for Methionine Versus Leucine
10.1038/s41598-018-26254-2 · 2018 · External reference
L‐Leucine Stimulates Glutamate Dehydrogenase Activity and Glutamate Synthesis by Regulating mTORC1/SIRT4 Pathway in Pig Liver
2018 · External reference
Modified Sijunzi Decoction Delays Spleen Tissue Aging in Mice Through mTOR Signaling Pathway
2020 · External reference
Application of RRLC‐QTOF‐MS‐Based Metabonomics and UPE for Investigating Spleen‐Qi Deficiency Syndrome With Panax ginseng Treatment
10.1016/j.jep.2020.112822 · 2020 · External reference
Study on Changes of SOD and MDA in Spleen‐Qi Deficiency Type Gastrointestinal Disease Treated With Sijunzi Decoction
1995 · External reference
Effect of Chiropractic Manipulation on Disrupted Epithelium Barrier and Its Mechanism of Specialized Pro‐Resolving Mediators in a Spleen‐Deficiency Murine Model
2019 · External reference
Imbalance of Th1/Th2 Cytokines in Spleen‐Qi Deficiency Pattern Model Rats and Intervention Effect of Sijunzi Decoction
2004 · External reference
Experimental Study on Mitochondrial DNA Damage in Myocardium and Brain Tissue of Aging Rats With Spleen Deficiency Pattern
2009 · External reference
Analysis of DNA Damage Induced by Free Radicals in Spleen‐Qi Deficiency Pattern
2013 · External reference
Effect of Fuzheng Guben Pill on Intestinal Microbiota of Mice
1993 · External reference
Interaction of Banxia Xiexin Decoction and Its Different Combinations With Gastrointestinal Bacteria
2021 · External reference
The Status of Studies on the Mechanism of Microcirculatory Dysfunction in the Process of Diabetic Kidney Injury
10.1186/s13098-025-01718-4 · 2025 · External reference
Effect of Yixintai on Mitochondrial Biogenesis in Rats With Chronic Heart Failure of Qi Deficiency and Blood Stasis Pattern
2026 · External reference
Zuogui Pill Ameliorates DNA Damage and the Senescence‐Associated Secretory Phenotype in Ovarian Stem Cells to Delay Ovarian Ageing Through Activation of SIRT1
10.1016/j.phymed.2026.158114 · 2026 · External reference
The Function of Bazhen Decoction in Rescuing Progeroid Cell Senescence via Facilitating G‐Quadruplex Resolving and Telomere Elongation
10.1016/j.jep.2023.117694 · 2024 · External reference
Liuwei Dihuang Prevents Postmenopausal Atherosclerosis and Endothelial Cell Apoptosis via Inhibiting DNMT1‐Medicated ERalpha Methylation
10.1016/j.jep.2019.112531 · 2020 · External reference
Guilu Erxian Glue () Inhibits Chemotherapy‐Induced Bone Marrow Hematopoietic Stem Cell Senescence in Mice May via p16(INK4a)‐Rb Signaling Pathway
10.1007/s11655-020-3098-3 · 2020 · External reference
Buyang Huanwu Decoction Stabilizes Atherosclerotic Vulnerable Plaques by Regulating Intestinal Flora, TLR4‐NF‐kappaB‐NLRP3 Inflammatory Pathway and Mitophagy
10.1016/j.phymed.2025.156751 · 2025 · External reference
Buyang Huanwu Decoction Delays Vascular Aging in Rats Through Exosomal miR‐590‐5p Signal‐Mediated Macrophage Polarization
2025 · External reference
Elucidating the Anti‐Aging Mechanism of Si Jun Zi Tang by Integrating Network Pharmacology and Experimental Validation In Vivo
10.18632/aging.204055 · 2022 · External reference
Kai‐Xin‐San Alleviates Alzheimer's Disease by Targeting the DHFR‐Mediated Folate‐Mitochondrial Axis
10.1016/j.jep.2026.121230 · 2026 · External reference
Kai‐Xin‐San Ameliorates Mild Cognitive Impairment in SAMP8 Mice by Inhibiting Neuroinflammation and Pyroptosis via NLRP3/Caspase‐1 Pathway Modulation
10.3389/fphar.2025.1528011 · 2025 · External reference
The Traditional Formula Kai‐Xin‐San Alleviates Polyglutamine‐Mediated Neurotoxicity by Modulating Proteostasis Network in Caenorhabditis elegans
10.1089/rej.2018.2149 · 2020 · External reference
Huangjing Yangji Decoction Ameliorates Skeletal Muscle Aging and Mitochondrial Dysfunction via SIRT1/ATF5‐Mediated Mitochondrial Unfolded Protein Response
10.1016/j.phymed.2025.157432 · 2025 · External reference
Scientific Connotation of Yuanzhi San in Treating Alzheimer's Disease by “Supplementing Qi, Resolving Phlegm and Opening the Orifices” Based on Ubiquitin‐Proteasome Pathway
2021 · External reference
Zuogui and Yougui Pills Extend Lifespan and Improve Ageing Biomarkers via Kaempferol‐Mediated Mitophagy in Caenorhabditis elegans
10.1007/s10522-025-10317-9 · 2025 · External reference
Mechanism of Zuogui Pill and Yougui Pill Intervening in PINK1/Parkin Signaling Pathway to Regulate Autophagy in Postmenopausal Osteoporosis
2023 · External reference
Bazi Bushen Alleviates Skin Senescence by Orchestrating Skin Homeostasis in SAMP6 Mice
10.1111/jcmm.17833 · 2023 · External reference
Effect of Guilu Erxian Glue on AMPK/mTOR/ULK1 Pathway‐Mediated Autophagy in IL‐1β‐Induced Cultured Chondrocytes
2024 · External reference
Guilu Erxian Glue Activates PINK1/Parkin‐Mediated Mitophagy to Induce Osteoblast Differentiation
2025 · External reference
Yishen Huashi Granule Modulated Lipid Metabolism in Diabetic Nephropathy via PI3K/AKT/mTOR Signaling Pathways
10.1016/j.heliyon.2023.e14171 · 2023 · External reference
Exploration of Buyang Huanwu Decoction Delaying Vascular Aging Based on miR‐665/DRAM1 Signal‐Mediated Autophagy
2024 · External reference
Regulatory Effect of Sijunzi Decoction and Its Single Herb Decoctions on Intestinal Microbiota in Spleen Deficiency Rats
2019 · External reference
Effect of Sijunzi Decoction on Intestinal Microbiota of Aging Mice
2006 · External reference
Bufei Yishen Formula Protects the Airway Epithelial Barrier and Ameliorates COPD by Enhancing Autophagy Through the Sirt1/AMPK/Foxo3 Signaling Pathway
10.1186/s13020-024-00905-1 · 2024 · External reference
Wuzi Yanzong Administration Alleviates Sertoli Cell Injury by Recovering AKT/mTOR‐Mediated Autophagy and the mTORC1‐mTROC2 Balance in Aging‐Induced Testicular Dysfunction
10.1016/j.jep.2023.116865 · 2024 · External reference
Wen‐Shen‐Tong‐Luo‐Zhi‐Tong‐Decoction Inhibits Bone Loss in Senile Osteoporosis Model Mice by Promoting Testosterone Production
10.1016/j.jep.2024.119033 · 2025 · External reference
Protective Effect and Mechanism of Tongqiao Huoxue Decoction Regulating Microglial Phenotype on Alzheimer's Disease
2025 · External reference
Study on the Molecular Mechanisms of Liuwei Dihuang Decoction Against Aging‐Related Cognitive Impairment Based on Network Pharmacology and Experimental Verification
10.1016/j.heliyon.2024.e32526 · 2024 · External reference
Study on Effect of Renshen Yangrong Decoction on Improving Absorption Function of Small Intestinal Mucosal Epithelial Striated Border in Aged Mice
2001 · External reference
Kai‐Xin‐San Protects Against Mitochondrial Dysfunction in Alzheimer's Disease Through SIRT3/NLRP3 Pathway
10.1186/s13020-023-00722-y · 2023 · External reference
KaiXinSan‐JiaWei Ameliorates Cognitive Dysfunction in APP/PS1 Mice by Intervening in Gut Microbiota and Its Metabolites
10.3389/fphar.2025.1483883 · 2025 · External reference
Relationship Between the Senescence of Leydig Cells and the Regulation of Insulin/Insuli‐Like Growth Factor‐1 Signaling Pathway in Rats Delayed by Heshouwuyin
2020 · External reference
Liu Jun Zi Decoction Extends Lifespan and Healthspan Through p16/p21 Signaling in Caenorhabditis elegans
10.1007/s10522-025-10345-5 · 2025 · External reference
Beneficial Effects of the Herbal Medicine Zuo Gui Wan in a Mice Model of Alzheimer's Disease via Drp1‐Mediated Inhibition of Mitochondrial Fission and Activation of AMPK/PGC‐1α‐Regulated Mitochondrial Bioenergetics
10.1016/j.jep.2025.119425 · 2025 · External reference
Research on the Mechanism of Zuogui Wan in Ameliorating Oligoasthenozoospermia in Rats via Modulating Cuproptosis‐Related Pathways
10.1016/j.jep.2025.120990 · 2026 · External reference
Buyang Huanwu Decoction Improves Energy Metabolism Disorders After Cerebral Ischemia‐Reperfusion by Regulating the SIRT1/AMPK Signaling Pathway to Promote Glycolysis and the Tricarboxylic Acid Cycle
10.1186/s13020-025-01163-5 · 2025 · External reference
Metabonomics Study of Jinkui Shenqi Pill Improving Learning and Memory Ability in D‐Galactose‐Induced Aging Rats
2020 · External reference
Study on the Anti‐Skin Aging Effect and Mechanism of Sijunzi Tang Based on Network Pharmacology and Experimental Validation
10.1016/j.jep.2024.118421 · 2024 · External reference
Exploring the Anti‐Ferroptosis Mechanism of Kai‐Xin‐San Against Alzheimer's Disease Through Integrating Network Pharmacology, Bioinformatics, and Experimental Validation Strategy In Vivo and In Vitro
10.1016/j.jep.2024.117915 · 2024 · External reference
Study on Bushen Huoxue Formula Regulating Mitochondrial Respiratory Chain Complexes and ROS/SOD to Improve Ovarian Function in Rats
2025 · External reference
ZiBuPiYin Recipe Prevented and Treated Cognitive Decline in ZDF Rats With Diabetes‐Associated Cognitive Decline via Microbiota‐Gut‐Brain Axis Dialogue
10.3389/fcell.2021.651517 · 2021 · External reference
Liuwei Dihuang Prevents Human Umbilical Vein Endothelial Cells Senescence via the JPX‐STING‐IRF3 Pathway
10.2174/1386207326666230901163717 · 2025 · External reference
Zuogui Pills Ameliorate Chemotherapy‐Induced Ovarian Aging by Improving Stemness, Regulating Cell Cycle and Reducing Apoptosis of Oogonial Stem Cells via the Notch1/Nrf2 Pathway
10.1016/j.jep.2024.119105 · 2025 · External reference
Mechanism Study of Buyang Huanwu Decoction Promoting Autophagy to Inhibit H2O2‐Induced Senescence of Human Umbilical Vein Endothelial Cells
2024 · External reference
Bu‐Fei Decoction Ameliorates Naive CD4(+) T Cell Senescence and Attenuates Age‐Related COPD by Regulating the C1qbp‐cGAS‐STING Signaling Pathway
10.1016/j.phymed.2025.157513 · 2025 · External reference
Jianpi Qingre Tongluo Prescription Alleviates the Senescence‐Associated Secretory Phenotype With Osteoarthritis by Regulating STAG1/TP53/P21 Signaling Pathway
10.1016/j.jep.2024.118953 · 2025 · External reference
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Bazi Bushen Capsule Alleviates Skin Photoaging by Targeting the KEAP1‐NRF2 Pathway
10.1016/j.phymed.2025.157360 · 2025 · External reference
Chinese Herbal Formula, Modified Guilu Erxian Glue, Alleviates Apoptosis of Hematopoietic Stem Cells by Regulating SLAM‐SAP Signal Pathway in Aplastic Anemia Mice Model
10.1016/j.jep.2024.118575 · 2024 · External reference
Bazi Bushen Capsule Attenuates Cognitive Deficits by Inhibiting Microglia Activation and Cellular Senescence
10.1080/13880209.2022.2131839 · 2022 · External reference
Research on the Mechanism of Buyang Huanwu Decoction in the Amelioration of Age‐Associated Memory Impairment Based on the ‘Co‐Occurrence Network Regulation of Intestinal Microecology‐Host Metabolism‐Immune Function’
10.1016/j.jep.2024.118819 · 2025 · External reference
Liuweidihuang Pill Alleviates Inflammation of the Testis via AMPK/SIRT1/NF‐κB Pathway in Aging Rats
10.1155/2020/2792738 · 2020 · External reference
Therapeutic Effect and Mechanism of Yougui Wan in Rats With Intervertebral Disk Degeneration
10.1186/s13018-024-04554-w · 2024 · External reference
Renal Protective Effect and Mechanism of Yishen Huashi Granule on Chronic Glomerulonephritis Model Rats Through miR‐339‐5p Targeted Regulation of TGF‐β1/Smad Pathway
2023 · External reference
Buyang Huanwu Decoction Alleviates Vascular Cognitive Impairment by Inhibiting Neuroinflammation via Regulation of the p53/cGAS/STING Pathway
10.1016/j.jep.2026.121319 · 2026 · External reference
Elucidation of the Potential Molecular Mechanisms of Buyang Huanwu Decoction in Delaying Cardiac Aging: Based on Network Pharmacology, Bioinformatics, and In Vivo/In Vitro Experimental Validation
10.1016/j.jep.2025.120624 · 2026 · External reference
Regulatory Effect of Modified Danggui Buxue Decoction on Immune Function in Aged Mice
1995 · External reference
Research Progress on the Mechanism of Buyang Huanwu Decoction Against Organ Fibrosis
2022 · External reference
Liuwei Dihuang Formula Ameliorates Perimenopausal Atherosclerosis by Modulating the Microbiota‐Dependent TMA‐TMAO Metabolic Axis
10.1016/j.phymed.2025.157318 · 2025 · External reference
Liuwei Dihuang Decoction Alleviates Cognitive Dysfunction in Mice With D‐Galactose‐Induced Aging by Regulating Lipid Metabolism and Oxidative Stress via the Microbiota‐Gut‐Brain Axis
2022 · External reference
Yi‐Shen‐Hua‐Shi Granule Ameliorates Diabetic Kidney Disease by the “Gut‐Kidney Axis”
10.1016/j.jep.2023.116257 · 2023 · External reference
Buyang Huanwu Decoction Modulates the Gut Microbiota‐C/EBPbeta/AEP Axis to Ameliorate Cognitive Impairment in Alzheimer's Disease Mice
10.1111/cns.70480 · 2025 · External reference
Integrative Brain Tissue Metabolomics and Gut Microbiota Sequencing Analysis to Study the Antidepressant Mechanism of Suanzaoren Decoction
2025 · External reference
Niuhuang Qingxin Wan Ameliorates Depressive‐Like Behaviors and Improves Hippocampal Neurogenesis Through Modulating TrkB/ERK/CREB Signaling Pathway in Chronic Restraint Stress or Corticosterone Challenge Mice
10.3389/fphar.2023.1274343 · 2023 · External reference
Clinical Efficacy of Niuhuang Qingxin Wan (Formula From Bureau) in Treating Depressive Disorder and Its Effect on Near‐Infrared Brain Functional Imaging
2025 · External reference
Mitochondrial Dysfunction in Aging
10.1016/j.arr.2023.101955 · 2023 · External reference
Metabolic Function of Autophagy Is Essential for Cell Survival
10.1080/15548627.2023.2165753 · 2023 · External reference
Targeting Mitochondrial Autophagy for Anti‐Aging
10.1038/s41420-025-02913-y · 2025 · External reference
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