Research graph
References from Dual Roles of p53‐Related Protein Kinase in Cytoskeletal Remodeling and Translational Control. Local targets link to admitted publications; unresolved targets remain external evidence.
Cloning and Characterization of a p53‐Related Protein Kinase Expressed in Interleukin‐2‐Activated Cytotoxic T‐Cells, Epithelial Tumor Cell Lines, and the Testes
10.1074/jbc.m105669200 · 2001 · External reference
A Small Ras‐Like Protein Ray/Rab1c Modulates the p53‐Regulating Activity of PRPK
10.1016/j.bbrc.2006.03.071 · 2006 · External reference
Defects in t 6 A tRNA Modification due to GON7 and YRDC Mutations Lead to Galloway‐Mowat Syndrome
10.1038/s41467-019-11951-x · 2019 · External reference
LRRK2 Kinase Regulates α‐Synuclein Propagation via RAB35 Phosphorylation
10.1038/s41467-018-05958-z · 2018 · External reference
A Substrate Binding Model for the KEOPS tRNA Modifying Complex
10.1038/s41467-020-19990-5 · 2020 · External reference
Mutations in KEOPS‐Complex Genes Cause Nephrotic Syndrome With Primary Microcephaly
10.1038/ng.3933 · 2017 · External reference
Kinase/Phosphatase Overexpression Reveals Pathways Regulating Hippocampal Neuron Morphology
10.1038/msb.2010.52 · 2010 · External reference
Novel TP53RK Variants Cause Varied Clinical Features of Galloway–Mowat Syndrome Without Nephrotic Syndrome in Three Unrelated Chinese Patients
10.3389/fnmol.2023.1116949 · 2023 · External reference
Unraveling the Pathobiological Role of the Fungal KEOPS Complex in Cryptococcus neoformans
10.1128/mbio.02944-22 · 2022 · External reference
Identifying TP53RK as a Key Regulator of Colorectal Cancer Survival and a Potential Therapeutic Target
10.1038/s41598-025-21082-7 · 2025 · External reference
Analysis of an 11·6 Kb Region From the Right Arm of Chromosome VII of Saccharomyces cerevisiae Between the RAD2 and the MES1 Genes Reveals the Presence of Three New Genes
10.1002/(sici)1097-0061(19970315)13:3<287::aid-yea75>3.0.co;2-5 · 1997 · External reference
The Human EKC/KEOPS Complex Is Recruited to Cullin2 Ubiquitin Ligases by the Human Tumour Antigen PRAME
10.1371/journal.pone.0042822 · 2012 · External reference
Higher‐Order Substrate Recognition of eIF2α by the RNA‐Dependent Protein Kinase PKR
10.1016/j.cell.2005.06.044 · 2005 · External reference
Gcn4 Misregulation Reveals a Direct Role for the Evolutionary Conserved EKC/KEOPS in the t6A Modification of tRNAs
10.1093/nar/gkr178 · 2011 · External reference
Biosynthesis of Threonylcarbamoyl Adenosine (t6A), a Universal tRNA Nucleoside
10.1074/jbc.m112.344028 · 2012 · External reference
A Genome‐Wide Screen Identifies the Evolutionarily Conserved KEOPS Complex as a Telomere Regulator
10.1016/j.cell.2005.12.044 · 2006 · External reference
Identifying Direct Contacts Between Protein Complex Subunits From Their Conditional Dependence in Proteomics Datasets
10.1371/journal.pcbi.1005625 · 2017 · External reference
The Universal YrdC/Sua5 Family Is Required for the Formation of Threonylcarbamoyladenosine in tRNA
10.1093/nar/gkp152 · 2009 · External reference
Functional Homology Between Yeast piD261/Bud32 and Human PRPK: Both Phosphorylate p53 and PRPK Partially Complements piD261/Bud32 Deficiency
10.1016/s0014-5793(03)00770-1 · 2003 · External reference
Structure‐Function Analysis of Yeast piD261/Bud32, an Atypical Protein Kinase Essential for Normal Cell Life
10.1042/bj20011376 · 2002 · External reference
Phosphorylation and Activation of the Atypical Kinase p53‐Related Protein Kinase (PRPK) by Akt/PKB
10.1007/s00018-007-7179-7 · 2007 · External reference
Acidophilic Character of Yeast PID261/BUD32, a Putative Ancestor of Eukaryotic Protein Kinases
10.1016/s0006-291x(02)02090-9 · 2002 · External reference
Congenital Microcephaly With Hiatus Hernia and Nephrotic Syndrome in Two Sibs
10.1136/jmg.5.4.319 · 1968 · External reference
Identification of TP53RK‐Binding Protein (TPRKB) Dependency in TP53‐Deficient Cancers
10.1158/1541-7786.mcr-19-0144 · 2019 · External reference
Screening E3 Substrates Using a Live Phage Display Library
10.1371/journal.pone.0076622 · 2013 · External reference
Structural Snapshots of Human tRNA Modifying Enzymes
10.1016/j.jmb.2025.169106 · 2025 · External reference
KEOPS Complex Promotes Homologous Recombination via DNA Resection
10.1093/nar/gkz228 · 2019 · External reference
Structure of the Archaeal Kae1/Bud32 Fusion Protein MJ1130: A Model for the Eukaryotic EKC/KEOPS Subcomplex
10.1038/emboj.2008.157 · 2008 · External reference
p53‐Related Protein Kinase Confers Poor Prognosis and Represents a Novel Therapeutic Target in Multiple Myeloma
10.1182/blood-2016-09-738500 · 2017 · External reference
Case Report: Novel Compound Heterozygous TPRKB Variants Cause Galloway‐Mowat Syndrome
10.3389/fped.2024.1360867 · 2024 · External reference
Genetics and Phenotypic Heterogeneity of Galloway‐Mowat Syndrome
10.1186/s12964-025-02307-8 · 2025 · External reference
A Familial Case of Galloway‐Mowat Syndrome due to a Novel TP53RK Mutation: A Case Report
10.1186/s12881-018-0649-y · 2018 · External reference
Drosophila p53‐Related Protein Kinase Is Required for PI3K/TOR Pathway‐Dependent Growth
10.1242/dev.086918 · 2013 · External reference
Unraveling Capsule Biosynthesis and Signaling Networks in Cryptococcus neoformans
10.1128/spectrum.02866-22 · 2022 · External reference
Yeast Homolog of a Cancer‐Testis Antigen Defines a New Transcription Complex
10.1038/sj.emboj.7601235 · 2006 · External reference
Phosphorylation of Rab29 at Ser185 Regulates Its Localization and Role in the Lysosomal Stress Response in Concert With LRRK2
10.1242/jcs.261003 · 2023 · External reference
Mechanism of N6‐Threonylcarbamoyladenonsine (t6A) Biosynthesis: Isolation and Characterization of the Intermediate Threonylcarbamoyl‐AMP
10.1021/bi301233d · 2012 · External reference
Novel Families of Putative Protein Kinases in Bacteria and Archaea: Evolution of the “Eukaryotic” Protein Kinase Superfamily
10.1101/gr.8.10.1038 · 1998 · External reference
Crystal Structure of the Human PRPK‐TPRKB Complex
10.1038/s42003-021-01683-4 · 2021 · External reference
An Extensive Allelic Series of Drosophila kae1 Mutants Reveals Diverse and Tissue‐Specific Requirements for t6A Biogenesis
10.1261/rna.053934.115 · 2015 · External reference
Yeast KEOPS Complex Regulates Telomere Length Independently of Its t6A Modification Function
10.1016/j.jgg.2018.03.004 · 2018 · External reference
Cereblon Is a Direct Protein Target for Immunomodulatory and Antiproliferative Activities of Lenalidomide and Pomalidomide
10.1038/leu.2012.119 · 2012 · External reference
Analysis of the Interaction Between piD261/Bud32, an Evolutionarily Conserved Protein Kinase of Saccharomyces Cerevisiae, and the Grx4 Glutaredoxin
10.1042/bj20030638 · 2004 · External reference
The Kinase Bud32 Regulates Iron Homeostasis in Fungal Pathogen Cryptococcus neoformans
10.3389/fimmu.2025.1624237 · 2025 · External reference
RAB35 Is Required for Murine Hippocampal Development and Functions by Regulating Neuronal Cell Distribution
10.1038/s42003-023-04826-x · 2023 · External reference
New Aspects of a Small GTPase RAB35 in Brain Development and Function
10.4103/nrr.nrr-d-23-01543 · 2025 · External reference
The Protein Kinase Complement of the Human Genome
10.1126/science.1075762 · 2002 · External reference
Atomic Structure of the KEOPS Complex: An Ancient Protein Kinase‐Containing Molecular Machine
10.1016/j.molcel.2008.10.002 · 2008 · External reference
Sua5p a Single‐Stranded Telomeric DNA‐Binding Protein Facilitates Telomere Replication
10.1038/emboj.2009.92 · 2009 · External reference
Identification of CGI‐121, a Novel PRPK (p53‐Related Protein Kinase)‐Binding Protein
10.1016/s0006-291x(03)00333-4 · 2003 · External reference
p53 Related Protein Kinase Is Required for Arp2/3‐Dependent Actin Dynamics of Hemocytes in Drosophila melanogaster
10.3389/fcell.2022.859105 · 2022 · External reference
The Role of Modifications in Codon Discrimination by tRNA Lys UUU
10.1038/nsmb861 · 2004 · External reference
Structures of KEOPS Bound to tRNA Reveal Functional Roles of the Kinase Bud32
10.1038/s41467-024-54787-w · 2024 · External reference
Rabs Set the Stage for Polarity
10.1080/21541248.2016.1277840 · 2018 · External reference
Phosphorylation of the Saccharomyces cerevisiae Grx4p Glutaredoxin by the Bud32p Kinase Unveils a Novel Signaling Pathway Involving Sch9p, a Yeast Member of the Akt / PKB Subfamily
10.1111/j.1742-4658.2008.06721.x · 2008 · External reference
In Vitro Biosynthesis of a Universal t6A tRNA Modification in Archaea and Eukarya
10.1093/nar/gks1287 · 2013 · External reference
Functional Assignment of KEOPS/EKC Complex Subunits in the Biosynthesis of the Universal t6A tRNA Modification
10.1093/nar/gkt720 · 2013 · External reference
Targeting PRPK and TOPK for Skin Cancer Prevention and Therapy
10.1038/s41388-018-0350-9 · 2018 · External reference
Modulation of the Proteostasis Machinery to Overcome Stress Caused by Diminished Levels of t(6)A‐Modified tRNAs in Drosophila
2017 · External reference
The Drosophila EKC/KEOPS Complex: Roles in Protein Synthesis Homeostasis and Animal Growth
10.4161/fly.25227 · 2013 · External reference
The Levels of a Universally Conserved tRNA Modification Regulate Cell Growth
10.1074/jbc.m115.665406 · 2015 · External reference
The Highly Conserved KEOPS/EKC Complex Is Essential for a Universal tRNA Modification, t6A: Proteins Essential for a tRNA Modification, t6A
10.1038/emboj.2010.343 · 2011 · External reference
Biochemical Evidence That Saccharomyces cerevisiae YGR262c Gene, Required for Normal Growth, Encodes a Novel Ser/Thr‐Specific Protein Kinase
10.1016/s0014-5793(97)00980-0 · 1997 · External reference
Diversity of the Biosynthesis Pathway for Threonylcarbamoyladenosine (t6A), a Universal Modification of tRNA
10.4161/15476286.2014.992277 · 2014 · External reference
Global Translational Impacts of the Loss of the tRNA Modification t(6)A in Yeast
10.15698/mic2016.01.473 · 2016 · External reference
Galloway‐Mowat Syndrome: New Insights From Bioinformatics and Expression During Xenopus Embryogenesis
10.1016/j.gep.2021.119215 · 2021 · External reference
Proteomics. Tissue‐Based Map of the Human Proteome
10.1126/science.1260419 · 2015 · External reference
Rab35 Functions in Axon Elongation Are Regulated by P53‐Related Protein Kinase in a Mechanism That Involves Rab35 Protein Degradation and the Microtubule‐Associated Protein 1B
10.1523/jneurosci.4064-15.2016 · 2016 · External reference
Proteomic Analysis of the Human KEOPS Complex Identifies C14ORF142 as a Core Subunit Homologous to Yeast Gon7
10.1093/nar/gkw1181 · 2017 · External reference
Reconstitution and Characterization of Eukaryotic N6‐Threonylcarbamoylation of tRNA Using a Minimal Enzyme System
10.1093/nar/gkt322 · 2013 · External reference
Structural and Functional Characterization of KEOPS Dimerization by Pcc1 and Its Role in t6A Biosynthesis
10.1093/nar/gkw542 · 2016 · External reference
TP53RK Drives the Progression of Chronic Kidney Disease by Phosphorylating Birc5
10.1002/advs.202301753 · 2023 · External reference
A Novel Naphthalimide Compound Restores p53 Function in Non‐Small Cell Lung Cancer by Reorganizing the Bak Center Dot Bcl‐Xl Complex and Triggering Transcriptional Regulation
10.1074/jbc.m115.669978 · 2016 · External reference
Crystal Structures of the Gon7/Pcc1 and Bud32/Cgi121 Complexes Provide a Model for the Complete Yeast KEOPS Complex
10.1093/nar/gkv155 · 2015 · External reference
Molecular Basis of A. thaliana KEOPS Complex in Biosynthesizing tRNA t6A
10.1093/nar/gkae179 · 2024 · External reference
Targeting PRPK Function Blocks Colon Cancer Metastasis
10.1158/1535-7163.mct-17-0628 · 2018 · External reference
The T‐LAK Cell‐Originated Protein Kinase Signal Pathway Promotes Colorectal Cancer Metastasis
10.1016/j.ebiom.2017.04.003 · 2017 · External reference
