References

Lesions of the Rat Perirhinal Cortex Spare the Acquisition of a Complex Configural Visual Discrimination Yet Impair Object Recognition

10.1037/a0018320 · 2010 · External reference

Ventromedial Prefrontal Cortex Is Obligatory for Consolidation and Reconsolidation of Object Recognition Memory

10.1093/cercor/bhj114 · 2006 · External reference

Magnitude of the Object Recognition Deficit Associated With Perirhinal Cortex Damage in Rats: Effects of Varying the Lesion Extent and the Duration of the Sample Period

10.1037/a0013829 · 2009 · External reference

Mitochondrial Control of Fuel Switching via Carnitine Biosynthesis

10.1126/science.ady5532 · 2026 · External reference

Estradiol Rapidly Increases GluA2‐Mushroom Spines and Decreases GluA2‐Filopodia Spines in Hippocampus CA1

10.1002/hipo.22768 · 2017 · External reference

Genetic Reduction of eEF2 Kinase Alleviates Pathophysiology in Alzheimer's Disease Model Mice

10.1172/jci122954 · 2019 · External reference

Impaired Eukaryotic Elongation Factor 1A Expression in Alzheimer's Disease

10.1159/000438925 · 2016 · External reference

Local Cholesterol Metabolism Orchestrates Remyelination

10.1016/j.tins.2022.01.001 · 2022 · External reference

Progressive Impairment of Directional and Spatially Precise Trajectories by TgF344‐Alzheimer's Disease Rats in the Morris Water Task

10.1038/s41598-018-34368-w · 2018 · External reference

Spine Dynamics: Are They All the Same?

10.1016/j.neuron.2017.08.008 · 2017 · External reference

A Synaptic Model of Memory: Long‐Term Potentiation in the Hippocampus

10.1038/361031a0 · 1993 · External reference

Morris Water Maze Test for Learning and Memory Deficits in Alzheimer's Disease Model Mice

2011 · External reference

Memory, Navigation and Theta Rhythm in the Hippocampal‐Entorhinal System

10.1038/nn.3304 · 2013 · External reference

Phosphatidylethanolamine Metabolism in Health and Disease

10.1016/bs.ircmb.2015.10.001 · 2016 · External reference

Plasma GSH Levels and Alzheimer's Disease. A Prospective Approach.: Results From the HELIAD Study

10.1016/j.freeradbiomed.2020.10.027 · 2021 · External reference

Search Strategy Analysis of Tg4‐42 Alzheimer Mice in the Morris Water Maze Reveals Early Spatial Navigation Deficits

10.1038/s41598-022-09270-1 · 2022 · External reference

SwissADME: A Free Web Tool to Evaluate Pharmacokinetics, Drug‐Likeness and Medicinal Chemistry Friendliness of Small Molecules

10.1038/srep42717 · 2017 · External reference

Stress and Glucocorticoids Impair Retrieval of Long‐Term Spatial Memory

10.1038/29542 · 1998 · External reference

Synapse Loss in Frontal Cortex Biopsies in Alzheimer's Disease: Correlation With Cognitive Severity

10.1002/ana.410270502 · 1990 · External reference

The Neuropathological Diagnosis of Alzheimer's Disease

10.1186/s13024-019-0333-5 · 2019 · External reference

Applications of the Morris Water Maze in the Study of Learning and Memory

10.1016/s0165-0173(01)00067-4 · 2001 · External reference

Thematic Review Series: Brain Lipids. Cholesterol Metabolism in the Central Nervous System During Early Development and in the Mature Animal

10.1194/jlr.r400004-jlr200 · 2004 · External reference

Stress‐Induced Memory Retrieval Impairments: Different Time‐Course Involvement of Corticosterone and Glucocorticoid Receptors in Dorsal and Ventral Hippocampus

10.1038/npp.2012.170 · 2012 · External reference

Inborn Errors of Metabolism With Myopathy: Defects of Fatty Acid Oxidation and the Carnitine Shuttle System

10.1016/j.pcl.2017.11.006 · 2018 · External reference

Immune‐Induced Fever Is Mediated by IL‐6 Receptors on Brain Endothelial Cells Coupled to STAT3‐Dependent Induction of Brain Endothelial Prostaglandin Synthesis

10.1523/jneurosci.3520-14.2014 · 2014 · External reference

Discovery of MK‐8722: A Systemic, Direct Pan‐Activator of AMP‐Activated Protein Kinase

10.1021/acsmedchemlett.7b00417 · 2018 · External reference

Glutathione: Overview of Its Protective Roles, Measurement, and Biosynthesis

10.1016/j.mam.2008.08.006 · 2009 · External reference

Stress‐Induced Disturbances in Morris Water‐Maze Performance: Interstrain Variability

10.1016/0031-9384(95)00009-8 · 1995 · External reference

Escalated Handling of Young C57BL/6 Mice Results in Altered Morris Water Maze Performance

10.3109/03009734.2013.847511 · 2014 · External reference

Detailed Classification of Swimming Paths in the Morris Water Maze: Multiple Strategies Within One Trial

10.1038/srep14562 · 2015 · External reference

Synaptic Plasticity in the Hippocampus of a APP/PS1 Mouse Model of Alzheimer's Disease Is Impaired in Old but Not Young Mice

10.1371/journal.pone.0009764 · 2010 · External reference

Combination of Metabolomic and Phospholipid‐Profiling Approaches for the Study of Alzheimer's Disease

10.1016/j.jprot.2014.01.014 · 2014 · External reference

Pyroglutamic Acid Improves the Age Associated Memory Impairment

10.1111/j.1472-8206.1990.tb00485.x · 1990 · External reference

Defective Lipolysis and Altered Energy Metabolism in Mice Lacking Adipose Triglyceride Lipase

10.1126/science.1123965 · 2006 · External reference

On the Delay‐Dependent Involvement of the Hippocampus in Object Recognition Memory

10.1016/j.nlm.2004.03.005 · 2004 · External reference

AMP‐Activated Protein Kinase: An Energy Sensor That Regulates All Aspects of Cell Function

10.1101/gad.17420111 · 2011 · External reference

AMPK—Sensing Energy While Talking to Other Signaling Pathways

10.1016/j.cmet.2014.09.013 · 2014 · External reference

The AMP‐Activated Protein Kinase—Fuel Gauge of the Mammalian Cell?

10.1111/j.1432-1033.1997.00259.x · 1997 · External reference

AMPK: A Nutrient and Energy Sensor That Maintains Energy Homeostasis

10.1038/nrm3311 · 2012 · External reference

Endogenous Anxiety and Stress Responses in Water Maze and Barnes Maze Spatial Memory Tasks

10.1016/j.bbr.2008.10.015 · 2009 · External reference

The Role of Acetylcholine in Learning and Memory

10.1016/j.conb.2006.09.002 · 2006 · External reference

Early Activation of Experience‐Independent Dendritic Spine Turnover in a Mouse Model of Alzheimer's Disease

2017 · External reference

A Large‐Scale Nanoscopy and Biochemistry Analysis of Postsynaptic Dendritic Spines

10.1038/s41593-021-00874-w · 2021 · External reference

The Case for Rejecting the Amyloid Cascade Hypothesis

10.1038/nn.4017 · 2015 · External reference

Recognition of Early Stage Thigmotaxis in Morris Water Maze Test With Convolutional Neural Network

10.1371/journal.pone.0197003 · 2018 · External reference

The Brain Metabolite Kynurenic Acid Inhibits alpha7 Nicotinic Receptor Activity and Increases Non‐alpha7 Nicotinic Receptor Expression: Physiopathological Implications

10.1523/jneurosci.21-19-07463.2001 · 2001 · External reference

Structurally Different Lysophosphatidylethanolamine Species Stimulate Neurite Outgrowth in Cultured Cortical Neurons via Distinct G‐Protein‐Coupled Receptors and Signaling Cascades

10.1016/j.bbrc.2020.11.119 · 2021 · External reference

Alzheimer's Disease: The Challenge of the Second Century

10.1126/scitranslmed.3002369 · 2011 · External reference

PKC Activation During Training Restores Mushroom Spine Synapses and Memory in the Aged Rat

10.1016/j.nbd.2013.03.012 · 2013 · External reference

Dietary Choline Intake Is Beneficial for Cognitive Function and Delays Cognitive Decline: A 22‐Year Large‐Scale Prospective Cohort Study From China Health and Nutrition Survey

10.3390/nu16172845 · 2024 · External reference

Acetylcholine Bidirectionally Regulates Learning and Memory

10.1016/j.jnrt.2022.100002 · 2022 · External reference

APOE ε4 and Alzheimer's Disease Diagnosis Associated Differences in L‐Carnitine, GBB, TMAO, and Acylcarnitines in Blood and Brain

10.1016/j.retram.2022.103362 · 2023 · External reference

Acetyl‐L‐Carnitine Permeability Across the Blood‐Brain Barrier and Involvement of Carnitine Transporter OCTN2

10.1002/bdd.371 · 2003 · External reference

Indirect AMP‐Activated Protein Kinase Activators Prevent Incision‐Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice

10.1124/jpet.119.258400 · 2019 · External reference

Regulation and Function of AMPK in Physiology and Diseases

10.1038/emm.2016.81 · 2016 · External reference

Overactive Neuronal eEF2K/eEF2 Signaling Is Associated With Cognitive Impairment and Apathy‐Like Behavior

10.1038/s41380-025-03408-z · 2025 · External reference

Antagonists Targeting eEF2 Kinase Rescue Multiple Aspects of Pathophysiology in Alzheimer's Disease Model Mice

10.1111/jnc.15562 · 2022 · External reference

Targeted Lipidomics to Measure Phospholipids and Sphingomyelins in Plasma: A Pilot Study to Understand the Impact of Race/Ethnicity in Alzheimer's Disease

10.1021/acs.analchem.1c03821 · 2022 · External reference

Brain Glutathione Levels Associate With Cognitive Performance in Older Adults

10.1111/jnc.70343 · 2026 · External reference

Longitudinal Association Between Phosphatidylcholines, Neuroimaging Measures of Alzheimer's Disease Pathophysiology, and Cognition in the Mayo Clinic Study of Aging

10.1016/j.neurobiolaging.2019.03.005 · 2019 · External reference

Energy Matters: Presynaptic Metabolism and the Maintenance of Synaptic Transmission

10.1038/s41583-021-00535-8 · 2021 · External reference

Carnitine and γ‐Butyrobetaine Stimulate Elimination of Meldonium due to Competition for OCTN2‐Mediated Transport

10.1111/bcpt.12729 · 2017 · External reference

Mitochondrial Dysfunction and Oxidative Stress in Neurodegenerative Diseases

10.1038/nature05292 · 2006 · External reference

Plasma Lipidome Is Dysregulated in Alzheimer's Disease and Is Associated With Disease Risk Genes

10.1038/s41398-021-01362-2 · 2021 · External reference

Recent Evidence for an Expanded Role of the Kynurenine Pathway of Tryptophan Metabolism in Neurological Diseases

10.1016/j.neuropharm.2016.03.024 · 2017 · External reference

Inhibition of AMP‐Activated Protein Kinase Signaling Alleviates Impairments in Hippocampal Synaptic Plasticity Induced by Amyloid β

10.1523/jneurosci.1694-14.2014 · 2014 · External reference

Dysregulation of the mTOR Pathway Mediates Impairment of Synaptic Plasticity in a Mouse Model of Alzheimer's Disease

10.1371/journal.pone.0012845 · 2010 · External reference

Amyloid β: Linking Synaptic Plasticity Failure to Memory Disruption in Alzheimer's Disease

10.1111/j.1471-4159.2011.07506.x · 2012 · External reference

Suppression of eIF2α Kinases Alleviates Alzheimer's Disease–Related Plasticity and Memory Deficits

10.1038/nn.3486 · 2013 · External reference

Spatial and Working Memory Is Linked to Spine Density and Mushroom Spines

10.1371/journal.pone.0139739 · 2015 · External reference

Differential Effects of Structurally Different Lysophosphatidylethanolamine Species on Proliferation and Differentiation in Pre‐Osteoblast MC3T3‐E1 Cells

10.1038/s41598-024-84176-8 · 2025 · External reference

The Long‐Term Potential of LTP

10.1038/nrn1258 · 2003 · External reference

Hippocampal Glutathione Depletion With Enhanced Iron Level in Patients With Mild Cognitive Impairment and Alzheimer's Disease Compared With Healthy Elderly Participants

10.1093/braincomms/fcac215 · 2022 · External reference

AMP‐Activated Protein Kinase Is Essential for the Maintenance of Energy Levels During Synaptic Activation

10.1016/j.isci.2018.10.006 · 2018 · External reference

Mechanisms of Synaptic Dysfunction in Alzheimer's Disease

1995 · External reference

Palmitate Is Increased in the Cerebrospinal Fluid of Humans With Obesity and Induces Memory Impairment in Mice via Pro‐Inflammatory TNF‐α

10.1016/j.celrep.2020.01.072 · 2020 · External reference

AMPK in the Brain: Its Roles in Glucose and Neural Metabolism

10.1111/febs.16151 · 2022 · External reference

Systemic Pan‐AMPK Activator MK‐8722 Improves Glucose Homeostasis but Induces Cardiac Hypertrophy

10.1126/science.aah5582 · 2017 · External reference

Carnitine: Transport and Physiological Functions in the Brain

10.1016/j.mam.2004.06.001 · 2004 · External reference

Cholinergic Modulation of Cognitive Processing: Insights Drawn From Computational Models

10.3389/fnbeh.2012.00024 · 2012 · External reference

Activation of the AMPK Signaling and Brain Function: A Friend or Foe?

10.1111/jnc.70283 · 2025 · External reference

Suppression of Neuronal p27 Impairs Cognitive Function in Middle‐Aged Mice

10.1016/j.nbd.2026.107440 · 2026 · External reference

Selective Corticosteroid Antagonists Modulate Specific Aspects of Spatial Orientation Learning

10.1037/0735-7044.106.1.62 · 1992 · External reference

Dendritic Spines Shape Analysis—Classification or Clusterization? Perspective

10.3389/fnsyn.2020.00031 · 2020 · External reference

Plasma Lipidomics Approach in Early and Specific Alzheimer's Disease Diagnosis

10.3390/jcm11175030 · 2022 · External reference

Metabolic Regulation of Neuronal Plasticity by the Energy Sensor AMPK

10.1371/journal.pone.0008996 · 2010 · External reference

Immune‐To‐Brain Signaling: How Important Are the Blood–Brain Barrier‐Independent Pathways?

10.1007/s12035-008-8026-z · 2008 · External reference

Blood‐Brain Barriers in Obesity

10.1208/s12248-017-0079-3 · 2017 · External reference

Rapid Golgi Analysis Method for Efficient and Unbiased Classification of Dendritic Spines

10.1371/journal.pone.0107591 · 2014 · External reference

Responses of Single Neurons in the Hippocampus of the Macaque Related to Recognition Memory

10.1007/bf00228398 · 1993 · External reference

AMP‐Activated Protein Kinase: A Cellular Energy Sensor That Comes in 12 Flavours

10.1111/febs.13698 · 2016 · External reference

AMP‐Activated Protein Kinase: A Potential Player in Alzheimer's Disease

10.1111/j.1471-4159.2011.07331.x · 2011 · External reference

The Glutathione Cycle Shapes Synaptic Glutamate Activity

10.1073/pnas.1817885116 · 2019 · External reference

Alzheimer's Disease Is a Synaptic Failure

10.1126/science.1074069 · 2002 · External reference

Low Plasma Lysophosphatidylcholines Are Associated With Impaired Mitochondrial Oxidative Capacity in Adults in the Baltimore Longitudinal Study of Aging

10.1111/acel.12915 · 2019 · External reference

The Metabolic Sensor AMPK: Twelve Enzymes in One

10.1016/j.molmet.2024.102042 · 2024 · External reference

Effects of the Excitatory Amino Acid Receptor Antagonists Kynurenate and Indole‐2‐Carboxylic Acid on Behavioral and Neurochemical Outcome Following Experimental Brain Injury

10.1523/jneurosci.13-12-05383.1993 · 1993 · External reference

Age‐Related Changes in Hippocampal AD Pathology, Actin Remodeling Proteins and Spatial Memory Behavior of Male APP/PS1 Mice

10.1016/j.bbr.2019.112182 · 2019 · External reference

Integrated Brain and Plasma Dual‐Channel Metabolomics to Explore the Treatment Effects of Alpinia oxyphylla Fructus on Alzheimer's Disease

10.1371/journal.pone.0285401 · 2023 · External reference

Suppression of Neuronal AMPKβ2 Isoform Impairs Recognition Memory and Synaptic Plasticity

10.1016/j.nbd.2024.106664 · 2024 · External reference

Phosphatidylcholine Ameliorates LPS‐Induced Systemic Inflammation and Cognitive Impairments via Mediating the Gut–Brain Axis Balance

10.1021/acs.jafc.0c06383 · 2020 · External reference

Synaptic Therapy in Alzheimer's Disease: A CREB‐Centric Approach

10.1007/s13311-014-0327-5 · 2015 · External reference

Oxidative Stress, Synaptic Dysfunction, and Alzheimer's Disease

10.3233/jad-161088 · 2017 · External reference

AMPK Is Abnormally Activated in Tangle‐ and Pre‐Tangle‐Bearing Neurons in Alzheimer's Disease and Other Tauopathies

10.1007/s00401-010-0759-x · 2011 · External reference

Morris Water Maze: Procedures for Assessing Spatial and Related Forms of Learning and Memory

10.1038/nprot.2006.116 · 2006 · External reference

Assessing Spatial Learning and Memory in Rodents

10.1093/ilar/ilu013 · 2014 · External reference

Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery

10.1021/acschemneuro.6b00029 · 2016 · External reference

AMPK‐Mediated Regulation of Lipid Metabolism by Phosphorylation

10.1248/bpb.b17-00724 · 2018 · External reference

Decreased Levels of Blood AMPKα1 but Not AMPKα2 Isoform in Patients With Mild Cognitive Impairment and Alzheimer's Disease: A Pilot Study

10.3233/jad-191189 · 2020 · External reference

Therapeutic Potential of AMP‐Activated Protein Kinase in Alzheimer's Disease

10.3233/jad-181043 · 2019 · External reference

Alzheimer's Disease Pathogenesis: Standing at the Crossroad of Lipid Metabolism and Immune Response

10.1186/s13024-025-00857-6 · 2025 · External reference

Blockade of Interleukin‐1 Induced Hyperthermia by Subdiaphragmatic Vagotomy: Evidence for Vagal Mediation of Immune‐Brain Communication

10.1016/0304-3940(94)11105-r · 1995 · External reference

Using Mice to Model Alzheimer's Dementia: An Overview of the Clinical Disease and the Preclinical Behavioral Changes in 10 Mouse Models

10.3389/fgene.2014.00088 · 2014 · External reference

Increased Lysophosphatidylethanolamine and Diacylglycerol Levels in Alzheimer's Disease Plasma

10.47739/2378-9565.alzheimersdisease.1001 · 2014 · External reference

Comprehensive Review of the Expanding Roles of the Carnitine Pool in Metabolic Physiology: Beyond Fatty Acid Oxidation

10.1186/s12967-025-06341-5 · 2025 · External reference

Differential Neuronal Encoding of Novelty, Familiarity and Recency in Regions of the Anterior Temporal Lobe

10.1016/s0028-3908(98)00030-6 · 1998 · External reference

Structural Basis for AMP Binding to Mammalian AMP‐Activated Protein Kinase

10.1038/nature06161 · 2007 · External reference

ULK1‐Regulated AMP Sensing by AMPK and Its Application for the Treatment of Chronic Kidney Disease

10.1016/j.kint.2024.08.024 · 2024 · External reference

Isoform‐Specific Effects of Neuronal Inhibition of AMPK Catalytic Subunit on LTD Impairments in a Mouse Model of Alzheimer's Disease

10.1016/j.neurobiolaging.2024.05.009 · 2024 · External reference

Brain‐Specific Suppression of AMPKα2 Isoform Impairs Cognition and Hippocampal LTP by PERK‐Mediated eIF2α Phosphorylation

10.1038/s41380-020-0739-z · 2021 · External reference

Aged Blood Impairs Hippocampal Neural Precursor Activity and Activates Microglia via Brain Endothelial Cell VCAM1

10.1038/s41591-019-0440-4 · 2019 · External reference

PAN‐AMPK Activation Improves Renal Function in a Rat Model of Progressive Diabetic Nephropathy

10.1124/jpet.119.258244 · 2019 · External reference

Brain‐Specific Repression of AMPKα1 Alleviates Pathophysiology in Alzheimer's Model Mice

10.1172/jci133982 · 2020 · External reference

Kynurenine 3‐Monooxygenase Inhibition in Blood Ameliorates Neurodegeneration

10.1016/j.cell.2011.05.020 · 2011 · External reference