Research graph
References from BBOX1 Deficiency Exacerbates Liver Fibrosis Through Carnitine Biosynthesis Disruption Rescued by Carnitine Supplementation. Local targets link to admitted publications; unresolved targets remain external evidence.
Research and Application of Medicines for Treating Liver Fibrosis: Current Status and Prospects
10.3389/fphar.2025.1582258 · 2025 · External reference
Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease
10.3390/ijms23137280 · 2022 · External reference
RAGE Is a Key Regulator of Ductular Reaction‐Mediated Fibrosis During Cholestasis
2025 · External reference
Comprehensive Review of the Expanding Roles of the Carnitine Pool in Metabolic Physiology: Beyond Fatty Acid Oxidation
10.1186/s12967-025-06341-5 · 2025 · External reference
Genomic Structure, Alternative Maturation and Tissue Expression of the Human BBOX1 Gene
10.1016/j.bbalip.2006.09.014 · 2006 · External reference
CRIP1 Suppresses BBOX1‐Mediated Carnitine Metabolism to Promote Stemness in Hepatocellular Carcinoma
10.15252/embj.2021110218 · 2022 · External reference
BBOX1, LACC1, MMP7 and SSTR1 as Common Predictors in Obesity and Non‐Alcoholic Fatty Liver Disease
10.1016/j.gendis.2024.101310 · 2025 · External reference
Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
10.1124/pr.119.018440 · 2020 · External reference
TRPC6 Suppresses Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation via CaMK4‐CREB Pathway
10.1111/bph.17431 · 2025 · External reference
Understanding the Pathogenetic Mechanisms Underlying Altered Neuronal Function Associated With CAMK2B Mutations
10.1016/j.neubiorev.2023.105299 · 2023 · External reference
Hot and Cold Fibrosis: The Role of Serum Biomarkers to Assess Immune Mechanisms and ECM‐Cell Interactions in Human Fibrosis
10.1016/j.jhep.2025.02.039 · 2025 · External reference
Metabolic Dysfunction‐Associated Steatotic Liver Disease in Adults: A Review
10.1001/jama.2025.19615 · 2026 · External reference
Acetyl‐L‐Carnitine in Hepatic Encephalopathy
10.1007/s11011-013-9376-4 · 2013 · External reference
Rifaximin Prevents T‐Lymphocytes and Macrophages Infiltration in Cerebellum and Restores Motor Incoordination in Rats With Mild Liver Damage
2021 · External reference
Monoacylglycerol Lipase Inhibition Protects From Liver Injury in Mouse Models of Sclerosing Cholangitis
10.1002/hep.30929 · 2020 · External reference
Bile Acids: Emerging Role in Management of Liver Diseases
10.1007/s12072-015-9656-7 · 2015 · External reference
Trimethylamine N‐Oxide: A Meta‐Organismal Axis Linking the Gut and Fibrosis
2024 · External reference
Liver Transplant‐Facilitated CD161(+)Vα7.2(+) MAIT Cell Recovery Demonstrates Clinical Benefits in Hepatic Failure Patients
10.1038/s41467-025-59308-x · 2025 · External reference
Metabolic Dysfunction‐Associated Steatotic Liver Disease: From Pathogenesis to Current Therapeutic Options
10.3390/ijms25115640 · 2024 · External reference
Artemether Ameliorates Non‐Alcoholic Steatohepatitis by Repressing Lipogenesis, Inflammation, and Fibrosis in Mice
10.3389/fphar.2022.851342 · 2022 · External reference
Peroxisome Proliferator‐Activated Receptors Regulate Hepatic Immunity and Assist in the Treatment of Primary Biliary Cholangitis
10.3389/fimmu.2022.940688 · 2022 · External reference
Delta‐Like homolog1/GATA Binding Protein 2 Axis Mediates Leptin Inhibition of PPARγ2 Expression in Hepatic Stellate Cells In Vitro
10.1016/j.lfs.2017.11.050 · 2018 · External reference
State of CD8(+) T Cells in Progression From Nonalcoholic Steatohepatitis to Hepatocellular Carcinoma: From Pathogenesis to Immunotherapy
10.1016/j.biopha.2023.115131 · 2023 · External reference
Mechanosensitive Calcium Ion Channels Piezo1: A Therapeutic Target in Liver Disease
10.1016/j.omtn.2025.102695 · 2025 · External reference
Calcium‐Sensing Receptor: A Potential Target for Liver Health and Diseases
10.1186/s12967-025-07182-y · 2025 · External reference
TRPC6 Is Altered in COVID‐19 Pneumonia
10.1016/j.cbi.2022.109982 · 2022 · External reference
Benzothiazole Amide Analogues as Antagonists of TRPC 6 Channels: A Therapeutic Approach for Kidney Fibrosis
10.1016/j.ejmech.2025.117628 · 2025 · External reference
TRPC6 Inhibition by Z3571: A Structure‐Based Strategy to Ameliorate Glomerular and Tubular Dysfunction in Chronic Kidney Disease
10.1016/j.bcp.2025.117557 · 2026 · External reference
Myocardial Hypertrophy and Fibrosis Are Associated With Cardiomyocyte Beta‐Catenin and TRPC6/Calcineurin/NFAT Signaling in Spontaneously Hypertensive Rats With 5/6 Nephrectomy
10.3390/ijms22094645 · 2021 · External reference
A Novel Transient Receptor Potential C3/C6 Selective Activator Induces the Cellular Uptake of Antisense Oligonucleotides
10.1093/nar/gkae245 · 2024 · External reference
Inflammatory Factor IL1α Induces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/ca(2+)/CaMK2b Pathway
10.1007/s12264-023-01128-4 · 2024 · External reference
Calcium Signaling Induces a Partial EMT
10.15252/embr.202051872 · 2021 · External reference
Structural Mechanism of the Agonist Binding on Human TRPC3 Channel
10.1038/s41467-025-64435-6 · 2025 · External reference
Direct Activation of Human TRPC6 and TRPC3 Channels by Diacylglycerol
10.1038/16711 · 1999 · External reference
GS‐0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease
10.1053/j.gastro.2018.07.027 · 2018 · External reference
Clinical and Molecular Biomarkers for Diagnosis and Staging of NAFLD
10.3390/ijms222111905 · 2021 · External reference
Lipid Alterations in Chronic Liver Disease and Liver Cancer
10.1016/j.jhepr.2022.100479 · 2022 · External reference
Effect of Hypertension on Long‐Term Adverse Clinical Outcomes and Liver Fibrosis Progression in MASLD
10.1016/j.jhep.2025.08.017 · 2026 · External reference
Non‐Alcoholic Fatty Liver Disease: A Multisystem Disease Requiring a Multidisciplinary and Holistic Approach
10.1016/s2468-1253(21)00020-0 · 2021 · External reference
Antineuroinflammatory Effects of Lycopene via Activation of Adenosine Monophosphate‐Activated Protein Kinase‐alpha1/Heme Oxygenase‐1 Pathways
10.1016/j.neurobiolaging.2013.06.020 · 2014 · External reference
CaMKIIdelta Interacts Directly With IKKbeta and Modulates NF‐kappaB Signalling in Adult Cardiac Fibroblasts
10.1016/j.cellsig.2018.07.008 · 2018 · External reference
Isoliensinine Ameliorates Cognitive Dysfunction in AlCl(3)/D‐Gal‐Induced Alzheimer's Disease‐Like Mice by Inhibiting the Calcium Signaling Pathway
10.1016/j.jep.2025.119567 · 2025 · External reference
Ischemic Area‐Targeting and Self‐Monitoring Nanoprobes Ameliorate Myocardial Ischemia/Reperfusion Injury by Scavenging ROS and Counteracting Cardiac Inflammation
2025 · External reference
Transcriptional Regulation of Stress Kinase JNK2 in Pro‐Arrhythmic CaMKIIdelta Expression in the Aged Atrium
10.1093/cvr/cvy011 · 2018 · External reference
Gamma‐Butyrobetaine Hydroxylase (BBOX1) Exerts Suppressive Effects on HepG2 Hepatoblastoma Cells
10.1007/s12032-024-02496-1 · 2024 · External reference
TRP Channels in Cardiac and Intestinal Fibrosis
10.1016/j.semcdb.2018.11.002 · 2019 · External reference
Receptor Channel TRPC6 Orchestrate the Activation of Human Hepatic Stellate Cell Under Hypoxia Condition
10.1016/j.yexcr.2015.03.023 · 2015 · External reference
Metabolic Dysfunction‐Associated Steatotic Liver Disease in Adults: A Review
10.1001/jama.2025.19615 · ExternalCitation · doi-reference
Monoacylglycerol Lipase Inhibition Protects From Liver Injury in Mouse Models of Sclerosing Cholangitis
10.1002/hep.30929 · ExternalCitation · doi-reference
Acetyl‐L‐Carnitine in Hepatic Encephalopathy
10.1007/s11011-013-9376-4 · ExternalCitation · doi-reference
Gamma‐Butyrobetaine Hydroxylase (BBOX1) Exerts Suppressive Effects on HepG2 Hepatoblastoma Cells
10.1007/s12032-024-02496-1 · ExternalCitation · doi-reference
Bile Acids: Emerging Role in Management of Liver Diseases
10.1007/s12072-015-9656-7 · ExternalCitation · doi-reference
Inflammatory Factor IL1α Induces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/ca(2+)/CaMK2b Pathway
10.1007/s12264-023-01128-4 · ExternalCitation · doi-reference
Genomic Structure, Alternative Maturation and Tissue Expression of the Human BBOX1 Gene
10.1016/j.bbalip.2006.09.014 · ExternalCitation · doi-reference
TRPC6 Inhibition by Z3571: A Structure‐Based Strategy to Ameliorate Glomerular and Tubular Dysfunction in Chronic Kidney Disease
10.1016/j.bcp.2025.117557 · ExternalCitation · doi-reference
State of CD8(+) T Cells in Progression From Nonalcoholic Steatohepatitis to Hepatocellular Carcinoma: From Pathogenesis to Immunotherapy
10.1016/j.biopha.2023.115131 · ExternalCitation · doi-reference
TRPC6 Is Altered in COVID‐19 Pneumonia
10.1016/j.cbi.2022.109982 · ExternalCitation · doi-reference
CaMKIIdelta Interacts Directly With IKKbeta and Modulates NF‐kappaB Signalling in Adult Cardiac Fibroblasts
10.1016/j.cellsig.2018.07.008 · ExternalCitation · doi-reference
Benzothiazole Amide Analogues as Antagonists of TRPC 6 Channels: A Therapeutic Approach for Kidney Fibrosis
10.1016/j.ejmech.2025.117628 · ExternalCitation · doi-reference
BBOX1, LACC1, MMP7 and SSTR1 as Common Predictors in Obesity and Non‐Alcoholic Fatty Liver Disease
10.1016/j.gendis.2024.101310 · ExternalCitation · doi-reference
Isoliensinine Ameliorates Cognitive Dysfunction in AlCl(3)/D‐Gal‐Induced Alzheimer's Disease‐Like Mice by Inhibiting the Calcium Signaling Pathway
10.1016/j.jep.2025.119567 · ExternalCitation · doi-reference
Hot and Cold Fibrosis: The Role of Serum Biomarkers to Assess Immune Mechanisms and ECM‐Cell Interactions in Human Fibrosis
10.1016/j.jhep.2025.02.039 · ExternalCitation · doi-reference
Effect of Hypertension on Long‐Term Adverse Clinical Outcomes and Liver Fibrosis Progression in MASLD
10.1016/j.jhep.2025.08.017 · ExternalCitation · doi-reference
Lipid Alterations in Chronic Liver Disease and Liver Cancer
10.1016/j.jhepr.2022.100479 · ExternalCitation · doi-reference
Delta‐Like homolog1/GATA Binding Protein 2 Axis Mediates Leptin Inhibition of PPARγ2 Expression in Hepatic Stellate Cells In Vitro
10.1016/j.lfs.2017.11.050 · ExternalCitation · doi-reference
Understanding the Pathogenetic Mechanisms Underlying Altered Neuronal Function Associated With CAMK2B Mutations
10.1016/j.neubiorev.2023.105299 · ExternalCitation · doi-reference
Antineuroinflammatory Effects of Lycopene via Activation of Adenosine Monophosphate‐Activated Protein Kinase‐alpha1/Heme Oxygenase‐1 Pathways
10.1016/j.neurobiolaging.2013.06.020 · ExternalCitation · doi-reference
Mechanosensitive Calcium Ion Channels Piezo1: A Therapeutic Target in Liver Disease
10.1016/j.omtn.2025.102695 · ExternalCitation · doi-reference
TRP Channels in Cardiac and Intestinal Fibrosis
10.1016/j.semcdb.2018.11.002 · ExternalCitation · doi-reference
Receptor Channel TRPC6 Orchestrate the Activation of Human Hepatic Stellate Cell Under Hypoxia Condition
10.1016/j.yexcr.2015.03.023 · ExternalCitation · doi-reference
Non‐Alcoholic Fatty Liver Disease: A Multisystem Disease Requiring a Multidisciplinary and Holistic Approach
10.1016/s2468-1253(21)00020-0 · ExternalCitation · doi-reference
Direct Activation of Human TRPC6 and TRPC3 Channels by Diacylglycerol
10.1038/16711 · ExternalCitation · doi-reference
Liver Transplant‐Facilitated CD161(+)Vα7.2(+) MAIT Cell Recovery Demonstrates Clinical Benefits in Hepatic Failure Patients
10.1038/s41467-025-59308-x · ExternalCitation · doi-reference
Structural Mechanism of the Agonist Binding on Human TRPC3 Channel
10.1038/s41467-025-64435-6 · ExternalCitation · doi-reference
GS‐0976 Reduces Hepatic Steatosis and Fibrosis Markers in Patients With Nonalcoholic Fatty Liver Disease
10.1053/j.gastro.2018.07.027 · ExternalCitation · doi-reference
Transcriptional Regulation of Stress Kinase JNK2 in Pro‐Arrhythmic CaMKIIdelta Expression in the Aged Atrium
10.1093/cvr/cvy011 · ExternalCitation · doi-reference
A Novel Transient Receptor Potential C3/C6 Selective Activator Induces the Cellular Uptake of Antisense Oligonucleotides
10.1093/nar/gkae245 · ExternalCitation · doi-reference
TRPC6 Suppresses Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation via CaMK4‐CREB Pathway
10.1111/bph.17431 · ExternalCitation · doi-reference
Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
10.1124/pr.119.018440 · ExternalCitation · doi-reference
Comprehensive Review of the Expanding Roles of the Carnitine Pool in Metabolic Physiology: Beyond Fatty Acid Oxidation
10.1186/s12967-025-06341-5 · ExternalCitation · doi-reference
Calcium‐Sensing Receptor: A Potential Target for Liver Health and Diseases
10.1186/s12967-025-07182-y · ExternalCitation · doi-reference
CRIP1 Suppresses BBOX1‐Mediated Carnitine Metabolism to Promote Stemness in Hepatocellular Carcinoma
10.15252/embj.2021110218 · ExternalCitation · doi-reference
Calcium Signaling Induces a Partial EMT
10.15252/embr.202051872 · ExternalCitation · doi-reference
Peroxisome Proliferator‐Activated Receptors Regulate Hepatic Immunity and Assist in the Treatment of Primary Biliary Cholangitis
10.3389/fimmu.2022.940688 · ExternalCitation · doi-reference
Artemether Ameliorates Non‐Alcoholic Steatohepatitis by Repressing Lipogenesis, Inflammation, and Fibrosis in Mice
10.3389/fphar.2022.851342 · ExternalCitation · doi-reference
Research and Application of Medicines for Treating Liver Fibrosis: Current Status and Prospects
10.3389/fphar.2025.1582258 · ExternalCitation · doi-reference
Myocardial Hypertrophy and Fibrosis Are Associated With Cardiomyocyte Beta‐Catenin and TRPC6/Calcineurin/NFAT Signaling in Spontaneously Hypertensive Rats With 5/6 Nephrectomy
10.3390/ijms22094645 · ExternalCitation · doi-reference
Clinical and Molecular Biomarkers for Diagnosis and Staging of NAFLD
10.3390/ijms222111905 · ExternalCitation · doi-reference
Mitochondrial Dysfunction Plays Central Role in Nonalcoholic Fatty Liver Disease
10.3390/ijms23137280 · ExternalCitation · doi-reference
Metabolic Dysfunction‐Associated Steatotic Liver Disease: From Pathogenesis to Current Therapeutic Options
10.3390/ijms25115640 · ExternalCitation · doi-reference
