Research graph
References from Theoretical study on the catalytic mechanism of oxyluciferin hydrolysis by luciferin‐regenerating enzyme in firefly bioluminescence substrate regeneration. Local targets link to admitted publications; unresolved targets remain external evidence.
Real‐time bioluminescence imaging of nitroreductase in mouse model
10.1021/acs.analchem.6b01160 · 2016 · External reference
Mechanism‐based design of a photoactivatable firefly luciferase
10.1021/ja4013535 · 2013 · External reference
An allylated firefly luciferin analogue with luciferase specific response in living cells
10.1039/c7cc09720d · 2018 · External reference
Bioluminescence color‐tuning firefly luciferases: engineering and prospects for real‐time intracellular pH imaging and heavy metal biosensing
10.3390/bios12060400 · 2022 · External reference
Firefly bioluminescence quantum yield and colour change by pH‐sensitive green emission
10.1038/nphoton.2007.251 · 2007 · External reference
Design and synthesis of an alkynyl luciferin analogue for bioluminescence imaging
10.1002/chem.201503944 · 2016 · External reference
Quantum yield of near‐infrared bioluminescence with firefly luciferin analog: AkaLumine
10.1016/j.jphotochem.2022.114270 · 2023 · External reference
A dual‐color far‐red to near‐infrared firefly luciferin analogue designed for multiparametric bioluminescence imaging
10.1002/anie.201405955 · 2014 · External reference
Discovery of red‐shifting mutations in Firefly luciferase using high‐throughput biochemistry
10.1021/acs.biochem.3c00708 · 2024 · External reference
A highly efficient, thermostable and cadmium selective firefly luciferase suitable for ratiometric metal and pH biosensing and for sensitive ATP assays
10.1039/c9pp00174c · 2020 · External reference
Kinetics of the firefly luciferase catalyzed reactions
10.1021/bi00702a015 · 1974 · External reference
The production of oxyluciferin during the firefly luciferase light reaction
10.1016/0003-9861(75)90205-2 · 1975 · External reference
Kinetics of inhibition of firefly luciferase by oxyluciferin and dehydroluciferyl‐adenylate
10.1039/b809935a · 2008 · External reference
Female preference for male courtship flashes in Photinus ignitus fireflies
10.1093/beheco/14.1.135 · 2003 · External reference
Oxyluciferin, a luminescence product of firefly luciferase, is enzymatically regenerated into luciferin
10.1074/jbc.m105528200 · 2001 · External reference
Firefly bioluminescence III. Conversion of oxyluciferin to luciferin in firefly
10.1016/s0040-4039(01)91738-1 · 1974 · External reference
Biosynthesis of luciferin in Pyrophorus pellucens
10.1039/c39760000153 · 1976 · External reference
Realization of firefly bioluminescence cycle in vitro and in cells
10.1016/j.bios.2022.114860 · 2023 · External reference
Stereoisomeric bio‐inversion key to biosynthesis of firefly D‐luciferin
10.1016/j.febslet.2006.08.073 · 2006 · External reference
Firefly luciferase exhibits bimodal action depending on the luciferin chirality
10.1016/j.bbrc.2005.03.202 · 2005 · External reference
Conformational dynamics in the acyl‐CoA synthetases, adenylation domains of non‐ribosomal peptide synthetases, and firefly luciferase
10.1021/cb900156h · 2009 · External reference
Luciferin regeneration in Firefly bioluminescence via proton‐transfer‐facilitated hydrolysis, condensation and chiral inversion
10.1002/cphc.201900306 · 2019 · External reference
RACE‐based amplification of cDNA and expression of a luciferin‐regenerating enzyme (LRE): an attempt towards persistent bioluminescent signal
10.1016/j.enzmictec.2010.05.008 · 2010 · External reference
Applications of luciferin biosynthesis: bioluminescence assays for L‐cysteine and luciferase
10.1016/j.ab.2009.09.014 · 2010 · External reference
Biosynthesis‐inspired deracemizative production of d‐luciferin by combining luciferase and thioesterase
10.1016/j.bbagen.2017.04.010 · 2017 · External reference
Mechanistic model for the firefly luciferin regeneration in biomimetic conditions: a model for the in vivo process?
10.1039/c7ob00603a · 2017 · External reference
A biocompatible, highly efficient click reaction and its applications
10.1039/c3ob41241e · 2014 · External reference
Genomic and experimental data provide new insights into luciferin biosynthesis and bioluminescence evolution in fireflies
10.1038/s41598-020-72900-z · 2020 · External reference
An isomorphous replacement method for efficient de novo phasing for serial femtosecond crystallography
10.1038/srep14017 · 2015 · External reference
H++: a server for estimating pKas and adding missing hydrogens to macromolecules
10.1093/nar/gki464 · 2005 · External reference
Firefly luciferase is targeted to peroxisomes in mammalian cells
10.1073/pnas.84.10.3264 · 1987 · External reference
Peroxisomes in human fibroblasts have a basic pH
10.1038/71375 · 2000 · External reference
AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings
10.1021/acs.jcim.1c00203 · 2021 · External reference
Addressing docking pose selection with structure‐based deep learning: recent advances, challenges and opportunities
10.1016/j.csbj.2024.05.024 · 2024 · External reference
Engineering of an ancestral McbA with enhanced domain mobility extends biocatalytic amide synthesis scope
10.1002/adsc.70232 · 2026 · External reference
PUR‐GEN: a web server for automated generation of polyurethane fragment libraries
10.1016/j.csbj.2024.12.004 · 2024 · External reference
ff19SB: amino‐acid‐specific protein backbone parameters trained against quantum mechanics energy surfaces in solution
10.1021/acs.jctc.9b00591 · 2019 · External reference
Development and testing of a general amber force field
10.1002/jcc.20035 · 2004 · External reference
Unresolved reference
2009 · External reference
Application of the multimolecule and multiconformational RESP methodology to biopolymers: charge derivation for DNA, RNA, and proteins
10.1002/jcc.540161106 · 1995 · External reference
Comparison of simple potential functions for simulating liquid water
10.1063/1.445869 · 1983 · External reference
Langevin stabilization of molecular dynamics
10.1063/1.1332996 · 2001 · External reference
Molecular dynamics with coupling to an external bath
10.1063/1.448118 · 1984 · External reference
Particle mesh Ewald: an N·log(N) method for Ewald sums in large systems
10.1063/1.464397 · 1993 · External reference
Numerical integration of the cartesian equations of motion of a system with constraints: molecular dynamics of n‐alkanes
1977 · External reference
Unresolved reference
2021 · External reference
Fast and accurate predictions of binding free energies using MM‐PBSA and MM‐GBSA
10.1002/jcc.21372 · 2010 · External reference
Crystal structure of firefly luciferase in a second catalytic conformation supports a domain alternation mechanism
10.1021/bi300934s · 2012 · External reference
Hybrid models for combined quantum mechanical and molecular mechanical approaches
10.1021/jp9536514 · 1996 · External reference
Conformational diversity induces nanosecond‐timescale chemical disorder in the HIV‐1 protease reaction pathway
10.1039/c9sc01464k · 2019 · External reference
QUASI: a general purpose implementation of the QM/MM approach and its application to problems in catalysis
10.1016/s0166-1280(03)00285-9 · 2003 · External reference
ChemShell—a modular software package for QM/MM simulations
10.1002/wcms.1163 · 2013 · External reference
Software update: the ORCA program system—version 5.0
10.1002/wcms.1606 · 2022 · External reference
DL_POLY_2.0: a general‐purpose parallel molecular dynamics simulation package
10.1016/s0263-7855(96)00043-4 · 1996 · External reference
TeraChem: a graphical processing unit‐accelerated electronic structure package for large‐scale ab initio molecular dynamics
10.1002/wcms.1494 · 2021 · External reference
Investigation of the interaction between firefly luciferase and oxyluciferin or its analogues by steady state and subnanosecond time‐resolved fluorescence
10.1016/1011-1344(93)06970-e · 1994 · External reference
Engineering of an ancestral McbA with enhanced domain mobility extends biocatalytic amide synthesis scope
10.1002/adsc.70232 · ExternalCitation · doi-reference
A dual‐color far‐red to near‐infrared firefly luciferin analogue designed for multiparametric bioluminescence imaging
10.1002/anie.201405955 · ExternalCitation · doi-reference
Design and synthesis of an alkynyl luciferin analogue for bioluminescence imaging
10.1002/chem.201503944 · ExternalCitation · doi-reference
Luciferin regeneration in Firefly bioluminescence via proton‐transfer‐facilitated hydrolysis, condensation and chiral inversion
10.1002/cphc.201900306 · ExternalCitation · doi-reference
Development and testing of a general amber force field
10.1002/jcc.20035 · ExternalCitation · doi-reference
Fast and accurate predictions of binding free energies using MM‐PBSA and MM‐GBSA
10.1002/jcc.21372 · ExternalCitation · doi-reference
Application of the multimolecule and multiconformational RESP methodology to biopolymers: charge derivation for DNA, RNA, and proteins
10.1002/jcc.540161106 · ExternalCitation · doi-reference
ChemShell—a modular software package for QM/MM simulations
10.1002/wcms.1163 · ExternalCitation · doi-reference
TeraChem: a graphical processing unit‐accelerated electronic structure package for large‐scale ab initio molecular dynamics
10.1002/wcms.1494 · ExternalCitation · doi-reference
Software update: the ORCA program system—version 5.0
10.1002/wcms.1606 · ExternalCitation · doi-reference
The production of oxyluciferin during the firefly luciferase light reaction
10.1016/0003-9861(75)90205-2 · ExternalCitation · doi-reference
Investigation of the interaction between firefly luciferase and oxyluciferin or its analogues by steady state and subnanosecond time‐resolved fluorescence
10.1016/1011-1344(93)06970-e · ExternalCitation · doi-reference
Applications of luciferin biosynthesis: bioluminescence assays for L‐cysteine and luciferase
10.1016/j.ab.2009.09.014 · ExternalCitation · doi-reference
Biosynthesis‐inspired deracemizative production of d‐luciferin by combining luciferase and thioesterase
10.1016/j.bbagen.2017.04.010 · ExternalCitation · doi-reference
Firefly luciferase exhibits bimodal action depending on the luciferin chirality
10.1016/j.bbrc.2005.03.202 · ExternalCitation · doi-reference
Realization of firefly bioluminescence cycle in vitro and in cells
10.1016/j.bios.2022.114860 · ExternalCitation · doi-reference
Addressing docking pose selection with structure‐based deep learning: recent advances, challenges and opportunities
10.1016/j.csbj.2024.05.024 · ExternalCitation · doi-reference
PUR‐GEN: a web server for automated generation of polyurethane fragment libraries
10.1016/j.csbj.2024.12.004 · ExternalCitation · doi-reference
RACE‐based amplification of cDNA and expression of a luciferin‐regenerating enzyme (LRE): an attempt towards persistent bioluminescent signal
10.1016/j.enzmictec.2010.05.008 · ExternalCitation · doi-reference
Stereoisomeric bio‐inversion key to biosynthesis of firefly D‐luciferin
10.1016/j.febslet.2006.08.073 · ExternalCitation · doi-reference
Quantum yield of near‐infrared bioluminescence with firefly luciferin analog: AkaLumine
10.1016/j.jphotochem.2022.114270 · ExternalCitation · doi-reference
Firefly bioluminescence III. Conversion of oxyluciferin to luciferin in firefly
10.1016/s0040-4039(01)91738-1 · ExternalCitation · doi-reference
QUASI: a general purpose implementation of the QM/MM approach and its application to problems in catalysis
10.1016/s0166-1280(03)00285-9 · ExternalCitation · doi-reference
DL_POLY_2.0: a general‐purpose parallel molecular dynamics simulation package
10.1016/s0263-7855(96)00043-4 · ExternalCitation · doi-reference
Real‐time bioluminescence imaging of nitroreductase in mouse model
10.1021/acs.analchem.6b01160 · ExternalCitation · doi-reference
Discovery of red‐shifting mutations in Firefly luciferase using high‐throughput biochemistry
10.1021/acs.biochem.3c00708 · ExternalCitation · doi-reference
AutoDock Vina 1.2.0: new docking methods, expanded force field, and python bindings
10.1021/acs.jcim.1c00203 · ExternalCitation · doi-reference
ff19SB: amino‐acid‐specific protein backbone parameters trained against quantum mechanics energy surfaces in solution
10.1021/acs.jctc.9b00591 · ExternalCitation · doi-reference
Kinetics of the firefly luciferase catalyzed reactions
10.1021/bi00702a015 · ExternalCitation · doi-reference
Crystal structure of firefly luciferase in a second catalytic conformation supports a domain alternation mechanism
10.1021/bi300934s · ExternalCitation · doi-reference
Conformational dynamics in the acyl‐CoA synthetases, adenylation domains of non‐ribosomal peptide synthetases, and firefly luciferase
10.1021/cb900156h · ExternalCitation · doi-reference
Mechanism‐based design of a photoactivatable firefly luciferase
10.1021/ja4013535 · ExternalCitation · doi-reference
Hybrid models for combined quantum mechanical and molecular mechanical approaches
10.1021/jp9536514 · ExternalCitation · doi-reference
Peroxisomes in human fibroblasts have a basic pH
10.1038/71375 · ExternalCitation · doi-reference
Firefly bioluminescence quantum yield and colour change by pH‐sensitive green emission
10.1038/nphoton.2007.251 · ExternalCitation · doi-reference
Genomic and experimental data provide new insights into luciferin biosynthesis and bioluminescence evolution in fireflies
10.1038/s41598-020-72900-z · ExternalCitation · doi-reference
An isomorphous replacement method for efficient de novo phasing for serial femtosecond crystallography
10.1038/srep14017 · ExternalCitation · doi-reference
Kinetics of inhibition of firefly luciferase by oxyluciferin and dehydroluciferyl‐adenylate
10.1039/b809935a · ExternalCitation · doi-reference
Biosynthesis of luciferin in Pyrophorus pellucens
10.1039/c39760000153 · ExternalCitation · doi-reference
A biocompatible, highly efficient click reaction and its applications
10.1039/c3ob41241e · ExternalCitation · doi-reference
An allylated firefly luciferin analogue with luciferase specific response in living cells
10.1039/c7cc09720d · ExternalCitation · doi-reference
Mechanistic model for the firefly luciferin regeneration in biomimetic conditions: a model for the in vivo process?
10.1039/c7ob00603a · ExternalCitation · doi-reference
A highly efficient, thermostable and cadmium selective firefly luciferase suitable for ratiometric metal and pH biosensing and for sensitive ATP assays
10.1039/c9pp00174c · ExternalCitation · doi-reference
Conformational diversity induces nanosecond‐timescale chemical disorder in the HIV‐1 protease reaction pathway
10.1039/c9sc01464k · ExternalCitation · doi-reference
Langevin stabilization of molecular dynamics
10.1063/1.1332996 · ExternalCitation · doi-reference
Comparison of simple potential functions for simulating liquid water
10.1063/1.445869 · ExternalCitation · doi-reference
Molecular dynamics with coupling to an external bath
10.1063/1.448118 · ExternalCitation · doi-reference
Particle mesh Ewald: an N·log(N) method for Ewald sums in large systems
10.1063/1.464397 · ExternalCitation · doi-reference
Firefly luciferase is targeted to peroxisomes in mammalian cells
10.1073/pnas.84.10.3264 · ExternalCitation · doi-reference
Oxyluciferin, a luminescence product of firefly luciferase, is enzymatically regenerated into luciferin
10.1074/jbc.m105528200 · ExternalCitation · doi-reference
Female preference for male courtship flashes in Photinus ignitus fireflies
10.1093/beheco/14.1.135 · ExternalCitation · doi-reference
H++: a server for estimating pKas and adding missing hydrogens to macromolecules
10.1093/nar/gki464 · ExternalCitation · doi-reference
Bioluminescence color‐tuning firefly luciferases: engineering and prospects for real‐time intracellular pH imaging and heavy metal biosensing
10.3390/bios12060400 · ExternalCitation · doi-reference
