Research graph
References from Red blood cell transfusion in sickle cell disease: From clinical necessity to immunological complexity. Local targets link to admitted publications; unresolved targets remain external evidence.
Sickle cell disease, a review
10.3390/hemato3020024 · 2022 · External reference
Recommendations for the use of red blood cell exchange in sickle cell disease
10.1016/j.transci.2019.03.004 · 2019 · External reference
Sickle cell disease update: new treatments and challenging nutritional interventions
10.3390/nu16020258 · 2024 · External reference
Infection and potential challenge of childhood mortality in sickle cell disease: a comprehensive review of the literature from a global perspective
10.3390/thalassrep13030019 · 2023 · External reference
Infection in sickle cell disease: a review
10.1016/j.ijid.2009.03.010 · 2010 · External reference
Sickle cell disease—genetics, pathophysiology, clinical presentation and treatment
10.3390/ijns5020020 · 2019 · External reference
Sickle cell disease in Africa: a neglected cause of early childhood mortality
10.1016/j.amepre.2011.09.013 · 2011 · External reference
Global burden of sickle cell anaemia in children under five, 2010‐2050: modelling based on demographics, excess mortality, and interventions
10.1371/journal.pmed.1001484 · 2013 · External reference
Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model‐based map and population estimates
10.1016/s0140-6736(12)61229-x · 2013 · External reference
World sickle cell day 2016: a time for appraisal
10.4103/0971-5916.191917 · 2016 · External reference
Sickle cell disease in tribal populations in India
10.4103/0971-5916.159492 · 2015 · External reference
Epidemiology of sickle cell disease in Saudi Arabia
10.4103/0256-4947.81540 · 2011 · External reference
Marked regional variations in the prevalence of sickle cell disease and beta‐thalassemia in Saudi Arabia: findings from the premarital screening and genetic counseling program
10.1016/j.jegh.2011.06.002 · 2011 · External reference
Comparative study between chronic automated red blood cell exchange and manual exchange transfusion in patients with sickle cell disease: a single‐center experience from Saudi Arabia
10.4103/ajts.ajts_13_21 · 2023 · External reference
Position paper on the management of sickle cell disease in Saudi Arabia: understanding disease landscape, identifying challenges, and exploring opportunities in transfusion therapies
10.3390/jcm14103494 · 2025 · External reference
The burden of sickle cell disease in Saudi Arabia: a single‐institution large retrospective study
10.2147/ijgm.s393233 · 2023 · External reference
Sickle cell disease in children and adolescents: a review of the historical, clinical, and public health perspective of sub‐Saharan Africa and beyond
10.1155/2022/3885979 · 2022 · External reference
Red cell alloimmunization in sickle‐cell anaemia patients
10.26719/2007.13.5.1181 · 2007 · External reference
Red cell alloimmunization and autoimmunization among sickle cell disease and thalassemia patients in Jazan Province, Saudi Arabia
10.2147/ijgm.s360320 · 2022 · External reference
Red blood cell alloimmunization and autoimmunization in blood transfusion‐dependent sickle cell disease and beta‐thalassemia patients in Al‐Ahsa region, Saudi Arabia
10.1155/2023/3239960 · 2023 · External reference
Red cell alloimmunisation among sickle cell disease and thalassemia patients following Rh‐ and K‐matched red cell transfusion in southwestern Saudi Arabia: a multicenter study
10.2147/ijgm.s444949 · 2024 · External reference
The prevalence of transfusion‐transmitted infections and nucleic acid testing among blood donors in Majmaah, Saudi Arabia
10.1016/j.jiph.2018.04.008 · 2018 · External reference
Prevalence of transfusion‐transmitted infections in Saudi Arabia blood donors: a nationwide, cross‐sectional study
10.15537/smj.2022.43.12.20220634 · 2022 · External reference
Seroprevalence of transfusion‐transmitted infections among blood donors in Makkah, Saudi Arabia
10.3855/jidc.19559 · 2024 · External reference
Indications and complications of transfusions in sickle cell disease
10.1002/pbc.24179 · 2012 · External reference
Parvovirus B19 infection in children with sickle cell disease in the hydroxyurea era
10.1177/1535370216636723 · 2016 · External reference
Patterns of blood transfusion in sickle cell disease hospitalizations
10.3390/hemato5010004 · 2024 · External reference
Prospects for primary stroke prevention in children with sickle cell anaemia
10.1111/j.1365-2141.2011.09005.x · 2012 · External reference
Neurovascular manifestations of sickle cell disease
10.3390/hemato5030023 · 2024 · External reference
Asthma is an independent risk factor for acute chest syndrome in children with sickle cell disease in French Guiana
10.3390/children11121541 · 2024 · External reference
Clinical insights into sickle cell disease: a comprehensive multicenter retrospective analysis of clinical characteristics and outcomes across different age groups
10.3390/jcm13237224 · 2024 · External reference
Hemolytic transfusion reactions in sickle cell disease: underappreciated and potentially fatal
10.3324/haematol.2019.224709 · 2020 · External reference
Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews
2018 · External reference
Simple chronic transfusion therapy, a crucial therapeutic option for sickle cell disease, improves but does not normalize blood rheology: what should be our goals for transfusion therapy?
10.3233/ch-189006 · 2018 · External reference
Impact of red cell exchange transfusion on inflammatory markers in sickle cell disease
10.4084/mjhid.2025.011 · 2025 · External reference
Guidelines for the early management of patients with acute ischemic stroke: 2019 update to the 2018 guidelines
10.1161/str.0000000000000211 · 2019 · External reference
Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease
10.1182/blood-2010-01-261123 · 2011 · External reference
Controlled trial of transfusions for silent cerebral infarcts in sickle cell anemia
10.1056/nejmoa1401731 · 2014 · External reference
Design of the Silent Cerebral Infarct Transfusion (SIT) trial
10.3109/08880010903360367 · 2010 · External reference
Exchange versus simple transfusion for acute chest syndrome in sickle cell anemia adults
10.1111/j.1537-2995.2008.02075.x · 2009 · External reference
Triaging acute chest syndrome clinical decision‐making using bedside SaO2/FiO2 ratio
10.1182/blood-2024-199293 · 2024 · External reference
Acute chest syndrome in sickle cell disease
10.1016/j.tmrv.2023.150755 · 2023 · External reference
Long‐term secondary prevention: management of blood pressure after a transient ischemic attack or stroke
10.1161/strokeaha.121.035851 · 2022 · External reference
Clinical practice: secondary prevention after ischemic stroke or transient ischemic attack
10.1056/nejmcp1107281 · 2012 · External reference
Secondary stroke prevention
10.1016/s1474-4422(13)70255-2 · 2014 · External reference
Hope on the horizon: new and future therapies for sickle cell disease
10.3390/jcm12175692 · 2023 · External reference
Beyond ischemia: the rare occurrence of hemorrhagic strokes in pediatric sickle cell anemia
2024 · External reference
Stroke in sickle cell disease and the promise of recent disease‐modifying agents
10.1016/j.jns.2022.120412 · 2022 · External reference
Thrombo‐inflammation in COVID‐19 and sickle cell disease: two faces of the same coin
2023 · External reference
Blood transfusion utilization in patients with severe coronavirus disease 2019 in the Republic of Korea: a nationwide population‐based study
10.3390/jcm13237327 · 2024 · External reference
Acute chest syndrome: sickle cell disease
10.1111/j.1600-0609.2011.01647.x · 2011 · External reference
Perioperative management of sickle cell disease
10.4084/mjhid.2018.032 · 2018 · External reference
Preoperative transfusion in patients with sickle‐cell disease
10.1016/s0140-6736(12)61995-3 · 2013 · External reference
The transfusion alternatives preoperatively in sickle cell disease (TAPS) study: a randomised, controlled, multicentre clinical trial
10.1016/s0140-6736(12)61726-7 · 2013 · External reference
Mechanisms of bone impairment in sickle bone disease
10.3390/ijerph18041832 · 2021 · External reference
The current role of hydroxyurea in the treatment of sickle cell anemia
10.3390/jcm13216404 · 2024 · External reference
Newer modalities and updates in the management of sickle cell disease: a systematic review
10.2147/jbm.s477507 · 2024 · External reference
From stress to sick(le) and back again—oxidative/antioxidant mechanisms, genetic modulation, and cerebrovascular disease in children with sickle cell anemia
10.3390/antiox12111977 · 2023 · External reference
Fat embolism syndrome in sickle cell disease
10.3390/jcm9113601 · 2020 · External reference
Psychosocial challenges of persons with sickle cell anemia: a narrative review
10.1097/md.0000000000036147 · 2023 · External reference
Red blood cell exchange in patients with sickle cell disease—indications and management: a review and consensus report by the therapeutic apheresis subsection of the AABB
10.1111/trf.14806 · 2018 · External reference
Transfusion therapy in children with sickle cell disease
10.1097/mph.0000000000000645 · 2017 · External reference
Vaso‐occlusive crisis in sickle cell disease: a vicious cycle of secondary events
10.1186/s12967-021-03074-z · 2021 · External reference
Targeting novel mechanisms of pain in sickle cell disease
10.1182/blood-2017-05-782003 · 2017 · External reference
Sickle cell anemia and its phenotypes
10.1146/annurev-genom-083117-021320 · 2018 · External reference
Risk factors for acute chest syndrome among children with sickle cell anemia hospitalized for vaso‐occlusive crises
10.1038/s41598-023-48527-1 · 2024 · External reference
Platelets decline during vaso‐occlusive crisis as a predictor of acute chest syndrome in sickle cell disease
10.1002/ajh.24214 · 2015 · External reference
Ischemia‐reperfusion injury in sickle cell disease: from basics to therapeutics
10.1016/j.ajpath.2018.12.012 · 2019 · External reference
Organ failure due to systemic injury in acute pancreatitis
10.1053/j.gastro.2018.12.041 · 2019 · External reference
Unraveling the complex genomic interplay of sickle cell disease among the Saudi population: a case‐control GWAS analysis
10.3390/ijms26062817 · 2025 · External reference
Current and future therapeutics for treating patients with sickle cell disease
10.3390/cells13100848 · 2024 · External reference
Newborn screening for sickle cell disease: Indian experience
10.3390/ijns4040031 · 2018 · External reference
The direct medical costs of sickle cell disease in Saudi Arabia: insights from a single center study
10.3390/healthcare13040420 · 2025 · External reference
Real‐world evidence on disease burden and economic impact of sickle cell disease in Italy
10.3390/jcm12010117 · 2023 · External reference
Sickle cell anemia and inflammation: a review of stones and landmarks paving the road in the last 25 years
10.3390/hematolrep17010002 · 2025 · External reference
Sickle cell disease in Bahia, Brazil: the social production of health policies and institutional neglect
10.3390/soc12040108 · 2022 · External reference
Sickle cell disease in the Democratic Republic of Congo: assessing physicians' knowledge and practices
10.3390/tropicalmed5030127 · 2020 · External reference
Challenges of newborn hearing screening programs in Saudi Arabia: a systematic review
10.3390/audiolres15020034 · 2025 · External reference
International newborn screening: where are we in Saudi Arabia?
10.1007/s44197-024-00263-z · 2024 · External reference
American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support
10.1182/bloodadvances.2019001143 · 2020 · External reference
How I safely transfuse patients with sickle‐cell disease and manage delayed hemolytic transfusion reactions
10.1182/blood-2018-02-785964 · 2018 · External reference
Sickle cell disease: when and how to transfuse
10.1182/asheducation-2016.1.625 · 2016 · External reference
Epidemiology of stroke in sickle cell disease
10.3390/jcm10184232 · 2021 · External reference
Pediatric stroke: a review of common etiologies and management strategies
2023 · External reference
Sickle cell disease
10.1159/000540149 · 2024 · External reference
Human leukocyte antigen alloimmunization prevention mechanisms in blood transfusion
10.4103/ajts.ajts_144_21 · 2023 · External reference
A review of the relationship between the immune response, inflammation, oxidative stress, and the pathogenesis of sickle cell anaemia
2023 · External reference
Enhancing CAR T‐cell function with domains of innate immunity sensors
10.3390/ijms26031339 · 2025 · External reference
Red blood cell alloimmunization in sickle cell disease: pathophysiology, risk factors, and transfusion management
10.1182/blood-2011-11-327361 · 2012 · External reference
Experimental models of B cell tolerance in transplantation
10.1016/j.smim.2011.08.018 · 2012 · External reference
Maintaining T cell tolerance of alloantigens: lessons from animal studies
10.1111/ajt.14984 · 2018 · External reference
Cytokines in inflammatory disease
10.3390/ijms20236008 · 2019 · External reference
Inflammation in sickle cell disease
10.3233/ch-189012 · 2018 · External reference
Expanding roles for CD4+ T cells in immunity to viruses
10.1038/nri3152 · 2012 · External reference
The interaction of innate immune and adaptive immune system
10.1002/mco2.714 · 2024 · External reference
Immunomodulation—a general review of the current state‐of‐the‐art and new therapeutic strategies for targeting the immune system
10.3389/fimmu.2023.1127704 · 2023 · External reference
Rituximab for prevention of delayed hemolytic transfusion reaction in sickle cell disease
10.3324/haematol.12074 · 2007 · External reference
Rituximab (monoclonal anti‐CD20 antibody): mechanisms of action and resistance
10.1038/sj.onc.1206939 · 2003 · External reference
Prevention of a first stroke by transfusions in children with sickle cell anemia and abnormal results on transcranial Doppler ultrasonography
10.1056/nejm199807023390102 · 1998 · External reference
Discontinuing prophylactic transfusions used to prevent stroke in sickle cell disease
10.1056/nejmoa050460 · 2005 · External reference
Hydroxyurea versus chronic transfusion for maintenance of transcranial Doppler flow velocities in children with sickle cell anaemia—TWiTCH: a multicentre, open‐label, phase 3, non‐inferiority trial
10.1016/s0140-6736(15)01041-7 · 2016 · External reference
Impact of immune‐modulatory drugs on regulatory T cells
10.1097/tp.0000000000001379 · 2016 · External reference
ABO, RH, and KEL1 antigens, phenotypes and haplotypes in southwestern Saudi Arabia
2021 · External reference