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Type 1 diabetic akita mouse hearts are insulin sensitive but manifest structurally abnormal mitochondria that remain coupled despite increased uncoupling protein 3

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Gender disparity of streptozotocin‐induced intrinsic contractile dysfunction in murine ventricular myocytes: Role of chronic activation of Akt

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Ablation of mitochondrial calcium uniporter alleviates cardiac dysfunction in type 1 diabetes

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10.3390/cells12020204 · 2023 · External reference

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Increased RyR2 activity is exacerbated by calcium leak‐induced mitochondrial ROS

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Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides

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Up‐regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2

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Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia

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Estrogens protect pancreatic beta‐cells from apoptosis and prevent insulin‐deficient diabetes mellitus in mice

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Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT

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Genetic ablation of ryanodine receptor 2 phosphorylation at Ser‐2808 aggravates Ca(2+)‐dependent cardiomyopathy by exacerbating diastolic Ca2+ release

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Cardiac energy metabolism in heart failure

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Increased mitochondrial emission of reactive oxygen species and calpain activation are required for doxorubicin‐induced cardiac and skeletal muscle myopathy

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Mitochondrial dysfunction in human hypertrophic cardiomyopathy is linked to cardiomyocyte architecture disruption and corrected by improving NADH‐driven mitochondrial respiration

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Increased inducibility of ventricular tachycardia and decreased heart rate variability in a mouse model for type 1 diabetes: Effect of pravastatin

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Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation

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FoxO1 regulates adipose transdifferentiation and iron influx by mediating Tgfbeta1 signaling pathway

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Loss of FoxO1 activates an alternate mechanism of mitochondrial quality control for healthy adipose browning

10.1042/cs20230973 · 2024 · External reference

SR‐mitochondria crosstalk shapes Ca signalling to impact pathophenotype in disease models marked by dysregulated intracellular Ca release

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Catecholaminergic polymorphic ventricular tachycardia is caused by mutation‐linked defective conformational regulation of the ryanodine receptor

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Rapid changes in NADH and flavin autofluorescence in rat cardiac trabeculae reveal large mitochondrial complex II reserve capacity

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Estrogen protects cardiac function and energy metabolism in dilated cardiomyopathy induced by loss of cardiac IRS1 and IRS2

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Effects of diabetes on ryanodine receptor Ca release channel (RyR2) and Ca2+ homeostasis in rat heart

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A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early‐onset NIDDM in nonobese C57BL/6 (Akita) mutant mice

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