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References from Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma. Local targets link to admitted publications; unresolved targets remain external evidence.
Mesenchymal stem cells induce PD‐L1 expression through the secretion of CCL5 in breast cancer cells
10.1002/jcp.30135 · 2021 · External reference
MCT4‐driven CAF‐mediated metabolic reprogramming in breast cancer microenvironment is a vulnerability targetable by miR‐425‐5p
10.1038/s41420-024-01910-x · 2024 · External reference
Promotion of cholangiocarcinoma growth by diverse cancer‐associated fibroblast subpopulations
10.1016/j.ccell.2021.03.012 · 2021 · External reference
Colorectal cancer‐associated fibroblasts inhibit effector T cells via NECTIN2 signaling
10.1016/j.canlet.2024.216985 · 2024 · External reference
Cancer‐associated fibroblasts secrete Wnt2 to promote cancer progression in colorectal cancer
10.1002/cam4.2523 · 2019 · External reference
Fibroblast activation protein‐targeted near‐infrared photoimmunotherapy depletes immunosuppressive cancer‐associated fibroblasts and remodels local tumor immunity
10.1038/s41416-024-02639-1 · 2024 · External reference
Stromal reprogramming through dual PDGFRalpha/beta blockade boosts the efficacy of anti‐PD‐1 immunotherapy in fibrotic tumors
10.1158/0008-5472.can-22-1890 · 2023 · External reference
Complex formation between platelet‐derived growth factor receptor beta and transforming growth factor beta receptor regulates the differentiation of mesenchymal stem cells into cancer‐associated fibroblasts
10.18632/oncotarget.26124 · 2018 · External reference
Altered p53 functionality in cancer‐associated fibroblasts contributes to their cancer‐supporting features
10.1073/pnas.1719076115 · 2018 · External reference
Tumor‐associated fibroblasts predominantly come from local and not circulating precursors
10.1073/pnas.1600363113 · 2016 · External reference
Mutually exclusive expression of COL11A1 by CAFs and tumour cells in a large panCancer and a salivary gland carcinoma cohort
10.1007/s12105-021-01370-0 · 2022 · External reference
STING and IRF3 in stromal fibroblasts enable sensing of genomic stress in cancer cells to undermine oncolytic viral therapy
10.1038/s41556-020-0527-7 · 2020 · External reference
Reprogramming of normal fibroblasts into ovarian cancer‐associated fibroblasts via non‐vesicular paracrine signaling induces an activated fibroblast phenotype
10.1016/j.bbamcr.2024.119801 · 2024 · External reference
Evidence of steady‐state fibroblast subtypes in the normal human breast as cells‐of‐origin for perturbed‐state fibroblasts in breast cancer
10.1186/s13058-024-01763-3 · 2024 · External reference
Autophagy loss impedes cancer‐associated fibroblast activation via downregulating proline biosynthesis
10.1080/15548627.2022.2093026 · 2023 · External reference
Expected and unexpected effects after systemic inhibition of Hippo transcriptional output in cancer
10.1038/s41467-024-46531-1 · 2024 · External reference
Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
10.1172/jci42874 · 2011 · External reference
Multiple myeloma cells recruit tumor‐supportive macrophages through the CXCR4/CXCL12 axis and promote their polarization toward the M2 phenotype
10.18632/oncotarget.2207 · 2014 · External reference
Senescence defines a distinct subset of myofibroblasts that orchestrates immunosuppression in pancreatic cancer
10.1158/2159-8290.cd-23-0428 · 2024 · External reference
Cancer‐associated fibroblasts serve as decoys to suppress NK cell anticancer cytotoxicity in breast Cancer
10.1158/2159-8290.cd-24-0131 · 2025 · External reference
Phase 1 trial of RO6874813, a novel bispecific FAP‐DR5 antibody, in patients with solid tumors
10.1158/1535-7163.targ-17-a092 · 2018 · External reference
TGF‐β signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia
10.1126/science.1090922 · 2004 · External reference
Cell‐autonomous Cxcl1 sustains tolerogenic circuitries and stromal inflammation via neutrophil‐derived TNF in pancreatic cancer
10.1158/2159-8290.cd-22-1046 · 2023 · External reference
IL1‐Induced JAK/STAT signaling is antagonized by TGFbeta to shape CAF heterogeneity in pancreatic ductal adenocarcinoma
10.1158/2159-8290.cd-18-0710 · 2019 · External reference
Bone marrow stromal cells induce chromatin remodeling in multiple myeloma cells leading to transcriptional changes
10.1038/s41467-024-47793-5 · 2024 · External reference
BL‐8040, a CXCR4 antagonist, in combination with pembrolizumab and chemotherapy for pancreatic cancer: The COMBAT trial
10.1038/s41591-020-0880-x · 2020 · External reference
The influence of clinical risk factors on the classification of human cancer‐associated fibroblasts in PDAC and pancreatitis patients
2025 · External reference
Pancreatic cancer‐associated fibroblasts modulate macrophage differentiation via sialic acid‐siglec interactions
10.1038/s42003-024-06087-8 · 2024 · External reference
Cancer‐associated fibroblasts share characteristics and protumorigenic activity with mesenchymal stromal cells
10.1158/0008-5472.can-16-2586 · 2017 · External reference
Analyzing the role of cancer‐associated fibroblast activation on macrophage polarization
10.1002/1878-0261.13454 · 2023 · External reference
Cross‐tissue organization of the fibroblast lineage
10.1038/s41586-021-03549-5 · 2021 · External reference
Cancer‐associated fibroblast driven paracrine IL‐6/STAT3 signaling promotes migration and dissemination in invasive lobular carcinoma
10.1186/s13058-025-02074-x · 2025 · External reference
Mechanotransduction and YAP‐dependent matrix remodelling is required for the generation and maintenance of cancer‐associated fibroblasts
10.1038/ncb2756 · 2013 · External reference
Impaired LAIR‐1‐mediated immune control due to collagen degradation in fibrosis
10.1016/j.jaut.2024.103219 · 2024 · External reference
Single‐cell multi‐stage spatial evolutional map of esophageal carcinogenesis
10.1016/j.ccell.2025.02.009 · 2025 · External reference
Spatial and functional dissection of cancer‐associated fibroblasts‐mediated immune modulation in H. pylori‐associated gastric cancer
10.1186/s12943-025-02490-9 · 2025 · External reference
Disrupting biological sensors of force promotes tissue regeneration in large organisms
10.1038/s41467-021-25410-z · 2021 · External reference
Crosstalk of glutamine metabolism between cancer‐associated fibroblasts and cancer cells
10.1016/j.cellsig.2025.111874 · 2025 · External reference
Endoplasmic reticulum stress signals in the tumour and its microenvironment
10.1038/s41568-020-00312-2 · 2021 · External reference
Single‐cell resolution spatial analysis of antigen‐presenting cancer‐associated fibroblast niches
10.1016/j.ccell.2025.09.001 · 2025 · External reference
Single‐cell transcriptome analysis reveals a cancer‐associated fibroblast marker gene signature in hepatocellular carcinoma that predicts prognosis
10.1016/j.iliver.2022.12.002 · 2023 · External reference
HMGA1 induces FGF19 to drive pancreatic carcinogenesis and stroma formation
10.1172/jci151601 · 2023 · External reference
A first‐in‐class pan‐lysyl oxidase inhibitor impairs stromal remodeling and enhances gemcitabine response and survival in pancreatic cancer
10.1038/s43018-023-00614-y · 2023 · External reference
ATRA mechanically reprograms pancreatic stellate cells to suppress matrix remodelling and inhibit cancer cell invasion
10.1038/ncomms12630 · 2016 · External reference
Opposing Wnt signals regulate cervical squamocolumnar homeostasis and emergence of metaplasia
10.1038/s41556-020-00619-0 · 2021 · External reference
Androgen receptor functions as transcriptional repressor of cancer‐associated fibroblast activation
10.1172/jci99159 · 2018 · External reference
Ovarian carcinoma‐associated mesenchymal stem cells arise from tissue‐specific normal stroma
10.1002/stem.2932 · 2019 · External reference
Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow‐dependent drug resistance
10.3324/haematol.2019.221077 · 2020 · External reference
AREG and EREG are predictive biomarkers of response to EGFR inhibition in gastroesophageal cancer
10.1158/0008-5472.can-25-0073 · 2025 · External reference
Cancer‐associated fibroblast phenotypes are associated with patient outcome in non‐small cell lung cancer
10.1016/j.ccell.2023.12.021 · 2024 · External reference
Cancer‐associated fibroblast classification in single‐cell and spatial proteomics data
10.1038/s41467-023-39762-1 · 2023 · External reference
Synthesis and expression of CDw75 antigen in human colorectal cancer
2009 · External reference
Fibroblast heterogeneity and immunosuppressive environment in Human breast cancer
10.1016/j.ccell.2018.01.011 · 2018 · External reference
High expression of FAP in colorectal cancer is associated with angiogenesis and immunoregulation processes
10.3389/fonc.2020.00979 · 2020 · External reference
Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer
10.1038/s41467-024-47068-z · 2024 · External reference
Inhibition of JNK signaling overcomes cancer‐associated fibroblast‐mediated immunosuppression and enhances the efficacy of immunotherapy in bladder cancer
10.1158/0008-5472.can-24-0940 · 2024 · External reference
Fructose drives colorectal cancer progression by regulating crosstalk between cancer‐associated fibroblasts and tumour cells
10.1136/gutjnl-2025-335014 · 2025 · External reference
Targeting hypersialylation in multiple myeloma represents a novel approach to enhance NK cell‐mediated tumor responses
10.1182/bloodadvances.2021006805 · 2022 · External reference
Interleukin‐8‐neutralizing monoclonal antibody bms‐986253 plus Nivolumab (Nivo) in Biomarker‐enriched, primarily anti‐Pd‐(L)1‐experienced patients with advanced cancer: Initial phase 1 results
2020 · External reference
An IL‐1beta‐driven neutrophil‐stromal cell axis fosters a BAFF‐rich protumor microenvironment in individuals with multiple myeloma
10.1038/s41590-024-01808-x · 2024 · External reference
The multiple myeloma microenvironment is defined by an inflammatory stromal cell landscape
10.1038/s41590-021-00931-3 · 2021 · External reference
Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23
10.1038/nrd.2015.9 · 2016 · External reference
Fibroblastic reticular cells of the lymph node are required for retention of resting but not activated CD8+ T cells
10.1073/pnas.1412910111 · 2014 · External reference
CAF‐derived HGF promotes cell proliferation and drug resistance by up‐regulating the c‐met/PI3K/Akt and GRP78 signalling in ovarian cancer cells
10.1042/bsr20160470 · 2017 · External reference
CDK16+ Luminal progenitor cell‐like tumor cells interacted with POSTN+ cancer‐associated fibroblasts associate with chemo‐resistance In breast cancer
10.1002/smtd.202401192 · 2025 · External reference
Single‐cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy
10.1158/2159-8290.cd-19-0644 · 2020 · External reference
Oncogenic KRAS‐dependent stromal interleukin‐33 directs the pancreatic microenvironment to promote tumor growth
10.1158/2159-8290.cd-24-0100 · 2024 · External reference
The loss of RNA N(6)‐adenosine methyltransferase Mettl14 in tumor‐associated macrophages promotes CD8+ T cell dysfunction and tumor growth
10.1016/j.ccell.2021.04.016 · 2021 · External reference
Oncogenic KRAS creates an aspartate metabolism signature in colorectal cancer cells
2021 · External reference
VLA‐1 binding to Collagen IV controls effector T cell suppression by myeloid‐derived suppressor cells in the splenic red pulp
10.3389/fimmu.2020.616531 · 2020 · External reference
Targeting stromal cell sialylation reverses T cell‐mediated immunosuppression in the tumor microenvironment
10.1016/j.celrep.2023.112475 · 2023 · External reference
Cross‐species single‐cell analysis of pancreatic ductal adenocarcinoma reveals antigen‐presenting cancer‐associated fibroblasts
10.1158/2159-8290.cd-19-0094 · 2019 · External reference
Cancer‐associated fibroblasts are activated in incipient neoplasia to orchestrate tumor‐promoting inflammation in an NF‐kappaB‐dependent manner
10.1016/j.ccr.2009.12.041 · 2010 · External reference
Merkel cell carcinoma‐derived exosome‐shuttle miR‐375 induces fibroblast polarization by inhibition of RBPJ and p53
10.1038/s41388-020-01576-6 · 2021 · External reference
Signaling pathways in cancer‐associated fibroblasts: Recent advances and future perspectives
10.1002/cac2.12392 · 2023 · External reference
Cancer‐associated fibroblasts strengthen cell proliferation and EGFR TKIs resistance through aryl hydrocarbon receptor dependent signals in non‐small cell lung cancer
2022 · External reference
Spatially organized tumor‐stroma boundary determines the efficacy of immunotherapy in colorectal cancer patients
10.1038/s41467-024-54710-3 · 2024 · External reference
Cancer‐specific PERK signaling drives invasion and metastasis through CREB3L1
10.1038/s41467-017-01052-y · 2017 · External reference
Cancer‐associated fibroblast subtypes modulate the tumor‐immune microenvironment and are associated with skin cancer malignancy
10.1038/s41467-024-53908-9 · 2024 · External reference
Interleukin‐34 enhances the tumor promoting function of colorectal cancer‐associated fibroblasts
10.3390/cancers12123537 · 2020 · External reference
Bone marrow fibroblasts parallel multiple myeloma progression in patients and mice: In vitro and in vivo studies
10.1038/leu.2013.254 · 2014 · External reference
Cancer‐associated fibroblast compositions change with breast cancer progression linking the ratio of S100A4+ and PDPN+ CAFs to clinical outcome
10.1038/s43018-020-0082-y · 2020 · External reference
177Lu‐LNC1004 Radioligand therapy in patients with end‐stage metastatic cancers: A single‐center, single‐arm, phase II study
10.1158/1078-0432.ccr-24-3918 · 2025 · External reference
Molecular features of cancer‐associated fibroblast subtypes and their implication on cancer pathogenesis, prognosis, and immunotherapy resistance
10.1158/1078-0432.ccr-20-4226 · 2021 · External reference
FAP‐targeting biomimetic nanosystem to restore the activated cancer‐associated fibroblasts to quiescent state for breast cancer radiotherapy
10.1016/j.ijpharm.2025.125190 · 2025 · External reference
3D Extracellular matrix regulates the activity of T cells and cancer associated fibroblasts in breast cancer
10.3389/fonc.2021.764204 · 2021 · External reference
Phase I/II trial of the CXCR4 inhibitor plerixafor in combination with bortezomib as a chemosensitization strategy in relapsed/refractory multiple myeloma
10.1002/ajh.25627 · 2019 · External reference
Cancer cell ‐ fibroblast crosstalk via HB‐EGF, EGFR, and MAPK signaling promotes the expression of macrophage chemo‐attractants in squamous cell carcinoma
10.1016/j.isci.2024.110635 · 2024 · External reference
Reprogramming of lipid metabolism in cancer‐associated fibroblasts potentiates migration of colorectal cancer cells
10.1038/s41419-020-2434-z · 2020 · External reference
Cancer‐associated fibroblasts induce epithelial‐mesenchymal transition of bladder cancer cells through paracrine IL‐6 signalling
2019 · External reference
Spatial positioning and matrix programs of cancer‐associated fibroblasts promote T‐cell exclusion in Human lung tumors
10.1158/2159-8290.cd-21-1714 · 2022 · External reference
Lactate‐induced activation of tumor‐associated fibroblasts and IL‐8‐mediated macrophage recruitment promote lung cancer progression
10.1016/j.redox.2024.103209 · 2024 · External reference
The consensus molecular subtypes of colorectal cancer
10.1038/nm.3967 · 2015 · External reference
Loss of stromal IMP1 promotes a tumorigenic microenvironment in the colon
10.1158/1541-7786.mcr-15-0224 · 2015 · External reference
Biomarkers for cancer‐associated fibroblasts
10.1186/s40364-020-00245-w · 2020 · External reference
The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis
10.1038/s41467-022-34464-6 · 2023 · External reference
Cancer‐associated fibroblasts maintain critical pancreatic cancer cell lipid homeostasis in the tumor microenvironment
10.1016/j.celrep.2024.114972 · 2024 · External reference
Single‐cell analysis reveals prognostic fibroblast subpopulations linked to molecular and immunological subtypes of lung cancer
10.1038/s41467-023-35832-6 · 2023 · External reference
Collaboration of cancer‐associated fibroblasts and tumour‐associated macrophages for neuroblastoma development
10.1002/path.4769 · 2016 · External reference
Senescent cancer‐associated fibroblasts secrete active MMP‐2 that promotes keratinocyte dis‐cohesion and invasion
10.1038/bjc.2014.438 · 2014 · External reference
Interaction with colon cancer cells hyperactivates TGF‐beta signaling in cancer‐associated fibroblasts
10.1038/onc.2012.536 · 2014 · External reference
Glycolysis reprogramming in CAFs promotes oxaliplatin resistance in pancreatic cancer through circABCC4 mediated PKM2 nuclear translocation
10.1038/s41419-025-07431-4 · 2025 · External reference
NNMT inhibition in cancer‐associated fibroblasts restores antitumour immunity
10.1038/s41586-025-09303-5 · 2025 · External reference
Mesenchymal lineage heterogeneity underlies nonredundant functions of pancreatic cancer‐associated fibroblasts
10.1158/2159-8290.cd-21-0601 · 2022 · External reference
Colorectal cancer cells activate adjacent fibroblasts resulting in FGF1/FGFR3 signaling and increased invasion
10.1016/j.ajpath.2010.12.008 · 2011 · External reference
TGF‐beta builds a dual immune barrier in colorectal cancer by impairing T cell recruitment and instructing immunosuppressive SPP1+ macrophages
10.1038/s41588-025-02380-2 · 2025 · External reference
Phase I clinical trial of the bifunctional EGFR/TGF‐β fusion protein ficerafusp Alfa (BCA101) alone and in combination with Pembrolizumab for advanced solid tumors
10.1158/1078-0432.ccr-25-0100 · 2025 · External reference
Cancer‐associated fibroblast spatial heterogeneity and EMILIN1 expression in the tumor microenvironment modulate TGF‐beta activity and CD8+ T‐cell infiltration in breast cancer
10.7150/thno.90627 · 2024 · External reference
Cellular heterogeneity during mouse pancreatic ductal adenocarcinoma progression at single‐cell resolution
2019 · External reference
STK25 inhibits cancer‐associated fibroblast activation to overcome cetuximab resistance in colorectal cancer
10.1002/ctm2.70678 · 2026 · External reference
CD26‐negative and CD26‐positive tissue‐resident fibroblasts contribute to functionally distinct CAF subpopulations in breast cancer
10.1038/s41467-023-35793-w · 2023 · External reference
Oncogenic KRAS drives lipofibrogenesis to promote angiogenesis and colon cancer progression
10.1158/2159-8290.cd-22-1467 · 2023 · External reference
circFARP1 enables cancer‐associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis
10.1186/s12943-022-01501-3 · 2022 · External reference
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms
10.1016/j.ccell.2021.09.003 · 2021 · External reference
Interferon‐driven CAF reprogramming augments immunogenic response to neoadjuvant radiotherapy in colorectal cancer
10.1016/j.xcrm.2025.102251 · 2025 · External reference
Targeting cancer‐associated fibroblast‐secreted WNT2 restores dendritic cell‐mediated antitumour immunity
10.1136/gutjnl-2020-322924 · 2022 · External reference
FUT8‐mediated aberrant N‐glycosylation of B7H3 suppresses the immune response in triple‐negative breast cancer
10.1038/s41467-021-22618-x · 2021 · External reference
Single‐cell analysis defines a pancreatic fibroblast lineage that supports anti‐tumor immunity
10.1016/j.ccell.2021.06.017 · 2021 · External reference
PD‐L1 induction by cancer‐associated fibroblast‐derived factors in lung adenocarcinoma cells
10.3390/cancers11091257 · 2019 · External reference
Stromal contribution to the colorectal cancer transcriptome
10.1038/ng.3224 · 2015 · External reference
Origin of myofibroblasts in the fibrotic liver in mice
2014 · External reference
Targeting fibroblast derived thrombospondin 2 disrupts an immune‐exclusionary environment at the tumor front in colorectal cancer
10.1038/s41467-025-66485-2 · 2025 · External reference
Siglec‐7/‐9 ligands shield tumor cells from NK cell attack
10.1186/2051-1426-1-s1-p157 · 2013 · External reference
SOX4 mediates cancer‐associated fibroblasts related radioresistance in hepatocellular carcinoma
2025 · External reference
Spatial multiomics reveals a subpopulation of fibroblasts associated with cancer stemness in human hepatocellular carcinoma
10.1186/s13073-024-01367-8 · 2024 · External reference
Integrative analysis of bulk and single‐cell gene expression profiles to identify bone marrow mesenchymal cell heterogeneity and prognostic significance in multiple myeloma
10.1186/s12967-025-06637-6 · 2025 · External reference
Targeting CXCR4‐dependent immunosuppressive Ly6C(low) monocytes improves antiangiogenic therapy in colorectal cancer
10.1073/pnas.1710754114 · 2017 · External reference
Recruitment of mesenchymal stem cells into prostate tumours promotes metastasis
10.1038/ncomms2766 · 2013 · External reference
The biology and function of fibroblasts in cancer
10.1038/nrc.2016.73 · 2016 · External reference
Cancer‐associated fibroblasts affect intratumoral CD8+ and FoxP3+ T cells via IL6 in the tumor microenvironment
10.1158/1078-0432.ccr-18-0205 · 2018 · External reference
PD‐L1‐expressing cancer‐associated fibroblasts induce tumor immunosuppression and contribute to poor clinical outcome in esophageal cancer
10.1007/s00262-023-03531-2 · 2023 · External reference
Refining colorectal cancer classification and clinical stratification through a single‐cell atlas
10.1186/s13059-022-02677-z · 2022 · External reference
New insights into macrophage polarization and its prognostic role in patients with colorectal cancer liver metastasis
2024 · External reference
Single‐cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer
10.1158/2159-8290.cd-19-1384 · 2020 · External reference
PD‐L1‐directed PlGF/VEGF blockade synergizes with chemotherapy by targeting CD141+ cancer‐associated fibroblasts in pancreatic cancer
10.1038/s41467-022-33991-6 · 2022 · External reference
Cancer‐associated fibroblasts reuse cancer‐derived lactate to maintain a fibrotic and immunosuppressive microenvironment in pancreatic cancer
2023 · External reference
The origin and contribution of cancer‐associated fibroblasts in colorectal carcinogenesis
10.1053/j.gastro.2021.11.037 · 2022 · External reference
Neuro‐mesenchymal interaction mediated by a beta2‐adrenergic nerve growth factor feedforward loop promotes colorectal cancer progression
10.1158/2159-8290.cd-24-0287 · 2025 · External reference
Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy
10.1016/j.cell.2021.07.020 · 2021 · External reference
IL1R1+ cancer‐associated fibroblasts drive tumor development and immunosuppression in colorectal cancer
10.1038/s41467-023-39953-w · 2023 · External reference
The fibroblast growth factor receptor signaling pathway as a mediator of intrinsic resistance to EGFR‐specific tyrosine kinase inhibitors in non‐small cell lung cancer
10.1016/j.drup.2009.05.001 · 2009 · External reference
LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity
10.1038/s41586-022-05272-1 · 2022 · External reference
Hypoxic cancer‐associated fibroblasts increase NCBP2‐AS2/HIAR to promote endothelial sprouting through enhanced VEGF signaling
10.1126/scisignal.aan8247 · 2019 · External reference
Cancer‐associated fibroblasts induce antigen‐specific deletion of CD8+ T cells to protect tumour cells
10.1038/s41467-018-03347-0 · 2018 · External reference
Targeting CAFs‐mediated stromal signaling in a patient‐derived organotypic colorectal tumor model
10.1158/1535-7163.mct-24-0756 · 2025 · External reference
1214 Understanding the mechanism of cancer‐associated fibroblast subpopulation mediated immunomodulation in colorectal cancer
10.1136/jitc-2025-sitc2025.1214 · 2025 · External reference
Tumor‐associated mesenchymal stromal cells modulate macrophage phagocytosis in stromal‐rich colorectal cancer via PD‐1 signaling
10.1016/j.isci.2024.110701 · 2024 · External reference
Stromal cells promote matrix deposition, remodelling and an immunosuppressive tumour microenvironment in a 3D model of colon cancer
10.3390/cancers13235998 · 2021 · External reference
Bone marrow endothelial cells sustain a tumor‐specific CD8+ T cell subset with suppressive function in myeloma patients
10.1080/2162402x.2018.1486949 · 2019 · External reference
FGF19‐Induced inflammatory CAF promoted neutrophil extracellular trap formation in the liver metastasis of colorectal cancer
2023 · External reference
Cancer‐associated fibroblasts promote imatinib resistance in gastrointestinal stromal tumors through PGK1‐mediated metabolic reprogramming
10.1158/0008-5472.can-25-1404 · 2026 · External reference
The type I collagen paradox in PDAC progression: Microenvironmental protector turned tumor accomplice
10.1186/s12967-025-06778-8 · 2025 · External reference
Over‐expressed phospholamban in cancer‐associated fibroblasts is a driver for CMS4 subtype colorectal cancer formation
10.1016/j.jcmgh.2025.101524 · 2025 · External reference
Single‐cell RNA sequencing reveals a pro‐invasive cancer‐associated fibroblast subgroup associated with poor clinical outcomes in patients with gastric cancer
10.7150/thno.60540 · 2022 · External reference
CAF‐secreted LOX promotes PD‐L1 expression via histone lactylation and regulates tumor EMT through TGFbeta/IGF1 signaling in gastric cancer
10.1016/j.cellsig.2024.111462 · 2024 · External reference
Integrating microarray‐based spatial transcriptomics and RNA‐seq reveals tissue architecture in colorectal cancer
10.1186/s40537-024-00992-9 · 2024 · External reference
Stromal microenvironment shapes the intratumoral architecture of pancreatic cancer
10.1016/j.cell.2019.05.012 · 2019 · External reference
Targeting pyruvate carboxylase by a small molecule suppresses breast cancer progression
2020 · External reference
TSG‐6 promotes cancer cell aggressiveness in a CD44‐dependent manner and reprograms normal fibroblasts to create a pro‐metastatic microenvironment in colorectal cancer
10.7150/ijbs.69178 · 2022 · External reference
Spatial regulation of cancer‐associated fibroblasts and tumor cells via pH‐responsive bispecific antibody delivery for enhanced chemo‐immunotherapy synergy
2025 · External reference
Cancer‐associated fibroblast‐specific lncRNA LINC01614 enhances glutamine uptake in lung adenocarcinoma
10.1186/s13045-022-01359-4 · 2022 · External reference
Transfer of damaged mitochondria from cancer cells to cancer‐associated fibroblasts promotes tyrosine kinase inhibitor tolerance in EGFR‐mutant lung cancer
10.1158/0008-5472.can-25-0433 · 2026 · External reference
Thermosensitive hydrogel loaded with alpha‐mangostin for enhanced antitumor effect of doxorubicin
10.1021/acsbiomaterials.4c02408 · 2025 · External reference
Carcinoma‐associated fibroblast‐derived lysyl oxidase‐rich extracellular vesicles mediate collagen crosslinking and promote epithelial‐mesenchymal transition via p‐FAK/p‐paxillin/YAP signaling
10.1038/s41368-023-00236-1 · 2023 · External reference
Pancreatic cancer‐derived extracellular vesicles enhance chemoresistance by delivering KRAS(G12D) protein to cancer‐associated fibroblasts
10.1016/j.ymthe.2025.01.023 · 2025 · External reference
Spatial multi‐omics landscape of colorectal cancer macro‐ and micrometastases
10.1016/j.ccell.2026.06.009 · 2026 · External reference
Conserved spatial subtypes and cellular neighborhoods of cancer‐associated fibroblasts revealed by single‐cell spatial multi‐omics
10.1016/j.ccell.2025.03.004 · 2025 · External reference
Turning cold tumors into hot tumors to ignite immunotherapy
10.1186/s12943-025-02477-6 · 2025 · External reference
Cancer‐associated fibroblast‐derived IL‐8 upregulates PD‐L1 expression in gastric Cancer through the NF‐kappaB pathway
10.1245/s10434-023-14586-x · 2024 · External reference
Single‐cell and spatial transcriptome profiling reveal CTHRC1+ fibroblasts promote EMT through WNT5A signaling in colorectal cancer
10.1186/s12967-025-06236-5 · 2025 · External reference
A high‐throughput, three‐dimensional multiple myeloma model recapitulating tumor‐stroma interactions for CAR‐immune cell‐mediated cytotoxicity assay
2025 · External reference
CAF‐derived LRRC15 orchestrates macrophage polarization and limits PD‐1 immunotherapy efficacy in glioblastoma
10.1093/neuonc/noaf157 · 2025 · External reference
Pan‐cancer single‐cell analysis reveals the heterogeneity and plasticity of cancer‐associated fibroblasts in the tumor microenvironment
10.1038/s41467-022-34395-2 · 2022 · External reference
Pan‐cancer spatially resolved single‐cell analysis reveals the crosstalk between cancer‐associated fibroblasts and tumor microenvironment
10.1186/s12943-023-01876-x · 2023 · External reference
Mesenchymal stem cells secretomes' affect multiple myeloma translation initiation
10.1016/j.cellsig.2016.03.003 · 2016 · External reference
TGFbeta attenuates tumour response to PD‐L1 blockade by contributing to exclusion of T cells
10.1038/nature25501 · 2018 · External reference
CD38‐Driven mitochondrial trafficking promotes bioenergetic plasticity in multiple myeloma
10.1158/0008-5472.can-18-0773 · 2019 · External reference
ANKRD1 is a mesenchymal‐specific driver of cancer‐associated fibroblast activation bridging androgen receptor loss to AP‐1 activation
10.1038/s41467-024-45308-w · 2024 · External reference
Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
10.1038/nature09262 · 2010 · External reference
The presence of cancer‐associated fibroblast in breast cavity side margins is in correlation with the expression of oncoproteins by adjacent epithelial cells: A new era in cancerous potential
10.1007/s00432-024-05943-8 · 2024 · External reference
Cell confinement by micropatterning induces phenotypic changes in cancer‐associated fibroblasts
10.1016/j.actbio.2024.12.007 · 2025 · External reference
Novel treatment strategy targeting interleukin‐6 induced by cancer associated fibroblasts for peritoneal metastasis of gastric cancer
10.1038/s41598-025-88033-0 · 2025 · External reference
Meflin‐positive cancer‐associated fibroblasts inhibit pancreatic carcinogenesis
10.1158/0008-5472.can-19-0454 · 2019 · External reference
Virtual microdissection identifies distinct tumor‐ and stroma‐specific subtypes of pancreatic ductal adenocarcinoma
10.1038/ng.3398 · 2015 · External reference
Targeting PDGF signaling of cancer‐associated fibroblasts blocks feedback activation of HIF‐1alpha and tumor progression of clear cell ovarian cancer
10.1016/j.xcrm.2024.101532 · 2024 · External reference
Clinical challenges of consensus molecular subtype CMS4 colon cancer in the era of precision medicine
10.1158/1078-0432.ccr-23-3964 · 2024 · External reference
Publisher correction: Single‐cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
10.1038/s41467-020-18511-8 · 2020 · External reference
Characterization of the bone marrow architecture of multiple myeloma using spatial transcriptomics
10.1038/s42003-025-08975-z · 2025 · External reference
Very late antigen‐1 marks functional tumor‐resident CD8 T cells and correlates with survival of melanoma patients
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