Research graph
References from P <sub>2</sub> X <sub>3</sub> receptor antagonism improves hindlimb blood flow during exercise in a conscious ovine model of hypertensive heart failure with preserved ejection fraction. Local targets link to admitted publications; unresolved targets remain external evidence.
P2×3 receptor antagonist (AF‐219) in refractory chronic cough: A randomised, double‐blind, placebo‐controlled phase 2 study
10.1016/s0140-6736(14)61255-1 · 2015 · External reference
Evidence of impaired functional sympatholysis in patients with heart failure with preserved ejection fraction
10.1152/ajpheart.00450.2023 · 2023 · External reference
Sympathetic response to 1‐leg cycling exercise predicts exercise capacity in patients with heart failure with preserved ejection fraction
2025 · External reference
Outcome of heart failure with preserved ejection fraction in a population‐based study
10.1056/nejmoa051530 · 2006 · External reference
Vasomotor responses in the human arm during leg exercise
10.1161/01.res.9.2.264 · 1961 · External reference
Purinergic signalling: ATP release
10.1023/a:1012388618693 · 2001 · External reference
Impaired chronotropic and vasodilator reserves limit exercise capacity in patients with heart failure and a preserved ejection fraction
10.1161/circulationaha.106.632745 · 2006 · External reference
Cell swelling‐induced ATP release and gadolinium‐sensitive channels
10.1152/ajpcell.00317.2001 · 2002 · External reference
Vasoconstriction in active skeletal muscles: A potential role for P2X purinergic receptors?
10.1152/japplphysiol.00173.2003 · 2003 · External reference
Do P2X purinergic receptors regulate skeletal muscle blood flow during exercise?
10.1152/ajpheart.00572.2003 · 2004 · External reference
Direct assessment of muscle sympathetic nerve activity during exercise in heart failure with preserved ejection fraction: A case report
10.1016/j.cardfail.2020.11.001 · 2020 · External reference
The concept of cotransmission: Focus on ATP as a cotransmitter and its significance in health and disease
10.1017/s1062798713000586 · 2014 · External reference
Purinergic signalling: Therapeutic developments
10.3389/fphar.2017.00661 · 2017 · External reference
Systolic and diastolic heart failure in the community
10.1001/jama.296.18.2209 · 2006 · External reference
Directly recorded cardiac sympathetic nerve activity is not elevated and β‐blockers further impair exercise capacity in ovine heart failure with preserved ejection fraction
10.1152/physiol.2025.40.s1.0663 · 2025 · External reference
Characterization of a novel ovine model of hypertensive heart failure with preserved ejection fraction
10.1152/ajpheart.00548.2024 · 2024 · External reference
Heart‐rate recovery immediately after exercise as a predictor of mortality
10.1056/nejm199910283411804 · 1999 · External reference
Assessing diagnosis in heart failure: Which features are any use?
10.1093/qjmed/90.5.335 · 1997 · External reference
Exercise intolerance in patients with heart failure: JACC state‐of‐the‐art review
10.1016/j.jacc.2019.01.072 · 2019 · External reference
Determination of fraction of left ventricular volume ejected per beat and of ventricular end‐diastolic and residual volumes: Experimental and clinical observations with a precordial dilution technic
10.1161/01.cir.25.4.674 · 1962 · External reference
The discovery and development of gefapixant
10.1016/j.autneu.2021.102859 · 2021 · External reference
Release of nucleosides and nucleotides from the rabbit heart by sympathetic nerve stimulation
10.1111/j.1748-1716.1982.tb07142.x · 1982 · External reference
Cardiovascular and respiratory responses to changes in central command during isometric exercise at constant muscle tension
10.1113/jphysiol.1972.sp009979 · 1972 · External reference
Heart failure with preserved ejection fraction
10.1038/s41572-024-00540-y · 2024 · External reference
Mechanisms of sympathetic restraint in human skeletal muscle during exercise: Role of α‐adrenergic and nonadrenergic mechanisms
10.1152/ajpheart.00208.2020 · 2020 · External reference
Contribution of intravascular versus interstitial purines and nitric oxide in the regulation of exercise hyperaemia in humans
10.1113/jphysiol.2012.234963 · 2012 · External reference
Muscle sympathetic nerve activity during exercise
10.1007/s12576-019-00669-6 · 2019 · External reference
Effect of ischemia on responses of group III and IV afferents to contraction
10.1152/jappl.1984.57.3.644 · 1984 · External reference
Impaired exercise hemodynamic responses in patients with HFpEF without a sympathetic vasoconstrictor reserve
10.1016/j.autneu.2025.103309 · 2025 · External reference
P2×3 receptor antagonism attenuates the progression of heart failure
10.1038/s41467-023-37077-9 · 2023 · External reference
Impaired skeletal muscle vasodilation during exercise in heart failure with preserved ejection fraction
10.1016/j.ijcard.2016.02.139 · 2016 · External reference
Coexpression of P2×3 and P2×2 receptor subunits in varying amounts generates heterogeneous populations of P2X receptors that evoke a spectrum of agonist responses comparable to that seen in sensory neurons
10.1016/s0022-3565(24)38849-4 · 2001 · External reference
Analysis of relative gene expression data using real‐time quantitative PCR and the 2− ΔΔCT method
10.1006/meth.2001.1262 · 2001 · External reference
Chronic ablation of TRPV1‐sensitive skeletal muscle afferents attenuates the muscle metaboreflex
10.1152/ajpregu.00129.2021 · 2021 · External reference
Microneurographic studies of the mechanisms of sympathetic nerve responses to static exercise in humans
10.1161/01.res.57.3.461 · 1985 · External reference
P2×2/3 and P2×3 receptors contribute to the metaboreceptor component of the exercise pressor reflex
10.1152/japplphysiol.00774.2010 · 2010 · External reference
The exercise pressor reflex: Its cardiovascular effects, afferent mechanisms, and central pathways
10.1146/annurev.ph.45.030183.001305 · 1983 · External reference
Muscle interstitial ATP and norepinephrine concentrations in the human leg during exercise and ATP infusion
10.1152/japplphysiol.00638.2009 · 2009 · External reference
Local release of ATP into the arterial inflow and venous drainage of human skeletal muscle: Insight from ATP determination with the intravascular microdialysis technique
10.1113/jphysiol.2010.203034 · 2011 · External reference
Trends in prevalence and outcome of heart failure with preserved ejection fraction
10.1056/nejmoa052256 · 2006 · External reference
Activation of the carotid body increases directly recorded cardiac sympathetic nerve activity and coronary blood flow in conscious sheep
10.1152/ajpregu.00246.2020 · 2021 · External reference
Exercise intolerance in older adults with heart failure with preserved ejection fraction: JACC state‐of‐the‐art review
10.1016/j.jacc.2021.07.014 · 2021 · External reference
GLP1R attenuates sympathetic response to high glucose via carotid body inhibition
10.1161/circresaha.121.319874 · 2022 · External reference
Heart failure with preserved ejection fraction: Similarities and differences between women and men
10.1016/j.ijcard.2020.01.003 · 2020 · External reference
Heart failure with preserved ejection fraction in perspective
10.1161/circresaha.119.313572 · 2019 · External reference
Purinergic receptors in the carotid body as a new drug target for controlling hypertension
10.1038/nm.4173 · 2016 · External reference
Amplified P2×3 pathway activity in muscle afferent dorsal root ganglion neurons and exercise pressor reflex regulation in hindlimb ischaemia–reperfusion
10.1113/ep091616 · 2024 · External reference
Heart failure with preserved ejection fraction: A review
10.1001/jama.2023.2020 · 2023 · External reference
Autonomic nervous system and sudden cardiac death: Experimental basis and clinical observations for post‐myocardial infarction risk stratification
1992 · External reference
Cardiac vagal nerve activity increases during exercise to enhance coronary blood flow
10.1161/circresaha.123.323017 · 2023 · External reference
Reinstating respiratory heart rate variability improves hemodynamic responses during exercise in heart failure with reduced ejection fraction
10.1007/s00395-025-01110-3 · 2025 · External reference
Gefapixant, a P2×3 receptor antagonist, for the treatment of refractory or unexplained chronic cough in a phase 2b randomized controlled trial
10.1016/s2213-2600(19)30471-0 · 2020 · External reference
Gefapixant in two randomised dose‐escalation studies in chronic cough
10.1183/13993003.01615-2019 · 2020 · External reference
Relation between central and peripheral hemodynamics during exercise in patients with chronic heart failure. Muscle blood flow is reduced with maintenance of arterial perfusion pressure
10.1161/01.cir.80.4.769 · 1989 · External reference
Direct recording of cardiac and renal sympathetic nerve activity shows differential control in renovascular hypertension
10.1161/hypertensionaha.117.10749 · 2018 · External reference
Sympathetic nerve discharge is coupled to muscle cell pH during exercise in humans
10.1172/jci113730 · 1988 · External reference
Stimulation of renal sympathetic activity by static contraction: Evidence for mechanoreceptor‐induced reflexes from skeletal muscle
10.1161/01.res.64.3.592 · 1989 · External reference
Differential control of heart rate and sympathetic nerve activity during dynamic exercise. Insight from intraneural recordings in humans
10.1172/jci112841 · 1987 · External reference
Exertional fatigue due to skeletal muscle dysfunction in patients with heart failure
10.1161/01.cir.87.2.470 · 1993 · External reference
Localization of ATP‐gated P2X receptor immunoreactivity in rat sensory and sympathetic ganglia
10.1016/s0304-3940(98)00774-5 · 1998 · External reference
