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References from Large‐conductance calcium‐activated potassium (BK) channels regulate respiratory, metabolic and behavioural responses to CO 2 /pH in mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Intracellular Ca2+ activates a fast voltage‐sensitive K+ current in vertebrate sympathetic neurones
10.1038/296746a0 · 1982 · External reference
Ca2 +‐ and voltage‐activated K+ (BK) channels in the nervous system: One gene, a myriad of physiological functions
10.3390/ijms24043407 · 2023 · External reference
KCNMA1‐linked channelopathy
10.1085/jgp.201912457 · 2019 · External reference
Control of breathing in experimental anemia
10.1016/0034-5687(70)90056-3 · 1970 · External reference
Long‐term effects of the perinatal environment on respiratory control
10.1152/japplphysiol.01086.2007 · 2008 · External reference
Tissue‐specific expression of a drosophila calcium‐activated potassium channel
10.1523/jneurosci.15-09-06250.1995 · 1995 · External reference
Thermal tachypnea in avian embryos
2017 · External reference
The role of calcium‐activated potassium channels in respiratory control
10.1016/s1569-9048(02)00044-7 · 2002 · External reference
Do existing measures of Poincaré plot geometry reflect nonlinear features of heart rate variability?
2001 · External reference
A combined blockade of glycine and calcium‐dependent potassium channels abolishes the respiratory rhythm
10.1016/j.neuroscience.2003.07.014 · 2003 · External reference
Contribution of BK(Ca) channels of neurons in rostral ventrolateral medulla to CO‐mediated central regulation of respiratory rhythm in medullary slices of neonatal rats
10.1016/j.resp.2012.05.006 · 2012 · External reference
BK channels in the central nervous system
10.1016/bs.irn.2016.04.001 · 2016 · External reference
Molecular mechanisms of BK channel activation
10.1007/s00018-008-8609-x · 2009 · External reference
Postnatal developmental changes in CO2 sensitivity in rats
10.1152/japplphysiol.00378.2006 · 2006 · External reference
Minocycline attenuates panicogenic responses in a CO2‐induced panic attack model: A translational approach
10.1038/s41398-026-03836-7 · 2026 · External reference
Modulation of the BK channel by estrogens: Examination at single channel level
10.1080/09687860600802803 · 2006 · External reference
Unresolved reference
1981 · External reference
A barometric method for measuring ventilation in newborn infants
10.1542/peds.16.1.81 · 1955 · External reference
Calcium‐sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder
10.1038/ng1585 · 2005 · External reference
Large conductance voltage‐ and calcium‐activated K+ (BK) channel in health and disease
10.3389/fphar.2024.1373507 · 2024 · External reference
Acids in the brain: A factor in panic?
10.1177/0269881109104847 · 2010 · External reference
Calcium‐activated potassium channels: Multiple contributions to neuronal function
10.1177/1073858403009003011 · 2003 · External reference
Analysis of the human tissue‐specific expression by genome‐wide integration of transcriptomics and antibody‐based proteomics
10.1074/mcp.m113.035600 · 2014 · External reference
Multiple targets of chemosensitive signaling in locus coeruleus neurons: Role of K+ and Ca2+ channels
10.1152/ajpcell.00346.2002 · 2003 · External reference
The locus coeruleus and central chemosensitivity
10.1016/j.resp.2010.04.024 · 2010 · External reference
Principles and standards for reporting animal experiments in The Journal of Physiology and Experimental Physiology
10.1113/jp270818 · 2015 · External reference
Acute stress induces down‐regulation of large‐conductance Ca2+‐activated potassium channels in the lateral amygdala
10.1113/jphysiol.2011.223784 · 2012 · External reference
Survival and growth of C57BL/6J mice lacking the BK channel, Kcnma1: Lower adult body weight occurs together with higher body fat
10.14814/phy2.13137 · 2017 · External reference
Electrophysiological properties of a novel ca2 +‐activated K+ channel expressed in human osteoblasts
10.1007/s00223-008-9167-9 · 2008 · External reference
Testosterone decreases urinary bladder smooth muscle excitability via novel signaling mechanism involving direct activation of the BK channels
10.1152/ajprenal.00238.2016 · 2016 · External reference
Postnatal development and activation of L‐type ca2 + currents in locus coeruleus neurons: Implications for a role for ca2 + in central chemosensitivity
10.1152/japplphysiol.01585.2011 · 2012 · External reference
The role of ca2 + and BK channels of locus coeruleus (LC) neurons as a brake to the CO2 chemosensitivity response of rats
10.1016/j.neuroscience.2018.03.031 · 2018 · External reference
Effect of 17β‐estradiol on mRNA expression of large‐conductance, voltage‐dependent, and calcium‐activated potassium channel alpha and beta subunits in guinea pig
10.1385/endo:20:3:227 · 2003 · External reference
Prevalence, severity, and comorbidity of 12‐month DSM‐IV disorders in the National Comorbidity Survey Replication
10.1001/archpsyc.62.6.617 · 2005 · External reference
Distribution of high‐conductance ca2 +‐activated K+ channels in rat brain: Targeting to axons and nerve terminals
10.1523/jneurosci.16-03-00955.1996 · 1996 · External reference
Measuring energy metabolism with open‐flow respirometric systems: Which design to choose?
10.2307/2390179 · 1996 · External reference
Molecular determinants of BK channel functional diversity and functioning
10.1152/physrev.00001.2016 · 2017 · External reference
Catecholamine neurons in rats modulate sleep, breathing, central chemoreception, and breathing variability
10.1113/jphysiol.2005.099325 · 2006 · External reference
De novo loss‐of‐function KCNMA1 variants are associated with a new multiple malformation syndrome and a broad spectrum of developmental and neurological phenotypes
10.1093/hmg/ddz117 · 2019 · External reference
Increased large conductance calcium‐activated potassium (BK) channel expression accompanied by STREX variant downregulation in the developing mouse CNS
2006 · External reference
Functional apical large conductance, ca2 +‐activated, and voltage‐dependent K+ channels are required for maintenance of airway surface liquid volume
10.1074/jbc.m110.185074 · 2011 · External reference
Sexual differences in locus coeruleus neurons and related behavior in C57BL/6J mice
10.1186/s13293-023-00550-7 · 2023 · External reference
A human calcium‐activated potassium channel gene expressed in vascular smooth muscle
1995 · External reference
BK channelopathies and KCNMA1‐linked disease models
10.1146/annurev-physiol-030323-042845 · 2024 · External reference
Unresolved reference
2015 · External reference
Overactive bladder and incontinence in the absence of the BK large conductance ca2 +‐activated K+ channel
10.1074/jbc.m405621200 · 2004 · External reference
An emerging spectrum of variants and clinical features in KCNMA1‐linked channelopathy
10.1080/19336950.2021.1938852 · 2021 · External reference
Dynamic‐ and frequency‐specific regulation of sleep oscillations by cortical potassium channels
10.1016/j.cub.2019.07.056 · 2019 · External reference
Panic disorder is closely associated with respiratory obstructive illnesses
10.1164/ajrccm.179.3.256a · 2009 · External reference
BK channel regulation of afterpotentials and burst firing in cerebellar Purkinje neurons
10.1523/jneurosci.0192-20.2021 · 2021 · External reference
Melatonin promotes sleep by activating the BK channel in C. elegans
10.1073/pnas.2010928117 · 2020 · External reference
Update on requirements for ethics and welfare reporting in The Journal of Physiology
10.1113/jp286666 · 2024 · External reference
Gender difference in BK channel expression in amygdala complex of rat brain
10.1016/j.bbrc.2008.12.004 · 2009 · External reference
Contribution of ca2 +‐dependent conductances to membrane potential fluctuations of medullary respiratory neurons of newborn rats in vitro
10.1113/jphysiol.2003.049312 · 2003 · External reference
Respiration‐modulated membrane potential and chemosensitivity of locus coeruleus neurones in the in vitro brainstem‐spinal cord of the neonatal rat
10.1111/j.1469-7793.1998.381bb.x · 1998 · External reference
Sex‐ and age‐specific respiratory alterations induced by prenatal exposure to the cannabinoid receptor agonist WIN 55,212–2 in rats
10.1111/bph.16044 · 2023 · External reference
Brainstem catecholaminergic neurones and breathing control during postnatal development in male and female rats
10.1113/jp275731 · 2018 · External reference
ASIC1a channels in the locus coeruleus mediate hypercapnic acidosis detection and CO2‐induced panic behavior
10.1007/s00213-025-06866-z · 2025 · External reference
Intracellular pH regulation of neurons in chemosensitive and nonchemosensitive areas of brain slices
10.1016/s0034-5687(01)00281-x · 2001 · External reference
Cellular mechanisms involved in CO2 and acid signaling in chemosensitive neurons
10.1152/ajpcell.00282.2004 · 2004 · External reference
Locus coeruleus noradrenaline depletion and its differential impact on CO2‐induced panic and hyperventilation in male and female mice
10.1016/j.pnpbp.2024.111063 · 2024 · External reference
High‐conductance potassium channels of the SLO family
10.1038/nrn1992 · 2006 · External reference
Paxilline inhibition of the alpha‐subunit of the high‐conductance calcium‐activated potassium channel
10.1016/0028-3908(96)00137-2 · 1996 · External reference
Cerebellar ataxia and purkinje cell dysfunction caused by ca2 +‐activated K+ channel deficiency
10.1073/pnas.0401702101 · 2004 · External reference
Ca2 +‐activated K+ channels of the BK‐type in the mouse brain
10.1007/s00418-005-0124-7 · 2006 · External reference
Panic‐like escape response elicited in mice by exposure to CO2, but not hypoxia
10.1016/j.pnpbp.2017.10.018 · 2018 · External reference
Intranasal oxytocin alleviates postsurgical pain and comorbid anxiety in mice: Participation of BK(Ca) channels in the hippocampus
10.1016/j.neuropharm.2024.110243 · 2025 · External reference
A5 noradrenergic neurons and breathing control in neonate rats
10.1007/s00424-021-02550-1 · 2021 · External reference
AMPA receptor subunit expression in trigeminal neurons during postnatal development
10.1002/1096-9861(20001106)427:1<109::aid-cne7>3.0.co;2-t · 2000 · External reference
Acute activation of maxi‐K channels (hSlo) by estradiol binding to the beta subunit
10.1126/science.285.5435.1929 · 1999 · External reference
L‐type calcium channels modulation by estradiol
10.1007/s12035-016-0045-6 · 2017 · External reference
Neurobiology of panic and pH chemosensation in the brain
10.31887/dcns.2011.13.4/jwemmie · 2011 · External reference
Membrane properties and adrenergic responses in locus coeruleus neurons of young rats
10.1523/jneurosci.07-11-03687.1987 · 1987 · External reference
Membrane properties of rat locus coeruleus neurones
10.1016/0306-4522(84)90265-3 · 1984 · External reference
Differential effects of estrogen and progesterone on potassium channels expressed in Xenopus oocytes
10.1016/j.steroids.2007.10.010 · 2008 · External reference
Mechanisms underlying a critical period of respiratory development in the rat
10.1016/j.resp.2019.04.006 · 2019 · External reference
Calcium‐activated potassium currents differentially modulate respiratory rhythm generation
10.1111/j.1460-9568.2008.06214.x · 2008 · External reference
Large‐conductance calcium‐activated potassium channels in the neurons of pre‐bötzinger complex and their participation in the regulation of central respiratory activity in neonatal rats
10.1016/j.neulet.2010.06.077 · 2010 · External reference
Calcium‐regulated potassium currents secure respiratory rhythm generation after loss of glycinergic inhibition
10.1111/j.1460-9568.2006.04877.x · 2006 · External reference
Upregulation of Beta4 subunit of BKCa channels in the anterior cingulate cortex contributes to mechanical allodynia associated anxiety‐like behaviors
10.1186/s13041-020-0555-z · 2020 · External reference
Paxilline inhibits BK channels by an almost exclusively closed‐channel block mechanism
10.1085/jgp.201411259 · 2014 · External reference