Research graph
References from <i>In vitro</i> and <i>in vivo</i> model systems for <i>Orthoflavivirus</i> antiviral therapeutics: current landscape and strategic considerations. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.1038/s41564-020-0714-0
10.1038/s41564-020-0714-0 · External reference
10.3390/v15112200
10.3390/v15112200 · External reference
10.3390/v6114703
10.3390/v6114703 · External reference
10.3389/fimmu.2024.1362780
10.3389/fimmu.2024.1362780 · External reference
10.1038/nature12060
10.1038/nature12060 · External reference
10.3390/v17010074
10.3390/v17010074 · External reference
10.1021/acsmedchemlett.1c00617
10.1021/acsmedchemlett.1c00617 · External reference
10.3390/v15040860
10.3390/v15040860 · External reference
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10.1007/s42690-025-01627-z
10.1007/s42690-025-01627-z · External reference
10.1038/s41564-019-0476-8
10.1038/s41564-019-0476-8 · External reference
10.3389/fmicb.2024.1458166
10.3389/fmicb.2024.1458166 · External reference
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10.1038/s41467-025-58609-5
10.1038/s41467-025-58609-5 · External reference
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10.7554/elife.64670
10.7554/elife.64670 · External reference
10.1371/journal.pmed.1001638
10.1371/journal.pmed.1001638 · External reference
10.4269/ajtmh.24-0420
10.4269/ajtmh.24-0420 · External reference
10.1371/journal.pntd.0009385
10.1371/journal.pntd.0009385 · External reference
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10.4103/ijmr.ijmr_642_19
10.4103/ijmr.ijmr_642_19 · External reference
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10.3390/microorganisms11071634
10.3390/microorganisms11071634 · External reference
10.2807/1560-7917.es.2023.28.11.2200543
10.2807/1560-7917.es.2023.28.11.2200543 · External reference
10.12998/wjcc.v3.i5.430
10.12998/wjcc.v3.i5.430 · External reference
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10.1128/mbio.02946-24
10.1128/mbio.02946-24 · External reference
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2024 · External reference
10.1016/j.virol.2006.09.015
10.1016/j.virol.2006.09.015 · External reference
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10.3389/fcimb.2023.1284651
10.3389/fcimb.2023.1284651 · External reference
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10.7717/peerj.19748
10.7717/peerj.19748 · External reference
10.1016/j.antiviral.2008.08.004
10.1016/j.antiviral.2008.08.004 · External reference
10.3390/v13060956
10.3390/v13060956 · External reference
10.1371/journal.ppat.1012683
10.1371/journal.ppat.1012683 · External reference
10.3390/molecules25235695
10.3390/molecules25235695 · External reference
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10.1002/advs.202405829
10.1002/advs.202405829 · External reference
10.2210/pdb7i9s/pdb
10.2210/pdb7i9s/pdb · External reference
10.3390/molecules29174047
10.3390/molecules29174047 · External reference
10.1126/scitranslmed.abb2181
10.1126/scitranslmed.abb2181 · External reference
10.1021/acs.jmedchem.3c02336
10.1021/acs.jmedchem.3c02336 · External reference
10.1038/s41598-023-29517-9
10.1038/s41598-023-29517-9 · External reference
10.3390/metabo13020309
10.3390/metabo13020309 · External reference
10.1128/jvi.01258-23
10.1128/jvi.01258-23 · External reference
10.1021/cg4016383
10.1021/cg4016383 · External reference
10.1073/pnas.2304139120
10.1073/pnas.2304139120 · External reference
10.3390/pharmaceutics16091111
10.3390/pharmaceutics16091111 · External reference
10.1038/s41586-025-09689-2
10.1038/s41586-025-09689-2 · External reference
10.3390/pathogens14090925
10.3390/pathogens14090925 · External reference
10.1016/j.antiviral.2023.105737
10.1016/j.antiviral.2023.105737 · External reference
10.1101/2025.06.19.660642
10.1101/2025.06.19.660642 · External reference
10.1371/journal.ppat.1013609
10.1371/journal.ppat.1013609 · External reference
10.1016/j.jneuroim.2023.578148
10.1016/j.jneuroim.2023.578148 · External reference
10.1016/j.antiviral.2025.106205
10.1016/j.antiviral.2025.106205 · External reference
10.3389/fcimb.2022.890750
10.3389/fcimb.2022.890750 · External reference
10.1038/s41467-023-44339-z
10.1038/s41467-023-44339-z · External reference
10.1128/spectrum.05027-22
10.1128/spectrum.05027-22 · External reference
10.1128/aac.01148-08
10.1128/aac.01148-08 · External reference
10.1177/108705719900400206
10.1177/108705719900400206 · External reference
The development, optimization and validation of an assay for high throughput antiviral drug screening against Dengue virus
2009 · External reference
10.1016/j.jviromet.2008.03.012
10.1016/j.jviromet.2008.03.012 · External reference
10.3390/ph16111625
10.3390/ph16111625 · External reference
10.1038/s41586-023-05790-6
10.1038/s41586-023-05790-6 · External reference
10.1177/2472555220911456
10.1177/2472555220911456 · External reference
10.1128/aac.49.12.4980-4988.2005
10.1128/aac.49.12.4980-4988.2005 · External reference
10.1007/978-981-10-8727-1_12
10.1007/978-981-10-8727-1_12 · External reference
10.1038/s41467-026-68943-x
10.1038/s41467-026-68943-x · External reference
10.1128/jvi.00681-24
10.1128/jvi.00681-24 · External reference
10.21769/bioprotoc.5084
10.21769/bioprotoc.5084 · External reference
10.1099/0022-1317-40-3-531
10.1099/0022-1317-40-3-531 · External reference
10.1186/s13071-015-1210-x
10.1186/s13071-015-1210-x · External reference
10.4269/ajtmh.2005.72.74
10.4269/ajtmh.2005.72.74 · External reference
Arbovirus neutralization tests with Peruvian sera in Vero cell cultures
1972 · External reference
The viral range in vitro of a malignant human epithelial cell (strain HeLa, Gel). I. Multiplication of herpes simplex, pseudorabies, and vaccinia viruses
1954 · External reference
10.1128/am.19.5.751-756.1970
10.1128/am.19.5.751-756.1970 · External reference
10.1099/0022-1317-30-1-123
10.1099/0022-1317-30-1-123 · External reference
The influence of arboviral infection on the susceptibility of cultured cells to immune injury in vitro
1975 · External reference
10.1016/j.antiviral.2005.02.001
10.1016/j.antiviral.2005.02.001 · External reference
10.1016/s1201-9712(97)90015-1
10.1016/s1201-9712(97)90015-1 · External reference
10.1084/jem.66.2.133
10.1084/jem.66.2.133 · External reference
10.1126/science.101.2634.640
10.1126/science.101.2634.640 · External reference
10.1126/science.131.3407.1102
10.1126/science.131.3407.1102 · External reference
10.4269/ajtmh.1952.1.30
10.4269/ajtmh.1952.1.30 · External reference
New hemorrhagic fevers of children in the Philippines and Thailand
1960 · External reference
10.4269/ajtmh.1940.s1-20.471
10.4269/ajtmh.1940.s1-20.471 · External reference
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1991 · External reference
10.1016/0035-9203(52)90042-4
10.1016/0035-9203(52)90042-4 · External reference
10.3201/eid2205.160065
10.3201/eid2205.160065 · External reference
10.3390/vaccines12060597
10.3390/vaccines12060597 · External reference
10.1111/j.1699-0463.1978.tb00054.x
10.1111/j.1699-0463.1978.tb00054.x · External reference
10.1002/jmv.20224
10.1002/jmv.20224 · External reference
10.1186/s41182-016-0025-6
10.1186/s41182-016-0025-6 · External reference
10.1016/j.antiviral.2024.105878
10.1016/j.antiviral.2024.105878 · External reference
10.1128/jvi.02085-14
10.1128/jvi.02085-14 · External reference
10.1074/jbc.m110.214189
10.1074/jbc.m110.214189 · External reference
10.1038/srep34550
10.1038/srep34550 · External reference
10.1177/1087057113482586
10.1177/1087057113482586 · External reference
10.1128/jvi.01130-20
10.1128/jvi.01130-20 · External reference
10.1007/s12551-020-00619-2
10.1007/s12551-020-00619-2 · External reference
10.1021/acsinfecdis.2c00571
10.1021/acsinfecdis.2c00571 · External reference
10.1128/jvi.00045-13
10.1128/jvi.00045-13 · External reference
10.1371/journal.ppat.1005737
10.1371/journal.ppat.1005737 · External reference
10.1002/cmdc.202000237
10.1002/cmdc.202000237 · External reference
10.1016/j.bbrc.2016.11.098
10.1016/j.bbrc.2016.11.098 · External reference
10.1038/s41467-020-18709-w
10.1038/s41467-020-18709-w · External reference
10.1016/j.molcel.2023.06.023
10.1016/j.molcel.2023.06.023 · External reference
10.1038/nrd.2018.77
10.1038/nrd.2018.77 · External reference
10.1016/j.heliyon.2018.e01023
10.1016/j.heliyon.2018.e01023 · External reference
10.1177/1087057111412183
10.1177/1087057111412183 · External reference
10.1016/j.antiviral.2024.106053
10.1016/j.antiviral.2024.106053 · External reference
10.1016/j.jbc.2023.105257
10.1016/j.jbc.2023.105257 · External reference
10.1126/science.aaf6116
10.1126/science.aaf6116 · External reference
10.3390/pathogens10101233
10.3390/pathogens10101233 · External reference
10.1242/dev.140707
10.1242/dev.140707 · External reference
10.1016/j.trsl.2022.06.013
10.1016/j.trsl.2022.06.013 · External reference
10.15283/ijsc24043
10.15283/ijsc24043 · External reference
10.15283/ijsc24047
10.15283/ijsc24047 · External reference
10.1002/cpcb.66
10.1002/cpcb.66 · External reference
10.26599/co.2025.9410020
10.26599/co.2025.9410020 · External reference
10.3390/v18020238
10.3390/v18020238 · External reference
10.1038/s41467-025-63323-3
10.1038/s41467-025-63323-3 · External reference
10.3389/fmicb.2019.00811
10.3389/fmicb.2019.00811 · External reference
10.1021/acsptsci.1c00078
10.1021/acsptsci.1c00078 · External reference
10.1016/j.virusres.2024.199331
10.1016/j.virusres.2024.199331 · External reference
10.3390/v17010001
10.3390/v17010001 · External reference
10.1371/journal.pntd.0010291
10.1371/journal.pntd.0010291 · External reference
10.1002/cpdd.1574
10.1002/cpdd.1574 · External reference
10.1007/s00705-021-05298-2
10.1007/s00705-021-05298-2 · External reference
10.1038/s41467-019-14115-z
10.1038/s41467-019-14115-z · External reference
10.1016/j.onehlt.2023.100506
10.1016/j.onehlt.2023.100506 · External reference
10.1126/sciadv.adr8338
10.1126/sciadv.adr8338 · External reference
10.1128/jvi.77.4.2578-2586.2003
10.1128/jvi.77.4.2578-2586.2003 · External reference
10.1099/0022-1317-79-3-437
10.1099/0022-1317-79-3-437 · External reference
10.1099/vir.0.000079
10.1099/vir.0.000079 · External reference
10.1016/j.antiviral.2018.04.012
10.1016/j.antiviral.2018.04.012 · External reference
10.1016/j.antiviral.2019.05.005
10.1016/j.antiviral.2019.05.005 · External reference
10.3390/pathogens11080879
10.3390/pathogens11080879 · External reference
10.1371/journal.pntd.0008191
10.1371/journal.pntd.0008191 · External reference
10.3389/fimmu.2014.00151
10.3389/fimmu.2014.00151 · External reference
10.1111/j.1600-065x.1995.tb00090.x
10.1111/j.1600-065x.1995.tb00090.x · External reference
10.3390/v12111295
10.3390/v12111295 · External reference
10.1371/journal.pntd.0007072
10.1371/journal.pntd.0007072 · External reference
10.1002/hep4.1504
10.1002/hep4.1504 · External reference
10.1016/j.antiviral.2022.105255
10.1016/j.antiviral.2022.105255 · External reference
10.1099/jgv.0.000246
10.1099/jgv.0.000246 · External reference
10.1038/s41598-018-22618-w
10.1038/s41598-018-22618-w · External reference
10.1371/journal.pntd.0006417
10.1371/journal.pntd.0006417 · External reference
10.3390/vaccines11121857
10.3390/vaccines11121857 · External reference
10.3389/fcimb.2023.1275823
10.3389/fcimb.2023.1275823 · External reference
10.1080/22221751.2021.1941276
10.1080/22221751.2021.1941276 · External reference
10.1128/jvi.02979-13
10.1128/jvi.02979-13 · External reference
10.1371/journal.pone.0020472
10.1371/journal.pone.0020472 · External reference
10.1099/0022-1317-67-4-631
10.1099/0022-1317-67-4-631 · External reference
10.3390/v15081632
10.3390/v15081632 · External reference
10.1016/j.chom.2018.04.003
10.1016/j.chom.2018.04.003 · External reference
10.1080/22221751.2025.2465327
10.1080/22221751.2025.2465327 · External reference
10.1371/journal.ppat.1013850
10.1371/journal.ppat.1013850 · External reference
10.1080/22221751.2023.2300466
10.1080/22221751.2023.2300466 · External reference
10.1371/journal.ppat.1014420
10.1371/journal.ppat.1014420 · External reference
10.1016/j.antiviral.2022.105331
10.1016/j.antiviral.2022.105331 · External reference
10.3390/v13081641
10.3390/v13081641 · External reference
10.1128/jvi.01982-18
10.1128/jvi.01982-18 · External reference
10.3389/fimmu.2021.621164
10.3389/fimmu.2021.621164 · External reference
10.3389/fsufs.2024.1455455
10.3389/fsufs.2024.1455455 · External reference
10.3390/v14061208
10.3390/v14061208 · External reference
10.3389/fcimb.2022.834888
10.3389/fcimb.2022.834888 · External reference
10.1186/s13567-016-0319-z
10.1186/s13567-016-0319-z · External reference
10.3390/v14010114
10.3390/v14010114 · External reference
10.4049/jimmunol.100.1.194
10.4049/jimmunol.100.1.194 · External reference
10.1126/scitranslmed.aau9135
10.1126/scitranslmed.aau9135 · External reference
10.1126/scitranslmed.ade5795
10.1126/scitranslmed.ade5795 · External reference
10.3390/pathogens9040247
10.3390/pathogens9040247 · External reference
10.1038/s41467-018-04777-6
10.1038/s41467-018-04777-6 · External reference
10.1038/s41467-017-02499-9
10.1038/s41467-017-02499-9 · External reference
10.1093/infdis/jiu061
10.1093/infdis/jiu061 · External reference
10.1056/nejmoa2500179
10.1056/nejmoa2500179 · External reference
10.1038/s41586-021-03990-6
10.1038/s41586-021-03990-6 · External reference
10.1099/vir.0.045088-0
10.1099/vir.0.045088-0 · External reference
10.1146/annurev-virology-092917-043439
10.1146/annurev-virology-092917-043439 · External reference
10.3389/fmicb.2019.00525
10.3389/fmicb.2019.00525 · External reference
10.3389/fimmu.2020.01055
10.3389/fimmu.2020.01055 · External reference
10.1007/s40263-024-01082-3
10.1007/s40263-024-01082-3 · External reference
10.1093/cid/ciad284
10.1093/cid/ciad284 · External reference
10.1007/978-981-10-8727-1_23
10.1007/978-981-10-8727-1_23 · External reference
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10.3390/v17020212
10.3390/v17020212 · External reference
10.1080/21645515.2017.1285472
10.1080/21645515.2017.1285472 · External reference
10.3390/vaccines13101038
10.3390/vaccines13101038 · External reference
10.1073/pnas.0703498104
10.1073/pnas.0703498104 · External reference
10.1128/mbio.03606-22
10.1128/mbio.03606-22 · External reference
10.3390/v12101116
10.3390/v12101116 · External reference
10.1371/journal.pntd.0008223
10.1371/journal.pntd.0008223 · External reference
10.1016/j.antiviral.2022.105495
10.1016/j.antiviral.2022.105495 · External reference
10.3390/s25154775
10.3390/s25154775 · External reference
10.1016/j.ebiom.2025.105728
10.1016/j.ebiom.2025.105728 · External reference
10.1186/s12985-025-02888-3
10.1186/s12985-025-02888-3 · External reference
10.1038/s41573-024-01102-3
10.1038/s41573-024-01102-3 · External reference
