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References from Coexpression of IGF1R and TSHR in extraocular muscles of patients with thyroid-associated orbitopathy. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1530/eje-21-0479
10.1530/eje-21-0479 · External reference
10.1111/cen.14296
10.1111/cen.14296 · External reference
10.1016/j.ajo.2011.02.018
10.1016/j.ajo.2011.02.018 · External reference
10.1210/jc.2012-3119
10.1210/jc.2012-3119 · External reference
10.1210/jc.2018-01493
10.1210/jc.2018-01493 · External reference
A review of TSHR- and IGF-1R-related pathogenesis and treatment of Graves’ orbitopathy
10.3389/fimmu.2023.1062045 · 2023 · External reference
10.4049/jimmunol.181.6.4397
10.4049/jimmunol.181.6.4397 · External reference
Bidirectional TSH and IGF-1 receptor cross talk mediates stimulation of hyaluronan secretion by Graves’ disease immunoglobins
10.1210/jc.2014-3566 · 2015 · External reference
Arrestin-β-1 Physically Scaffolds TSH and IGF1 Receptors to Enable Crosstalk
10.1210/en.2019-00055 · 2019 · External reference
10.1210/er.2018-00066
10.1210/er.2018-00066 · External reference
Building the Case for Insulin-Like Growth Factor Receptor-I Involvement in Thyroid-Associated Ophthalmopathy
2016 · External reference
Immunotherapies for thyroid eye disease
10.1097/med.0000000000000493 · 2019 · External reference
10.1210/clinem/dgab824
10.1210/clinem/dgab824 · External reference
10.1056/nejmoa1910434
10.1056/nejmoa1910434 · External reference
Insulin-Like Growth Factor Pathway and the Thyroid
10.3389/fendo.2021.653627 · 2021 · External reference
Teprotumumab for Thyroid Eye Disease-related Strabismus
10.1097/iop.0000000000002611 · 2024 · External reference
The role of rectus muscle myectomy in the management of large-angle strabismus for Graves’ ophthalmopathy
10.1038/eye.2017.28 · 2017 · External reference
Peripheral blood mononuclear cells - Can they provide a clue to the pathogenesis of Graves’ Orbitopathy?
10.1007/s12020-021-02865-0 · 2022 · External reference
Comparison of orbital fibroblasts from Graves’ ophthalmopathy and healthy control
10.1016/j.heliyon.2024.e28397 · 2024 · External reference
Thyroid-associated ophthalmopathy and ferroptosis: a review of pathological mechanisms and therapeutic strategies
10.3389/fimmu.2024.1475923 · 2024 · External reference
10.1089/thy.2007.0404
10.1089/thy.2007.0404 · External reference
Octreotide inhibits secretion of IGF-1 from orbital fibroblasts in patients with thyroid-associated ophthalmopathy via inhibition of the NF-κB pathway
10.1371/journal.pone.0249988 · 2021 · External reference
10.1167/iovs.14-14873
10.1167/iovs.14-14873 · External reference
Therapeutic IGF-I receptor inhibition alters fibrocyte immune phenotype in thyroid-associated ophthalmopathy
10.1073/pnas.2114244118 · 2021 · External reference
10.1007/978-1-0716-1948-3_13
10.1007/978-1-0716-1948-3_13 · External reference
Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening
10.1093/toxsci/kfz238 · 2020 · External reference
TSH-Mediated TNFα Production in Human Fibrocytes Is Inhibited by Teprotumumab, an IGF-1R Antagonist
10.1371/journal.pone.0130322 · 2015 · External reference
10.1210/jc.2014-1580
10.1210/jc.2014-1580 · External reference
Novel insights into the pathogenesis of thyroid eye disease through ferroptosis-related gene signature and immune infiltration analysis
2024 · External reference
10.1016/j.modpat.2023.100398
10.1016/j.modpat.2023.100398 · External reference
Dual-isotope imaging allows in vivo immunohistochemistry using radiolabelled antibodies in tumours
10.1016/j.nucmedbio.2019.01.010 · 2019 · External reference
A simple method for quantitating confocal fluorescent images
2021 · External reference
Linsitinib, an IGF-1R inhibitor, attenuates disease development and progression in a model of thyroid eye disease
10.3389/fendo.2023.1211473 · 2023 · External reference
Single-cell transcriptomics in thyroid eye disease
10.4103/tjo.tjo-d-23-00096 · 2024 · External reference
Unraveling the molecular architecture of autoimmune thyroid diseases at spatial resolution
10.1038/s41467-024-50192-5 · 2024 · External reference
Single-cell multiomic analysis unveils the immune landscape dynamics of graves’ ophthalmopathy
10.1038/s42003-025-08115-7 · 2025 · External reference
Single-cell BCR and transcriptome analysis reveals peripheral immune signatures in patients with thyroid-associated ophthalmopathy
2024 · External reference
Single-cell RNA sequencing depicts the local cell landscape in thyroid-associated ophthalmopathy
10.1016/j.xcrm.2022.100699 · 2022 · External reference
CD169+ classical monocyte as an important participant in Graves’ ophthalmopathy through CXCL12-CXCR4 axis
10.1016/j.isci.2024.109213 · 2024 · External reference
Thyroid-associated ophthalmopathy: Emergence of teprotumumab as a promising medical therapy
10.1016/j.beem.2020.101383 · 2020 · External reference
Integrating Differential Gene Expression Analysis with Perturbagen-Response Signatures May Identify Novel Therapies for Thyroid-Associated Orbitopathy
10.1167/tvst.9.9.39 · 2020 · External reference
10.1038/s41573-023-00688-4
10.1038/s41573-023-00688-4 · External reference
10.1007/978-1-0716-1948-3_13
10.1007/978-1-0716-1948-3_13 · ExternalCitation · doi-reference
Peripheral blood mononuclear cells - Can they provide a clue to the pathogenesis of Graves’ Orbitopathy?
10.1007/s12020-021-02865-0 · ExternalCitation · doi-reference
10.1016/j.ajo.2011.02.018
10.1016/j.ajo.2011.02.018 · ExternalCitation · doi-reference
Thyroid-associated ophthalmopathy: Emergence of teprotumumab as a promising medical therapy
10.1016/j.beem.2020.101383 · ExternalCitation · doi-reference
Comparison of orbital fibroblasts from Graves’ ophthalmopathy and healthy control
10.1016/j.heliyon.2024.e28397 · ExternalCitation · doi-reference
CD169+ classical monocyte as an important participant in Graves’ ophthalmopathy through CXCL12-CXCR4 axis
10.1016/j.isci.2024.109213 · ExternalCitation · doi-reference
10.1016/j.modpat.2023.100398
10.1016/j.modpat.2023.100398 · ExternalCitation · doi-reference
Dual-isotope imaging allows in vivo immunohistochemistry using radiolabelled antibodies in tumours
10.1016/j.nucmedbio.2019.01.010 · ExternalCitation · doi-reference
Single-cell RNA sequencing depicts the local cell landscape in thyroid-associated ophthalmopathy
10.1016/j.xcrm.2022.100699 · ExternalCitation · doi-reference
The role of rectus muscle myectomy in the management of large-angle strabismus for Graves’ ophthalmopathy
10.1038/eye.2017.28 · ExternalCitation · doi-reference
Unraveling the molecular architecture of autoimmune thyroid diseases at spatial resolution
10.1038/s41467-024-50192-5 · ExternalCitation · doi-reference
10.1038/s41573-023-00688-4
10.1038/s41573-023-00688-4 · ExternalCitation · doi-reference
Single-cell multiomic analysis unveils the immune landscape dynamics of graves’ ophthalmopathy
10.1038/s42003-025-08115-7 · ExternalCitation · doi-reference
10.1056/nejmoa1910434
10.1056/nejmoa1910434 · ExternalCitation · doi-reference
Therapeutic IGF-I receptor inhibition alters fibrocyte immune phenotype in thyroid-associated ophthalmopathy
10.1073/pnas.2114244118 · ExternalCitation · doi-reference
10.1089/thy.2007.0404
10.1089/thy.2007.0404 · ExternalCitation · doi-reference
Development of an In Vitro Human Thyroid Microtissue Model for Chemical Screening
10.1093/toxsci/kfz238 · ExternalCitation · doi-reference
Teprotumumab for Thyroid Eye Disease-related Strabismus
10.1097/iop.0000000000002611 · ExternalCitation · doi-reference
Immunotherapies for thyroid eye disease
10.1097/med.0000000000000493 · ExternalCitation · doi-reference
10.1111/cen.14296
10.1111/cen.14296 · ExternalCitation · doi-reference
10.1167/iovs.14-14873
10.1167/iovs.14-14873 · ExternalCitation · doi-reference
Integrating Differential Gene Expression Analysis with Perturbagen-Response Signatures May Identify Novel Therapies for Thyroid-Associated Orbitopathy
10.1167/tvst.9.9.39 · ExternalCitation · doi-reference
10.1210/clinem/dgab824
10.1210/clinem/dgab824 · ExternalCitation · doi-reference
Arrestin-β-1 Physically Scaffolds TSH and IGF1 Receptors to Enable Crosstalk
10.1210/en.2019-00055 · ExternalCitation · doi-reference
10.1210/er.2018-00066
10.1210/er.2018-00066 · ExternalCitation · doi-reference
10.1210/jc.2012-3119
10.1210/jc.2012-3119 · ExternalCitation · doi-reference
10.1210/jc.2014-1580
10.1210/jc.2014-1580 · ExternalCitation · doi-reference
Bidirectional TSH and IGF-1 receptor cross talk mediates stimulation of hyaluronan secretion by Graves’ disease immunoglobins
10.1210/jc.2014-3566 · ExternalCitation · doi-reference
10.1210/jc.2018-01493
10.1210/jc.2018-01493 · ExternalCitation · doi-reference
TSH-Mediated TNFα Production in Human Fibrocytes Is Inhibited by Teprotumumab, an IGF-1R Antagonist
10.1371/journal.pone.0130322 · ExternalCitation · doi-reference
Octreotide inhibits secretion of IGF-1 from orbital fibroblasts in patients with thyroid-associated ophthalmopathy via inhibition of the NF-κB pathway
10.1371/journal.pone.0249988 · ExternalCitation · doi-reference
10.1530/eje-21-0479
10.1530/eje-21-0479 · ExternalCitation · doi-reference
Insulin-Like Growth Factor Pathway and the Thyroid
10.3389/fendo.2021.653627 · ExternalCitation · doi-reference
Linsitinib, an IGF-1R inhibitor, attenuates disease development and progression in a model of thyroid eye disease
10.3389/fendo.2023.1211473 · ExternalCitation · doi-reference
A review of TSHR- and IGF-1R-related pathogenesis and treatment of Graves’ orbitopathy
10.3389/fimmu.2023.1062045 · ExternalCitation · doi-reference
Thyroid-associated ophthalmopathy and ferroptosis: a review of pathological mechanisms and therapeutic strategies
10.3389/fimmu.2024.1475923 · ExternalCitation · doi-reference
10.4049/jimmunol.181.6.4397
10.4049/jimmunol.181.6.4397 · ExternalCitation · doi-reference
Single-cell transcriptomics in thyroid eye disease
10.4103/tjo.tjo-d-23-00096 · ExternalCitation · doi-reference
