Research graph
References from Intestinal neutral ceramidase exacerbates MASH pathogenesis. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/j.cell.2021.04.015
10.1016/j.cell.2021.04.015 · External reference
Key takeaways from the updated multidisciplinary European MASLD guidelines
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10.1016/j.immuni.2025.03.017
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Microbiota Contribute to Obesity-related Increases in the Pulmonary Response to Ozone
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10.1038/nm.3444
10.1038/nm.3444 · External reference
Gut dysbiosis is linked to severe steatosis and enhances its diagnostic performance in MASLD
10.1136/egastro-2025-100204 · 2025 · External reference
10.1038/nature13564
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10.1016/j.cmet.2015.06.007
10.1016/j.cmet.2015.06.007 · External reference
Resolving fibrosis by stimulating HSC-dependent extracellular matrix degradation
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10.1111/liv.12331
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Targeting alkaline ceramidase 3 alleviates the severity of nonalcoholic steatohepatitis by reducing oxidative stress
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10.1016/j.plipres.2008.04.003
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Neutral Ceramidase Mediates Nonalcoholic Steatohepatitis by Regulating Monounsaturated Fatty Acids and Gut IgA+ B Cells
10.1002/hep.31628 · 2021 · External reference
Goblet cells: guardians of gut immunity and their role in gastrointestinal diseases
10.1136/egastro-2024-100098 · 2024 · External reference
10.1093/glycob/cwg054
10.1093/glycob/cwg054 · External reference
10.1016/j.chom.2022.09.001
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Bacterial and host fucosylation maintain IgA homeostasis to limit intestinal inflammation in mice
10.1038/s41564-024-01873-w · 2025 · External reference
Deficiency of Intestinal α1-2-Fucosylation Exacerbates Ethanol-Induced Liver Disease in Mice
10.1111/acer.14405 · 2020 · External reference
Intestinal Neutral Ceramidase Deficiency Triggers Regulatory T Cell Response via Gd3 to Protect the Host from Intestinal Inflammation
10.1002/advs.202512681 · 2026 · External reference
Exosome-like nanoparticles from Mulberry bark prevent DSS-induced colitis via the AhR/COPS8 pathway
10.15252/embr.202153365 · 2022 · External reference
Inhibition of Sphingosine‐1‐Phosphate‐Induced Th17 Cells Ameliorates Alcohol‐Associated Steatohepatitis in Mice
10.1002/hep.31321 · 2021 · External reference
Neutral ceramidase-dependent regulation of macrophage metabolism directs intestinal immune homeostasis and controls enteric infection
10.1016/j.celrep.2022.110560 · 2022 · External reference
Author Correction: Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut-liver axis
10.1038/s42255-025-01215-y · 2025 · External reference
10.3390/nu16162660
10.3390/nu16162660 · External reference
Parabacteroides distasonis: intriguing aerotolerant gut anaerobe with emerging antimicrobial resistance and pathogenic and probiotic roles in human health
10.1080/19490976.2021.1922241 · 2021 · External reference
T cell-mediated regulation of the microbiota protects against obesity
10.1126/science.aat9351 · 2019 · External reference
Alistipes putredinis Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease in Rats via Gut Microbiota Remodeling and Inflammatory Suppression
10.3390/nu17122013 · 2025 · External reference
10.1136/gutjnl-2021-325189
10.1136/gutjnl-2021-325189 · External reference
Cell-free enzymatic synthesis of GDP-L-fucose from mannose
10.1186/s13568-019-0798-1 · 2019 · External reference
Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation
10.1080/19490976.2024.2446375 · 2025 · External reference
10.1158/0008-5472.can-03-0974
10.1158/0008-5472.can-03-0974 · External reference
10.1126/science.7732381
10.1126/science.7732381 · External reference
Fucoidan prevents high-fat diet-induced obesity in animals by suppression of fat accumulation
10.1002/ptr.4965 · 2014 · External reference
10.1016/j.ejphar.2007.11.015
10.1016/j.ejphar.2007.11.015 · External reference
Fucoidan prevents concanavalin A-induced liver injury through induction of endogenous IL-10 in mice
2006 · External reference
Gut-lung axis in asthma and obesity: role of the gut microbiome
10.3389/falgy.2025.1618466 · 2025 · External reference
10.1038/nm.3423
10.1038/nm.3423 · External reference
Metabolic Dysfunction-associated Fatty Liver Disease is Associated with Greater Impairment of Lung Function than Nonalcoholic Fatty Liver Disease
10.14218/jcth.2021.00306 · 2022 · External reference
COPD and MAFLD: Prevalence, Clinical Characteristics, and Impact on Frequent Exacerbations
10.1164/ajrccm.2025.211.abstracts.a6153 · 2025 · External reference
Risk factors for pulmonary function alterations in children with metabolic dysfunction-associated fatty liver disease
10.1038/s41598-025-27313-1 · 2025 · External reference
Obesity and disease severity magnify disturbed microbiome-immune interactions in asthma patients
10.1038/s41467-019-13751-9 · 2019 · External reference
Obesity Reshapes the Microbial Population Structure along the Gut-Liver-Lung Axis in Mice
10.3390/biomedicines10020494 · 2022 · External reference
10.4049/jimmunol.1500395
10.4049/jimmunol.1500395 · External reference
Intestinal TM6SF2 protects against metabolic dysfunction-associated steatohepatitis through the gut-liver axis
10.1038/s42255-024-01177-7 · 2025 · External reference
The role of the microbiome in NAFLD and NASH
10.15252/emmm.201809302 · 2019 · External reference
10.1053/j.gastro.2021.08.041
10.1053/j.gastro.2021.08.041 · External reference
10.1016/j.chom.2024.02.001
10.1016/j.chom.2024.02.001 · External reference
Hippurate as a metabolomic marker of gut microbiome diversity: Modulation by diet and relationship to metabolic syndrome
10.1038/s41598-017-13722-4 · 2017 · External reference
10.1126/science.1223813
10.1126/science.1223813 · External reference
10.1038/nm.2307
10.1038/nm.2307 · External reference
Host-microbe co-metabolism via MCAD generates circulating metabolites including hippuric acid
10.1038/s41467-023-36138-3 · 2023 · External reference
10.1111/apt.17177
10.1111/apt.17177 · External reference
10.1136/gutjnl-2024-334412
10.1136/gutjnl-2024-334412 · External reference
Coordinated action of a gut–liver pathway drives alcohol detoxification and consumption
10.1038/s42255-024-01063-2 · 2024 · External reference
Hepatic fibrosis in Ahr(-/-) mice - Response
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10.1016/j.immuni.2013.08.003
10.1016/j.immuni.2013.08.003 · External reference
The Environmental Sensor AHR Protects from Inflammatory Damage by Maintaining Intestinal Stem Cell Homeostasis and Barrier Integrity
10.1016/j.immuni.2019.05.024 · 2019 · External reference
10.1146/annurev-immunol-032713-120245
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10.1038/s41577-019-0125-8 · External reference
10.1016/j.chom.2014.08.017
10.1016/j.chom.2014.08.017 · External reference
Intestinal α1-2-Fucosylation Contributes to Obesity and Steatohepatitis in Mice
10.1016/j.jcmgh.2021.02.009 · 2021 · External reference
Intestinal Fut2 deficiency exacerbated alcohol-related liver disease by disrupting nicotinamide metabolism
10.1002/ctm2.70447 · 2025 · External reference
10.1016/j.jaci.2008.03.004
10.1016/j.jaci.2008.03.004 · External reference
Obesity and hormonal influences on asthma: Mechanisms, management challenges, and emerging therapeutic strategies
10.1016/j.jaci.2024.09.018 · 2024 · External reference
