Research graph
References from Mechanosensitive ion channels in intestinal homeostasis and disease. Local targets link to admitted publications; unresolved targets remain external evidence.
Mechanotransduction in gastrointestinal smooth muscle cells: role of mechanosensitive ion channels
10.1152/ajpgi.00481.2020 · 2021 · External reference
10.1038/s41580-024-00773-5
10.1038/s41580-024-00773-5 · External reference
10.1126/science.1193270
10.1126/science.1193270 · External reference
Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2
10.1038/s41467-024-47208-5 · 2024 · External reference
Piezo1: structural pharmacology and mechanotransduction mechanisms
10.1016/j.tips.2025.06.009 · 2025 · External reference
Mammalian TRP ion channels are insensitive to membrane stretch
10.1242/jcs.238360 · 2019 · External reference
10.1038/s41575-021-00543-0
10.1038/s41575-021-00543-0 · External reference
Piezo channels in the intestinal tract
10.3389/fphys.2024.1356317 · 2024 · External reference
Mechanosensing Piezo channels in gastrointestinal disorders
10.1172/jci171955 · 2023 · External reference
10.1074/jbc.m108125200
10.1074/jbc.m108125200 · External reference
TREK-1 channel expression in smooth muscle as a target for regulating murine intestinal contractility: therapeutic implications for motility disorders
10.3389/fphys.2018.00157 · 2018 · External reference
10.1038/s41563-022-01400-4
10.1038/s41563-022-01400-4 · External reference
PIEZO-dependent mechanosensing is essential for intestinal stem cell fate decision and maintenance
10.1126/science.adj7615 · 2024 · External reference
Piezo1 regulates colon stem cells to maintain epithelial homeostasis through SCD1-Wnt-β-catenin and programming fatty acid metabolism
10.1016/j.celrep.2025.115400 · 2025 · External reference
10.1038/s41586-024-08581-9
10.1038/s41586-024-08581-9 · External reference
The Arp2/3 complex maintains gut epithelial integrity under mechanical challenge
10.1016/j.cub.2025.08.026 · 2025 · External reference
Epithelial tension controls intestinal cell extrusion
10.1126/science.adr8753 · 2025 · External reference
10.1113/jp272718
10.1113/jp272718 · External reference
10.1073/pnas.1804938115
10.1073/pnas.1804938115 · External reference
Piezo2 interacts with E-cadherin in specialized gastrointestinal epithelial mechanoreceptors
10.1085/jgp.202213324 · 2024 · External reference
Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes
10.1016/j.apsb.2024.04.016 · 2024 · External reference
Intestinal distension orchestrates neuronal activity in the enteric nervous system of adult mice
10.1113/jp284171 · 2023 · External reference
10.1016/j.cell.2025.02.031
10.1016/j.cell.2025.02.031 · External reference
Smooth muscle cell Piezo1 depletion results in impaired contractile properties in murine small bowel
10.1038/s42003-025-07697-6 · 2025 · External reference
Essential roles of the unfolded protein response in intestinal physiology
10.1136/egastro-2024-100129 · 2024 · External reference
The mechanosensitive ion channel PIEZO1 in intestinal epithelial cells mediates inflammation through the NOD-like receptor 3 pathway in Crohn’s disease
10.1093/ibd/izac152 · 2023 · External reference
Epithelial Piezo1 deletion ameliorates intestinal barrier damage by regulating ferroptosis in ulcerative colitis
10.1016/j.freeradbiomed.2024.08.039 · 2024 · External reference
Intestinal Piezo1 aggravates intestinal barrier dysfunction during sepsis by mediating Ca2+ influx
10.1186/s12967-024-05076-z · 2024 · External reference
Gut cannabinoid receptor 1 regulates alcohol binge-induced intestinal permeability
10.1136/egastro-2024-100173 · 2025 · External reference
10.1016/j.lfs.2021.119254
10.1016/j.lfs.2021.119254 · External reference
Activation of goblet cell Piezo1 alleviates mucus barrier damage in mice exposed to WAS by inhibiting H3K9me3 modification
10.1186/s13578-023-00952-5 · 2023 · External reference
Goblet cells: guardians of gut immunity and their role in gastrointestinal diseases
10.1136/egastro-2024-100098 · 2024 · External reference
Piezo1 promotes colitis progression by modulating the Nrf2/NF-κB/NLRP3 signaling pathway
10.1016/j.bcp.2025.117293 · 2025 · External reference
Piezo1-specific Deletion in Macrophage Protects the Progression of Chronic Inflammatory Bowel Disease in Mice
10.1016/j.jcmgh.2025.101495 · 2025 · External reference
Mechanically activated ion channel Piezo1 modulates macrophage polarization and stiffness sensing
10.1038/s41467-021-23482-5 · 2021 · External reference
The TMEM63B channel facilitates intestinal motility and enhances proliferation of intestinal stem cells
10.3390/cells13211784 · 2024 · External reference
Pathophysiological role of ion channels and transporters in gastrointestinal mucosal diseases
10.1007/s00018-021-04011-5 · 2021 · External reference
Ion channel regulation of gut immunity
10.1085/jgp.202113042 · 2023 · External reference
10.1016/j.neuron.2022.11.015
10.1016/j.neuron.2022.11.015 · External reference
10.1016/j.cell.2023.07.007
10.1016/j.cell.2023.07.007 · External reference
10.1097/j.pain.0000000000003399
10.1097/j.pain.0000000000003399 · External reference
10.1136/gutjnl-2020-321530
10.1136/gutjnl-2020-321530 · External reference
Dectin-1 induces TRPV1 sensitization and contributes to visceral hypersensitivity of irritable bowel syndrome in male mice
10.1002/ejp.2311 · 2024 · External reference
Molecular mechanisms and pathways in visceral pain
10.3390/cells14151146 · 2025 · External reference
Mechanosensory Piezo2 regulated by gut microbiota participates in the development of visceral hypersensitivity and intestinal dysmotility
10.1080/19490976.2025.2497399 · 2025 · External reference
10.1002/glia.24599
10.1002/glia.24599 · External reference
10.1136/gutjnl-2024-334037
10.1136/gutjnl-2024-334037 · External reference
Pain experience of people with inflammatory bowel disease: a qualitative study
10.1136/bmjgast-2025-001866 · 2025 · External reference
10.1136/gut.2007.138982
10.1136/gut.2007.138982 · External reference
10.1053/j.gastro.2015.12.034
10.1053/j.gastro.2015.12.034 · External reference
10.1053/j.gastro.2015.04.011
10.1053/j.gastro.2015.04.011 · External reference
10.1152/physrev.00036.2022
10.1152/physrev.00036.2022 · External reference
Piezo1 in intestinal smooth muscle cells: emerging perspectives
10.1113/jp287636 · 2026 · External reference
10.1152/ajpgi.00016.2017
10.1152/ajpgi.00016.2017 · External reference
10.1053/j.gastro.2022.01.043
10.1053/j.gastro.2022.01.043 · External reference
10.1113/jp283383
10.1113/jp283383 · External reference
10.1016/j.cell.2023.07.006
10.1016/j.cell.2023.07.006 · External reference
Dyssynergia phenotypes in obstructed defecation: insights from Fecobionics assessment
10.1136/bmjgast-2025-002212 · 2026 · External reference
10.1136/gutjnl-2023-329963
10.1136/gutjnl-2023-329963 · External reference
Biomechanical Properties of Strictures in Crohn’s Disease: Can Dynamic Contrast-Enhanced Ultrasonography and Magnetic Resonance Enterography Predict Stiffness?
10.3390/diagnostics12061370 · 2022 · External reference
Magnetic Resonance Elastography for Assessing Fibrosis in Patients with Crohn’s Disease: A Pilot Study
10.1007/s10620-021-07311-9 · 2022 · External reference
Ultrasound shear wave elastography in pediatric stricturing small bowel Crohn disease: correlation with histology and second harmonic imaging microscopy
10.1007/s00247-022-05446-z · 2023 · External reference
Mechanosensitive Ion Channel PIEZO1 as a Key Regulator of Intestinal Fibrosis in Crohn’s Disease
10.1093/ibd/izaf041 · 2025 · External reference
Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in Crohn’s disease
10.1172/jci173835 · 2024 · External reference
TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis in Crohn’s disease
10.1172/jci179472 · 2024 · External reference
10.1016/j.cell.2025.08.029
10.1016/j.cell.2025.08.029 · External reference
10.1053/j.gastro.2023.07.014
10.1053/j.gastro.2023.07.014 · External reference
10.1038/s41588-025-02225-y
10.1038/s41588-025-02225-y · External reference
Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut-on-a-Chip
10.1002/advs.202516040 · 2026 · External reference
Activation of myofibroblast TRPA1 by steroids and pirfenidone ameliorates fibrosis in experimental Crohn’s disease
10.1016/j.jcmgh.2017.12.005 · 2018 · External reference
Restoring Prostacyclin/PGI2-PTGIR signaling alleviates intestinal fibrosis in Crohn’s disease via fibroblast-specific YAP/TAZ inhibition
10.1093/ecco-jcc/jjaf084 · 2025 · External reference
Intestinal strictures in Crohn’s disease: an update from 2023
10.1002/ueg2.12568 · 2024 · External reference
10.1111/bph.17351
10.1111/bph.17351 · External reference
10.1056/nejmoa1602812
10.1056/nejmoa1602812 · External reference
Assessment of transmural treatment response in known Crohn’s disease: a prospective blinded study of the intermodality agreement between intestinal ultrasound and magnetic resonance enterography
10.1136/bmjgast-2025-002175 · 2026 · External reference
10.1038/s41556-021-00699-6
10.1038/s41556-021-00699-6 · External reference
10.1016/j.stem.2021.04.002
10.1016/j.stem.2021.04.002 · External reference
In situ modulation of intestinal organoid epithelial curvature through photoinduced viscoelasticity directs crypt morphogenesis
10.1126/sciadv.add5668 · 2023 · External reference
Mechanochemical bistability of intestinal organoids enables robust morphogenesis
10.1038/s41567-025-02792-1 · 2025 · External reference
Tissue geometry drives deterministic organoid patterning
10.1126/science.aaw9021 · 2022 · External reference
10.1038/s41467-022-29279-4
10.1038/s41467-022-29279-4 · External reference
Bioinspired hyaluronic acid-based hydrogel fuels bi-directional lung organoid maturation via PIEZO1 and ITGB1-mediated mechanosensation
10.1002/admi.202400194 · 2024 · External reference
