Research graph
References from How to manage: acute-on-chronic liver failure. Local targets link to admitted publications; unresolved targets remain external evidence.
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Liver transplantation for critically ill patients with acute on chronic liver failure: a prospective national programme of waitlist prioritisation
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Liver transplantation in the most severely ill cirrhotic patients: A multicenter study in acute-on-chronic liver failure grade 3
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Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures
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Liver failure determines the outcome in patients of acute-on-chronic liver failure (ACLF): comparison of APASL ACLF research consortium (AARC) and CLIF-SOFA models
10.1007/s12072-017-9816-z · 2017 · External reference
NACSELD acute‐on‐chronic liver failure (NACSELD‐ACLF) score predicts 30‐day survival in hospitalized patients with cirrhosis
10.1002/hep.29773 · 2018 · External reference
EASL-CLIF criteria outperform NACSELD criteria for diagnosis and prognostication in ACLF
10.1016/j.jhep.2021.05.033 · 2021 · External reference
Transplantation for EASL-CLIF and APASL acute-on-chronic liver failure (ACLF) patients: The TEA cohort to evaluate long-term post-Transplant outcomes
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Development and validation of the A-TANGO organ failure score for acute-on-chronic liver failure in global cohorts
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The prognostic value of acute-on-chronic liver failure during the course of severe alcoholic hepatitis
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10.1111/jgh.13593
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Cirrhotic patients with portal hypertension-related bleeding and an indication for early-TIPS: a large multicentre audit with real-life results
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10.1016/j.jhep.2026.07.030
10.1016/j.jhep.2026.07.030 · External reference
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Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS
10.1016/j.jhep.2020.04.024 · 2020 · External reference
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10.1016/j.jhep.2020.06.010 · 2021 · External reference
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10.1186/cc9335 · 2010 · External reference
Point-of-care ultrasound of the inferior vena cava for intravascular volume assessment during intravenous albumin infusion in patients with cirrhosis
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Point-of-Care Echocardiography and Hemodynamic Monitoring in Cirrhosis and Acute-on-Chronic Liver Failure in the COVID-19 Era
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Perioperative monitoring in liver transplant patients
10.1016/j.jceh.2012.06.003 · 2012 · External reference
Exploration of skin perfusion in cirrhotic patients with septic shock
10.1016/j.jhep.2014.10.012 · 2015 · External reference
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10.1002/hep.25573 · External reference
Low‐Dose Hydrocortisone in Cirrhotic Patients With Septic Shock: A Double‐Blind Randomised Placebo‐Controlled Trial
10.1111/liv.70257 · 2025 · External reference
Perioperative extracorporeal membrane oxygenation in liver transplantation—bridge to transplantation, intraoperative salvage, and postoperative support: outcomes and predictors for survival in a large-volume liver transplant center
10.1016/j.ajt.2024.08.021 · 2025 · External reference
10.1002/hep.30592
10.1002/hep.30592 · External reference
Acute kidney injury in patients with acute-on-chronic liver failure: clinical significance and management
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10.1016/j.jhep.2024.03.031 · External reference
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10.1002/hep.26980 · External reference
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Liver Failure, Hepatic Encephalopathy, and Infection Contribute to Mortality Risk in a Global Cirrhosis Cohort
10.1016/j.cgh.2025.06.021 · 2026 · External reference
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10.1136/flgastro-2025-103330 · External reference
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Antibiotics With or Without Rifaximin for Acute Hepatic Encephalopathy in Critically Ill Patients With Cirrhosis: A Double-Blind, Randomized Controlled (ARiE) Trial
10.14309/ajg.0000000000002575 · 2024 · External reference
L‐ornithine L‐aspartate in acute treatment of severe hepatic encephalopathy: A double‐blind randomized controlled trial
10.1002/hep.32255 · 2022 · External reference
Ammonia measurement in cirrhosis: International Delphi consensus recommendations from ISHEN
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Acute encephalopathy without hyperammonemia has a different presentation than overt HE and displays a similarly severe prognosis
10.1097/hep.0000000000001252 · 2025 · External reference
Plasma ammonia levels predict hospitalisation with liver-related complications and mortality in clinically stable outpatients with cirrhosis
10.1016/j.jhep.2022.07.014 · 2022 · External reference
Development and validation of the AMMON-OHE model to predict risk of overt hepatic encephalopathy occurrence in outpatients with cirrhosis
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Multidisciplinary approach to malnutrition and physical frailty in patients with decompensated cirrhosis
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10.1097/ccm.0000000000001525
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An Open-label Randomized Controlled Trial of Early Initiation of Nasogastric Feeding After Endotherapy in Variceal Bleeding: A Proof-of-concept Study
10.1016/j.jceh.2023.07.413 · 2024 · External reference
Micronutrients in Liver Disease: Roles, Risk Factors for Deficiency, and Recommendations for Supplementation
10.1002/ncp.10451 · 2020 · External reference
10.1016/j.jhep.2021.09.003
10.1016/j.jhep.2021.09.003 · External reference
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10.1002/hep.30794 · External reference
10.1053/j.gastro.2011.11.027
10.1053/j.gastro.2011.11.027 · External reference
Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicenter randomized trial (GRAFT study)
10.1016/j.jhep.2021.07.033 · 2021 · External reference
Granulocyte-colony stimulating factor therapy improves survival in patients with hepatitis B virus-associated acute-on-chronic liver failure
10.3748/wjg.v19.i7.1104 · 2013 · External reference
Effects of granulocyte-colony stimulating factor (G-CSF) on stem cell mobilization in patients with liver failure
10.1016/j.ejim.2016.09.006 · 2016 · External reference
Factors Associated with Survival of Patients With Severe Acute-On-Chronic Liver Failure Before and After Liver Transplantation
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Long-term outcome following liver transplantation of patients with ACLF grade 3
10.1016/j.jhep.2024.06.039 · 2025 · External reference
Unresolved reference
External reference
The novel SALT-M score predicts 1-year post-transplant mortality in patients with severe acute-on-chronic liver failure
10.1016/j.jhep.2023.05.028 · 2023 · External reference
Evaluation of the transplantation of ACLF grade 3 model (TAM) in the multicenter French experience
10.1097/lvt.0000000000000111 · 2023 · External reference
Liver transplantation for critically ill cirrhotic patients: Stratifying utility based on pretransplant factors
10.1111/ajt.15852 · 2020 · External reference
Liver transplantation for acute-on-chronic liver failure
10.1016/s2468-1253(23)00363-1 · 2024 · External reference
Liver Transplantation in the Context of Acute-On-Chronic Liver Failure (ACLF): Where Do We Stand in 2025?
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Uncertainty in the impact of liver support systems in acute-on-chronic liver failure: a systematic review and network meta-analysis
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Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on- chronic liver failure
10.1016/j.jhep.2023.03.013 · 2023 · External reference
Plasma exchange for acute and acute-on-chronic liver failure: A systematic review and meta-analysis
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Acute-on-chronic liver failure (ACLF): the ‘Kyoto Consensus’—steps from Asia
10.1007/s12072-024-10773-4 · 2025 · External reference
High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial
10.1016/j.jhep.2015.08.018 · 2016 · External reference
LBO-002 Plasma exchange with albumin 5% significantly increases 90-day overall survival in acute-on-chronic liver failure: topline results of the APACHE trial
10.1016/s0168-8278(26)00306-5 · 2026 · External reference
10.1007/s00134-024-07404-9
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10.1002/hep.26980 · ExternalCitation · doi-reference
Survival in infection-related acute-on-chronic liver failure is defined by extrahepatic organ failures
10.1002/hep.27077 · ExternalCitation · doi-reference
NACSELD acute‐on‐chronic liver failure (NACSELD‐ACLF) score predicts 30‐day survival in hospitalized patients with cirrhosis
10.1002/hep.29773 · ExternalCitation · doi-reference
10.1002/hep.30592
10.1002/hep.30592 · ExternalCitation · doi-reference
10.1002/hep.30794
10.1002/hep.30794 · ExternalCitation · doi-reference
10.1002/hep.30934
10.1002/hep.30934 · ExternalCitation · doi-reference
L‐ornithine L‐aspartate in acute treatment of severe hepatic encephalopathy: A double‐blind randomized controlled trial
10.1002/hep.32255 · ExternalCitation · doi-reference
Micronutrients in Liver Disease: Roles, Risk Factors for Deficiency, and Recommendations for Supplementation
10.1002/ncp.10451 · ExternalCitation · doi-reference
10.1007/s00134-024-07404-9
10.1007/s00134-024-07404-9 · ExternalCitation · doi-reference
Liver failure determines the outcome in patients of acute-on-chronic liver failure (ACLF): comparison of APASL ACLF research consortium (AARC) and CLIF-SOFA models
10.1007/s12072-017-9816-z · ExternalCitation · doi-reference
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10.1007/s12072-019-09946-3 · ExternalCitation · doi-reference
Acute-on-chronic liver failure (ACLF): the ‘Kyoto Consensus’—steps from Asia
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10.1016/0016-5085(78)90401-8
10.1016/0016-5085(78)90401-8 · ExternalCitation · doi-reference
Immunopathogenesis of acute on chronic liver failure
10.1016/j.ajt.2024.02.001 · ExternalCitation · doi-reference
Perioperative extracorporeal membrane oxygenation in liver transplantation—bridge to transplantation, intraoperative salvage, and postoperative support: outcomes and predictors for survival in a large-volume liver transplant center
10.1016/j.ajt.2024.08.021 · ExternalCitation · doi-reference
10.1016/j.cgh.2014.08.041
10.1016/j.cgh.2014.08.041 · ExternalCitation · doi-reference
Liver Failure, Hepatic Encephalopathy, and Infection Contribute to Mortality Risk in a Global Cirrhosis Cohort
10.1016/j.cgh.2025.06.021 · ExternalCitation · doi-reference
Re-bleeding rates and survival after early transjugular intrahepatic portosystemic shunt (TIPS) in clinical practice
10.1016/j.dld.2017.08.002 · ExternalCitation · doi-reference
Transplantation for EASL-CLIF and APASL acute-on-chronic liver failure (ACLF) patients: The TEA cohort to evaluate long-term post-Transplant outcomes
10.1016/j.eclinm.2022.101476 · ExternalCitation · doi-reference
Effects of granulocyte-colony stimulating factor (G-CSF) on stem cell mobilization in patients with liver failure
10.1016/j.ejim.2016.09.006 · ExternalCitation · doi-reference
Perioperative monitoring in liver transplant patients
10.1016/j.jceh.2012.06.003 · ExternalCitation · doi-reference
An Open-label Randomized Controlled Trial of Early Initiation of Nasogastric Feeding After Endotherapy in Variceal Bleeding: A Proof-of-concept Study
10.1016/j.jceh.2023.07.413 · ExternalCitation · doi-reference
10.1016/j.jhep.2010.02.023
10.1016/j.jhep.2010.02.023 · ExternalCitation · doi-reference
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10.1016/j.jhep.2014.06.012 · ExternalCitation · doi-reference
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10.1016/j.jhep.2014.08.010 · ExternalCitation · doi-reference
Exploration of skin perfusion in cirrhotic patients with septic shock
10.1016/j.jhep.2014.10.012 · ExternalCitation · doi-reference
High-volume plasma exchange in patients with acute liver failure: An open randomised controlled trial
10.1016/j.jhep.2015.08.018 · ExternalCitation · doi-reference
Liver transplantation in the most severely ill cirrhotic patients: A multicenter study in acute-on-chronic liver failure grade 3
10.1016/j.jhep.2017.06.009 · ExternalCitation · doi-reference
Cirrhotic patients with portal hypertension-related bleeding and an indication for early-TIPS: a large multicentre audit with real-life results
10.1016/j.jhep.2017.09.002 · ExternalCitation · doi-reference
The prognostic value of acute-on-chronic liver failure during the course of severe alcoholic hepatitis
10.1016/j.jhep.2018.02.022 · ExternalCitation · doi-reference
10.1016/j.jhep.2018.03.005
10.1016/j.jhep.2018.03.005 · ExternalCitation · doi-reference
10.1016/j.jhep.2018.06.024
10.1016/j.jhep.2018.06.024 · ExternalCitation · doi-reference
Rebleeding and mortality risk are increased by ACLF but reduced by pre-emptive TIPS
10.1016/j.jhep.2020.04.024 · ExternalCitation · doi-reference
Determinants of mortality in patients with cirrhosis and uncontrolled variceal bleeding
10.1016/j.jhep.2020.06.010 · ExternalCitation · doi-reference
10.1016/j.jhep.2020.11.010
10.1016/j.jhep.2020.11.010 · ExternalCitation · doi-reference
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10.1016/j.jhep.2020.11.019 · ExternalCitation · doi-reference
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10.1016/j.jhep.2020.11.048 · ExternalCitation · doi-reference
EASL-CLIF criteria outperform NACSELD criteria for diagnosis and prognostication in ACLF
10.1016/j.jhep.2021.05.033 · ExternalCitation · doi-reference
Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicenter randomized trial (GRAFT study)
10.1016/j.jhep.2021.07.033 · ExternalCitation · doi-reference
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Plasma ammonia levels predict hospitalisation with liver-related complications and mortality in clinically stable outpatients with cirrhosis
10.1016/j.jhep.2022.07.014 · ExternalCitation · doi-reference
Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on- chronic liver failure
10.1016/j.jhep.2023.03.013 · ExternalCitation · doi-reference
10.1016/j.jhep.2023.03.017
10.1016/j.jhep.2023.03.017 · ExternalCitation · doi-reference
EASL Clinical Practice Guidelines on acute-on-chronic liver failure
10.1016/j.jhep.2023.04.021 · ExternalCitation · doi-reference
Development and validation of the AMMON-OHE model to predict risk of overt hepatic encephalopathy occurrence in outpatients with cirrhosis
10.1016/j.jhep.2023.05.022 · ExternalCitation · doi-reference
The novel SALT-M score predicts 1-year post-transplant mortality in patients with severe acute-on-chronic liver failure
10.1016/j.jhep.2023.05.028 · ExternalCitation · doi-reference
10.1016/j.jhep.2024.03.031
10.1016/j.jhep.2024.03.031 · ExternalCitation · doi-reference
Long-term outcome following liver transplantation of patients with ACLF grade 3
10.1016/j.jhep.2024.06.039 · ExternalCitation · doi-reference
EASL Clinical Practice Guidelines on the management of hepatitis B virus infection
10.1016/j.jhep.2025.03.018 · ExternalCitation · doi-reference
Development and validation of the A-TANGO organ failure score for acute-on-chronic liver failure in global cohorts
10.1016/j.jhep.2026.02.017 · ExternalCitation · doi-reference
Ammonia measurement in cirrhosis: International Delphi consensus recommendations from ISHEN
10.1016/j.jhep.2026.03.020 · ExternalCitation · doi-reference
10.1016/j.jhep.2026.07.030
10.1016/j.jhep.2026.07.030 · ExternalCitation · doi-reference
Portal hypertension in cirrhosis: Pathophysiological mechanisms and therapy
10.1016/j.jhepr.2021.100316 · ExternalCitation · doi-reference
Point-of-care ultrasound of the inferior vena cava for intravascular volume assessment during intravenous albumin infusion in patients with cirrhosis
10.1016/j.jhepr.2025.101559 · ExternalCitation · doi-reference
Liver transplantation for critically ill patients with acute on chronic liver failure: a prospective national programme of waitlist prioritisation
10.1016/j.lanepe.2024.101067 · ExternalCitation · doi-reference
10.1016/s0140-6736(21)01701-3
10.1016/s0140-6736(21)01701-3 · ExternalCitation · doi-reference
Bacterial infection in the pathogenesis of variceal bleeding
10.1016/s0140-6736(98)06020-6 · ExternalCitation · doi-reference
LBO-002 Plasma exchange with albumin 5% significantly increases 90-day overall survival in acute-on-chronic liver failure: topline results of the APACHE trial
10.1016/s0168-8278(26)00306-5 · ExternalCitation · doi-reference
The efficacy and safety of nucleos(t)ide analogues in the treatment of HBV-related acute-on-chronic liver failure: a meta-analysis
10.1016/s1665-2681(19)30998-6 · ExternalCitation · doi-reference
Liver transplantation for acute-on-chronic liver failure
10.1016/s2468-1253(23)00363-1 · ExternalCitation · doi-reference
Global prevalence and characteristics of infections and clinical outcomes in hospitalised patients with cirrhosis: a prospective cohort study for the CLEARED Consortium
10.1016/s2468-1253(24)00224-3 · ExternalCitation · doi-reference
10.1038/ajg.2017.471
10.1038/ajg.2017.471 · ExternalCitation · doi-reference
microRNA associated with hepatocyte injury and systemic inflammation may predict adverse outcomes in cirrhotic patients
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Factors Associated with Survival of Patients With Severe Acute-On-Chronic Liver Failure Before and After Liver Transplantation
10.1053/j.gastro.2018.12.007 · ExternalCitation · doi-reference
Defining Organ Failures in Patients With Cirrhosis: Consensus Statements
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