Research graph
References from Microbiota-host genetic interactions modulate MASLD risk in <i> PNPLA3 <sup>I148M</sup> </i> carriers via ceramides and are reversible by targeted microbial interventions. Local targets link to admitted publications; unresolved targets remain external evidence.
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): A State-of-the-Art Review
10.7570/jomes23052 · 2023 · External reference
Prevalence of at-risk MASH, MetALD and alcohol-associated steatotic liver disease in the general population
10.1111/apt.17958 · 2024 · External reference
10.1016/j.cgh.2018.05.057
10.1016/j.cgh.2018.05.057 · External reference
10.1016/j.metabol.2015.12.012
10.1016/j.metabol.2015.12.012 · External reference
NAFLD: PNPLA3 and obesity: a synergistic relationship in NAFLD
10.1038/nrgastro.2017.74 · 2017 · External reference
PNPLA3 is a triglyceride lipase that mobilizes polyunsaturated fatty acids to facilitate hepatic secretion of large-sized very low-density lipoprotein
10.1038/s41467-024-49224-x · 2024 · External reference
10.1016/j.cld.2015.10.005
10.1016/j.cld.2015.10.005 · External reference
10.1038/ng.257
10.1038/ng.257 · External reference
Impact of PNPLA3 I148M on Clinical Outcomes in Patients With MASLD
10.1111/liv.16133 · 2025 · External reference
10.3748/wjg.v18.i22.2813
10.3748/wjg.v18.i22.2813 · External reference
Toward Genetic Prediction of Nonalcoholic Fatty Liver Disease Trajectories: PNPLA3 and Beyond
10.1053/j.gastro.2020.01.053 · 2020 · External reference
PNPLA3 I148M Interacts With Environmental Triggers to Cause Human Disease
10.1111/liv.16106 · 2025 · External reference
Non-alcoholic fatty liver and the gut microbiota
10.1016/j.molmet.2016.06.003 · 2016 · External reference
10.1038/nature12506
10.1038/nature12506 · External reference
Local barriers configure systemic communications between the host and microbiota
10.1126/science.abo2366 · 2022 · External reference
10.1016/j.cell.2014.01.026
10.1016/j.cell.2014.01.026 · External reference
10.1016/j.cell.2011.04.022
10.1016/j.cell.2011.04.022 · External reference
10.1002/hep.31897
10.1002/hep.31897 · External reference
Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment
10.1038/s41467-022-31312-5 · 2022 · External reference
10.1080/17474124.2017.1343143
10.1080/17474124.2017.1343143 · External reference
Lipid droplets: platforms with multiple functions in cancer hallmarks
10.1038/s41419-020-2297-3 · 2020 · External reference
Role of hepatic peroxisome proliferator-activated receptor γ in non-alcoholic fatty liver disease
10.1530/joe-22-0155 · 2023 · External reference
10.1016/j.plipres.2012.06.001
10.1016/j.plipres.2012.06.001 · External reference
PNPLA3-associated mitochondrial dysfunction
10.1038/s41588-023-01636-z · 2024 · External reference
Mitochondria, oxidative stress and nonalcoholic fatty liver disease: A complex relationship
10.1111/eci.13622 · 2022 · External reference
The beginning of GPX2 and 30 years later
10.1016/j.freeradbiomed.2022.06.232 · 2022 · External reference
10.1016/j.cmet.2014.08.002
10.1016/j.cmet.2014.08.002 · External reference
Ceramide synthase 6 (CerS6) is upregulated in alcohol-associated liver disease and exhibits sex-based differences in the regulation of energy homeostasis and lipid droplet accumulation
10.1016/j.molmet.2023.101804 · 2023 · External reference
Effects of bile acids on the growth, composition and metabolism of gut bacteria
10.1038/s41522-024-00566-w · 2024 · External reference
10.1038/labinvest.2010.107
10.1038/labinvest.2010.107 · External reference
10.1093/toxsci/kfp094
10.1093/toxsci/kfp094 · External reference
The PNPLA3 I148M variant increases ketogenesis and decreases hepatic de novo lipogenesis and mitochondrial function in humans
10.1016/j.cmet.2023.10.008 · 2023 · External reference
Procedures for Fecal Microbiota Transplantation in Murine Microbiome Studies
10.3389/fcimb.2021.711055 · 2021 · External reference
Key features and guidelines for the application of microbial alpha diversity metrics
10.1038/s41598-024-77864-y · 2025 · External reference
NCBI Taxonomy: a comprehensive update on curation, resources and tools
10.1093/database/baaa062 · 2020 · External reference
Gut bacterium Intestinimonas butyriciproducens improves host metabolic health: evidence from cohort and animal intervention studies
10.1186/s40168-024-02002-9 · 2025 · External reference
Lactobacillus spp. for Gastrointestinal Health: Current and Future Perspectives
10.3389/fimmu.2022.840245 · 2022 · External reference
10.1021/jf403288r
10.1021/jf403288r · External reference
Dietary fibre directs microbial tryptophan metabolism via metabolic interactions in the gut microbiota
10.1038/s41564-024-01737-3 · 2024 · External reference
Targeting PI3K/AKT signaling pathway in obesity
10.1016/j.biopha.2023.114244 · 2023 · External reference
10.1038/ismej.2012.6
10.1038/ismej.2012.6 · External reference
Mode of action of Akkermansia muciniphila in the intestinal dialogue: role of extracellular proteins, metabolites and cell envelope components
10.20517/mrr.2023.05 · 2023 · External reference
Paradoxical lower serum triglyceride levels and higher type 2 diabetes mellitus susceptibility in obese individuals with the PNPLA3 148M variant
10.1371/journal.pone.0039362 · 2012 · External reference
10.1016/s0140-6736(05)67402-8
10.1016/s0140-6736(05)67402-8 · External reference
10.1038/s41591-024-03283-1
10.1038/s41591-024-03283-1 · External reference
Targeted inhibition of hepatic de novo ceramide synthesis ameliorates MASH
10.1126/sciadv.adx2681 · 2025 · External reference
10.1146/annurev-physiol-031620-093815
10.1146/annurev-physiol-031620-093815 · External reference
10.2337/db16-0663
10.2337/db16-0663 · External reference
