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References from Regulatory T cells in autoimmune liver diseases. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1053/j.gastro.2024.01.049
10.1053/j.gastro.2024.01.049 · External reference
10.1136/gutjnl-2020-322362
10.1136/gutjnl-2020-322362 · External reference
Priming and Maintenance of Adaptive Immunity in the Liver
10.1146/annurev-immunol-090122-041354 · 2024 · External reference
The history and promise of Treg cells
10.1016/j.immuni.2025.11.011 · 2025 · External reference
Altered aryl-hydrocarbon-receptor signalling affects regulatory and effector cell immunity in autoimmune hepatitis
10.1016/j.jhep.2020.06.044 · 2021 · External reference
5-Aza-2-deoxycytidine alleviates the progression of primary biliary cholangitis by suppressing the FoxP3 methylation and promoting the Treg/Th17 balance
10.1016/j.intimp.2021.107820 · 2021 · External reference
10.1016/j.jhep.2021.03.016
10.1016/j.jhep.2021.03.016 · External reference
10.1002/hep.31739
10.1002/hep.31739 · External reference
10.1155/2020/3019378
10.1155/2020/3019378 · External reference
Conventional type 1 dendritic cells are essential for the development of primary biliary cholangitis
10.1111/liv.15961 · 2024 · External reference
10.1016/j.jhep.2018.05.018
10.1016/j.jhep.2018.05.018 · External reference
10.1136/gutjnl-2025-337652
10.1136/gutjnl-2025-337652 · External reference
10.1038/s41423-019-0199-z
10.1038/s41423-019-0199-z · External reference
Inflammatory Phenotype of Intrahepatic Sulfatide-Reactive Type II NKT Cells in Humans With Autoimmune Hepatitis
10.3389/fimmu.2019.01065 · 2019 · External reference
10.1002/hep.29782
10.1002/hep.29782 · External reference
10.1038/s41423-020-00592-6
10.1038/s41423-020-00592-6 · External reference
10.1038/s41579-023-00904-3
10.1038/s41579-023-00904-3 · External reference
Gut microbiota depletion exacerbates cholestatic liver injury via loss of FXR signalling
10.1038/s42255-021-00452-1 · 2021 · External reference
10.1136/gutjnl-2018-317836
10.1136/gutjnl-2018-317836 · External reference
10.1136/gutjnl-2016-313332
10.1136/gutjnl-2016-313332 · External reference
10.1136/gutjnl-2015-310500
10.1136/gutjnl-2015-310500 · External reference
10.1038/s41575-022-00690-y
10.1038/s41575-022-00690-y · External reference
10.1053/j.gastro.2020.12.058
10.1053/j.gastro.2020.12.058 · External reference
10.1136/gutjnl-2018-317791
10.1136/gutjnl-2018-317791 · External reference
10.1136/gutjnl-2020-323565
10.1136/gutjnl-2020-323565 · External reference
Characteristics of regulatory T-cell function in patients with chronic hepatitis B and C coinfection
10.1111/jvh.13298 · 2020 · External reference
10.1016/j.jhep.2021.07.032
10.1016/j.jhep.2021.07.032 · External reference
10.1016/j.jhep.2021.08.029
10.1016/j.jhep.2021.08.029 · External reference
10.1002/hep.23792
10.1002/hep.23792 · External reference
10.1016/j.jhep.2012.02.029
10.1016/j.jhep.2012.02.029 · External reference
Immune Alterations in Patients With Type 1 Autoimmune Hepatitis Persist Upon Standard Immunosuppressive Treatment
10.1002/hep4.1202 · 2018 · External reference
10.1016/j.jhep.2014.05.034
10.1016/j.jhep.2014.05.034 · External reference
Expanded but dysfunctional regulatory T cells in treatment-naïve autoimmune hepatitis
10.1007/s12072-025-10986-1 · 2026 · External reference
Increased apoptosis of regulatory T cells in patients with active autoimmune hepatitis
10.1038/s41419-017-0010-y · 2017 · External reference
10.4049/jimmunol.1502276
10.4049/jimmunol.1502276 · External reference
Regulatory T-cell conditioning endows activated effector T cells with suppressor function in autoimmune hepatitis/autoimmune sclerosing cholangitis
10.1002/hep.29307 · 2017 · External reference
Altered natural killer cell cytokine profile in type 2 autoimmune hepatitis
10.1016/j.clim.2017.12.004 · 2018 · External reference
Inhibition of estrogen receptor alpha stabilizes regulatory T cell function in autoimmune hepatitis
10.1016/j.jhepr.2025.101678 · 2026 · External reference
Serum Leptin Serves as an Inflammatory Activity Marker and Predicts Steroid Response in Autoimmune Hepatitis
10.1016/j.jceh.2020.04.014 · 2020 · External reference
HERV1-env Induces Unfolded Protein Response Activation in Autoimmune Liver Disease: A Potential Mechanism for Regulatory T Cell Dysfunction
10.4049/jimmunol.2100186 · 2023 · External reference
Inflammasome Priming Mediated via Toll-Like Receptors 2 and 4, Induces Th1-Like Regulatory T Cells in De Novo Autoimmune Hepatitis
10.3389/fimmu.2018.01612 · 2018 · External reference
An imbalance between CD80 and CD86 levels and CD4 regulatory T cell number and transendocytosis function exists in the liver in autoimmune hepatitis
10.1093/cei/uxag013 · 2026 · External reference
Serum amyloid A1–induced intrahepatic regulatory T-cell dysfunction drives autoimmune hepatitis progression
10.1097/hep.0000000000001419 · 2026 · External reference
Glucose Metabolism Reprogramming of Regulatory T Cells in Concanavalin A-Induced Hepatitis
10.3389/fphar.2021.726128 · 2021 · External reference
Carcinoembryonic antigen-related cell adhesion molecule 1 controls IL-2-dependent regulatory T-cell induction in immune-mediated hepatitis in mice
10.1002/hep.29812 · 2018 · External reference
Ginsenosides Regulates Innate Immunity to Affect Immune Microenvironment of AIH Through Hippo-YAP/TAZ Signaling Pathway
10.3389/fimmu.2022.851560 · 2022 · External reference
10.1182/blood-2008-03-144980
10.1182/blood-2008-03-144980 · External reference
Failure of thymic deletion and instability of autoreactive Tregs drive autoimmunity in immune-privileged liver
10.1172/jci.insight.141462 · 2021 · External reference
Bifidobacterium mitigates autoimmune hepatitis by regulating IL-33-induced Treg/Th17 imbalance via the TLR2/4 signaling pathway
2024 · External reference
Berberine alleviates concanavalin A-induced autoimmune hepatitis in mice by modulating the gut microbiota
10.1097/hc9.0000000000000381 · 2024 · External reference
Protective effects of YCHD on the autoimmune hepatitis mice model induced by Ad-CYP2D6 through modulating the Th1/Treg ratio and intestinal flora
10.3389/fimmu.2024.1488125 · 2024 · External reference
Ethyl acetate extract from Herpetospermun cardigerum wall. Ameliorated concanavalin A-induced autoimmune hepatitis in mice by reprofiling gut microenvironment to modulate IDO1/KYN and PI3K/AKT/NF-κB pathways
10.1016/j.jep.2025.119578 · 2025 · External reference
10.1002/hep.21123
10.1002/hep.21123 · External reference
10.1016/j.jaut.2006.04.005
10.1016/j.jaut.2006.04.005 · External reference
10.1002/hep.22651
10.1002/hep.22651 · External reference
10.1136/jcp.2006.044776
10.1136/jcp.2006.044776 · External reference
10.1056/nejmoa0810440
10.1056/nejmoa0810440 · External reference
Increased sensitivity of Treg cells from patients with PBC to low dose IL-12 drives their differentiation into IFN-γ secreting cells
10.1016/j.jaut.2018.07.020 · 2018 · External reference
Regulatory T cells with a defect in inhibition on co-stimulation deteriorated primary biliary cholangitis
10.18632/oncotarget.22658 · 2017 · External reference
BAFF promotes regulatory T-cell apoptosis and blocks cytokine production by activating B cells in primary biliary cirrhosis
10.1590/1414-431x20132665 · 2013 · External reference
Impaired indoleamine 2,3-dioxygenase production contributes to the development of autoimmunity in primary biliary cirrhosis
10.1080/08916930701619730 · 2008 · External reference
10.1002/hep.21385
10.1002/hep.21385 · External reference
10.4049/jimmunol.177.3.1655
10.4049/jimmunol.177.3.1655 · External reference
10.1053/j.gastro.2008.02.020
10.1053/j.gastro.2008.02.020 · External reference
10.1016/j.jaut.2015.01.011
10.1016/j.jaut.2015.01.011 · External reference
The effects of low-dose IL-2 on Th17/Treg cell imbalance in primary biliary cholangitis mouse models
10.1186/s12876-024-03176-0 · 2024 · External reference
Dissecting the causal role of immunophenotypes in primary sclerosing cholangitis risk: A Mendelian randomization study
10.1097/md.0000000000038626 · 2024 · External reference
10.1016/j.jhep.2013.12.027
10.1016/j.jhep.2013.12.027 · External reference
STAT activation in regulatory CD4+ T cells of patients with primary sclerosing cholangitis
10.1002/iid3.1248 · 2024 · External reference
Regulatory T cell stability determines the efficiency of bile duct regeneration during cholangitis
10.1016/j.celrep.2025.116557 · 2025 · External reference
10.1038/s41591-023-02372-x
10.1038/s41591-023-02372-x · External reference
10.1007/s10875-012-9801-1
10.1007/s10875-012-9801-1 · External reference
10.1136/gutjnl-2022-327075
10.1136/gutjnl-2022-327075 · External reference
10.4049/jimmunol.1800711
10.4049/jimmunol.1800711 · External reference
10.1038/nature12726
10.1038/nature12726 · External reference
10.1016/j.jhep.2016.12.001
10.1016/j.jhep.2016.12.001 · External reference
Bile acids engage the SIPR-STAT3 signaling axis to modulate regulatory T cell responses in fibrosing cholangiopathies
10.1016/j.jhep.2025.05.032 · 2025 · External reference
10.1002/hep.21697
10.1002/hep.21697 · External reference
Analysis of regulatory T cells and IgG4-positive plasma cells among patients of IgG4-related sclerosing cholangitis and autoimmune liver diseases
10.1007/s00535-010-0199-3 · 2010 · External reference
Possible involvement of CCL1-CCR8 interaction in lymphocytic recruitment in IgG4-related sclerosing cholangitis
10.1016/j.jhep.2013.06.016 · 2013 · External reference
10.1136/gut.2009.200972
10.1136/gut.2009.200972 · External reference
Targeting TGF-β signal transduction for fibrosis and cancer therapy
10.1186/s12943-022-01569-x · 2022 · External reference
Low-dose interleukin 2 in patients with type 1 diabetes: a phase 1/2 randomised, double-blind, placebo-controlled trial
10.1016/s2213-8587(13)70113-x · 2013 · External reference
10.1016/j.kint.2016.09.022
10.1016/j.kint.2016.09.022 · External reference
An IL-2 mutein engineered to promote expansion of regulatory T cells arrests ongoing autoimmunity in mice
10.1126/sciimmunol.aba5264 · 2020 · External reference
10.1093/ecco-jcc/jjv144
10.1093/ecco-jcc/jjv144 · External reference
sFgl2 gene-modified MSCs regulate the differentiation of CD4+ T cells in the treatment of autoimmune hepatitis
10.1186/s13287-023-03550-x · 2023 · External reference
A Rapamycin-Based GMP-Compatible Process for the Isolation and Expansion of Regulatory T Cells for Clinical Trials
10.1016/j.omtm.2018.01.006 · 2018 · External reference
10.1016/j.tibtech.2019.12.009
10.1016/j.tibtech.2019.12.009 · External reference
10.1182/blood-2016-07-727834
10.1182/blood-2016-07-727834 · External reference
Erythropoietin administration expands regulatory T cells in patients with autoimmune hepatitis
10.1016/j.jaut.2021.102629 · 2021 · External reference
Changes in peripheral blood 25 - hydroxyvitamin D3, Th17 cells, and CD4+ regulatory T cells and their clinical significance in patients with primary biliary cirrhosis
2016 · External reference
10.1136/gutjnl-2024-333297
10.1136/gutjnl-2024-333297 · External reference
Treg-specific IL-2 therapy can reestablish intrahepatic immune regulation in autoimmune hepatitis
10.1016/j.jaut.2020.102591 · 2021 · External reference
Regulatory T cells in inflamed liver are dysfunctional in murine primary biliary cholangitis
10.1093/cei/uxad117 · 2024 · External reference
Interleukin 2 Promotes Hepatic Regulatory T Cell Responses and Protects From Biliary Fibrosis in Murine Sclerosing Cholangitis
10.1002/hep.30061 · 2018 · External reference
10.1136/annrheumdis-2018-214229
10.1136/annrheumdis-2018-214229 · External reference
Low-Dose Interleukin-2 for Refractory Autoimmune Hepatitis
10.1002/hep.30059 · 2018 · External reference
Chimeric antigen receptor (CAR) T-cell therapy: Engineering immune cells to treat liver diseases
10.1016/j.jhep.2025.06.007 · 2025 · External reference
10.4049/jimmunol.0901216
10.4049/jimmunol.0901216 · External reference
Identification of a novel PDC-E2 epitope in primary biliary cholangitis: Application for engineered Treg therapy
10.1016/j.jaut.2024.103327 · 2024 · External reference
10.1002/hep.24039
10.1002/hep.24039 · External reference
10.1002/hep.26023
10.1002/hep.26023 · External reference
Liver homing of clinical grade Tregs after therapeutic infusion in patients with autoimmune hepatitis
10.1016/j.jhepr.2019.08.001 · 2019 · External reference
Allogeneic Bone Marrow Mesenchymal Stem Cell Transplantation in Patients with UDCA-Resistant Primary Biliary Cirrhosis
10.1089/scd.2013.0500 · 2014 · External reference
Regulation of immune responses in primary biliary cholangitis: a transcriptomic analysis of peripheral immune cells
10.1097/hc9.0000000000000110 · 2023 · External reference
10.1053/j.gastro.2012.02.041
10.1053/j.gastro.2012.02.041 · External reference
Retinoic acid stabilizes antigen-specific regulatory T-cell function in autoimmune hepatitis type 2
10.1016/j.jaut.2014.02.001 · 2014 · External reference
10.1038/nature07674
10.1038/nature07674 · External reference
10.1053/j.gastro.2010.05.075
10.1053/j.gastro.2010.05.075 · External reference
CD4+CD25+ but not CD4+Foxp3+ T cells as a regulatory subset in primary biliary cirrhosis
10.1038/cmi.2010.40 · 2010 · External reference
10.1002/hep.22226
10.1002/hep.22226 · External reference