Research graph
References from LIM and SH3 protein 1 deficiency confers resistance to cytotoxic lymphocyte-mediated lysis and immunotherapy in gastric cancer by disrupting cytoskeleton dynamics. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1056/nejmoa1200690
10.1056/nejmoa1200690 · External reference
10.1056/nejmoa1606774
10.1056/nejmoa1606774 · External reference
Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer: Phase 2 Clinical KEYNOTE-059 Trial
10.1001/jamaoncol.2018.0013 · 2018 · External reference
10.1038/s41577-019-0218-4
10.1038/s41577-019-0218-4 · External reference
RNA N6-methyladenosine-binding protein YTHDFs redundantly attenuate cancer immunity by downregulating IFN-γ signaling in gastric cancer
2025 · External reference
10.1016/s1074-7613(01)00234-5
10.1016/s1074-7613(01)00234-5 · External reference
10.1038/nri2381
10.1038/nri2381 · External reference
10.1016/j.ccell.2024.09.010
10.1016/j.ccell.2024.09.010 · External reference
10.1182/blood-2012-05-429977
10.1182/blood-2012-05-429977 · External reference
10.1038/76877
10.1038/76877 · External reference
Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells
10.3390/cells8050463 · 2019 · External reference
Greek Fire, Poison Arrows, and Scorpion Bombs: How Tumor Cells Defend Against the Siege Weapons of Cytotoxic T Lymphocytes
10.3389/fimmu.2022.894306 · 2022 · External reference
10.1158/0008-5472.can-18-0441
10.1158/0008-5472.can-18-0441 · External reference
10.1016/j.chom.2014.07.005
10.1016/j.chom.2014.07.005 · External reference
10.2174/157016211798842107
10.2174/157016211798842107 · External reference
10.1002/mc.23158
10.1002/mc.23158 · External reference
QuPath: Open source software for digital pathology image analysis
10.1038/s41598-017-17204-5 · 2017 · External reference
10.1158/2159-8290.cd-21-0219
10.1158/2159-8290.cd-21-0219 · External reference
10.1016/j.jhep.2023.01.011
10.1016/j.jhep.2023.01.011 · External reference
Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma
10.1158/0008-5472.can-22-2593 · 2023 · External reference
10.1016/j.ccell.2024.06.009
10.1016/j.ccell.2024.06.009 · External reference
10.1158/2159-8290.cd-21-0683
10.1158/2159-8290.cd-21-0683 · External reference
Galectin-3 secreted by triple-negative breast cancer cells regulates T cell function
10.1016/j.neo.2024.101117 · 2025 · External reference
10.1083/jcb.201407130
10.1083/jcb.201407130 · External reference
Degranulation enhances presynaptic membrane packing, which protects NK cells from perforin-mediated autolysis
10.1371/journal.pbio.3001328 · 2021 · External reference
Laurdan in live cell imaging: Effect of acquisition settings, cell culture conditions and data analysis on generalized polarization measurements
10.1016/j.jphotobiol.2022.112404 · 2022 · External reference
10.3389/fimmu.2022.883178
10.3389/fimmu.2022.883178 · External reference
10.1136/ard-2023-225241
10.1136/ard-2023-225241 · External reference
10.1038/s41388-020-01397-7
10.1038/s41388-020-01397-7 · External reference
10.1194/jlr.m500439-jlr200
10.1194/jlr.m500439-jlr200 · External reference
10.1158/0008-5472.can-20-2569
10.1158/0008-5472.can-20-2569 · External reference
Cancer cells suppress NK cell activity by actin-driven polarization of inhibitory ligands to the immunological synapse
10.1073/pnas.2503259122 · 2025 · External reference
Immunotherapy Inhibits Tumor Cholesterol Synthesis via the IFNγ-IRF1-SREBF2 Axis
10.1158/2326-6066.cir-25-0242 · 2026 · External reference
Tumorous cholesterol biosynthesis curtails anti-tumor immunity by preventing MTOR-TFEB-mediated lysosomal degradation of CD274/PD-L1
10.1080/15548627.2025.2519066 · 2025 · External reference
10.1038/s41577-020-0306
10.1038/s41577-020-0306 · External reference
10.1080/10408363.2019.1660303
10.1080/10408363.2019.1660303 · External reference
Tumor microenvironment: barrier or opportunity towards effective cancer therapy
10.1186/s12929-022-00866-3 · 2022 · External reference
LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator
10.3390/cells11233817 · 2022 · External reference
10.1152/ajpgi.90247.2008
10.1152/ajpgi.90247.2008 · External reference
10.1523/jneurosci.0334-19.2019
10.1523/jneurosci.0334-19.2019 · External reference
ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation
10.1038/s41419-021-04213-6 · 2021 · External reference
10.1016/j.immuni.2021.02.020
10.1016/j.immuni.2021.02.020 · External reference
10.1158/0008-5472.can-21-4370
10.1158/0008-5472.can-21-4370 · External reference
TGFβ induces an atypical EMT to evade immune mechanosurveillance in lung adenocarcinoma dormant metastasis
10.1038/s43018-025-01094-y · 2026 · External reference
Lipid order and charge protect killer T cells from accidental death
10.1038/s41467-019-13385-x · 2019 · External reference
10.1016/j.taap.2012.01.007
10.1016/j.taap.2012.01.007 · External reference
Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease
10.1038/s41392-025-02332-6 · 2025 · External reference
10.1038/ni.2050
10.1038/ni.2050 · External reference
10.1146/annurev.immunol.26.021607.090404
10.1146/annurev.immunol.26.021607.090404 · External reference
10.1074/jbc.m800078200
10.1074/jbc.m800078200 · External reference
10.1073/pnas.0510454103
10.1073/pnas.0510454103 · External reference
T lymphocyte‑related immune response and immunotherapy in gastric cancer (Review)
10.3892/ol.2024.14670 · 2024 · External reference
10.1038/ni.2035
10.1038/ni.2035 · External reference
New Frontiers for the Cytoskeletal Protein LASP1
10.3389/fonc.2018.00391 · 2018 · External reference
Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling
10.3389/fimmu.2021.619069 · 2021 · External reference