Research graph
References from Hereditary spastic paraplegia: a practical approach. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1111/j.1365-2990.2004.00587.x
10.1111/j.1365-2990.2004.00587.x · External reference
10.1093/brain/aww111
10.1093/brain/aww111 · External reference
10.1016/j.jns.2016.03.018
10.1016/j.jns.2016.03.018 · External reference
Genotype–phenotype associations in hereditary spastic paraplegia: a systematic review and meta-analysis on 13,570 patients
10.1007/s00415-019-09633-1 · 2021 · External reference
10.1016/s1474-4422(08)70258-8
10.1016/s1474-4422(08)70258-8 · External reference
10.1016/s0140-6736(83)92879-9
10.1016/s0140-6736(83)92879-9 · External reference
Unresolved reference
External reference
An integrated modelling methodology for estimating global incidence and prevalence of hereditary spastic paraplegia subtypes SPG4, SPG7, SPG11, and SPG15
10.1186/s12883-022-02595-4 · 2022 · External reference
10.1159/000358801
10.1159/000358801 · External reference
The epidemiology of hereditary spastic paraplegia and associated common mental health outcomes in England and Northern Ireland
10.1186/s13023-025-03849-3 · 2025 · External reference
10.1016/j.mito.2010.07.006
10.1016/j.mito.2010.07.006 · External reference
10.1007/s10048-018-0545-9
10.1007/s10048-018-0545-9 · External reference
10.1007/s00415-014-7598-y
10.1007/s00415-014-7598-y · External reference
10.1155/ane/2779360
10.1155/ane/2779360 · External reference
10.1002/ana.24611
10.1002/ana.24611 · External reference
10.1016/s1474-4422(19)30235-2
10.1016/s1474-4422(19)30235-2 · External reference
How Do I Examine Rigidity and Spasticity?
10.1002/mdc3.12147 · 2015 · External reference
Autosomal dominant spastic paraplegias: a review of 89 families resulting from a portuguese survey
10.1001/jamaneurol.2013.1956 · 2013 · External reference
The prodromal phase of hereditary spastic paraplegia type 4: the preSPG4 cohort study
10.1093/brain/awac155 · 2023 · External reference
Hereditary spastic paraplegias: When to expect bladder dysfunction a genetic and urodynamic study
10.1111/ene.70003 · 2025 · External reference
Urological dysfunction in patients with hereditary spastic paraplegia
10.1002/nau.23957 · 2019 · External reference
10.1007/s00415-019-09573-w
10.1007/s00415-019-09573-w · External reference
The cognitive profile of hereditary spastic paraplegia: a systematic review of the literature
10.1007/s10072-025-08408-z · 2025 · External reference
MDSGene Systematic Review of Common Forms of Dominant Hereditary Spastic Paraplegia: Novel Insights
10.1002/mdc3.70559 · 2026 · External reference
10.1093/brain/awn026
10.1093/brain/awn026 · External reference
Cognitive impairment in hereditary spastic paraparesis: An overlooked aspect of a motor disorder
10.1007/s10072-026-08830-x · 2026 · External reference
10.1093/brain/awu121
10.1093/brain/awu121 · External reference
10.1093/brain/aws240
10.1093/brain/aws240 · External reference
Expanding Hereditary Spastic Paraplegias Limits: Biallelic SPAST Variants in Cerebral Palsy Mimics
10.1002/acn3.70206 · 2026 · External reference
10.3174/ajnr.a7017
10.3174/ajnr.a7017 · External reference
Neuroimaging in Hereditary Spastic Paraplegias: Current Use and Future Perspectives
10.3389/fneur.2018.01117 · 2019 · External reference
10.3174/ajnr.a5935
10.3174/ajnr.a5935 · External reference
Novel genotype-phenotype and MRI correlations in a large cohort of patients with SPG7 mutations
10.1212/nxg.0000000000000300 · 2018 · External reference
10.1136/jnnp.2009.180315
10.1136/jnnp.2009.180315 · External reference
SPG2 mimicking multiple sclerosis in a family identified using next generation sequencing
10.1016/j.jns.2017.01.069 · 2017 · External reference
10.1016/j.nmd.2008.10.009
10.1016/j.nmd.2008.10.009 · External reference
10.1371/journal.pone.0153283
10.1371/journal.pone.0153283 · External reference
Peripheral neuropathy in hereditary spastic paraplegia caused by REEP1 variants
10.1007/s00415-019-09196-1 · 2019 · External reference
Electrophysiological characterisation of motor and sensory tracts in patients with hereditary spastic paraplegia (HSP)
10.1186/1750-1172-8-158 · 2013 · External reference
10.1007/s10048-019-00565-6
10.1007/s10048-019-00565-6 · External reference
Massive Parallel Sequencing and the Problem of Overlapping Phenotypes in Hereditary Spastic Paraplegias and Spinocerebellar Ataxias
10.1134/s1022795422040111 · 2022 · External reference
10.1002/mds.26944
10.1002/mds.26944 · External reference
10.1136/jnnp-2023-332696
10.1136/jnnp-2023-332696 · External reference
Deciphering Spastic Ataxia: Clinical and Genetic Profiles
10.1212/nxg.0000000000200331 · 2025 · External reference
Spinocerebellar ataxia type 3/Machado-Joseph disease manifested as spastic paraplegia: A clinical and genetic study
10.3892/etm.2014.2136 · 2015 · External reference
10.1212/wnl.0000000000209455
10.1212/wnl.0000000000209455 · External reference
10.1093/brain/awp325
10.1093/brain/awp325 · External reference
10.1093/brain/awv320
10.1093/brain/awv320 · External reference
10.1212/nxg.0000000000000374
10.1212/nxg.0000000000000374 · External reference
Experienced complaints, activity limitations and loss of motor capacities in patients with pure hereditary spastic paraplegia: a web-based survey in the Netherlands
10.1186/s13023-020-1338-4 · 2020 · External reference
Spinal Direct Current Stimulation (tsDCS) in Hereditary Spastic Paraplegias (HSP): A sham-controlled crossover study
2019 · External reference
The therapeutic effects of physical treatment for patients with hereditary spastic paraplegia: a narrative review
10.3389/fneur.2023.1292527 · 2023 · External reference
The Effects of Functional Electrical Stimulation on Walking in Hereditary and Spontaneous Spastic Paraparesis
10.1111/j.1525-1403.2012.00494.x · 2013 · External reference
Dalfampridine in hereditary spastic paraplegia: a prospective, open study
10.1007/s00415-015-7707-6 · 2015 · External reference
The clinical effect of the GABA-agonist, progabide, on spasticity
10.1111/j.1600-0404.1984.tb07802.x · 1984 · External reference
10.1212/wnl.0000000000214514
10.1212/wnl.0000000000214514 · External reference
Levodopa-responsive parkinsonism in hereditary spastic paraplegia with thin corpus callosum
10.1016/j.parkreldis.2004.05.003 · 2004 · External reference
10.1007/s00415-013-7044-6
10.1007/s00415-013-7044-6 · External reference
10.1111/j.1468-1331.2007.01812.x
10.1111/j.1468-1331.2007.01812.x · External reference
Functional effects of botulinum toxin type-A treatment and subsequent stretching of spastic calf muscles: A study in patients with hereditary spastic paraplegia
10.2340/16501977-1909 · 2015 · External reference
10.3390/toxins17100503
10.3390/toxins17100503 · External reference
Efficacy of a Combined Treatment of Botulinum Toxin and Intensive Physiotherapy in Hereditary Spastic Paraplegia
10.3389/fnins.2020.00111 · 2020 · External reference
Randomized Trial of Botulinum Toxin Type A in Hereditary Spastic Paraplegia — The SPASTOX Trial
10.1002/mds.28523 · 2021 · External reference
Intrathecal baclofen therapy for the symptomatic treatment of hereditary spastic paraplegia
10.1016/j.clineuro.2014.05.024 · 2014 · External reference
10.7759/cureus.17690
10.7759/cureus.17690 · External reference
Efficacy and safety of mirabegron for treatment of neurogenic detrusor overactivity in adults with spinal cord injury or multiple sclerosis: a systematic review
10.1038/s41393-022-00853-3 · 2022 · External reference
10.1016/j.jns.2026.125788
10.1016/j.jns.2026.125788 · External reference
Serum NfL, but not GFAP, differentiates primary lateral sclerosis from adrenomyeloneuropathy and hereditary spastic paraplegia type 4
10.1080/21678421.2025.2557936 · 2026 · External reference
REEP1 gene mutation associated with Hereditary Spastic Paraplegia type 31 and Parkinsonism
10.1016/j.parkreldis.2025.107430 · 2025 · External reference
Hereditary spastic paraplegia initially diagnosed as cerebral palsy
2021 · External reference
Dopa responsive dystonia due to a GCH1 gene variant mimicking hereditary spastic paraparesis
10.1007/s10072-025-08079-w · 2025 · External reference
Loss of paraplegin drives spasticity rather than ataxia in a cohort of 241 patients with SPG7
10.1212/wnl.0000000000007606 · 2019 · External reference
10.1093/brain/awu060
10.1093/brain/awu060 · External reference
