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References from Emergence of the Endoderm in the Mammalian Embryo: From Cell Fate Specification to Gut Tube Formation. Local targets link to admitted publications; unresolved targets remain external evidence.
A morphogenetic wave in the chick embryo lateral mesoderm generates mesenchymal-epithelial transition through a 3D-rosette intermediate
10.1016/j.devcel.2023.03.017 · 2023 · External reference
Conserved features of non-primate bilaminar disc embryos and the germline
10.1016/j.stemcr.2021.03.011 · 2021 · External reference
Development and evolution of gut structures: from molecules to function
10.1007/s00441-019-03093-9 · 2019 · External reference
Rearranging gastrulation in the name of yolk: evolution of gastrulation in yolk-rich amniote eggs
10.1016/s0925-4773(98)00226-3 · 1999 · External reference
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo
10.1038/nrm2618 · 2009 · External reference
Hedgehog signaling regulates epithelial morphogenesis to position the ventral embryonic midline
10.1016/j.devcel.2020.04.016 · 2020 · External reference
Establishment of the visceral embryonic midline is a dynamic process that requires bilaterally symmetric BMP signaling
10.1016/j.devcel.2016.05.018 · 2016 · External reference
The primitive endoderm lineage of the mouse blastocyst: sequential transcription factor activation and regulation of differentiation by Sox17
10.1016/j.ydbio.2010.12.007 · 2011 · External reference
Genetic control of single lumen formation in the zebrafish gut
10.1038/ncb1621 · 2007 · External reference
Generation of multipotential mesendodermal progenitors from mouse embryonic stem cells via sustained Wnt pathway activation
10.1074/jbc.m704287200 · 2007 · External reference
Foxa2 identifies a cardiac progenitor population with ventricular differentiation potential
10.1038/ncomms14428 · 2017 · External reference
Mouse gastrulation: coordination of tissue patterning, specification and diversification of cell fate
10.1016/j.mod.2020.103617 · 2020 · External reference
Extraembryonic gut endoderm cells undergo programmed cell death during development
10.1038/s41556-024-01431-w · 2024 · External reference
The hypoblast of the chick embryo positions the primitive streak by antagonizing nodal signaling
10.1016/s1534-5807(02)00318-0 · 2002 · External reference
Gata6, Nanog and Erk signaling control cell fate in the inner cell mass through a tristable regulatory network
10.1242/dev.109678 · 2014 · External reference
Defining the three cell lineages of the human blastocyst by single-cell RNA-seq
2015 · External reference
Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators
10.1006/dbio.2000.9883 · 2000 · External reference
Foxa2-venus fusion reporter mouse line allows live-cell analysis of endoderm-derived organ formation
10.1002/dvg.22404 · 2013 · External reference
Foxa2 regulates polarity and epithelialization in the endoderm germ layer of the mouse embryo
10.1242/dev.028415 · 2009 · External reference
Molecular recording of mammalian embryogenesis
10.1038/s41586-019-1184-5 · 2019 · External reference
Early lineage segregation between epiblast and primitive endoderm in mouse blastocysts through the Grb2-MAPK pathway
10.1016/j.devcel.2006.02.020 · 2006 · External reference
Basement membrane perforations guide anterior-posterior axis formation
10.1038/s41467-025-61441-6 · 2025 · External reference
Journey of the mouse primitive endoderm: from specification to maturation
10.1098/rstb.2021.0252 · 2022 · External reference
Lhx1 functions together with Otx2, Foxa2, and Ldb1 to govern anterior mesendoderm, node, and midline development
10.1101/gad.268979.115 · 2015 · External reference
Spatial transcriptomic characterization of a Carnegie stage 7 human embryo
10.1038/s41556-024-01597-3 · 2025 · External reference
Single-cell transcriptomic analysis of cardiac differentiation from human PSCs reveals HOPX-dependent cardiomyocyte maturation
10.1016/j.stem.2018.09.009 · 2018 · External reference
Pituitary homeobox 2, a novel member of the bicoid-related family of homeobox genes, is a potential regulator of anterior structure formation
10.1093/hmg/6.3.457 · 1997 · External reference
Single-cell analysis of bidirectional reprogramming between early embryonic states identify mechanisms of differential lineage plasticities in mice
10.1016/j.devcel.2024.11.022 · 2025 · External reference
Single cell transcriptomics identifies a signaling network coordinating endoderm and mesoderm diversification during foregut organogenesis
10.1038/s41467-020-17968-x · 2020 · External reference
A spatiotemporal atlas of mouse gastrulation and early organogenesis to explore axial patterning and project in vitro models onto in vivo space
10.1016/j.celrep.2025.116047 · 2025 · External reference
Mechanical regulation of cuboidal-to-squamous epithelial transition in the Drosophila developing wing
10.1016/j.cub.2026.02.035 · 2026 · External reference
Spatiotemporal transcriptomics reveals the evolutionary history of the endoderm germ layer
10.1038/nature13996 · 2015 · External reference
A fate map of the epiblast of the early chick embryo
10.1242/dev.120.10.2879 · 1994 · External reference
A new hypothesis for foregut and heart tube formation based on differential growth and actomyosin contraction
2017 · External reference
Tracking early mammalian organogenesis – prediction and validation of differentiation trajectories at whole organism scale
10.1242/dev.201867 · 2024 · External reference
Developmental regulation of epithelial cell cuboidal-to-squamous transition in Drosophila follicle cells
10.1016/j.ydbio.2022.09.001 · 2022 · External reference
Depletion of definitive gut endoderm in Sox17-null mutant mice
10.1242/dev.129.10.2367 · 2002 · External reference
Lineage establishment and progression within the inner cell mass of the mouse blastocyst requires FGFR1 and FGFR2
10.1016/j.devcel.2017.05.003 · 2017 · External reference
FGF4 is required for lineage restriction and salt-and-pepper distribution of primitive endoderm factors but not their initial expression in the mouse
10.1242/dev.084996 · 2013 · External reference
The heart tube forms and elongates through dynamic cell rearrangement coordinated with foregut extension
10.1242/dev.152488 · 2018 · External reference
ECM-integrin signalling instructs cellular position sensing to pattern the early mouse embryo
10.1242/dev.200140 · 2022 · External reference
The VACTERL association: lessons from the Sonic hedgehog pathway
10.1034/j.1399-0004.2001.590503.x · 2001 · External reference
Fate and plasticity of the endoderm in the early chick embryo
10.1016/j.ydbio.2005.09.009 · 2006 · External reference
Canonical Wnt signaling and its antagonist regulate anterior-posterior axis polarization by guiding cell migration in mouse visceral endoderm
10.1016/j.devcel.2005.09.011 · 2005 · External reference
Crucial roles of Foxa2 in mouse anterior-posterior axis polarization via regulation of anterior visceral endoderm-specific genes
10.1073/pnas.0607779104 · 2007 · External reference
Hensen's node gives rise to the ventral midline of the foregut: implications for organizing head and heart development
10.1016/s0012-1606(02)00024-6 · 2003 · External reference
The transcriptional and functional properties of mouse epiblast stem cells resemble the anterior primitive streak
10.1016/j.stem.2013.09.014 · 2014 · External reference
Imprinted X-inactivation in extra-embryonic endoderm cell lines from mouse blastocysts
10.1242/dev.01715 · 2005 · External reference
The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages
10.1016/j.devcel.2008.07.017 · 2008 · External reference
Fate mapping the mouse embryo
10.1387/ijdb.10668985 · 1999 · External reference
Clonal analysis of epiblast fate during germ layer formation in the mouse embryo
10.1242/dev.113.3.891 · 1991 · External reference
FOXA2 is required for enhancer priming during pancreatic differentiation
10.1016/j.celrep.2019.06.034 · 2019 · External reference
Basement membranes at a glance
10.1242/jcs.263947 · 2025 · External reference
Organogenesis of the Caenorhabditis elegans intestine
10.1006/dbio.1999.9471 · 1999 · External reference
The primitive endoderm supports lineage plasticity to enable regulative development
10.1016/j.cell.2024.05.051 · 2024 · External reference
Integration of spatial and single-cell transcriptomic data elucidates mouse organogenesis
10.1038/s41587-021-01006-2 · 2022 · External reference
Anterior visceral endoderm directs ventral morphogenesis and placement of head and heart via BMP2 expression
10.1016/j.devcel.2011.08.027 · 2011 · External reference
Lineage contribution of the mesendoderm progenitors in the gastrulating mouse embryo
10.1016/j.devcel.2025.02.015 · 2025 · External reference
Developmental and mechanical roles of Reichert's membrane in mouse embryos
10.1098/rstb.2021.0257 · 2022 · External reference
Active cell movements coupled to positional induction are involved in lineage segregation in the mouse blastocyst
10.1016/j.ydbio.2009.04.036 · 2009 · External reference
Nodal specifies embryonic visceral endoderm and sustains pluripotent cells in the epiblast before overt axial patterning
10.1242/dev.02413 · 2006 · External reference
Rac1-dependent collective cell migration is required for specification of the anterior-posterior body axis of the mouse
10.1371/journal.pbio.1000442 · 2010 · External reference
Coupling of cell shape, matrix and tissue dynamics ensures embryonic patterning robustness
10.1038/s41556-025-01618-9 · 2025 · External reference
Single-cell landscape of transcriptional heterogeneity and cell fate decisions during mouse early gastrulation
10.1016/j.celrep.2017.07.009 · 2017 · External reference
Distinct requirements for FGFR1 and FGFR2 in primitive endoderm development and exit from pluripotency
10.1016/j.devcel.2017.05.004 · 2017 · External reference
Signaling regulation during gastrulation: insights from mouse embryos and in vitro systems
10.1016/bs.ctdb.2019.11.011 · 2020 · External reference
Molecular control of macroscopic forces drives formation of the vertebrate hindgut
10.1038/s41586-018-0865-9 · 2019 · External reference
The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo
10.1101/gad.215152.113 · 2013 · External reference
The endoderm: a divergent cell lineage with many commonalities
10.1242/dev.150920 · External reference
The emergent landscape of the mouse gut endoderm at single-cell resolution
10.1038/s41586-019-1127-1 · External reference
β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo
10.1038/s41467-020-19889-1 · 2020 · External reference
β-Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryo
10.1101/gad.251371.114 · 2014 · External reference
Unresolved reference
1929 · External reference
Spatial transcriptome for the molecular annotation of lineage fates and cell identity in mid-gastrula mouse embryo
10.1016/j.devcel.2020.11.018 · 2020 · External reference
Molecular architecture of lineage allocation and tissue organization in early mouse embryo
10.1038/s41586-019-1469-8 · 2019 · External reference
Loss of Cubilin, the intrinsic factor-vitamin B12 receptor, impairs visceral endoderm endocytosis and endodermal patterning in the mouse
10.1038/s41598-019-46559-0 · 2019 · External reference
Otx2 is required for visceral endoderm movement and for the restriction of posterior signals in the epiblast of the mouse embryo
10.1242/dev.128.5.753 · External reference
Role of the anterior visceral endoderm in restricting posterior signals in the mouse embryo
10.1387/ijdb.11291861 · External reference
Eomesodermin requires transforming growth factor-β/activin signaling and binds Smad2 to activate mesodermal genes
10.1074/jbc.m808704200 · 2009 · External reference
A single-cell molecular map of mouse gastrulation and early organogenesis
10.1038/s41586-019-0933-9 · 2019 · External reference
Distinct sequential cell behaviours direct primitive endoderm formation in the mouse blastocyst
10.1242/dev.021519 · 2008 · External reference
Emergence and patterning dynamics of mouse-definitive endoderm
10.1016/j.isci.2021.103556 · 2022 · External reference
Elongation of the nascent avian foregut requires coordination of intrinsic and extrinsic cell behaviors
10.1016/j.ydbio.2025.08.009 · 2025 · External reference
Spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation
2020 · External reference
Basement membrane mechanics drives patterned response to developmental signalling
2026 · External reference
Axis specification and morphogenesis in the mouse embryo require Nap1, a regulator of WAVE-mediated actin branching
10.1242/dev.02473 · 2006 · External reference
Morphogenesis of the primitive gut tube is generated by Rho/ROCK/myosin II-mediated endoderm rearrangements
10.1002/dvdy.22157 · 2009 · External reference
Dynamic morphogenetic events characterize the mouse visceral endoderm
10.1016/s0012-1606(03)00302-6 · 2003 · External reference
Primitive streak formation in mice is preceded by localized activation of Brachyury and Wnt3
10.1016/j.ydbio.2005.09.012 · 2005 · External reference
Induction and migration of the anterior visceral endoderm is regulated by the extra-embryonic ectoderm
10.1242/dev.01847 · 2005 · External reference
Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development
10.7554/elife.56079 · 2020 · External reference
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase expression during early mouse embryonic development
10.1387/ijdb.062168as · 2006 · External reference
Morphogenesis of the vertebrate intestine: from form to function
10.1146/annurev-cellbio-101123-044600 · 2025 · External reference
Epithelial cell plasticity drives endoderm formation during gastrulation
10.1038/s41556-021-00694-x · 2021 · External reference
Body cavity development is guided by morphogen transfer between germ layers
10.1016/j.celrep.2018.07.015 · 2018 · External reference
GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst
10.1016/j.devcel.2014.04.011 · 2014 · External reference
Angiomotin regulates visceral endoderm movements during mouse embryogenesis
10.1016/s0960-9822(03)00204-5 · 2003 · External reference
Vertebrate intestinal endoderm development
10.1002/dvdy.22540 · 2011 · External reference
Active cell migration drives the unilateral movements of the anterior visceral endoderm
10.1242/dev.01005 · 2004 · External reference
Single-cell phenomics reveals behavioural and mechanical heterogeneities underpinning collective migration during mouse anterior patterning
2023 · External reference
Calcium signaling is required for anterior patterning in the mouse embryo
10.1371/journal.pbio.3003430 · 2025 · External reference
Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid
10.1242/dev.122.11.3587 · 1996 · External reference
Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture
10.1242/dev.02005 · 2005 · External reference
Origin and role of distal visceral endoderm, a group of cells that determines anterior–posterior polarity of the mouse embryo
10.1038/ncb2251 · 2011 · External reference
Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation
10.1242/dev.02724 · 2007 · External reference
An integrated approach identifies the molecular underpinnings of murine anterior visceral endoderm migration
10.1016/j.devcel.2024.05.014 · 2024 · External reference
Not just inductive: a crucial mechanical role for the endoderm during heart tube assembly
10.1242/dev.073486 · 2012 · External reference
SOX17 links gut endoderm morphogenesis and germ layer segregation
10.1038/ncb3070 · 2014 · External reference
The extracellular matrix in development
10.1242/dev.175596 · 2020 · External reference
Origin and development of the zebrafish endoderm
10.1242/dev.126.4.827 · 1999 · External reference
Heterogeneities in Nanog expression drive stable commitment to pluripotency in the mouse blastocyst
10.1016/j.celrep.2015.02.010 · 2015 · External reference
Antagonism between Smad1 and Smad2 signaling determines the site of distal visceral endoderm formation in the mouse embryo
10.1083/jcb.200808044 · 2009 · External reference
Extra-embryonic Wnt3 regulates the establishment of the primitive streak in mice
10.1016/j.ydbio.2015.04.008 · 2015 · External reference
Stored elastic bending tension as a mediator of embryonic body folding
10.1016/j.celrep.2024.115200 · 2025 · External reference
Vertebrate endoderm development and organ formation
10.1146/annurev.cellbio.042308.113344 · 2009 · External reference
