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References from Evaluating the Causal Roles of Matrix Metalloproteinases in Metabolic Syndrome: A Mendelian Randomization Study Highlighting MMP12 in Blood Pressure Regulation. Local targets link to admitted publications; unresolved targets remain external evidence.
Metabolic Syndrome
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10.3390/ijms241310649
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10.1124/pharmrev.121.000349
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10.1038/s41598-021-99577-2
10.1038/s41598-021-99577-2 · External reference
Cardiovascular Organ Damage in Type 2 Diabetes Mellitus: the Role of Lipids and Inflammation
10.1186/s12933-019-0865-6 · 2019 · External reference
Mendelian Randomization
10.1001/jama.2017.17219 · 2017 · External reference
Overview of Mendelian Randomization Analysis
2020 · External reference
Mendelian Randomization
10.1038/s43586-021-00092-5 · 2022 · External reference
Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization: The STROBE-MR Statement
10.1001/jama.2021.18236 · 2021 · External reference
Genome-Wide Association Study of the Metabolic Syndrome in UK Biobank
10.1089/met.2019.0070 · 2019 · External reference
Computationally Efficient whole-genome Regression for Quantitative and Binary Traits
10.1038/s41588-021-00870-7 · 2021 · External reference
The Trans-ancestral Genomic Architecture of Glycemic Traits
10.1038/s41588-021-00852-9 · 2021 · External reference
Discovery and Refinement of Loci Associated with Lipid Levels
10.1038/ng.2797 · 2013 · External reference
Multi-Method Genome- and Epigenome-Wide Studies of Inflammatory Protein Levels in Healthy Older Adults
10.1186/s13073-020-00754-1 · 2020 · External reference
Genomic and Drug Target Evaluation of 90 Cardiovascular Proteins in 30,931 Individuals
10.1038/s42255-020-00287-2 · 2020 · External reference
A Genome-wide Association Study of Serum Proteins Reveals Shared Loci with Common Diseases
10.1038/s41467-021-27850-z · 2022 · External reference
10.1038/s41586-018-0175-2
10.1038/s41586-018-0175-2 · External reference
Association of Autoimmune Diseases With the Occurrence and 28-day Mortality of Sepsis: An Observational and Mendelian Randomization Study
2023 · External reference
Selection of Genetic Instruments in Mendelian Randomisation Studies of Sleep Traits
10.1016/j.sleep.2023.10.036 · 2023 · External reference
Circulating Inflammatory Cytokines and Risk of Five Cancers: A Mendelian Randomization Analysis
10.1186/s12916-021-02193-0 · 2022 · External reference
A Global Reference for Human Genetic Variation
10.1038/nature15393 · 2015 · External reference
A Simple Correction for Multiple Testing for Single-Nucleotide Polymorphisms in Linkage Disequilibrium With Each Other
10.1086/383251 · 2004 · External reference
Avoiding Bias from Weak Instruments in Mendelian Randomization Studies
10.1093/ije/dyr036 · 2011 · External reference
A Framework for the Investigation of Pleiotropy in Two-Sample Summary Data Mendelian Randomization
10.1002/sim.7221 · 2017 · External reference
Assessing the Suitability of Summary Data for Two-Sample Mendelian Randomization Analyses Using MR-Egger Regression: The Role of the I2 Statistic
2016 · External reference
Evaluating the Potential Role of Pleiotropy in Mendelian Randomization Studies
10.1093/hmg/ddy163 · 2018 · External reference
Polygenic Basis and Biomedical Consequences of Telomere Length Variation
10.1038/s41588-021-00944-6 · 2021 · External reference
10.1002/gepi.21965
10.1002/gepi.21965 · External reference
Robust Inference in Summary Data Mendelian Randomization via the Zero Modal Pleiotropy Assumption
10.1093/ije/dyx102 · 2017 · External reference
Improving the Visualization, Interpretation and Analysis of two-sample Summary Data Mendelian Randomization via the Radial Plot and Radial Regression
10.1093/ije/dyy101 · 2018 · External reference
Interpreting Findings from Mendelian Randomization Using the MR-Egger Method
10.1007/s10654-017-0255-x · 2017 · External reference
Detection of Widespread Horizontal Pleiotropy in Causal Relationships Inferred from Mendelian Randomization Between Complex Traits and Diseases
10.1038/s41588-018-0099-7 · 2018 · External reference
Sensitivity Analyses for Robust Causal Inference from Mendelian Randomization Analyses With Multiple Genetic Variants
10.1097/ede.0000000000000559 · 2017 · External reference
Matrix Metalloproteinase-12 is an Essential Mediator of Acute and Chronic Arterial Stiffening
2015 · External reference
Matrix Metalloproteinase-12 in Arterial Diseases: Context-Dependent Mechanisms of Vascular Remodeling and Therapeutic Implications
2026 · External reference
Polymorphisms of the Matrix Metalloproteinase Genes are Associated with Essential Hypertension in a Caucasian Population of Central Russia
10.1038/s41598-021-84645-4 · 2021 · External reference
10.3390/life11050414
10.3390/life11050414 · External reference
MMP12 Deletion Preferentially Attenuates Axial Stiffening of Aging Arteries
10.1115/1.4043322 · 2019 · External reference
Microbiota and Adipocyte Mitochondrial Damage in Type 2 Diabetes are Linked by Mmp12+ Macrophages
2022 · External reference
MMP-12 siRNA Improves the Homeostasis of the Small Intestine and Metabolic Dysfunction in High-fat Diet Feeding-Induced Obese Mice
10.1016/j.biomaterials.2021.121183 · 2021 · External reference
MMP-12 Regulates Proliferation of Mouse Macrophages via the ERK/P38 MAPK Pathways During Inflammation
10.1016/j.yexcr.2019.03.018 · 2019 · External reference
Intestinal IL-22RA1 Signaling Regulates Intrinsic and Systemic Lipid and Glucose Metabolism to Alleviate Obesity-Associated Disorders
10.1038/s41467-024-45568-6 · 2024 · External reference
Biomarkers in Metabolic Syndrome
10.1016/bs.acc.2022.07.003 · 2022 · External reference
10.1016/j.pcad.2024.10.012
10.1016/j.pcad.2024.10.012 · External reference
Cardiovascular-Kidney-Metabolic Health: A Presidential Advisory from the American Heart Association
10.1161/cir.0000000000001184 · 2023 · External reference
Modulating Matrix Metalloproteinase Activity in Obesity: Comparative Effects of Bariatric Surgery and GLP-1/GIP-Based Pharmacotherapy
10.3390/jcm14217648 · 2025 · External reference
Effect of Bariatric Surgery on Matrix Metalloproteinase Activity in Patients With Morbid Obesity
10.3389/fmed.2026.1836747 · 2026 · External reference
