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References from Obesity and Age Elevate Tissue-Resident Microbiota Akkermansia muciniphila to Induce Oxidative Stress and Promote Breast Cancer Risk. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics, 2025
10.3322/caac.21871 · 2025 · External reference
World Cancer Research Fund International: Continuous Update Project-systematic literature review and meta-analysis of observational cohort studies on physical activity, sedentary behavior, adiposity, and weight change and breast cancer risk
10.1007/s10552-019-01223-w · 2019 · External reference
Metabolic pathways in obesity-related breast cancer
10.1038/s41574-021-00487-0 · 2021 · External reference
Influence of gender and menopausal status on gut microbiota
10.1016/j.maturitas.2018.07.008 · 2018 · External reference
Influence of oral and gut microbiota in the health of menopausal women
10.3389/fmicb.2017.01884 · 2017 · External reference
Obesity and the human microbiome
10.1097/mog.0b013e328333d751 · 2010 · External reference
An obesity-associated gut microbiome with increased capacity for energy harvest
10.1038/nature05414 · 2006 · External reference
Menopause is associated with an altered gut microbiome and estrobolome, with implications for adverse cardiometabolic risk in the Hispanic community health study/study of latinos
10.1128/msystems.00273-22 · 2022 · External reference
Visceral adiposity in postmenopausal women is associated with a pro-inflammatory gut microbiome and immunogenic metabolic endotoxemia
10.1186/s40168-024-01901-1 · 2024 · External reference
Consumption of mediterranean versus western diet leads to distinct mammary gland microbiome populations
10.1016/j.celrep.2018.08.078 · 2018 · External reference
Neoadjuvant chemotherapy shifts breast tumor microbiota populations to regulate drug responsiveness and the development of metastasis
10.1158/1541-7786.mcr-19-0451 · 2020 · External reference
Diet alters entero-mammary signaling to regulate the breast microbiome and tumorigenesis
10.1158/0008-5472.can-20-2983 · 2021 · External reference
The human tumor microbiome is composed of tumor type-specific intracellular bacteria
10.1126/science.aay9189 · 2020 · External reference
Microbiota of human breast tissue
10.1128/aem.00242-14 · 2014 · External reference
The microbiome of aseptically collected human breast tissue in benign and malignant disease
10.1038/srep30751 · 2016 · External reference
Microbial alterations and risk factors of breast cancer: connections and mechanistic insights
10.3390/cells9051091 · 2020 · External reference
Microbe-associated molecular patterns differentially mediate carcinogenic alterations of the breast tissue in the context of obesity
10.1016/j.neo.2026.101284 · 2026 · External reference
Endocrine-targeting therapies shift the breast microbiome to reduce estrogen receptor-α breast cancer risk
10.1016/j.xcrm.2024.101880 · 2025 · External reference
Impact of gut permeability on the breast microbiome using a non-human primate model
10.1017/gmb.2022.9 · 2022 · External reference
Concomitant analyses of intratumoral microbiota and genomic features reveal distinct racial differences in breast cancer
10.1038/s41523-023-00505-6 · 2023 · External reference
Tumor-resident intracellular microbiota promotes metastatic colonization in breast cancer
10.1016/j.cell.2022.02.027 · 2022 · External reference
A procarcinogenic Colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates notch and beta-catenin axes
10.1158/2159-8290.cd-20-0537 · 2021 · External reference
Unresolved reference
2021 · External reference
UniProt: the universal protein knowledgebase
10.1093/nar/gkw1099 · 2017 · External reference
Species-level functional profiling of metagenomes and metatranscriptomes
10.1038/s41592-018-0176-y · 2018 · External reference
The MetaCyc database of metabolic pathways and enzymes - a 2019 update
10.1093/nar/gkz862 · 2020 · External reference
A novel metastatic estrogen receptor-expressing breast cancer model with antiestrogen responsiveness
10.3390/cancers15245773 · 2023 · External reference
Controlling the false discovery rate - a practical and powerful approach to multiple testing
10.1111/j.2517-6161.1995.tb02031.x · 1995 · External reference
Akkermansia muciniphila can reduce the damage of gluco/lipotoxicity, oxidative stress and inflammation, and normalize intestine microbiota in streptozotocin-induced diabetic rats
10.1093/femspd/fty028 · 2018 · External reference
Human breast microbiome correlates with prognostic features and immunological signatures in breast cancer
10.1186/s13073-021-00874-2 · 2021 · External reference
Metabolic obesity, adipose inflammation and elevated breast aromatase in women with normal body mass index
10.1158/1940-6207.capr-16-0314 · 2017 · External reference
Menopause is a determinant of breast adipose inflammation
10.1158/1940-6207.capr-14-0243 · 2015 · External reference
Systemic correlates of white adipose tissue inflammation in early-stage breast cancer
10.1158/1078-0432.ccr-15-2239 · 2016 · External reference
The microbiota of breast tissue and its association with breast cancer
10.1128/aem.01235-16 · 2016 · External reference
Akkermansia muciniphila uses human milk oligosaccharides to thrive in the early life conditions in vitro
10.1038/s41598-020-71113-8 · 2020 · External reference
Fecal Akkermansia muciniphila is associated with body composition and microbiota diversity in overweight and obese women with breast cancer participating in a presurgical weight loss trial
10.1016/j.jand.2018.08.164 · 2020 · External reference
Impact of microbiota on breast cancer hormone therapy
10.15698/cst2023.03.277 · 2023 · External reference
The role of Akkermansia muciniphila in cancer: mechanisms, therapeutic potential, and challenges
10.1002/imo2.70010 · 2025 · External reference
Oxidative stress in breast cancer: a biochemical map of reactive oxygen species production
10.3390/cimb46050282 · 2024 · External reference
Obesity increases DNA damage in the breast epithelium
10.1186/s13058-025-01961-7 · 2025 · External reference
The glutathione metabolite γ-glutamyl-glutamate partially activates glutamate NMDA receptors in central neurons with higher efficacy for GluN2B-containing receptors
10.3389/fphar.2021.794680 · 2021 · External reference
The clinical significance of serum oxidative stress biomarkers in breast cancer females
10.5603/mrj.a2018.0039 · 2019 · External reference
Is serum gamma glutamyltransferase a marker of oxidative stress?
10.1080/10715760410001694026 · 2004 · External reference
N-acetylcysteine pharmacology and applications in rare diseases-repurposing an old antioxidant
10.3390/antiox12071316 · 2023 · External reference
Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients
10.3892/ol.2012.931 · 2012 · External reference
The breast tissue microbiome, stroma, immune cells and breast cancer
10.1016/j.neo.2022.100786 · 2022 · External reference
ROS signaling in innate immunity via oxidative protein modifications
10.3389/fimmu.2024.1359600 · 2024 · External reference
ROS and ROS-mediated cellular signaling
10.1155/2016/4350965 · 2016 · External reference
The mechanisms of up-regulation of dendritic cell activity by oxidative stress
10.1189/jlb.3a0113-033rr · 2014 · External reference
Redox regulation of the immune response
10.1038/s41423-022-00902-0 · 2022 · External reference
Intestinal microbiota influence doxorubicin responsiveness in triple-negative breast cancer
10.3390/cancers14194849 · 2022 · External reference
Metabolic implications of immune checkpoint proteins in cancer
10.3390/cells11010179 · 2022 · External reference
Endocrine-targeted therapies modify the gut microbiome affecting responsiveness in ER plus breast cancer
10.1158/1538-7445.sabcs22-p1-02-05 · 2023 · External reference
Gut and breast microbiota as endocrine regulators of hormone receptor-positive breast cancer risk and therapy response
10.1210/endocr/bqac177 · 2022 · External reference
Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring
10.1016/j.ccell.2023.09.012 · 2023 · External reference