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References from ALKBH5 in Cancer-Associated Fibroblasts Governs an Epitranscriptomic Axis That Drives Pancreatic Cancer Metastasis. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics
10.3322/caac.21871 · 2025 · External reference
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Fibroblasts in pancreatic cancer: molecular and clinical perspectives
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Unraveling the therapeutic potential of the Hedgehog pathway in cancer
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The roles and implications of RNA m6A modification in cancer
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Post-transcriptional gene regulation by mRNA modifications
10.1038/nrm.2016.132 · 2017 · External reference
The role of m6A modification in the biological functions and diseases
10.1038/s41392-020-00450-x · 2021 · External reference
m6A eraser FTO impairs gemcitabine resistance in pancreatic cancer through influencing NEDD4 mRNA stability by regulating the PTEN/PI3K/AKT pathway
10.1186/s13046-023-02792-0 · 2023 · External reference
m6A methylation regulates hypoxia-induced pancreatic cancer glycolytic metabolism through ALKBH5-HDAC4-HIF1α positive feedback loop
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RNA m6A demethylase ALKBH5 protects against pancreatic ductal adenocarcinoma via targeting regulators of iron metabolism
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The role of N6-methyladenosine mRNA in the tumor microenvironment
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Identification, culture, and characterization of pancreatic stellate cells in rats and humans
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Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
10.1084/jem.20162024 · 2017 · External reference
Discovery of covalent and cell-active ALKBH5 inhibitors with potent antileukemia effects in vivo
10.1002/anie.202424928 · 2025 · External reference
RNA m6A methylation participates in regulation of postnatal development of the mouse cerebellum
10.1186/s13059-018-1435-z · 2018 · External reference
Oil red-O stains non-adipogenic cells: a precautionary note
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HISAT: a fast spliced aligner with low memory requirements
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featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
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10.1093/bioinformatics/bty560 · 2018 · External reference
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Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
10.1016/j.molcel.2010.05.004 · 2010 · External reference
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
10.1038/nmeth.2688 · 2013 · External reference
An improved ATAC-Seq protocol reduces background and enables interrogation of frozen tissues
10.1038/nmeth.4396 · 2017 · External reference
deepTools: a flexible platform for exploring deep-sequencing data
10.1093/nar/gku365 · 2014 · External reference
Model-based analysis of ChIP-Seq (MACS)
10.1186/gb-2008-9-9-r137 · 2008 · External reference
edgeR: a bioconductor package for differential expression analysis of digital gene expression data
10.1093/bioinformatics/btp616 · 2010 · External reference
ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization
10.1093/bioinformatics/btv145 · 2015 · External reference
Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture
10.1136/gut.43.1.128 · 1998 · External reference
Retinoic acid-induced pancreatic stellate cell quiescence reduces paracrine Wnt-β-catenin signaling to slow tumor progression
10.1053/j.gastro.2011.06.047 · 2011 · External reference
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility
10.1016/j.molcel.2012.10.015 · 2013 · External reference
Guidelines and definitions for research on epithelial-mesenchymal transition
10.1038/s41580-020-0237-9 · 2020 · External reference
Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
10.1038/nature19084 · 2016 · External reference
Leukemia inhibitory factor (LIF)
10.1016/j.cytogfr.2015.07.001 · 2015 · External reference
Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring
10.1038/s41586-019-1130-6 · 2019 · External reference
m6A modification negatively regulates translation by switching mRNA from polysome to P-body via IGF2BP3
10.1016/j.molcel.2023.10.040 · 2023 · External reference
POSTAR3: an updated platform for exploring post-transcriptional regulation coordinated by RNA-binding proteins
10.1093/nar/gkab702 · 2022 · External reference
RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT
10.1016/j.molcel.2012.07.026 · 2012 · External reference
Heat shock factor 1 (HSF1) specifically potentiates c-MYC-mediated transcription independently of the canonical heat shock response
10.1016/j.celrep.2023.112557 · 2023 · External reference
Super-enhancer-driven LIF promotes the mesenchymal transition in glioblastoma by activating ITGB2 signaling feedback in microglia
10.1093/neuonc/noae065 · 2024 · External reference
GeneHancer: genome-wide integration of enhancers and target genes in GeneCards
10.1093/database/bax028 · 2017 · External reference
A compendium of chromatin contact maps reveals spatially active regions in the human genome
10.1016/j.celrep.2016.10.061 · 2016 · External reference
The 3D genome browser: a web-based browser for visualizing 3D genome organization and long-range chromatin interactions
10.1186/s13059-018-1519-9 · 2018 · External reference
The mechanism and latest progress of m6A methylation in the progression of pancreatic cancer
10.7150/ijbs.104407 · 2025 · External reference
Crosstalk among m6A RNA methylation, hypoxia and metabolic reprogramming in TME: from immunosuppressive microenvironment to clinical application
10.1186/s13045-022-01304-5 · 2022 · External reference
StellaTUM: current consensus and discussion on pancreatic stellate cell research
10.1136/gutjnl-2011-301220 · 2012 · External reference
ALKBH5 ameliorated liver fibrosis and suppressed HSCs activation via triggering PTCH1 activation in an m6A dependent manner
10.1016/j.ejphar.2022.174900 · 2022 · External reference
RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner
10.1186/s12943-020-01158-w · 2020 · External reference
The m6A demethylase ALKBH5-mediated upregulation of DDIT4-AS1 maintains pancreatic cancer stemness and suppresses chemosensitivity by activating the mTOR pathway
10.1186/s12943-022-01647-0 · 2022 · External reference
Psychological stress-induced ALKBH5 deficiency promotes tumour innervation and pancreatic cancer via extracellular vesicle transfer of RNA
10.1038/s41556-025-01667-0 · 2025 · External reference
Reversal of pancreatic desmoplasia by re-educating stellate cells with a tumour microenvironment-activated nanosystem
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Targeting DTX2/UFD1-mediated FTO degradation to regulate antitumor immunity
10.1073/pnas.2407910121 · 2024 · External reference
HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers
10.1016/j.cell.2012.06.031 · 2012 · External reference
The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy
10.1016/j.cell.2014.05.045 · 2014 · External reference
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling
10.1038/s41467-022-34081-3 · 2022 · External reference
Disruption of super-enhancers in activated pancreatic stellate cells facilitates chemotherapy and immunotherapy in pancreatic cancer
10.1002/advs.202308637 · 2024 · External reference
Super-enhancer driven LIF/LIFR-STAT3-SOX2 regulatory feedback loop promotes cancer stemness in head and neck squamous cell carcinoma
10.1002/advs.202404476 · 2024 · External reference
Epigenetic profiling identifies LIF as a super-enhancer-controlled regulator of stem cell-like properties in osteosarcoma
10.1158/1541-7786.mcr-19-0470 · 2020 · External reference
HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis
10.1038/s41467-022-32034-4 · 2022 · External reference
Heat shock transcription factor 1 opens chromatin structure of interleukin-6 promoter to facilitate binding of an activator or a repressor
10.1074/jbc.m704471200 · 2007 · External reference
Regulation of HSF1 function in the heat stress response: implications in aging and disease
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