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References from Targeting WRN Helicase in Microsatellite-Instable Colorectal Cancer Induces Antitumor Immunity through Extrachromosomal Circular DNA Release. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics, 2024
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WRN helicase is a synthetic lethal target in microsatellite unstable cancers
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DNA helicases and their roles in cancer
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Werner syndrome helicase is required for the survival of cancer cells with microsatellite instability
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Synthetical lethality of Werner helicase and mismatch repair deficiency is mediated by p53 and PUMA in colon cancer
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Novel WRN helicase inhibitors selectively target microsatellite unstable cancer cells
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Discovery of WRN inhibitor HRO761 with synthetic lethality in MSI cancers
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Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase
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Werner helicase as a therapeutic target in mismatch repair deficient colorectal cancer
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A phase I/II open-label study of NDI-219216, a WRN inhibitor, in patients with advanced solid tumors with or without microsatellite instability/deficient mismatch repair
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eccDNAs are apoptotic products with high innate immunostimulatory activity
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PUMA mediates the apoptotic response to p53 in colorectal cancer cells
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PUMA amplifies necroptosis signaling by activating cytosolic DNA sensors
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Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth
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Repeat expansions confer WRN dependence in microsatellite-unstable cancers
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SMAC/Diablo-dependent apoptosis induced by nonsteroidal antiinflammatory drugs (NSAIDs) in colon cancer cells
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The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage
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Purification, full-length sequencing and genomic origin mapping of eccDNA
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Mcl-1 phosphorylation without degradation mediates sensitivity to HDAC inhibitors by liberating BH3-Only proteins
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Regorafenib inhibits colorectal tumor growth through PUMA-mediated apoptosis
10.1158/1078-0432.ccr-13-2944 · 2014 · External reference
PD-1/SHP-2 inhibits Tc1/Th1 phenotypic responses and the activation of T cells in the tumor microenvironment
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Organoid modeling of the tumor immune microenvironment
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Normal and cancerous tissues release extrachromosomal circular DNA (eccDNA) into the circulation
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Ligase I and ligase III mediate the DNA double-strand break ligation in alternative end-joining
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Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products
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Isolation of circular DNA molecules from whole cellular DNA by use of ATP-dependent deoxyribonuclease
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A small molecule inhibitor of the BLM helicase modulates chromosome stability in human cells
10.1016/j.chembiol.2012.10.016 · 2013 · External reference
The ATM substrate KAP1 controls DNA repair in heterochromatin: regulation by HP1 proteins and serine 473/824 phosphorylation
10.1158/1541-7786.mcr-11-0134 · 2012 · External reference
Genomic characterization of five commonly used endometrial cancer cell lines
10.3892/ijo.2020.5139 · 2020 · External reference
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
10.1126/science.aaa2630 · 2015 · External reference
A DR5/Ligase 3-mediated feedback loop perpetuates immunogenicity in mismatch repair deficient colorectal cancer
10.1053/j.gastro.2026.06.014 · 2026 · External reference
Extrachromosomal circular DNA: biogenesis, structure, functions and diseases
10.1038/s41392-022-01176-8 · 2022 · External reference
DNA sensing in mismatch repair-deficient tumor cells is essential for anti-tumor immunity
10.1016/j.ccell.2020.11.006 · 2021 · External reference
ATR inhibition potentiates ionizing radiation-induced interferon response via cytosolic nucleic acid-sensing pathways
10.15252/embj.2019104036 · 2020 · External reference
Werner helicase is a synthetic-lethal vulnerability in mismatch repair-deficient colorectal cancer refractory to targeted therapies, chemotherapy, and immunotherapy
10.1158/2159-8290.cd-20-1508 · 2021 · External reference
Microsatellite instability: a review of what the oncologist should know
10.1186/s12935-019-1091-8 · 2020 · External reference
Cloning of a mouse homologue of the human Werner syndrome gene and assignment to 8A4 by fluorescence in situ hybridization
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