Research graph
References from Targeting Cystine Addiction Suppresses Breast Cancer Lung Metastasis. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21834 · 2024 · External reference
Molecular principles of metastasis: a hallmark of cancer revisited
10.1038/s41392-020-0134-x · 2020 · External reference
Defining the landscape of metabolic dysregulations in cancer metastasis
10.1007/s10585-021-10140-9 · 2022 · External reference
Regulation of antioxidants in cancer
10.1016/j.molcel.2023.11.001 · 2024 · External reference
Oxidative stress inhibits distant metastasis by human melanoma cells
10.1038/nature15726 · 2015 · External reference
Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization
10.7554/elife.43627 · 2019 · External reference
Metastatic breast cancer cells are metabolically reprogrammed to maintain redox homeostasis during metastasis
10.1016/j.redox.2024.103276 · 2024 · External reference
Regulation of glutathione synthesis
10.1016/j.mam.2008.05.005 · 2009 · External reference
Comprehensive metabolic tracing reveals the origin and catabolism of cysteine in mammalian tissues and tumors
10.1158/0008-5472.can-22-3000 · 2023 · External reference
Transsulfuration activity can support cell growth upon extracellular cysteine limitation
10.1016/j.cmet.2019.09.009 · 2019 · External reference
Cysteine and folate metabolism are targetable vulnerabilities of metastatic colorectal cancer
10.3390/cancers13030425 · 2021 · External reference
Cystine/glutamate antiporter xCT deficiency reduces metastasis without impairing immune system function in breast cancer mouse models
10.1186/s13046-023-02830-x · 2023 · External reference
Extracellular redox state shift: a novel approach to target prostate cancer invasion
10.1016/j.freeradbiomed.2018.01.023 · 2018 · External reference
MYC gene amplification is often acquired in lethal distant breast cancer metastases of unamplified primary tumors
10.1038/modpathol.2011.171 · 2012 · External reference
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type
10.1016/j.cmet.2011.12.015 · 2012 · External reference
Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis.
10.1016/j.molonc.2016.02.004 · 2016 · External reference
Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
10.1038/nm.4232 · 2017 · External reference
Selective events in the metastatic process defined by analysis of the sequential dissemination of subpopulations of a mouse mammary tumor
10.1016/0304-3835(88)90013-1 · 1992 · External reference
Classifying human brain tumors by lipid imaging with mass spectrometry
10.1158/0008-5472.can-11-2465 · 2012 · External reference
SPUTNIK: an R package for filtering of spatially related peaks in mass spectrometry imaging data
10.1093/bioinformatics/bty622 · 2019 · External reference
A new approach to large multiomics data integration
10.1021/acs.analchem.5c01812 · 2025 · External reference
Hyperspectral visualization of mass spectrometry imaging data
10.1021/ac302330a · 2013 · External reference
Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo
10.1016/j.cmet.2012.05.001 · 2012 · External reference
MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG
10.1038/s41589-018-0136-y · 2018 · External reference
Micro-CT acquisition and image processing to track and characterize pulmonary nodules in mice
10.1038/s41596-022-00769-5 · 2023 · External reference
Ambient mass spectrometry using desorption electrospray ionization (DESI): instrumentation, mechanisms and applications in forensics, chemistry, and biology
10.1002/jms.922 · 2005 · External reference
Oxidative stress damages rRNA inside the ribosome and differentially affects the catalytic center
10.1093/nar/gkx1308 · 2018 · External reference
Early rRNA processing is a stress-dependent regulatory event whose inhibition maintains nucleolar integrity
10.1093/nar/gkab1231 · 2022 · External reference
Glutathione synthesis
10.1016/j.bbagen.2012.09.008 · 2013 · External reference
Glutathione peroxidase 3 localizes to the epithelial lining fluid and the extracellular matrix in interstitial lung disease
10.1038/srep29952 · 2016 · External reference
Understanding the role of cysteine in ferroptosis: progress & paradoxes
10.1111/febs.15842 · 2022 · External reference
Bile acid sequestrant inhibits gluconeogenesis via inducing hepatic cysteine dioxygenase type 1 to reduce cysteine availability
10.1152/ajpgi.00353.2024 · 2025 · External reference
Radiotherapy for lung metastases: conventional to stereotactic body radiation therapy
10.1016/j.semradonc.2022.11.007 · 2023 · External reference
BACH1 stabilization by antioxidants stimulates lung cancer metastasis
10.1016/j.cell.2019.06.005 · 2019 · External reference
Metabolic heterogeneity confers differences in melanoma metastatic potential
10.1038/s41586-019-1847-2 · 2020 · External reference
Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria
10.1016/j.celrep.2023.113464 · 2023 · External reference
Cysteine depletion, a key action to challenge cancer cells to ferroptotic cell death
10.3389/fonc.2020.00723 · 2020 · External reference
Differential dependence on cysteine from transsulfuration versus transport during T cell activation
10.1089/ars.2010.3496 · 2011 · External reference
Disruption of xCT inhibits cancer cell metastasis via the caveolin-1/beta-catenin pathway
10.1038/onc.2008.414 · 2009 · External reference
SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells
10.1038/s41467-023-39401-9 · 2023 · External reference
Cysteine is a limiting factor for glioma proliferation and survival
10.1002/1878-0261.13148 · 2022 · External reference
Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells
10.1016/s1535-6108(03)00050-3 · 2003 · External reference
Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine)
10.1016/s0021-9258(18)35980-5 · 1979 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
GPX4 overexpressed non-small cell lung cancer cells are sensitive to RSL3-induced ferroptosis
10.1038/s41598-023-35978-9 · 2023 · External reference
Cysteine depletion induces pancreatic tumor ferroptosis in mice
10.1126/science.aaw9872 · 2020 · External reference
Cysteine depletion sensitizes prostate cancer cells to agents that enhance DNA damage and to immune checkpoint inhibition
10.1186/s13046-023-02677-2 · 2023 · External reference
Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11
10.1158/2159-8290.cd-19-0338 · 2019 · External reference
