Research graph
References from IL-1α Expands SLC2A1highSPP1highIFNlow Myeloid Cells to Drive Immune Escape and Malignant Transformation of Precancers. Local targets link to admitted publications; unresolved targets remain external evidence.
Nivolumab for recurrent squamous-cell carcinoma of the head and neck
10.1056/nejmoa1602252 · 2016 · External reference
Pembrolizumab versus methotrexate, docetaxel, or cetuximab for recurrent or metastatic head-and-neck squamous cell carcinoma (KEYNOTE-040): a randomised, open-label, phase 3 study
10.1016/s0140-6736(18)31999-8 · 2019 · External reference
Potentially malignant disorders of the oral cavity and oral dysplasia: a systematic review and meta-analysis of malignant transformation rate by subtype
10.1002/hed.26006 · 2020 · External reference
Potentially malignant oral disorders and cancer transformation
10.21873/anticanres.12587 · 2018 · External reference
Malignant transformation of oral leukoplakia: a systematic review of observational studies
10.1111/jop.12339 · 2016 · External reference
Comprehensive genomic characterization of head and neck squamous cell carcinomas
10.1038/nature14129 · 2015 · External reference
Genomic signature of Fanconi anaemia DNA repair pathway deficiency in cancer
10.1038/s41586-022-05253-4 · 2022 · External reference
Mitigating SOX2-potentiated immune escape of head and neck squamous cell carcinoma with a STING-inducing nanosatellite vaccine
10.1158/1078-0432.ccr-17-2807 · 2018 · External reference
Intermetallic nanoassemblies potentiate systemic STING activation
10.1126/science.adx1893 · 2026 · External reference
BATF2 is a glutamine-responsive tumour suppressor required for type-I interferon-dependent anti-tumour immunity
10.1038/s41467-025-68027-2 · 2025 · External reference
Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy
10.1038/s41565-021-00962-9 · 2021 · External reference
Saturated fatty acids dampen the immunogenicity of cancer by suppressing STING
10.1016/j.celrep.2023.112303 · 2023 · External reference
Mass-tag labeling using acyl-PEG exchange for the determination of endogenous protein S-fatty acylation
10.1002/cpps.36 · 2017 · External reference
Confocal laser endomicroscope with distal MEMS scanner for real-time histopathology
10.1038/s41598-022-24210-9 · 2022 · External reference
Ultra-compact microsystems-based confocal endomicroscope
10.1109/tmi.2020.2971476 · 2020 · External reference
Hypoxia, angiogenesis, and oral cancer metastasis
2010 · External reference
Cell-programmed nutrient partitioning in the tumour microenvironment
10.1038/s41586-021-03442-1 · 2021 · External reference
Prognostic value of glycolysis markers in head and neck squamous cell carcinoma: a meta-analysis
10.18632/aging.202583 · 2021 · External reference
Fast and robust deconvolution of tumor infiltrating lymphocyte from expression profiles using least trimmed squares
10.1371/journal.pcbi.1006976 · 2019 · External reference
Benchmarking of cell type deconvolution pipelines for transcriptomics data
10.1038/s41467-020-19015-1 · 2020 · External reference
The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes
10.1073/pnas.0909357106 · 2009 · External reference
T-bet and eomesodermin are required for T cell-mediated antitumor immune responses
10.4049/jimmunol.1000749 · 2010 · External reference
Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
10.1038/ni1268 · 2005 · External reference
Rules of chemokine receptor association with T cell polarization in vivo
10.1172/jci13543 · 2001 · External reference
PD-1 status in CD8+ T cells associates with survival and anti-PD-1 therapeutic outcomes in head and neck cancer
10.1158/0008-5472.can-16-3167 · 2017 · External reference
An epithelial-immune circuit amplifies inflammasome and IL-6 responses to SARS-CoV-2
10.1016/j.chom.2022.12.005 · 2023 · External reference
Microbiota-dependent activation of CD4+ T cells induces CTLA-4 blockade-associated colitis via Fcγ receptors
10.1126/science.adh8342 · 2024 · External reference
Immunosuppressive myeloid cells induce nitric oxide-dependent DNA damage and p53 pathway activation in CD8+ T cells
10.1158/2326-6066.cir-20-0085 · 2021 · External reference
Distinct populations of immune-suppressive macrophages differentiate from monocytic myeloid-derived suppressor cells in cancer
10.1016/j.celrep.2020.108571 · 2020 · External reference
Visualizing structure and transitions in high-dimensional biological data
10.1038/s41587-019-0336-3 · 2019 · External reference
CXCL9:SPP1 macrophage polarity identifies a network of cellular programs that control human cancers
10.1126/science.ade2292 · 2023 · External reference
Evolution of myeloid-mediated immunotherapy resistance in prostate cancer
10.1038/s41586-024-08290-3 · 2025 · External reference
HPV16 drives cancer immune escape via NLRX1-mediated degradation of STING
10.1172/jci129497 · 2020 · External reference
Activation of STING requires palmitoylation at the Golgi
10.1038/ncomms11932 · 2016 · External reference
Efficacy and safety of nivolumab plus ipilimumab vs nivolumab alone for treatment of recurrent or metastatic squamous cell carcinoma of the head and neck: the phase 2 CheckMate 714 randomized clinical trial
10.1001/jamaoncol.2023.0147 · 2023 · External reference
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
10.1038/nature10138 · 2011 · External reference
The nature of myeloid-derived suppressor cells in the tumor microenvironment
10.1016/j.it.2016.01.004 · 2016 · External reference
A tumor-myeloid cell axis, mediated via the cytokines IL-1α and TSLP, promotes the progression of breast cancer
10.1038/s41590-018-0066-6 · 2018 · External reference
Hepatocyte necrosis induced by oxidative stress and IL-1α release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis
10.1016/j.ccr.2008.06.016 · 2008 · External reference
Inhibitor of kappaB kinase β regulates gastric carcinogenesis via interleukin-1α expression
10.1053/j.gastro.2010.03.047 · 2010 · External reference
Hematopoietic aging promotes cancer by fueling IL-1α-driven emergency myelopoiesis
10.1126/science.adn0327 · 2024 · External reference
IL (interleukin)-1α promotes nuclear factor-kappaB and AP-1-induced IL-8 expression, cell survival, and proliferation in head and neck squamous cell carcinomas
2001 · External reference
Cytokines IL-1α, IL-6, and GM-CSF constitutively secreted by oral squamous carcinoma induce down-regulation of CD80 costimulatory molecule expression: restoration by interferon gamma
10.1007/s00262-003-0433-4 · 2004 · External reference
Expression of IL-1α correlates with distant metastasis in patients with head and neck squamous cell carcinoma
10.18632/oncotarget.6054 · 2015 · External reference
Malignant transformation in 5071 southern Taiwanese patients with potentially malignant oral mucosal disorders
10.1186/1472-6831-14-99 · 2014 · External reference
Clinical and histological prognostic factors of recurrence and malignant transformation in a large series of oral potentially malignant disorders
10.3389/fonc.2022.886404 · 2022 · External reference
