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References from Macrophage-Induced Senescent Cancer-Associated Fibroblasts Promote SASP-Mediated Chemoresistance in Colorectal Cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21834 · 2024 · External reference
Management of colorectal cancer
10.1136/bmj.l4561 · 2019 · External reference
Comprehensive review of targeted therapy for colorectal cancer
10.1038/s41392-020-0116-z · 2020 · External reference
Macrophages and therapeutic resistance in cancer
10.1016/j.ccell.2015.02.015 · 2015 · External reference
Tumor microenvironment and epithelial mesenchymal transition as targets to overcome tumor multidrug resistance
10.1016/j.drup.2020.100715 · 2020 · External reference
Macrophages-aPKCι-CCL5 feedback loop modulates the progression and chemoresistance in cholangiocarcinoma
10.1186/s13046-021-02235-8 · 2022 · External reference
Perivascular M2 macrophages stimulate tumor relapse after chemotherapy
10.1158/0008-5472.can-14-3587 · 2015 · External reference
Cancer-associated fibroblasts as abettors of tumor progression at the crossroads of EMT and therapy resistance
10.1186/s12943-019-0994-2 · 2019 · External reference
THBS2 + cancer-associated fibroblasts promote EMT leading to oxaliplatin resistance via COL8A1-mediated PI3K/AKT activation in colorectal cancer
10.1186/s12943-024-02180-y · 2024 · External reference
Fibroblasts in cancer: unity in heterogeneity
10.1016/j.cell.2023.03.016 · 2023 · External reference
Exploiting senescence for the treatment of cancer
10.1038/s41568-022-00450-9 · 2022 · External reference
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
10.1038/s41580-020-00314-w · 2021 · External reference
Senescence and cancer - role and therapeutic opportunities
10.1038/s41571-022-00668-4 · 2022 · External reference
The senescence-associated secretory phenotype: the dark side of tumor suppression
10.1146/annurev-pathol-121808-102144 · 2010 · External reference
Unmasking senescence: context-dependent effects of SASP in cancer
10.1038/s41568-019-0156-2 · 2019 · External reference
Senescence and the tumor-immune landscape: implications for cancer immunotherapy
10.1016/j.semcancer.2022.02.005 · 2022 · External reference
Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
10.1371/journal.pbio.0060301 · 2008 · External reference
Rutin is a potent senomorphic agent to target senescent cells and can improve chemotherapeutic efficacy
10.1111/acel.13921 · 2024 · External reference
Two-step senescence-focused cancer therapies
10.1016/j.tcb.2018.04.006 · 2018 · External reference
Senescence-associated reprogramming promotes cancer stemness
10.1038/nature25167 · 2018 · External reference
RANK links senescence to stemness in the mammary epithelia, delaying tumor onset but increasing tumor aggressiveness
10.1016/j.devcel.2021.04.022 · 2021 · External reference
Tumor cell escape from therapy-induced senescence as a model of disease recurrence after dormancy
10.1158/0008-5472.can-18-3437 · 2019 · External reference
Immunosenescence: molecular mechanisms and diseases
10.1038/s41392-023-01451-2 · 2023 · External reference
Senescent T cells within suppressive tumor microenvironments: emerging target for tumor immunotherapy
10.1172/jci133679 · 2020 · External reference
Immunosenescence: a key player in cancer development
10.1186/s13045-020-00986-z · 2020 · External reference
Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer
10.1038/s41585-023-00827-x · 2024 · External reference
Senescent CAFs mediate immunosuppression and drive breast cancer progression
10.1158/2159-8290.cd-23-0426 · 2024 · External reference
Senescence defines a distinct subset of myofibroblasts that orchestrates immunosuppression in pancreatic cancer
10.1158/2159-8290.cd-23-0428 · 2024 · External reference
Senescent fibroblasts in melanoma initiation and progression: an integrated theoretical, experimental, and clinical approach
10.1158/0008-5472.can-13-1720 · 2013 · External reference
Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma restrict CD8+ T cell activation and limit responsiveness to immunotherapy in mice
10.1038/s41467-024-50441-7 · 2024 · External reference
Clinical and therapeutic relevance of cancer-associated fibroblasts
10.1038/s41571-021-00546-5 · 2021 · External reference
Cancer-associated fibroblasts in the single-cell era
10.1038/s43018-022-00411-z · 2022 · External reference
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
10.1038/s41467-022-32552-1 · 2022 · External reference
Cellular senescence: defining a path forward
10.1016/j.cell.2019.10.005 · 2019 · External reference
Hallmarks of cellular senescence
10.1016/j.tcb.2018.02.001 · 2018 · External reference
Biomarkers to identify and isolate senescent cells
10.1016/j.arr.2016.05.003 · 2016 · External reference
Comprehensive integration of single-cell data
10.1016/j.cell.2019.05.031 · 2019 · External reference
DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors
10.1016/j.cels.2019.03.003 · 2019 · External reference
Fast, sensitive and accurate integration of single-cell data with harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
Dimensionality reduction for visualizing single-cell data using UMAP
10.1038/nbt.4314 · 2019 · External reference
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
10.1126/science.1254257 · 2014 · External reference
GSVA: gene set variation analysis for microarray and RNA-seq data
10.1186/1471-2105-14-7 · 2013 · External reference
mclust 5: clustering, classification and density estimation using gaussian finite mixture models
10.32614/rj-2016-021 · 2016 · External reference
Inference and analysis of cell-cell communication using cellchat
10.1038/s41467-021-21246-9 · 2021 · External reference
NicheNet: modeling intercellular communication by linking ligands to target genes
10.1038/s41592-019-0667-5 · 2020 · External reference
Scalable and model-free detection of spatial patterns and colocalization
10.1101/gr.276851.122 · 2022 · External reference
Efficient discovery of robust prognostic biomarkers and signatures in solid tumors
10.1016/j.canlet.2025.217502 · 2025 · External reference
BEST: a web application for comprehensive biomarker exploration on large-scale data in solid tumors
10.1186/s40537-023-00844-y · 2023 · External reference
Cell composition analysis of bulk genomics using single-cell data
10.1038/s41592-019-0355-5 · 2019 · External reference
WGCNA: an R package for weighted correlation network analysis
10.1186/1471-2105-9-559 · 2008 · External reference
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan
10.1038/nature16932 · 2016 · External reference
Senescent intimal foam cells are deleterious at all stages of atherosclerosis
10.1126/science.aaf6659 · 2016 · External reference
SCENIC: single-cell regulatory network inference and clustering
10.1038/nmeth.4463 · 2017 · External reference
Cancer-associated fibroblasts undergoing neoadjuvant chemotherapy suppress rectal cancer revealed by single-cell and spatial transcriptomics
10.1016/j.xcrm.2023.101231 · 2023 · External reference
Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer
10.1038/s41467-022-28421-6 · 2022 · External reference
Predictive biomarkers for 5-fluorouracil and oxaliplatin-based chemotherapy in gastric cancers via profiling of patient-derived xenografts
10.1038/s41467-021-25122-4 · 2021 · External reference
Metformin and ICG-001 act synergistically to abrogate cancer stem cells-mediated chemoresistance in colorectal cancer by promoting apoptosis and autophagy
10.3390/cancers14051281 · 2022 · External reference
Exosome secretion related gene signature predicts chemoresistance in patients with colorectal cancer
10.1016/j.prp.2024.155313 · 2024 · External reference
Senescent stromal cells: roles in the tumor microenvironment
10.1016/j.trecan.2022.09.002 · 2023 · External reference
Alternative activation of macrophages
10.1038/nri978 · 2003 · External reference
New insights into M1/M2 macrophages: key modulators in cancer progression
10.1186/s12935-021-02089-2 · 2021 · External reference
A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells
10.1016/j.cell.2021.01.010 · 2021 · External reference
Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma
10.1016/j.cell.2020.11.041 · 2021 · External reference
The IL-1 family: regulators of immunity
10.1038/nri2691 · 2010 · External reference
Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders
10.1126/science.abb5916 · 2021 · External reference
A transcriptomic pan-cancer signature for survival prognostication and prediction of immunotherapy response based on endothelial senescence
10.1186/s12929-023-00915-5 · 2023 · External reference
The efficacy of chemotherapy is limited by intratumoral senescent cells expressing PD-L2
10.1038/s43018-023-00712-x · 2024 · External reference
Therapy-induced senescent tumor cell-derived extracellular vesicles promote colorectal cancer progression through SERPINE1-mediated NF-κB p65 nuclear translocation
10.1186/s12943-024-01985-1 · 2024 · External reference
Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
10.1016/j.ccell.2022.01.004 · 2022 · External reference
IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer
10.1038/s41467-023-39953-w · 2023 · External reference
Spatiotemporal immune landscape of colorectal cancer liver metastasis at single-cell level
10.1158/2159-8290.cd-21-0316 · 2022 · External reference
Profiling the heterogeneity of colorectal cancer consensus molecular subtypes using spatial transcriptomics
10.1038/s41698-023-00488-4 · 2024 · External reference