Research graph
References from Multiomics Dissection Reveals Natural Killer Cell–CD8+ T-cell Cooperation in Shaping an Immunostimulatory Tumor Microenvironment. Local targets link to admitted publications; unresolved targets remain external evidence.
Neoantigens in cancer immunotherapy
10.1126/science.aaa4971 · 2015 · External reference
Clonal heterogeneity and tumor evolution: past, present, and the future
10.1016/j.cell.2017.01.018 · 2017 · External reference
Suppression of metastases using a new lymphocyte checkpoint target for cancer immunotherapy
10.1158/2159-8290.cd-15-0944 · 2016 · External reference
The immunoreceptor TIGIT regulates antitumor and antiviral CD8(+) T cell effector function
10.1016/j.ccell.2014.10.018 · 2014 · External reference
Anti-TIGIT antibody tiragolumab alone or with atezolizumab in patients with advanced solid tumors: a phase 1a/1b nonrandomized controlled trial
10.1001/jamaoncol.2023.3867 · 2023 · External reference
Natural killer cells in antitumour adoptive cell immunotherapy
10.1038/s41568-022-00491-0 · 2022 · External reference
Antigen mRNA-transfected, allogeneic fibroblasts loaded with NKT-cell ligand confer antitumor immunity
10.1182/blood-2008-08-176446 · 2009 · External reference
Vaccination with antigen-transfected, NKT cell ligand-loaded, human cells elicits robust in situ immune responses by dendritic cells
10.1158/0008-5472.can-12-0759 · 2013 · External reference
Systemic DC activation modulates the tumor microenvironment and shapes the long-lived tumor-specific memory mediated by CD8+ T cells
10.1158/0008-5472.can-15-3219 · 2016 · External reference
Reinvigoration of innate and adaptive immunity via therapeutic cellular vaccine for patients with AML
10.1016/j.omto.2022.09.001 · 2022 · External reference
A single immunization with cellular vaccine confers dual protection against SARS-CoV-2 and cancer
10.1111/cas.15434 · 2022 · External reference
Tumor epitope spreading by a novel multivalent therapeutic cellular vaccine targeting cancer antigens to invariant NKT-triggered dendritic cells in situ
10.3389/fimmu.2024.1345037 · 2024 · External reference
Natural killer cell behavior in lymph nodes revealed by static and real-time imaging
10.1084/jem.20051474 · 2006 · External reference
The trafficking of natural killer cells
10.1111/j.1600-065x.2007.00563.x · 2007 · External reference
The immune contexture in human tumours: impact on clinical outcome
10.1038/nrc3245 · 2012 · External reference
Understanding the tumor immune microenvironment (TIME) for effective therapy
10.1038/s41591-018-0014-x · 2018 · External reference
Spatially segregated macrophage populations predict distinct outcomes in colon cancer
10.1158/2159-8290.cd-23-1300 · 2024 · External reference
Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing
10.1038/s41591-018-0045-3 · 2018 · External reference
Pan-cancer single-cell landscape of tumor-infiltrating T cells
10.1126/science.abe6474 · 2021 · External reference
A pan-cancer single-cell panorama of human natural killer cells
10.1016/j.cell.2023.07.034 · 2023 · External reference
A structured tumor-immune microenvironment in triple negative breast cancer revealed by multiplexed ion beam imaging
10.1016/j.cell.2018.08.039 · 2018 · External reference
Multiplex digital spatial profiling of proteins and RNA in fixed tissue
10.1038/s41587-020-0472-9 · 2020 · External reference
High-plex immunofluorescence imaging and traditional histology of the same tissue section for discovering image-based biomarkers
10.1038/s43018-023-00576-1 · 2023 · External reference
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics
10.1038/s41580-024-00768-2 · 2025 · External reference
High-definition spatial transcriptomic profiling of immune cell populations in colorectal cancer
10.1038/s41588-025-02193-3 · 2025 · External reference
Combination of cancer vaccine with CD122-biased IL-2/anti-IL-2 Ab complex shapes the stem-like effector NK and CD8+ T cells against tumor
10.1136/jitc-2022-006409 · 2023 · External reference
Comparing neoantigen cancer vaccines and immune checkpoint therapy unveils an effective vaccine and anti-TREM2 macrophage-targeting dual therapy
10.1016/j.celrep.2024.114875 · 2024 · External reference
TIMER3: an enhanced resource for tumor immune analysis
10.1093/nar/gkaf388 · 2025 · External reference
Treatment of established tumors with a novel vaccine that enhances major histocompatibility class II presentation of tumor antigen
1996 · External reference
Cold and hot tumors: from molecular mechanisms to targeted therapy
10.1038/s41392-024-01979-x · 2024 · External reference
KLRG1+ natural killer cells protect against pulmonary metastatic disease by immunosurveillance
10.4161/onci.28328 · 2014 · External reference
Developmental relationships of four exhausted CD8+ T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms
10.1016/j.immuni.2020.04.014 · 2020 · External reference
Transcription factor IRF8 orchestrates the adaptive natural killer cell response
10.1016/j.immuni.2018.04.018 · 2018 · External reference
Biallelic mutations in IRF8 impair human NK cell maturation and function
10.1172/jci86276 · 2017 · External reference
Chemokines and the immune response to cancer
10.1016/j.immuni.2021.01.012 · 2021 · External reference
Cancer immunotherapy using artificial adjuvant vector cells to deliver NY-ESO-1 antigen to dendritic cells in situ
10.1111/cas.15259 · 2022 · External reference
Immune networks and therapeutic targeting of iNKT cells in cancer
10.1016/j.it.2019.09.008 · 2019 · External reference
NKT-licensed in vivo dendritic cell-based immunotherapy as cellular immunodrugs for cancer treatment
10.1615/critrevoncog.2023048735 · 2024 · External reference
RNA-seq analysis reveals CCR5 as a key target for CRISPR gene editing to regulate in vivo NK cell trafficking
10.3390/cancers13040872 · 2021 · External reference
Rapid functional impairment of natural killer cells following tumor entry limits anti-tumor immunity
10.1038/s41467-024-44789-z · 2024 · External reference
A mandatory role for STAT4 in IL-12 induction of mouse T cell CCR5
10.4049/jimmunol.167.12.6877 · 2001 · External reference
Synergistic induction of CCL5, CXCL9 and CXCL10 by IFN-gamma and NLRs ligands on human fibroblast-like synoviocytes-a potential immunopathological mechanism for joint inflammation in rheumatoid arthritis
10.1016/j.intimp.2020.106356 · 2020 · External reference
Cooperation between constitutive and inducible chemokines enables T cell engraftment and immune attack in solid tumors
10.1016/j.ccell.2019.05.004 · 2019 · External reference
NK cell-triggered CCL5/IFNγ-CXCL9/10 axis underlies the clinical efficacy of neoadjuvant anti-HER2 antibodies in breast cancer
10.1186/s13046-023-02918-4 · 2024 · External reference
Quantifying spatial CXCL9 distribution with image analysis predicts improved prognosis of triple-negative breast cancer
10.3389/fgene.2024.1421573 · 2024 · External reference
C1q+ tumor-associated macrophages contribute to immunosuppression through fatty acid metabolic reprogramming in malignant pleural effusion
10.1136/jitc-2023-007441 · 2023 · External reference
Distinct TAM subset with cross-dressing capability determines the bifurcation of tumor immunity
10.1016/j.celrep.2025.115800 · 2025 · External reference
Author correction: a conserved dendritic-cell regulatory program limits antitumour immunity
10.1038/s41586-020-2326-5 · 2020 · External reference
Dendritic cell type 3 arises from Ly6C+ monocyte-dendritic cell progenitors
10.1016/j.immuni.2023.07.001 · 2023 · External reference
Tumour-retained activated CCR7+ dendritic cells are heterogeneous and regulate local anti-tumour cytolytic activity
10.1038/s41467-024-44787-1 · 2024 · External reference
