Research graph
References from Comprehensive Genomic Analysis of Normal and Cancer Cells Elucidates the Elevated Mutational Burden in Cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Clonal evolution in cancer
10.1038/nature10762 · 2012 · External reference
Half or more of the somatic mutations in cancers of self-renewing tissues originate prior to tumor initiation
10.1073/pnas.1221068110 · 2013 · External reference
Somatic mutation landscapes at single-molecule resolution
10.1038/s41586-021-03477-4 · 2021 · External reference
Single duplex DNA sequencing with CODEC detects mutations with high sensitivity
10.1038/s41588-023-01376-0 · 2023 · External reference
Measuring single cell divisions in human tissues from multi-region sequencing data
10.1038/s41467-020-14844-6 · 2020 · External reference
Comprehensive characteristics of somatic mutations in the normal tissues of patients with cancer and existence of somatic mutant clones linked to cancer development
10.1136/jmedgenet-2020-106905 · 2021 · External reference
Distinguishing excess mutations and increased cell death based on variant allele frequencies
10.1371/journal.pcbi.1010048 · 2022 · External reference
Somatic variation in normal tissues: friend or foe of cancer early detection?
10.1016/j.annonc.2022.09.156 · 2022 · External reference
Contrasting somatic mutation patterns in aging human neurons and oligodendrocytes
10.1016/j.cell.2024.02.025 · 2024 · External reference
Comprehensive and integrated genomic characterization of adult soft tissue sarcomas
10.1016/j.cell.2017.10.014 · 2017 · External reference
Clinical sequencing of soft tissue and bone sarcomas delineates diverse genomic landscapes and potential therapeutic targets
10.1038/s41467-022-30453-x · 2022 · External reference
Tissue-specific mutation accumulation in human adult stem cells during life
10.1038/nature19768 · 2016 · External reference
Somatic mutant clones colonize the human esophagus with age
10.1126/science.aau3879 · 2018 · External reference
The landscape of somatic mutation in normal colorectal epithelial cells
10.1038/s41586-019-1672-7 · 2019 · External reference
Age-related remodelling of oesophageal epithelia by mutated cancer drivers
10.1038/s41586-018-0811-x · 2019 · External reference
Tobacco smoking and somatic mutations in human bronchial epithelium
10.1038/s41586-020-1961-1 · 2020 · External reference
A body map of somatic mutagenesis in morphologically normal human tissues
10.1038/s41586-021-03836-1 · 2021 · External reference
The mutational landscape of human somatic and germline cells
10.1038/s41586-021-03822-7 · 2021 · External reference
The somatic mutation landscape of normal gastric epithelium
10.1038/s41586-025-08708-6 · 2025 · External reference
Extensive heterogeneity in somatic mutation and selection in the human bladder
10.1126/science.aba8347 · 2020 · External reference
The architecture of clonal expansions in morphologically normal tissue from cancerous and non-cancerous prostates
10.1186/s12943-022-01644-3 · 2022 · External reference
Intra-tumour diversification in colorectal cancer at the single-cell level
10.1038/s41586-018-0024-3 · 2018 · External reference
Macroscopic somatic clonal expansion in morphologically normal human urothelium
10.1126/science.aba7300 · 2020 · External reference
Pan-cancer analysis of whole genomes
10.1038/s41586-020-1969-6 · 2020 · External reference
Current cigarette smoking among adults in the United States
2024 · External reference
Percentage* of adults aged ≥65 years who drank four or more alcoholic drinks per week†, by sex and age - National Health Interview Survey, United States, 2020§
10.15585/mmwr.mm7133a5 · 2022 · External reference
10.15620/cdc:106273
10.15620/cdc:106273 · 2021 · External reference
Global prevalence of Helicobacter pylori infection and incidence of gastric cancer between 1980 and 2022
10.1053/j.gastro.2023.12.022 · 2024 · External reference
Viral Hepatitis National Strategic Plan for the United States: A Roadmap to Elimination, 2021-2025
2002 · External reference
Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States, 2019
10.3322/caac.21858 · 2024 · External reference
Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions
10.1126/science.1260825 · 2015 · External reference
Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention
10.1126/science.aaf9011 · 2017 · External reference
Only three driver gene mutations are required for the development of lung and colorectal cancers
10.1073/pnas.1421839112 · 2015 · External reference
Cell loss and the concept of potential doubling time
10.1002/(sici)1097-0320(19970901)29:1<34::aid-cyto3>3.0.co;2-d · 1997 · External reference
SU-E-T-256: radiation dose responses for chemoradiation therapy of pancreatic cancer: an analysis of compiled clinical data using biophysical models
10.1118/1.4735323 · 2012 · External reference
Estimate of radiobiologic parameters from clinical data for biologically based treatment planning for liver irradiation
10.1016/j.ijrobp.2007.10.037 · 2008 · External reference
Microsatellite instability in colorectal cancer
10.1053/j.gastro.2009.12.064 · 2010 · External reference
The human cell count and size distribution
10.1073/pnas.2303077120 · 2023 · External reference
Cell production rates in human tissues and tumours and their significance. Part II: clinical data
10.1053/ejso.1999.0907 · 2000 · External reference
Identification of lineage-uncommitted, long-lived, label-retaining cells in healthy human esophagus and stomach, and in metaplastic esophagus
10.1053/j.gastro.2012.12.022 · 2013 · External reference
Alveolar progenitor cells and the origin of lung cancer
10.1111/joim.13201 · 2021 · External reference
Cell number and distribution in human and rat airways
10.1165/ajrcmb.10.6.8003339 · 1994 · External reference
An estimation of the number of cells in the human body
10.3109/03014460.2013.807878 · 2013 · External reference
Cytokinetic analysis of lung cancer by in vivo bromodeoxyuridine labelling
10.1038/bjc.1993.228 · 1993 · External reference
The prevalence of Lynch syndrome and associated clinicopathologic features in patients with mismatch repair deficient gastric cancer
10.1200/jco.2025.43.4_suppl.380 · 2025 · External reference
Gastric stem cells: physiological and pathological perspectives
10.3389/fcell.2020.571536 · 2020 · External reference
The distribution of cellular turnover in the human body
10.1038/s41591-020-01182-9 · 2021 · External reference
The global health burden of infection-associated cancers in the year 2002
10.1002/ijc.21731 · 2006 · External reference
Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing
10.1038/s41588-019-0576-7 · 2020 · External reference
Supervised mutational signatures for obesity and other tissue-specific etiological factors in cancer
10.7554/elife.61082 · 2021 · External reference
Evaluating cancer etiology and risk with a mathematical model of tumor evolution
10.1038/s41467-022-34760-1 · 2022 · External reference
Mutational heterogeneity in cancer and the search for new cancer-associated genes
10.1038/nature12213 · 2013 · External reference
The path to cancer — three strikes and you’re out
10.1056/nejmp1508811 · 2015 · External reference
Cancer genome landscapes
10.1126/science.1235122 · 2013 · External reference
Massive genomic rearrangement acquired in a single catastrophic event during cancer development
10.1016/j.cell.2010.11.055 · 2011 · External reference
Punctuated evolution of prostate cancer genomes
10.1016/j.cell.2013.03.021 · 2013 · External reference
Big bang tumor growth and clonal evolution
10.1101/cshperspect.a028381 · 2018 · External reference
Somatic mutations and clonal dynamics in healthy and cirrhotic human liver
10.1038/s41586-019-1670-9 · 2019 · External reference
Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin
10.1126/science.aaa6806 · 2015 · External reference
The repertoire of mutational signatures in human cancer
10.1038/s41586-020-1943-3 · 2020 · External reference
The impact of rare germline variants on human somatic mutation processes
10.1038/s41467-022-31483-1 · 2022 · External reference
Heterogeneity and evolution of DNA mutation rates in microsatellite stable colorectal cancer
10.1126/scitranslmed.ado1641 · 2025 · External reference
Genetic progression and the waiting time to cancer
10.1371/journal.pcbi.0030225 · 2007 · External reference
Accumulation of driver and passenger mutations during tumor progression
10.1073/pnas.1010978107 · 2010 · External reference
Hitchhiking and epistasis give rise to cohort dynamics in adapting populations
10.1073/pnas.1702314114 · 2017 · External reference
Measuring the distribution of fitness effects in somatic evolution by combining clonal dynamics with dN/dS ratios
10.7554/elife.48714 · 2020 · External reference
Quantification of the selective advantage of driver mutations is dependent on the underlying model and stage of tumor evolution
10.1158/0008-5472.can-21-1064 · 2022 · External reference
Functional characterization of all CDKN2A missense variants and comparison to in silico models of pathogenicity
10.7554/elife.95347 · 2025 · External reference
“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin
10.1002/1097-0142(195309)6:5<963::aid-cncr2820060515>3.0.co;2-q · 1953 · External reference
Genomic differences between pure ductal carcinoma in situ and synchronous ductal carcinoma in situ with invasive breast cancer
10.18632/oncotarget.3162 · 2015 · External reference
Risk of advanced adenomas in siblings of individuals with advanced adenomas: a cross-sectional study
10.1053/j.gastro.2015.11.003 · 2016 · External reference
Cancer prevention: molecular and epidemiologic consensus
10.1126/science.aau3830 · 2018 · External reference
Lung adenocarcinoma promotion by air pollutants
10.1038/s41586-023-05874-3 · 2023 · External reference
Quantitative estimates of preventable and treatable deaths from 36 cancers worldwide: a population-based study
10.1016/s2214-109x(23)00406-0 · 2023 · External reference
Unresolved reference
2004 · External reference