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References from From Tissue Specificity to Systemic Cues: Shaping MYC-Driven Tumor Metabolism. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer metabolism: looking forward
10.1038/s41568-021-00378-6 · 2021 · External reference
The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism
10.1038/s41568-019-0216-7 · 2020 · External reference
Metabolic regulation of cell growth and proliferation
10.1038/s41580-019-0123-5 · 2019 · External reference
Metabolic reprogramming and cancer progression
10.1126/science.aaw5473 · 2020 · External reference
Understanding the Warburg effect: the metabolic requirements of cell proliferation
10.1126/science.1160809 · 2009 · External reference
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
10.1146/annurev-cellbio-092910-154237 · 2011 · External reference
Glucose feeds the TCA cycle via circulating lactate
10.1038/nature24057 · 2017 · External reference
MYC and tumor metabolism: chicken and egg
10.15252/embj.201796438 · 2017 · External reference
Regulation of cancer cell metabolism: oncogenic MYC in the driver’s seat
10.1038/s41392-020-00235-2 · 2020 · External reference
Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
10.1073/pnas.0810199105 · 2008 · External reference
The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type
10.1016/j.cmet.2011.12.015 · 2012 · External reference
MYC as a target for cancer treatment
10.1016/j.ctrv.2021.102154 · 2021 · External reference
Therapeutic targeting of “undruggable” MYC
10.1016/j.ebiom.2021.103756 · 2022 · External reference
MYC on the path to cancer
10.1016/j.cell.2012.03.003 · 2012 · External reference
Blocking lactate export by inhibiting the Myc target MCT1 disables glycolysis and glutathione synthesis
10.1158/0008-5472.can-13-2034 · 2014 · External reference
The MYC oncogene - the grand orchestrator of cancer growth and immune evasion
10.1038/s41571-021-00549-2 · 2022 · External reference
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
10.1038/318533a0 · 1985 · External reference
MYC oncogene elicits tumorigenesis associated with embryonic, ribosomal biogenesis, and tissue-lineage dedifferentiation gene expression changes
10.1038/s41388-022-02458-9 · 2022 · External reference
MYC, metabolism, and cancer
10.1158/2159-8290.cd-15-0507 · 2015 · External reference
Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc
10.1074/jbc.c000023200 · 2000 · External reference
Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays
10.1128/mcb.24.13.5923-5936.2004 · 2004 · External reference
Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer
10.1186/s40170-021-00270-9 · 2021 · External reference
MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer
10.1038/nature03043 · 2004 · External reference
Sequential adaptive changes in a c-Myc-driven model of hepatocellular carcinoma
10.1074/jbc.m117.782052 · 2017 · External reference
Interaction between MYC and MCL1 in the genesis and outcome of non-small-cell lung cancer
10.1158/0008-5472.can-10-3590 · 2011 · External reference
Environment impacts the metabolic dependencies of Ras-driven non-small cell lung cancer
10.1016/j.cmet.2016.01.007 · 2016 · External reference
Myc-driven murine prostate cancer shares molecular features with human prostate tumors
10.1016/s1535-6108(03)00197-1 · 2003 · External reference
AKT1 and MYC induce distinctive metabolic fingerprints in human prostate cancer
10.1158/0008-5472.can-14-1490 · 2014 · External reference
Obesogenic high-fat diet and MYC cooperate to promote lactate accumulation and tumor microenvironment remodeling in prostate cancer
10.1158/0008-5472.can-23-0519 · 2024 · External reference
High-fat diet fuels prostate cancer progression by rewiring the metabolome and amplifying the MYC program
10.1038/s41467-019-12298-z · 2019 · External reference
Metabolic vulnerabilities of prostate cancer: diagnostic and therapeutic opportunities
10.1101/cshperspect.a030569 · 2018 · External reference
Metabolic reprogramming in prostate cancer
10.1038/s41416-021-01435-5 · 2021 · External reference
Oncogenic PIK3CA mutations reprogram glutamine metabolism in colorectal cancer
10.1038/ncomms11971 · 2016 · External reference
In vivo reprogramming of cancer metabolism by MYC
10.3389/fcell.2017.00035 · 2017 · External reference
Lactate metabolism in human lung tumors
10.1016/j.cell.2017.09.019 · 2017 · External reference
Targeted inhibition of tumor-specific glutaminase diminishes cell-autonomous tumorigenesis
10.1172/jci75836 · 2015 · External reference
MYC-driven inhibition of the glutamate-cysteine ligase promotes glutathione depletion in liver cancer
10.15252/embr.201643068 · 2017 · External reference
The MYC oncogene cooperates with sterol-regulated element-binding protein to regulate lipogenesis essential for neoplastic growth
10.1016/j.cmet.2019.07.012 · 2019 · External reference
Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer
10.1038/nm.4055 · 2016 · External reference
Alteration of the lipid profile in lymphomas induced by MYC overexpression
10.1073/pnas.1409778111 · 2014 · External reference
Characterization of MYC-induced tumorigenesis by in situ lipid profiling
10.1021/ac400479j · 2013 · External reference
Myc expression drives aberrant lipid metabolism in lung cancer
10.1158/0008-5472.can-15-3403 · 2016 · External reference
A novel metabolic function of Myc in regulation of fatty acid synthesis in prostate cancer
10.1038/s41388-020-01553-z · 2021 · External reference
Targeting ELOVL6 to disrupt c-MYC driven lipid metabolism in pancreatic cancer enhances chemosensitivity
10.1038/s41467-025-56894-8 · 2025 · External reference
Disrupting the MYC-TFEB circuit impairs amino acid homeostasis and provokes metabolic anergy
10.1158/0008-5472.can-21-1168 · 2022 · External reference
MYC-driven small-cell lung cancer is metabolically distinct and vulnerable to arginine depletion
10.1158/1078-0432.ccr-18-4140 · 2019 · External reference
Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer
10.1172/jci139929 · 2021 · External reference
Prostate-specific oncogene OTUD6A promotes prostatic tumorigenesis via deubiquitinating and stabilizing c-Myc
10.1038/s41418-022-00960-x · 2022 · External reference
Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes
10.1038/s41416-019-0464-z · 2019 · External reference
c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism
10.1038/nature07823 · 2009 · External reference
MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism
10.1073/pnas.1507228112 · 2015 · External reference
MicroRNA-342-3p is a potent tumour suppressor in hepatocellular carcinoma
10.1016/j.jhep.2020.07.039 · 2021 · External reference
Tumour hypoxia in driving genomic instability and tumour evolution
10.1038/s41568-024-00781-9 · 2025 · External reference
Molecular crosstalk between MYC and HIF in cancer
10.3389/fcell.2020.590576 · 2020 · External reference
HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity
10.1016/j.ccr.2007.04.001 · 2007 · External reference
Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1
10.1128/mcb.00440-07 · 2007 · External reference
HIF-1α and HIF-2α differently regulate tumour development and inflammation of clear cell renal cell carcinoma in mice
10.1038/s41467-020-17873-3 · 2020 · External reference
HIF-alpha effects on c-Myc distinguish two subtypes of sporadic VHL-deficient clear cell renal carcinoma
10.1016/j.ccr.2008.10.016 · 2008 · External reference
Breast cancer stem cells secrete MIF to mediate tumor metabolic reprogramming that drives immune evasion
10.1158/0008-5472.can-23-2390 · 2024 · External reference
MIF loss impairs Myc-induced lymphomagenesis
10.1038/sj.cdd.4401653 · 2005 · External reference
Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells
10.1038/s41556-018-0083-6 · 2018 · External reference
MYC overexpression drives immune evasion in hepatocellular carcinoma that is reversible through restoration of proinflammatory macrophages
10.1158/0008-5472.can-22-0232 · 2023 · External reference
Lactate in the tumour microenvironment: from immune modulation to therapy
10.1016/j.ebiom.2021.103627 · 2021 · External reference
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
10.1038/nature13490 · 2014 · External reference
Immunoediting instructs tumor metabolic reprogramming to support immune evasion
10.1016/j.cmet.2022.12.003 · 2023 · External reference
Targeting MYC at the intersection between cancer metabolism and oncoimmunology
10.3389/fimmu.2024.1324045 · 2024 · External reference
Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5-24 million UK adults
10.1016/s0140-6736(14)60892-8 · 2014 · External reference
Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
10.1016/s0140-6736(08)60269-x · 2008 · External reference
Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies
10.1136/bmj.g7607 · 2015 · External reference
Intestinal MYC modulates obesity-related metabolic dysfunction
10.1038/s42255-021-00421-8 · 2021 · External reference
Proinflammatory CXCL12-CXCR4/CXCR7 signaling axis drives Myc-induced prostate cancer in Obese mice
10.1158/0008-5472.can-17-0284 · 2017 · External reference
Acetate metabolism in physiology, cancer, and beyond
10.1016/j.tcb.2019.05.005 · 2019 · External reference
The metabolic fate of acetate in cancer
10.1038/nrc.2016.87 · 2016 · External reference
The fat side of prostate cancer
10.1016/j.bbalip.2013.03.010 · 2013 · External reference
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc
10.1038/s42255-024-01037-4 · 2024 · External reference
Obesity and cancer, a case for insulin signaling
10.1038/cddis.2015.381 · 2015 · External reference
Rethinking the relationship between insulin and cancer
10.1016/j.tem.2020.05.004 · 2020 · External reference
Hyperinsulinemia enhances c-Myc-mediated mammary tumor development and advances metastatic progression to the lung in a mouse model of type 2 diabetes
10.1186/bcr3089 · 2012 · External reference
The insulin and IGF signaling pathway sustains breast cancer stem cells by IRS2/PI3K-mediated regulation of MYC
10.1016/j.celrep.2022.111759 · 2022 · External reference
MYC in cancer: from undruggable target to clinical trials
10.1038/s41573-025-01143-2 · 2025 · External reference
Myc-Driven glycolysis is a therapeutic target in glioblastoma
10.1158/1078-0432.ccr-15-2274 · 2016 · External reference
Pivotal role of fatty acid synthase in c-MYC driven hepatocarcinogenesis
10.3390/ijms21228467 · 2020 · External reference
Fatty acid synthase: an emerging target in cancer
10.3390/molecules25173935 · 2020 · External reference
Targeting lipid metabolism in metastatic prostate cancer
10.1177/17588359231152839 · 2023 · External reference
Identifying strategies to target the metabolic flexibility of tumours
10.1038/s42255-020-0195-8 · 2020 · External reference
Phase I study of imalumab (BAX69), a fully human recombinant antioxidized macrophage migration inhibitory factor antibody in advanced solid tumours
10.1111/bcp.14289 · 2020 · External reference
MYC drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to Aurora kinase inhibition
10.1016/j.ccell.2016.12.005 · 2017 · External reference
13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression
10.1016/j.cmet.2011.04.012 · 2011 · External reference
Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model
10.1016/j.mri.2017.07.014 · 2017 · External reference