Research graph
References from TLR9 Agonists Potentiate Adoptive T-cell Therapy in Cancer through a B-cell–CD2 Costimulatory Axis. Local targets link to admitted publications; unresolved targets remain external evidence.
Engineered cellular immunotherapies in cancer and beyond
10.1038/s41591-022-01765-8 · 2022 · External reference
Promises and challenges of adoptive T-cell therapies for solid tumours
10.1038/s41416-021-01353-6 · 2021 · External reference
Adoptive cellular therapies: the current landscape
10.1007/s00428-018-2484-0 · 2019 · External reference
CAR T-cell therapy for B-cell lymphoma
10.1016/j.currproblcancer.2021.100826 · 2022 · External reference
CAR-T cell therapy for cancer: current challenges and future directions
10.1038/s41392-025-02269-w · 2025 · External reference
CAR-T cell therapy: current limitations and potential strategies
10.1038/s41408-021-00459-7 · 2021 · External reference
Adoptive cell therapy for nonhematologic solid tumors
10.1200/jco.22.01618 · 2023 · External reference
Applications and clinical trial landscape using Toll-like receptor agonists to reduce the toll of cancer
10.1038/s41698-023-00364-1 · 2023 · External reference
Toll-like receptors as a therapeutic target in the era of immunotherapies
10.3389/fcell.2021.756315 · 2021 · External reference
Randomized, open-label, phase III study of tilsotolimod in combination with ipilimumab versus ipilimumab alone in patients with advanced refractory melanoma (ILLUMINATE-301)
10.1200/jco.24.00727 · 2025 · External reference
Vaccination with NY-ESO-1 protein and CpG in montanide induces integrated antibody/Th1 responses and CD8 T cells through cross-priming
10.1073/pnas.0703395104 · 2007 · External reference
SD-101 in combination with pembrolizumab in advanced melanoma: results of a phase Ib, multicenter study
10.1158/2159-8290.cd-18-0280 · 2018 · External reference
Toll-like receptor 9 agonists and combination therapies: strategies to modulate the tumour immune microenvironment for systemic anti-tumour immunity
10.1038/s41416-022-01876-6 · 2022 · External reference
B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: modulation by BCR and CD40, and relevance to T-independent antibody responses
10.3109/08916934.2014.993027 · 2015 · External reference
Comparison of human B cell activation by TLR7 and TLR9 agonists
10.1186/1471-2172-9-39 · 2008 · External reference
TLR signaling fine-tunes anti-influenza B cell responses without regulating effector T cell responses
10.4049/jimmunol.178.4.2182 · 2007 · External reference
TLR signaling in B-cell development and activation
10.1038/cmi.2012.61 · 2013 · External reference
B cells imprint adoptively transferred CD8+ T cells with enhanced tumor immunity
10.1136/jitc-2021-003078 · 2022 · External reference
Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains
10.1073/pnas.0813101106 · 2009 · External reference
GP100 expression is variable in intensity in melanoma
10.1007/s00262-024-03776-5 · 2024 · External reference
T-cell receptor gene therapy of established tumors in a murine melanoma model
10.1097/cji.0b013e31815c193f · 2008 · External reference
TLR9 agonist MGN1703 enhances B cell differentiation and function in lymph nodes
10.1016/j.ebiom.2019.07.005 · 2019 · External reference
TLR7/TLR9- and B cell receptor-signaling crosstalk: promotion of potentially dangerous B cells
10.3389/fimmu.2017.00775 · 2017 · External reference
CD5 expression is regulated during human T-cell activation by alternative polyadenylation, PTBP1, and miR-204
10.1002/eji.201545663 · 2016 · External reference
CD5 dynamically calibrates basal NF-κB signaling in T cells during thymic development and peripheral activation
10.1073/pnas.1922525117 · 2020 · External reference
T cell calcium signaling regulation by the co-receptor CD5
10.3390/ijms19051295 · 2018 · External reference
The complex integration of T-cell metabolism and immunotherapy
10.1158/2159-8290.cd-20-0569 · 2021 · External reference
SCENITH: a flow cytometry-based method to functionally profile energy metabolism with single-cell resolution
10.1016/j.cmet.2020.11.007 · 2020 · External reference
Transcriptional and epigenetic regulation of effector and memory CD8 T cell differentiation
10.3389/fimmu.2018.02826 · 2018 · External reference
BATF3 programs CD8+ T cell memory
10.1038/s41590-020-0786-2 · 2020 · External reference
FOXO1 is a master regulator of memory programming in CAR T cells
10.1038/s41586-024-07300-8 · 2024 · External reference
An essential role for the transcription factor runx1 in T cell maturation
10.1038/srep23533 · 2016 · External reference
The TCF1-Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness
10.1126/sciimmunol.aai8593 · 2016 · External reference
Single-cell characterization of anti-LAG-3 and anti-PD-1 combination treatment in patients with melanoma
10.1172/jci164809 · 2023 · External reference
Tumor and microenvironment evolution during immunotherapy with nivolumab
10.1016/j.cell.2017.09.028 · 2017 · External reference
Distinct immune cell populations define response to anti-PD-1 monotherapy and anti-PD-1/anti-CTLA-4 combined therapy
10.1016/j.ccell.2019.01.003 · 2019 · External reference
Interleukin-10 receptor signaling promotes the maintenance of a PD-1int TCF-1+ CD8+ T cell population that sustains anti-tumor immunity
10.1016/j.immuni.2021.11.004 · 2021 · External reference
CD40L stimulates tumor-infiltrating B-cells and improves ex vivo TIL expansion
10.1136/jitc-2024-011066 · 2025 · External reference
Regulation of CD8 T cell by B-cells: a narrative review
10.3389/fimmu.2023.1125605 · 2023 · External reference
Regulatory B cells inhibit cytotoxic T lymphocyte (CTL) activity and elimination of infected CD4 T cells after in vitro reactivation of HIV latent reservoirs
10.1371/journal.pone.0092934 · 2014 · External reference
CD8 T cell memory in B cell-deficient mice
10.1084/jem.183.5.2165 · 1996 · External reference
Long-term safety of rituximab (risks of viral and opportunistic infections)
10.1007/s11926-021-01037-3 · 2021 · External reference
Exhaustion of CTL memory and recrudescence of viremia in lymphocytic choriomeningitis virus-infected MHC class II-deficient mice and B cell-deficient mice
10.4049/jimmunol.157.7.3074 · 1996 · External reference
Spatial positioning of immune hotspots reflects the interplay between B and T cells in lung squamous cell carcinoma
10.1158/0008-5472.can-22-2589 · 2023 · External reference
B cell-rich niches support stem-like CD8+ T cells in cancer microenvironment
10.1016/j.ccell.2023.04.007 · 2023 · External reference
A high OXPHOS CD8 T cell subset is predictive of immunotherapy resistance in melanoma patients
10.1084/jem.20202084 · 2022 · External reference
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
10.1038/s41586-019-1325-x · 2019 · External reference
High levels of eomes promote exhaustion of anti-tumor CD8+ T cells
10.3389/fimmu.2018.02981 · 2018 · External reference
Critical role of CD2 co-stimulation in adaptive natural killer cell responses revealed in NKG2C-deficient humans
10.1016/j.celrep.2016.04.005 · 2016 · External reference
CD2 promotes human natural killer cell membrane nanotube formation
10.1371/journal.pone.0047664 · 2012 · External reference
The CD58-CD2 axis is co-regulated with PD-L1 via CMTM6 and shapes anti-tumor immunity
10.1016/j.ccell.2023.05.014 · 2023 · External reference
CD58 loss in tumor cells confers functional impairment of CAR T cells
10.1182/bloodadvances.2022007891 · 2022 · External reference
Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses
10.1172/jci.insight.99573 · 2018 · External reference
