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References from Targeting p300 Reverses Acidic Microenvironment–Induced PARP Inhibitor Resistance. Local targets link to admitted publications; unresolved targets remain external evidence.
Cancer statistics, 2025
10.3322/caac.21871 · 2025 · External reference
Maintenance olaparib in patients with newly diagnosed advanced ovarian cancer
10.1056/nejmoa1810858 · 2018 · External reference
FDA approval summary: olaparib monotherapy in patients with deleterious germline BRCA-mutated advanced ovarian cancer treated with three or more lines of chemotherapy
10.1158/1078-0432.ccr-15-0887 · 2015 · External reference
Synthetic lethal therapies for cancer: what’s next after PARP inhibitors?
10.1038/s41571-018-0055-6 · 2018 · External reference
Clinical and translational advances in ovarian cancer therapy
10.1038/s43018-023-00617-9 · 2023 · External reference
Understanding and overcoming resistance to PARP inhibitors in cancer therapy
10.1038/s41571-021-00532-x · 2021 · External reference
Tumour acidosis: from the passenger to the driver’s seat
10.1038/nrc.2017.77 · 2017 · External reference
Microenvironment acidity as a major determinant of tumor chemoresistance: proton pump inhibitors (PPIs) as a novel therapeutic approach
10.1016/j.drup.2015.08.004 · 2015 · External reference
Abiraterone acetate induces CREB1 phosphorylation and enhances the function of the CBP-p300 complex, leading to resistance in prostate cancer cells
10.1158/1078-0432.ccr-20-4391 · 2021 · External reference
Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation
10.1182/blood.2022019306 · 2025 · External reference
Protein lysine acetylation by p300/CBP
10.1021/cr500452k · 2015 · External reference
Preclinical development and characterization of IACS-16559, a dual bromodomain inhibitor of CBP/EP300, and its potential in AML subtypes
10.1158/1538-7445.am2025-447 · 2025 · External reference
TT125-802, a highly selective bromodomain inhibitor of CBP/p300, in patients with advanced solid tumors: an update on the phase I study
10.1016/j.ejca.2024.114644 · 2024 · External reference
Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies
10.1016/j.ccell.2023.11.001 · 2023 · External reference
Targeting the p300/CBP axis in lethal prostate cancer
10.1158/2159-8290.cd-20-0751 · 2021 · External reference
Mouse ovarian cancer models recapitulate the human tumor microenvironment and patient response to treatment
10.1016/j.celrep.2019.12.034 · 2020 · External reference
Development of a syngeneic mouse model for events related to ovarian cancer
10.1093/carcin/21.4.585 · 2000 · External reference
Cyclin E1 deregulation occurs early in secretory cell transformation to promote formation of fallopian tube-derived high-grade serous ovarian cancers
10.1158/0008-5472.can-13-2247 · 2014 · External reference
BET bromodomain inhibition synergizes with PARP inhibitor in epithelial ovarian cancer
10.1016/j.celrep.2017.11.095 · 2017 · External reference
The SETDB1-TRIM28 complex suppresses antitumor immunity
10.1158/2326-6066.cir-21-0754 · 2021 · External reference
MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens
10.1186/s13059-014-0554-4 · 2014 · External reference
m6A-independent genome-wide METTL3 and METTL14 redistribution drives the senescence-associated secretory phenotype
10.1038/s41556-021-00656-3 · 2021 · External reference
Toward better understanding of artifacts in variant calling from high-coverage samples
10.1093/bioinformatics/btu356 · 2014 · External reference
The Sequence Alignment/Map format and SAMtools
10.1093/bioinformatics/btp352 · 2009 · External reference
deepTools2: a next generation web server for deep-sequencing data analysis
10.1093/nar/gkw257 · 2016 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
RPPA SPACE: an R package for normalization and quantitation of Reverse-Phase Protein Array data
10.1093/bioinformatics/btac665 · 2022 · External reference
A pan-cancer proteomic perspective on The Cancer Genome Atlas
10.1038/ncomms4887 · 2014 · External reference
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
10.1038/nbt.1511 · 2008 · External reference
Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN
10.1038/nature24023 · 2017 · External reference
Novel hybrid molecule overcomes the limited response of solid tumours to HDAC inhibitors via suppressing JAK1-STAT3-BCL2 signalling
10.7150/thno.26627 · 2018 · External reference
Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells
2000 · External reference
Acidic ascites inhibits ovarian cancer cell proliferation and correlates with the metabolomic, lipidomic and inflammatory phenotype of human patients
10.1186/s12967-022-03763-3 · 2022 · External reference
Tumour microenvironment and metabolic plasticity in cancer and cancer stem cells: perspectives on metabolic and immune regulatory signatures in chemoresistant ovarian cancer stem cells
10.1016/j.semcancer.2018.10.002 · 2018 · External reference
Dysregulated pH: a perfect storm for cancer progression
10.1038/nrc3110 · 2011 · External reference
MRI of the tumor microenvironment
10.1002/jmri.10181 · 2002 · External reference
Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate
10.1038/nature07017 · 2008 · External reference
PARP inhibitors: synthetic lethality in the clinic
10.1126/science.aam7344 · 2017 · External reference
PARPi-FL-a fluorescent PARP1 inhibitor for glioblastoma imaging
10.1016/j.neo.2014.05.005 · 2014 · External reference
Enhancement of chemotherapy by manipulation of tumour pH
10.1038/sj.bjc.6690455 · 1999 · External reference
Acid suspends the circadian clock in hypoxia through inhibition of mTOR
10.1016/j.cell.2018.05.009 · 2018 · External reference
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
10.1038/nrm.2017.53 · 2017 · External reference
Targeting the DNA repair pathway in Ewing sarcoma
10.1016/j.celrep.2014.09.028 · 2014 · External reference
Targeting fatty acid oxidation to promote anoikis and inhibit ovarian cancer progression
10.1158/1541-7786.mcr-19-1057 · 2020 · External reference
ATF6-mediated signaling contributes to PARP inhibitor resistance in ovarian cancer
10.1158/1541-7786.mcr-22-0102 · 2023 · External reference
Targeting dePARylation selectively suppresses DNA repair-defective and PARP inhibitor-resistant malignancies
10.1126/sciadv.aav4340 · 2019 · External reference
The transcriptional coactivators p300 and CBP are histone acetyltransferases
10.1016/s0092-8674(00)82001-2 · 1996 · External reference
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours
10.1038/nature24028 · 2017 · External reference
Current development of CBP/p300 inhibitors in the last decade
10.1016/j.ejmech.2020.112861 · 2021 · External reference
Preclinical characterization of AZD5305, a next-generation, highly selective PARP1 inhibitor and trapper
10.1158/1078-0432.ccr-22-0301 · 2022 · External reference
Discovery and optimization of small-molecule ligands for the CBP/p300 bromodomains
10.1021/ja412434f · 2014 · External reference
BMP2-activated Erk/MAP kinase stabilizes Runx2 by increasing p300 levels and histone acetyltransferase activity
10.1074/jbc.m110.142307 · 2010 · External reference
ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression
10.1074/jbc.m700264200 · 2007 · External reference
ATR, CHK1 and WEE1 inhibitors cause homologous recombination repair deficiency to induce synthetic lethality with PARP inhibitors
10.1038/s41416-024-02745-0 · 2024 · External reference
Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models
10.1038/s41467-020-17127-2 · 2020 · External reference
An integrated encyclopedia of DNA elements in the human genome
10.1038/nature11247 · 2012 · External reference
Acetylation of poly(ADP-ribose) polymerase-1 by p300/CREB-binding protein regulates coactivation of NF-kappaB-dependent transcription
10.1074/jbc.m507553200 · 2005 · External reference
PARP inhibition: PARP1 and beyond
10.1038/nrc2812 · 2010 · External reference
Targeting polyploid giant cancer cells potentiates a therapeutic response and overcomes resistance to PARP inhibitors in ovarian cancer
10.1126/sciadv.adf7195 · 2023 · External reference
How protons pave the way to aggressive cancers
10.1038/s41568-023-00628-9 · 2023 · External reference
Proton export upregulates aerobic glycolysis
10.1186/s12915-022-01340-0 · 2022 · External reference
Regulation of inflammatory responses by pH-dependent transcriptional condensates
10.1016/j.cell.2025.06.033 · 2025 · External reference
pH and drug resistance in tumors
10.1054/drup.2000.0119 · 2000 · External reference
Drug resistance and cellular adaptation to tumor acidic pH microenvironment
10.1021/mp200292c · 2011 · External reference
Lactic acid and an acidic tumor microenvironment suppress anticancer immunity
10.3390/ijms21218363 · 2020 · External reference
Association between pH regulation of the tumor microenvironment and immunological state
10.3389/fonc.2023.1175563 · 2023 · External reference
PARPi triggers the STING-dependent immune response and enhances the therapeutic efficacy of immune checkpoint blockade independent of BRCAness
10.1158/0008-5472.can-18-1003 · 2019 · External reference
Tumor pH and metastasis: a malignant process beyond hypoxia
10.1007/s10555-018-09777-y · 2019 · External reference
The transcriptional co-activators CBP and p300 are activated via phenylephrine through the p42/p44 MAPK cascade
10.1074/jbc.m104626200 · 2002 · External reference
Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers
10.1126/scitranslmed.aal5148 · 2017 · External reference
Trapping of PARP1 and PARP2 by clinical PARP inhibitors
10.1158/0008-5472.can-12-2753 · 2012 · External reference
Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action
10.1126/scitranslmed.aaf9246 · 2016 · External reference
978P Clinical activity of TT125-802, a highly selective bromodomain inhibitor of CBP/p300, in advanced solid tumors: update on the ongoing phase I study
10.1016/j.annonc.2025.08.1547 · 2025 · External reference
Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): a PARP1-DNA trapper with high selectivity for PARP1 over PARP2 and other PARPs
10.1021/acs.jmedchem.1c01012 · 2021 · External reference
The PARP1 selective inhibitor saruparib (AZD5305) elicits potent and durable antitumor activity in patient-derived BRCA1/2-associated cancer models
10.1186/s13073-024-01370-z · 2024 · External reference