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References from PDE5A Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Mediated Cholesterol Trafficking through a Noncanonical cGMP-Dependent Pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Diversion of aspartate in ASS1-deficient tumours fosters de novo pyrimidine synthesis
10.1038/nature15529 · 2015 · External reference
Arginine and the metabolic regulation of nitric oxide synthesis in cancer
10.1242/dmm.033332 · 2018 · External reference
Targeting purine synthesis in ASS1-expressing tumors enhances the response to immune checkpoint inhibitors
10.1038/s43018-020-0106-7 · 2020 · External reference
Heterogeneity of cGMP signalling in tumour cells and the tumour microenvironment: challenges and chances for cancer pharmacology and therapeutics
10.1016/j.pharmthera.2023.108337 · 2023 · External reference
Phosphodiesterase-5 inhibitors in management of pulmonary hypertension: safety, tolerability, and efficacy
10.2147/dhps.s6215 · 2010 · External reference
Analysis of optimality in natural and perturbed metabolic networks
10.1073/pnas.232349399 · 2002 · External reference
Myocardial phosphodiesterases and their role in cGMP regulation
10.1097/fjc.0000000000000773 · 2020 · External reference
Phosphodiesterase-5 inhibitors use and risk for mortality and metastases among male patients with colorectal cancer
10.1038/s41467-020-17028-4 · 2020 · External reference
cGMP signalling: from bench to bedside. Conference on cGMP generators, effectors and therapeutic implications
10.1038/sj.embor.7400627 · 2006 · External reference
Palbociclib in combination with sunitinib exerts a synergistic anti-cancer effect in patient-derived xenograft models of various human cancers types
10.1016/j.canlet.2022.215665 · 2022 · External reference
Viral infection of the marine alga Emiliania huxleyi triggers lipidome remodeling and induces the production of highly saturated triacylglycerol
10.1111/nph.13852 · 2016 · External reference
Protocol for studying microbiome impact on host energy and reproduction in Drosophila
10.1016/j.xpro.2022.101253 · 2022 · External reference
Live-cell microscopy and fluorescence-based measurement of luminal pH in intracellular organelles
10.3389/fcell.2017.00071 · 2017 · External reference
Generation of a cGMP Indicator with an expanded dynamic range by optimization of amino acid linkers between a fluorescent protein and PDE5α.
10.1021/acssensors.6b00582 · 2017 · External reference
Intracellular and plasma membrane cholesterol labeling and quantification using filipin and GFP-D4
10.1007/978-1-4939-9136-5_11 · 2019 · External reference
Chromatin interaction analysis reveals changes in small chromosome and telomere clustering between epithelial and breast cancer cells
10.1186/s13059-015-0768-0 · 2015 · External reference
An atlas of human metabolism
10.1126/scisignal.aaz1482 · 2020 · External reference
The present and future of the Cancer Dependency Map
10.1038/s41568-024-00763-x · 2025 · External reference
iMAT: an integrative metabolic analysis tool
10.1093/bioinformatics/btq602 · 2010 · External reference
What is flux balance analysis?
10.1038/nbt.1614 · 2010 · External reference
Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol
10.1016/j.cell.2009.03.049 · 2009 · External reference
OPLS4: improving force field accuracy on challenging regimes of chemical space
10.1021/acs.jctc.1c00302 · 2021 · External reference
Novel procedure for modeling ligand/receptor induced fit effects
10.1021/jm050540c · 2006 · External reference
Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
10.1021/jm0306430 · 2004 · External reference
Glide: a new approach for rapid, accurate docking and scoring. 2. Enrichment factors in database screening
10.1021/jm030644s · 2004 · External reference
BNT162b2 mRNA Covid-19 vaccine in a nationwide mass vaccination setting
10.1056/nejmoa2101765 · 2021 · External reference
Population colorectal cancer screening with fecal occult blood test
2001 · External reference
Adherence to antidepressants is associated with lower mortality: a 4-year population-based cohort study
10.4088/jcp.14m09531 · 2016 · External reference
VASPFix’ for measurement of VASP phosphorylation in platelets and for monitoring effects of P2Y12 antagonists
10.1160/th13-07-0581 · 2014 · External reference
Mouse models for tumor metastasis
10.1007/978-1-62703-008-3_17 · 2012 · External reference
The role of PDE5-inhibitors in cardiopulmonary disorders: from basic evidence to clinical development
10.2174/092986707781389619 · 2007 · External reference
Early infiltration of innate immune cells to the liver depletes HNF4α and promotes extrahepatic carcinogenesis
10.1158/2159-8290.cd-22-1062 · 2023 · External reference
Ring finger protein 5 activates sterol regulatory element-binding protein 2 (SREBP2) to promote cholesterol biosynthesis via inducing polyubiquitination of SREBP chaperone SCAP
10.1074/jbc.ra119.011849 · 2020 · External reference
Dynamics and functions of lipid droplets
10.1038/s41580-018-0085-z · 2019 · External reference
USP28 controls SREBP2 and the mevalonate pathway to drive tumour growth in squamous cancer
10.1038/s41418-023-01173-6 · 2023 · External reference
SREBP-2 promotes stem cell-like properties and metastasis by transcriptional activation of c-Myc in prostate cancer
10.18632/oncotarget.7331 · 2016 · External reference
Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors
10.1038/nrd1112 · 2003 · External reference
YC-1 inhibited human platelet aggregation through NO-independent activation of soluble guanylate cyclase
10.1111/j.1476-5381.1995.tb16400.x · 1995 · External reference
Fluorescence image screening for chemical compounds modifying cholesterol metabolism and distribution
10.1194/jlr.d018184 · 2011 · External reference
Sterol O-acyltransferase (SOAT/ACAT) activity is required to form cholesterol crystals in hepatocyte lipid droplets
10.1016/j.bbalip.2024.159512 · 2024 · External reference
Cholesterol in the cell membrane-an emerging player in atherogenesis
10.3390/ijms23010533 · 2022 · External reference
Cholera toxin as a probe for membrane biology
10.3390/toxins13080543 · 2021 · External reference
Involvement of PI3K-Akt-Bad pathway in apoptosis induced by 2,6-di-O-methyl-beta-cyclodextrin, not 2,6-di-O-methyl-alpha-cyclodextrin, through cholesterol depletion from lipid rafts on plasma membranes in cells
10.1016/j.ejps.2009.07.010 · 2009 · External reference
Cholesterol depletion by MβCD enhances cell membrane tension and its variations-reducing integrity
10.1016/j.bpj.2019.03.016 · 2019 · External reference
Altered cholesterol metabolism in Niemann-Pick type C1 mouse brains affects mitochondrial function
10.1074/jbc.m412898200 · 2005 · External reference
Assessing mitochondrial dysfunction in cells
10.1042/bj20110162 · 2011 · External reference
Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans
10.1194/jlr.m093351 · 2019 · External reference
Lysosomal storage diseases
10.1038/s41572-018-0025-4 · 2018 · External reference
Cholesterol trafficking, lysosomal function, and atherosclerosis
10.1152/ajpcell.00415.2023 · 2024 · External reference
Endoplasmic reticulum calcium dictates the distribution of intracellular unesterified cholesterol
10.1016/j.ceca.2018.11.002 · 2018 · External reference
Recent developments in cGMP research: from mechanisms to medicines and back
10.1111/bph.15824 · 2022 · External reference
Impaired autophagy bridges lysosomal storage disease and epithelial dysfunction in the kidney
10.1038/s41467-017-02536-7 · 2018 · External reference
Niemann-Pick disease type C
1993 · External reference
Loss of NPC1 enhances phagocytic uptake and impairs lipid trafficking in microglia
10.1038/s41467-021-21428-5 · 2021 · External reference
Targeting NPC1 in renal cell carcinoma
10.3390/cancers16030517 · 2024 · External reference
Identification of NPC1 as the target of U18666A, an inhibitor of lysosomal cholesterol export and Ebola infection
10.7554/elife.12177 · 2015 · External reference
A human iPSC-derived inducible neuronal model of Niemann-Pick disease, type C1
10.1186/s12915-021-01133-x · 2021 · External reference
Protocol for probing regulated lysosomal activity and function in living cells
10.1016/j.xpro.2020.100132 · 2020 · External reference
Lithium ameliorates Niemann-Pick C1 disease phenotypes by impeding STING/SREBP2 activation
10.1016/j.isci.2023.106613 · 2023 · External reference
Synthetic lethality-mediated precision oncology via the tumor transcriptome
10.1016/j.cell.2021.03.030 · 2021 · External reference
Cyclic guanosine monophosphate signaling and phosphodiesterase-5 inhibitors in cardioprotection
10.1016/j.jacc.2011.09.086 · 2012 · External reference
Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice
10.1073/pnas.1112751108 · 2011 · External reference
Substituted cGMP analogs can act as selective agonists of the rod photoreceptor cGMP-gated cation channel
10.1007/bf02737085 · 1998 · External reference
Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol
10.1038/s41467-018-07590-3 · 2018 · External reference
Cholesterol auxotrophy as a targetable vulnerability in clear cell renal cell carcinoma
10.1158/2159-8290.cd-21-0211 · 2021 · External reference
Statins in risk-reduction and treatment of cancer
10.5306/wjco.v11.i8.573 · 2020 · External reference
Established and emerging therapeutic uses of PDE type 5 inhibitors in cardiovascular disease
10.1111/bph.14920 · 2020 · External reference
Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription
10.1038/s42003-025-07519-9 · 2025 · External reference
Tadalafil reduces myeloid-derived suppressor cells and regulatory T cells and promotes tumor immunity in patients with head and neck squamous cell carcinoma
10.1158/1078-0432.ccr-14-1711 · 2015 · External reference
Expression and function of phosphodiesterase type 5 in human breast cancer cell lines and tissues: implications for targeted therapy
10.1158/1078-0432.ccr-15-1900 · 2016 · External reference
PDE5 inhibition eliminates cancer stem cells via induction of PKA signaling
10.1038/s41419-017-0202-5 · 2018 · External reference
The role of cholesterol and cholesterol-driven membrane raft domains in prostate cancer
10.1177/1535370219870771 · 2019 · External reference
Alterations of lipid metabolism in cancer: implications in prognosis and treatment
10.3389/fonc.2020.577420 · 2020 · External reference
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer’s disease
10.1038/s43587-021-00138-z · 2021 · External reference
Systemic consequences of abnormal cholesterol handling: interdependent pathways of inflammation and dyslipidemia
10.3389/fimmu.2022.972140 · 2022 · External reference