Research graph
References from Circadian Genotypes in PER3 and Time of Prostate Cancer Radiotherapy Interact to Affect Risk of Late Side Effects. Local targets link to admitted publications; unresolved targets remain external evidence.
Global Cancer Statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21834 · 2024 · External reference
Cancer research UK prostate cancer statistics
2025 · External reference
Fifteen-year outcomes after monitoring, surgery, or radiotherapy for prostate cancer
10.1056/nejmoa2214122 · 2023 · External reference
Functional outcomes after localized prostate cancer treatment
10.1001/jama.2023.26491 · 2024 · External reference
Is it time to change radiotherapy: the dawning of chronoradiotherapy?
10.1016/j.clon.2019.02.010 · 2019 · External reference
Treatment time and circadian genotype interact to influence radiotherapy side-effects. A prospective European validation study using the REQUITE cohort
10.1016/j.ebiom.2022.104269 · 2022 · External reference
Differences in toxicity and outcome associated with circadian variations between patients undergoing daytime and evening radiotherapy for prostate adenocarcinoma
10.3109/07420528.2015.1130049 · 2016 · External reference
Genetic variants predict optimal timing of radiotherapy to reduce side-effects in breast cancer patients
10.1016/j.clon.2018.10.001 · 2019 · External reference
GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person
10.1038/ncomms10448 · 2016 · External reference
Transcriptomic plasticity of the circadian clock in response to photoperiod: a study in male melatonin-competent mice
10.1177/07487304241265439 · 2024 · External reference
REQUITE: a prospective multicentre cohort study of patients undergoing radiotherapy for breast, lung or prostate cancer
10.1016/j.radonc.2019.04.034 · External reference
Unresolved reference
2018 · External reference
The r4photobiology suite
10.13140/rg.2.1.4240.1763 · 2015 · External reference
Performance: an R package for assessment, comparison and testing of statistical models
10.21105/joss.03139 · 2021 · External reference
performance: Assessment of Regression Models Performance
2025 · External reference
Welcome to the tidyverse
10.21105/joss.01686 · 2019 · External reference
Tidymodels: a collection of packages for modeling and machine learning using tidyverse principles
2020 · External reference
Fitting linear mixed-effects models using lme4
10.18637/jss.v067.i01 · 2015 · External reference
glmnet: lasso and elastic-net regularized generalized linear models
2025 · External reference
ggeffects: Tidy data frames of marginal effects from regression models
10.21105/joss.00772 · 2018 · External reference
10.1007/978-3-319-24277-4
10.1007/978-3-319-24277-4 · 2016 · External reference
Reproducible summary tables with the gtsummary package
10.32614/rj-2021-053 · 2021 · External reference
STrengthening the REporting of genetic association studies (STREGA)-an extension of the STROBE statement
10.1002/gepi.20410 · 2009 · External reference
The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies
10.1016/s0140-6736(07)61602-x · 2007 · External reference
The positive circadian regulators CLOCK and BMAL1 control G2/M cell cycle transition through cyclin B1
10.1080/15384101.2018.1558638 · 2019 · External reference
Phase 3 trial of stereotactic body radiotherapy in localized prostate cancer
10.1056/nejmoa2403365 · 2024 · External reference
The time for chronotherapy in radiation oncology
10.3389/fonc.2021.687672 · 2021 · External reference
Comparison of toxicity associated with early morning versus late afternoon radiotherapy in patients with head-and-neck cancer: a prospective randomized trial of the National Cancer Institute of Canada clinical trials group (HN3)
10.1016/j.ijrobp.2008.07.009 · 2009 · External reference
Comparison of acute skin reaction following morning versus late afternoon radiotherapy in patients with breast cancer who have undergone curative surgical resection
10.1093/jrr/rrt141 · 2014 · External reference
Circadian variation in radiation-induced intestinal mucositis in patients with cervical carcinoma
10.1002/cncr.24867 · 2010 · External reference
A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference
10.1093/sleep/26.4.413 · 2003 · External reference
Lack of association between PER3 variable number tandem repeat and circadian rhythm sleep–wake disorders
10.1038/s41439-018-0017-7 · 2018 · External reference
Diurnal preference, mood and the response to morning light in relation to polymorphisms in the human clock gene PER3
10.1038/s41598-017-06769-w · 2017 · External reference
Dimerization and nuclear entry of mPER proteins in mammalian cells
10.1101/gad.14.11.1353 · 2000 · External reference
Role of the clock gene Period3 in the human cell-autonomous circadian clock
10.1111/gtc.12664 · 2019 · External reference
Circadian rhythm of cellular proliferation in the human rectal mucosa
10.1016/0016-5085(91)90019-h · 1991 · External reference
Circadian expression of clock genes in human oral mucosa and skin: association with specific cell-cycle phases
10.1016/s0002-9440(10)64135-1 · 2001 · External reference
Per3, a circadian gene, is required for Chk2 activation in human cells
10.1016/j.febslet.2010.11.003 · 2010 · External reference
Effects of radiotherapy in normal tissue
10.1056/nejmra2506017 · 2026 · External reference
Circadian control of the immune system
10.1038/nri3386 · 2013 · External reference
Circadian disruption, Per3, and human cytokine secretion
10.1177/1534735409352029 · 2009 · External reference
Diurnal transcriptome atlas of a primate across major neural and peripheral tissues
10.1126/science.aao0318 · 2018 · External reference
Comparison of radiation esophagitis associated with daytime versus evening radiotherapy in patients with esophageal carcinoma
10.1186/s13014-024-02575-7 · 2025 · External reference
