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References from Pediatric Brain Tumor Consortium Phase I Study of CD40 Agonist Sotigalimab in Pediatric and Young Adult Patients with Recurrent CNS Tumors and Newly Diagnosed DIPG. Local targets link to admitted publications; unresolved targets remain external evidence.
CD40 agonist antibodies in cancer immunotherapy
10.1146/annurev-med-062518-045435 · 2020 · External reference
Anti-CD40-mediated cancer immunotherapy: an update of recent and ongoing clinical trials
10.3109/08923973.2014.890626 · 2014 · External reference
Combination of an agonistic anti-CD40 monoclonal antibody and the COX-2 inhibitor celecoxib induces anti-glioma effects by promotion of type-1 immunity in myeloid cells and T-cells
10.1007/s00262-014-1561-8 · 2014 · External reference
CD40/CD40L expression correlates with the survival of patients with glioblastomas and an augmentation in CD40 signaling enhances the efficacy of vaccinations against glioma models
10.1093/neuonc/nov090 · 2015 · External reference
APX005M, a CD40 agonist antibody with unique epitope specificity and Fc receptor binding profile for optimal therapeutic application
10.1007/s00262-020-02814-2 · 2021 · External reference
CD40 agonistic monoclonal antibody APX005M (sotigalimab) and chemotherapy, with or without nivolumab, for the treatment of metastatic pancreatic adenocarcinoma: an open-label, multicentre, phase 1b study
10.1016/s1470-2045(20)30532-5 · 2021 · External reference
New emerging targets in cancer immunotherapy: the role of Cluster of Differentiation 40 (CD40/TNFR5)
10.1136/esmoopen-2019-000510 · 2019 · External reference
A phase II trial of the CD40 agonistic antibody sotigalimab (APX005M) in combination with nivolumab in subjects with metastatic melanoma with confirmed disease progression on anti-PD-1 therapy
10.1158/1078-0432.ccr-23-0475 · 2024 · External reference
Agonistic CD40 antibodies in cancer treatment
10.3390/cancers13061302 · 2021 · External reference
Mapping RNA-seq reads with STAR
10.1002/0471250953.bi1114s51 · 2015 · External reference
RSeQC: quality control of RNA-seq experiments
10.1093/bioinformatics/bts356 · 2012 · External reference
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
10.1093/bioinformatics/btt656 · 2014 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
clusterProfiler 4.0: a universal enrichment tool for interpreting omics data
10.1016/j.xinn.2021.100141 · 2021 · External reference
The Molecular Signatures Database (MSigDB) hallmark gene set collection
10.1016/j.cels.2015.12.004 · 2015 · External reference
Fast and accurate short read alignment with Burrows-Wheeler transform
10.1093/bioinformatics/btp324 · 2009 · External reference
The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data
10.1101/gr.107524.110 · 2010 · External reference
A framework for variation discovery and genotyping using next-generation DNA sequencing data
10.1038/ng.806 · 2011 · External reference
VarScan 2: somatic mutation and copy number alteration discovery in cancer by exome sequencing
10.1101/gr.129684.111 · 2012 · External reference
Strelka2: fast and accurate calling of germline and somatic variants
10.1038/s41592-018-0051-x · 2018 · External reference
Integrating mapping-, assembly- and haplotype-based approaches for calling variants in clinical sequencing applications
10.1038/ng.3036 · 2014 · External reference
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
10.1038/nbt.2514 · 2013 · External reference
SomaticSniper: identification of somatic point mutations in whole genome sequencing data
10.1093/bioinformatics/btr665 · 2012 · External reference
Scalable open science approach for mutation calling of tumor exomes using multiple genomic pipelines
10.1016/j.cels.2018.03.002 · 2018 · External reference
FACETS: allele-specific copy number and clonal heterogeneity analysis tool for high-throughput DNA sequencing
10.1093/nar/gkw520 · 2016 · External reference
The Ensembl Variant Effect Predictor
10.1186/s13059-016-0974-4 · 2016 · External reference
Comprehensive assessment of T-cell receptor beta-chain diversity in alphabeta T cells
10.1182/blood-2009-04-217604 · 2009 · External reference
Using synthetic templates to design an unbiased multiplex PCR assay
10.1038/ncomms3680 · 2013 · External reference
Ultra-sensitive detection of rare T cell clones
10.1016/j.jim.2011.09.001 · 2012 · External reference
Sufficient sampling for asymptotic minimum species richness estimators
10.1890/07-2147.1 · 2009 · External reference
Sotigalimab and/or nivolumab with chemotherapy in first-line metastatic pancreatic cancer: clinical and immunologic analyses from the randomized phase 2 PRINCE trial
10.1038/s41591-022-01829-9 · 2022 · External reference
A phase I study of APX005M and cabiralizumab with or without nivolumab in patients with melanoma, kidney cancer, or non-small cell lung cancer resistant to anti-PD-1/PD-L1
10.1158/1078-0432.ccr-21-0903 · 2021 · External reference
A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better
10.1186/s12943-023-01884-x · 2023 · External reference
A phase 2 study of sotigalimab, a CD40 agonist antibody, plus concurrent chemoradiation as neoadjuvant therapy for esophageal and gastroesophageal junction cancers
10.1158/2767-9764.crc-24-0513 · 2025 · External reference
A general requirement for FcγRIIB co-engagement of agonistic anti-TNFR antibodies
10.4161/cc.21842 · 2012 · External reference
Dendritic cell targeting with Fc-enhanced CD40 antibody agonists induces durable antitumor immunity in humanized mouse models of bladder cancer
10.1126/scitranslmed.abd1346 · 2021 · External reference
Conformation of the human immunoglobulin G2 hinge imparts superagonistic properties to immunostimulatory anticancer antibodies
10.1016/j.ccell.2014.11.001 · 2015 · External reference