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References from Intrathecal Allogeneic B7-H3–Targeted CAR γδ T Cells for Leptomeningeal Metastasis from Solid Tumors: Safety, Efficacy, and Immunologic Dynamics in a Phase I Trial. Local targets link to admitted publications; unresolved targets remain external evidence.
Epidemiology of brain metastases and leptomeningeal disease
10.1093/neuonc/noab101 · 2021 · External reference
Leptomeningeal metastasis: a review of the pathophysiology, diagnostic methodology, and therapeutic landscape
10.3390/curroncol30060442 · 2023 · External reference
Leptomeningeal metastases in melanoma patients: an update on and future perspectives for diagnosis and treatment
10.3390/ijms241411443 · 2023 · External reference
Leptomeningeal metastases from solid tumors: a Society for Neuro-Oncology and American Society of Clinical Oncology consensus review on clinical management and future directions
10.1093/neuonc/noae103 · 2024 · External reference
The evolving landscape of leptomeningeal metastases from NSCLC: an international, contemporary, multicenter cohort study
10.1016/j.annonc.2025.09.140 · 2026 · External reference
Leveraging molecular and immune-based therapies in leptomeningeal metastases
10.1007/s40263-022-00975-5 · 2023 · External reference
Concurrent intrathecal and intravenous nivolumab in leptomeningeal disease: phase 1 trial interim results
10.1038/s41591-022-02170-x · 2023 · External reference
Locoregional infusion of HER2-specific CAR T cells in children and young adults with recurrent or refractory CNS tumors: an interim analysis
10.1038/s41591-021-01404-8 · 2021 · External reference
Intrathecal bivalent CAR T cells targeting EGFR and IL13Rα2 in recurrent glioblastoma: phase 1 trial interim results
10.1038/s41591-024-02893-z · 2024 · External reference
Cancer immunotherapy by γδ T cells
10.1126/science.abq7248 · 2024 · External reference
Pan-cancer γδ TCR analysis uncovers clonotype diversity and prognostic potential
10.1016/j.xcrm.2024.101764 · 2024 · External reference
Structures of butyrophilin multimers reveal a plier-like mechanism for Vγ9Vδ2 T cell receptor activation
10.1016/j.immuni.2025.05.011 · 2025 · External reference
A phase I clinical trial of intrathecal injection of allogeneic CAR-γδT cells targeting B7H3 for the treatment of patients with recurrent glioblastoma
10.1016/j.annonc.2024.08.512 · 2024 · External reference
Leptomeningeal metastasis from solid tumours: EANO-ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up
10.1016/j.esmoop.2023.101624 · 2023 · External reference
Leptomeningeal metastases: a RANO proposal for response criteria
2017 · External reference
The Neurologic Assessment in Neuro-Oncology (NANO) scale: a tool to assess neurologic function for integration into the Response Assessment in Neuro-Oncology (RANO) criteria
10.1093/neuonc/nox029 · 2017 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2024 · External reference
DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors
10.1016/j.cels.2019.03.003 · 2019 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
Single-cell characterization of the immune microenvironment of melanoma brain and leptomeningeal metastases
10.1158/1078-0432.ccr-21-1694 · 2021 · External reference
Pan-cancer single-cell landscape of tumor-infiltrating T cells
10.1126/science.abe6474 · 2021 · External reference
Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease
10.1016/j.immuni.2021.07.007 · 2021 · External reference
Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
10.1038/s41586-022-05400-x · 2022 · External reference
The Molecular Signatures Database (MSigDB) hallmark gene set collection
10.1016/j.cels.2015.12.004 · 2015 · External reference
Dura immunity configures leptomeningeal metastasis immunosuppression for cerebrospinal fluid barrier invasion
10.1038/s43018-024-00858-2 · 2024 · External reference
Lipid-associated macrophages for osimertinib resistance and leptomeningeal metastases in NSCLC
10.1016/j.celrep.2024.114613 · 2024 · External reference
Single-cell map of diverse immune phenotypes in the breast tumor microenvironment
10.1016/j.cell.2018.05.060 · 2018 · External reference
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span
10.1126/sciimmunol.adn3954 · 2024 · External reference
Tumor-infiltrating gamma delta T-cells reveal exhausted subsets with remarkable heterogeneity in colorectal cancer
10.1002/ijc.34669 · 2023 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
Reversed graph embedding resolves complex single-cell trajectories
10.1038/nmeth.4402 · 2017 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
scRepertoire 2: enhanced and efficient toolkit for single-cell immune profiling
10.1371/journal.pcbi.1012760 · 2025 · External reference
Single-cell analysis of anti-BCMA CAR T cell therapy in patients with central nervous system autoimmunity
10.1126/sciimmunol.adj9730 · 2024 · External reference
Mfuzz: a software package for soft clustering of microarray data
10.6026/97320630002005 · 2007 · External reference
Interferon-γ orchestrates leptomeningeal anti-tumour response
10.1038/s41586-025-09012-z · 2025 · External reference
Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis
10.1126/science.aaz2193 · 2020 · External reference
Treatment of leptomeningeal carcinomatosis with continuous intraventricular infusion of recombinant interleukin-2
10.1016/0090-3019(91)90079-o · 1991 · External reference
Treatment of cancer with lymphokine-activated killer cells and interleukin-2
10.1056/nejm198710083171514 · 1987 · External reference
Adoptive immunotherapy of human meningeal gliomatosis and carcinomatosis with LAK cells and recombinant interleukin-2
10.3171/jns.1987.66.4.0519 · 1987 · External reference
Tissue-resident memory T cells populate the human brain
10.1038/s41467-018-07053-9 · 2018 · External reference
Transforming the understanding of brain immunity
10.1126/science.abo7649 · 2023 · External reference
Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation
10.1158/2159-8290.cd-13-0458 · 2014 · External reference
IFN-γ from lymphocytes induces PD-L1 expression and promotes progression of ovarian cancer
10.1038/bjc.2015.101 · 2015 · External reference
Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells
10.1126/scitranslmed.3006504 · 2013 · External reference
Characterisation of the immune microenvironment of primary breast cancer and brain metastasis reveals depleted T-cell response associated to ARG2 expression
10.1016/j.esmoop.2022.100636 · 2022 · External reference
Immunohistochemical analysis of B7-H3 expression in patients with lung cancer following various anti-cancer treatments
10.1007/s10637-023-01353-8 · 2023 · External reference
Influence of ADT on B7-H3 expression during CRPC progression from hormone-naïve prostate cancer
10.1038/s41417-023-00644-9 · 2023 · External reference
Quantification of cerebrospinal fluid tumor DNA in lung cancer patients with suspected leptomeningeal carcinomatosis
10.1038/s41698-024-00582-1 · 2024 · External reference
Serial monitoring of cerebrospinal fluid in patients with leptomeningeal metastases in lung cancer via the Ommaya reservoir as a predictive indicator of therapeutic efficacy and clinical prognosis
10.1038/s41698-025-01218-8 · 2026 · External reference