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References from Lenalidomide-Related Diarrhea in Patients with Multiple Myeloma Is Associated with Gut Microbiota Dysbiosis and Disruption of the Bile Acid Pool. Local targets link to admitted publications; unresolved targets remain external evidence.
Daratumumab, bortezomib, lenalidomide, and dexamethasone for multiple myeloma
10.1056/nejmoa2312054 · 2024 · External reference
Daratumumab/lenalidomide/dexamethasone in transplant-ineligible newly diagnosed myeloma: MAIA long-term outcomes
10.1038/s41375-024-02505-2 · 2025 · External reference
Daratumumab plus bortezomib, lenalidomide and dexamethasone for transplant-ineligible or transplant-deferred newly diagnosed multiple myeloma: the randomized phase 3 CEPHEUS trial
10.1038/s41591-024-03485-7 · 2025 · External reference
Lenalidomide maintenance after autologous stem-cell transplantation in newly diagnosed multiple myeloma: a meta-analysis
10.1200/jco.2017.72.6679 · 2017 · External reference
How I manage the toxicities of myeloma drugs
10.1182/blood-2017-01-725705 · 2017 · External reference
Lenalidomide maintenance after stem-cell transplantation for multiple myeloma
10.1056/nejmoa1114138 · 2012 · External reference
Updated analysis of CALGB (Alliance) 100104 assessing lenalidomide versus placebo maintenance after single autologous stem-cell transplantation for multiple myeloma: a randomised, double-blind, phase 3 trial
10.1016/s2352-3026(17)30140-0 · 2017 · External reference
Longitudinal Toxicity over Time (ToxT) analysis to evaluate tolerability: a case study of lenalidomide in CALGB 50401 (Alliance) trial
10.1016/s2352-3026(20)30067-3 · 2020 · External reference
Lenalidomide-induced diarrhea in patients with myeloma is caused by bile acid malabsorption that responds to treatment
10.1182/blood-2014-06-583302 · 2014 · External reference
The role of bile acids in chronic diarrhea
10.14309/ajg.0000000000000696 · 2020 · External reference
Bile acids and the gut microbiota: metabolic interactions and impacts on disease
10.1038/s41579-022-00805-x · 2023 · External reference
The pathophysiology of bile acid diarrhoea: differences in the colonic microbiome, metabolome and bile acids
10.1038/s41598-020-77374-7 · 2020 · External reference
Colesevelam for lenalidomide associated diarrhea in patients with multiple myeloma
10.1038/s41408-024-01136-1 · 2024 · External reference
Dietary-fat-induced taurocholic acid promotes pathobiont expansion and colitis in Il10-/- mice
10.1038/nature11225 · 2012 · External reference
Connecting dysbiosis, bile-acid dysmetabolism and gut inflammation in inflammatory bowel diseases
10.1136/gutjnl-2012-302578 · 2013 · External reference
Dysbiosis-Induced secondary bile acid deficiency promotes intestinal inflammation
10.1016/j.chom.2020.01.021 · 2020 · External reference
Altered microbial bile acid metabolism exacerbates T cell-driven inflammation during graft-versus-host disease
10.1038/s41564-024-01617-w · 2024 · External reference
A Clostridia-rich microbiota enhances bile acid excretion in diarrhea-predominant irritable bowel syndrome
10.1172/jci130976 · 2020 · External reference
Minimal residual disease negativity in multiple myeloma is associated with intestinal microbiota composition
10.1182/bloodadvances.2019032276 · 2019 · External reference
Fecal microbiota diversity disruption and clinical outcomes after auto-HCT: a multicenter observational study
10.1182/blood.2020006923 · 2021 · External reference
Sustained minimal residual disease negativity in multiple myeloma is associated with stool butyrate and healthier plant-based diets
10.1158/1078-0432.ccr-22-0723 · 2022 · External reference
Scalable log-ratio lasso regression for enhanced microbial feature selection with FLORAL
10.1016/j.crmeth.2024.100899 · 2024 · External reference
PICRUSt2 for prediction of metagenome functions
10.1038/s41587-020-0548-6 · 2020 · External reference
Taxonomic profiling and populational patterns of bacterial bile salt hydrolase (BSH) genes based on worldwide human gut microbiome
10.1186/s40168-019-0628-3 · 2019 · External reference
Cholestasis induced by bile duct ligation promotes changes in the intestinal microbiome in mice
10.1038/s41598-019-48784-z · 2019 · External reference
Diet rapidly and reproducibly alters the human gut microbiome
10.1038/nature12820 · 2014 · External reference
Associations between dietary patterns and bile acids—results from a cross-sectional study in vegans and omnivores
10.3390/nu12010047 · 2019 · External reference
In vitro interactions of dietary fibre enriched food ingredients with primary and secondary bile acids
10.3390/nu11061424 · 2019 · External reference
Guidance on the management of diarrhoea during cancer chemotherapy
10.1016/s1470-2045(14)70006-3 · 2014 · External reference
Development of the National Cancer Institute’s patient-reported outcomes version of the common terminology criteria for adverse events (PRO-CTCAE)
10.1093/jnci/dju244 · 2014 · External reference
Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist
10.1016/j.cmet.2013.01.003 · 2013 · External reference
Strain-dependent induction of primary bile acid 7-dehydroxylation by cholic acid
10.1186/s12866-024-03433-y · 2024 · External reference
Comprehensive evaluation of the bactericidal activities of free bile acids in the large intestine of humans and rodents
10.1194/jlr.m075143 · 2017 · External reference
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
10.1038/nature13828 · 2015 · External reference
A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis
10.1016/j.cgh.2009.04.024 · 2009 · External reference
Extensive impact of non-antibiotic drugs on human gut bacteria
10.1038/nature25979 · 2018 · External reference
Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial HIF augments tissue barrier function
10.1016/j.chom.2015.03.005 · 2015 · External reference
The impact of dietary fiber on gut microbiota in host health and disease
10.1016/j.chom.2018.05.012 · 2018 · External reference
6α-hydroxylated bile acids mediate TGR5 signalling to improve glucose metabolism upon dietary fiber supplementation in mice
10.1136/gutjnl-2021-326541 · 2023 · External reference
Effectiveness of diet, psychological, and exercise therapies for the management of bile acid diarrhoea in adults: a systematic review
10.1111/jhn.13005 · 2022 · External reference
Management of bile acid malabsorption using low-fat dietary interventions: a useful strategy applicable to some patients with diarrhoea-predominant irritable bowel syndrome?
10.7861/clinmedicine.15-6-536 · 2015 · External reference
A high-fiber plant-based diet in myeloma precursor disorders - results from the NUTRIVENTION clinical trial and preclinical vk*MYC model
10.1158/2159-8290.cd-25-1101 · 2026 · External reference
Amelioration of colitis by a gut bacterial consortium producing anti-inflammatory secondary bile acids
10.1128/spectrum.03330-22 · 2023 · External reference
Advancing human gut microbiota research by considering gut transit time
10.1136/gutjnl-2022-328166 · 2023 · External reference
Faecalibacterium prausnitzii ameliorates DSS-induced colitis via modulating bile acid metabolism and regulating FXR signaling
10.1007/s10620-025-09176-8 · 2025 · External reference
Safety and efficacy of liraglutide versus colesevelam for the treatment of bile acid diarrhoea: a randomised, double-blind, active-comparator, non-inferiority clinical trial
10.1016/s2468-1253(22)00198-4 · 2022 · External reference
Daratumumab versus lenalidomide as maintenance therapy in newly diagnosed multiple myeloma - interim efficacy results of a randomized clinical trial
10.1182/blood-2024-208094 · 2024 · External reference
Immune MRD status informs tumor MRD outcome prognostication in patients with multiple myeloma on lenalidomide maintenance
10.1158/1078-0432.ccr-25-0572 · 2025 · External reference
Validation of a self-administered diet history questionnaire using multiple diet records
10.1016/0895-4356(90)90099-b · 1990 · External reference
Impact of gut colonization with butyrate-producing microbiota on respiratory viral infection following allo-HCT
10.1182/blood-2018-01-828996 · 2018 · External reference