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References from Nonarmored GCC-Targeting CAR T-cell Therapy Demonstrates Significant Efficacy in Patients with Advanced Colorectal Cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
10.3322/caac.21834 · 2024 · External reference
Cancer treatment and survivorship statistics, 2022
10.3322/caac.21731 · 2022 · External reference
Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study
10.1016/s0140-6736(23)00772-9 · 2023 · External reference
Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial
10.1016/s0140-6736(12)61900-x · 2013 · External reference
Randomized trial of TAS-102 for refractory metastatic colorectal cancer
10.1056/nejmoa1414325 · 2015 · External reference
Chimeric antigen receptor T cells for sustained remissions in leukemia
10.1056/nejmoa1407222 · 2014 · External reference
Acute lymphoblastic leukaemia
10.1016/s0140-6736(19)33018-1 · 2020 · External reference
Anti-EGFR chimeric antigen receptor-modified T cells in metastatic pancreatic carcinoma: a phase I clinical trial
10.1016/j.jcyt.2020.04.088 · 2020 · External reference
Claudin18.2-specific CAR T cells in gastrointestinal cancers: phase 1 trial interim results
10.1038/s41591-022-01800-8 · 2022 · External reference
CAR-T cell therapy for breast cancer: from basic research to clinical application
10.7150/ijbs.70120 · 2022 · External reference
Phase I trial of autologous RNA-electroporated cMET-directed CAR T cells administered intravenously in patients with melanoma and breast carcinoma
10.1158/2767-9764.crc-22-0486 · 2023 · External reference
Chimeric antigen receptor T cells targeting CD19 and GCC in metastatic colorectal cancer: a nonrandomized clinical trial
10.1001/jamaoncol.2024.3891 · 2024 · External reference
Guanylyl cyclase is a heat-stable enterotoxin receptor
10.1016/0092-8674(90)90497-3 · 1990 · External reference
Determination of the binding site on the extracellular domain of guanylyl cyclase C to heat-stable enterotoxin
10.1074/jbc.274.44.31713 · 1999 · External reference
Two-metal-ion catalysis in adenylyl cyclase
10.1126/science.285.5428.756 · 1999 · External reference
Guanylyl cyclases and signaling by cyclic GMP
10.1016/s0031-6997(24)01457-1 · 2000 · External reference
Bacterial enterotoxins are associated with resistance to colon cancer
10.1073/pnas.0434905100 · 2003 · External reference
Guanylyl cyclase C agonists regulate progression through the cell cycle of human colon carcinoma cells
10.1073/pnas.141124698 · 2001 · External reference
Guanylyl cyclase C is a marker of intestinal metaplasia, dysplasia, and adenocarcinoma of the gastrointestinal tract
10.1016/j.humpath.2004.12.002 · 2005 · External reference
Consistent expression of guanylyl cyclase-C in primary and metastatic gastrointestinal cancers
10.1371/journal.pone.0189953 · 2017 · External reference
Expression of guanylyl cyclase C in tissue samples and the circulation of rectal cancer patients
10.18632/oncotarget.16406 · 2017 · External reference
GUCY2C-directed CAR-T cells oppose colorectal cancer metastases without autoimmunity
10.1080/2162402x.2016.1227897 · 2016 · External reference
Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells
10.1136/jitc-2024-009960 · 2024 · External reference
Novel GUCY2C targeting CAR-T therapy: efficacy in advanced colorectal cancer
10.1200/jco.2023.41.16_suppl.3559 · 2023 · External reference
Phase I study of GUCY2C CAR-T therapy IM96 in patients with metastatic colorectal cancer
10.1200/jco.2024.42.16_suppl.2518 · 2024 · External reference
ASTCT consensus grading for cytokine release syndrome and neurologic toxicity associated with immune effector cells
10.1016/j.bbmt.2018.12.758 · 2019 · External reference
Immune effector cell-associated hemophagocytic lymphohistiocytosis-like syndrome
10.1016/j.jtct.2023.03.006 · 2023 · External reference
In vivo imaging of human colon cancer xenografts in immunodeficient mice using a guanylyl cyclase C-specific ligand
10.1067/mnc.2002.122630 · 2002 · External reference
Results of a randomized, double-blind, placebo-controlled, phase III trial of trifluridine/tipiracil (TAS-102) monotherapy in Asian patients with previously treated metastatic colorectal cancer: the TERRA study
10.1200/jco.2017.74.3245 · 2018 · External reference
Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming
10.1038/nature21724 · 2017 · External reference
Diagnosis and treatment of metastatic colorectal cancer: a review
10.1001/jama.2021.0106 · 2021 · External reference
Extended RAS gene mutation testing in metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy: American Society of Clinical Oncology Provisional Clinical Opinion Update 2015
10.1200/jco.2015.63.9674 · 2016 · External reference
Targeting the human epidermal growth factor receptor 2 (HER2) oncogene in colorectal cancer
10.1093/annonc/mdy100 · 2018 · External reference
High HER-2 protein levels correlate with clinicopathological features in colorectal cancer
10.4103/0973-1482.155977 · 2016 · External reference
Fruquintinib plus sintilimab in previously bevacizumab-treated, pMMR/MSS refractory metastatic colorectal cancer: a phase 2 clinical trial
10.1007/s00262-025-04237-3 · 2025 · External reference