References

Pancreatic cancer

10.1016/s0140-6736(25)00261-2 · 2025 · External reference

A comprehensive survey of Ras mutations in cancer

10.1158/0008-5472.can-11-2612 · 2012 · External reference

Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse

10.1016/s1535-6108(03)00309-x · 2003 · External reference

SnapShot: splicing alterations in cancer

10.1016/j.cell.2019.12.011 · 2020 · External reference

Coordinated alterations in RNA splicing and epigenetic regulation drive leukaemogenesis

10.1038/s41586-019-1618-0 · 2019 · External reference

Altered RNA splicing by mutant p53 activates oncogenic RAS signaling in pancreatic cancer

10.1016/j.ccell.2020.05.010 · 2020 · External reference

RNA splicing dysregulation and the hallmarks of cancer

10.1038/s41568-022-00541-7 · 2023 · External reference

Emerging functions of SRSF1, splicing factor and oncoprotein, in RNA metabolism and cancer

10.1158/1541-7786.mcr-14-0131 · 2014 · External reference

SRSF1-regulated alternative splicing in breast cancer

10.1016/j.molcel.2015.09.005 · 2015 · External reference

Splicing factor SRSF1 promotes pancreatitis and KRASG12D-mediated pancreatic cancer

10.1158/2159-8290.cd-22-1013 · 2023 · External reference

Targeted protein degradation: from mechanisms to clinic

10.1038/s41580-024-00729-9 · 2024 · External reference

The ubiquitin code in the ubiquitin-proteasome system and autophagy

10.1016/j.tibs.2017.09.002 · 2017 · External reference

RNF126-mediated ubiquitination of FSP1 affects its subcellular localization and ferroptosis

10.1038/s41388-024-02949-x · 2024 · External reference

The regulation of the protein interaction network by monoubiquitination

10.1016/j.sbi.2022.102333 · 2022 · External reference

Deubiquitinating enzymes (DUBs): regulation, homeostasis, and oxidative stress response

10.1016/j.jbc.2021.101077 · 2021 · External reference

Non-degradative ubiquitination of protein kinases

10.1371/journal.pcbi.1004898 · 2016 · External reference

Ubiquitin-specific proteases in pancreatic cancer: molecular regulators of tumor progression and therapy resistance

10.1016/j.seminoncol.2025.152410 · 2025 · External reference

Targeting ubiquitin specific proteases (USPs) in cancer immunotherapy: from basic research to preclinical application

10.1186/s13046-023-02805-y · 2023 · External reference

Deubiquitinases and the new therapeutic opportunities offered to cancer

10.1530/erc-14-0516 · 2015 · External reference

The 65 and 110 kDa SR-related proteins of the U4/U6·U5 tri-snRNP are essential for the assembly of mature spliceosomes

10.1093/emboj/20.10.2553 · 2001 · External reference

USP39 regulates DNA damage response and chemo-radiation resistance by deubiquitinating and stabilizing CHK2

10.1016/j.canlet.2019.02.015 · 2019 · External reference

USP39 serves as a deubiquitinase to stabilize STAT1 and sustains type I IFN–induced antiviral immunity

10.4049/jimmunol.1901384 · 2020 · External reference

USP39 regulates NF-κB–mediated inflammatory responses through deubiquitinating K48-linked IκBα

10.4049/jimmunol.2200603 · 2023 · External reference

Deubiquitinase USP39 and E3 ligase TRIM26 balance the level of ZEB1 ubiquitination and thereby determine the progression of hepatocellular carcinoma

10.1038/s41418-021-00754-7 · 2021 · External reference

Visualizing and interpreting cancer genomics data via the Xena platform

10.1038/s41587-020-0546-8 · 2020 · External reference

MYC instructs and maintains pancreatic adenocarcinoma phenotype

10.1158/2159-8290.cd-19-0435 · 2020 · External reference

MYC- and MIZ1-dependent vesicular transport of double-strand RNA controls immune evasion in pancreatic ductal adenocarcinoma

10.1158/0008-5472.can-21-1677 · 2021 · External reference

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

10.1093/bioinformatics/btt656 · 2013 · External reference

SRSF1 interactome determined by proximity labeling reveals direct interaction with spliceosomal RNA helicase DDX23

10.1073/pnas.2322974121 · 2024 · External reference

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

10.1038/369678a0 · 1994 · External reference

Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells

10.1261/rna.041376.113 · 2014 · External reference

Proteome dynamics and proteome function of cardiac 19S proteasomes

10.1074/mcp.m110.006122 · 2011 · External reference

CRL4s: the CUL4-RING E3 ubiquitin ligases

10.1016/j.tibs.2009.07.002 · 2009 · External reference

Disrupting USP39 deubiquitinase function impairs the survival and migration of multiple myeloma cells through ZEB1 degradation

10.1186/s13046-024-03241-2 · 2024 · External reference

USP39 promote post-translational modifiers to stimulate the progress of cancer

10.1007/s12672-025-02573-5 · 2025 · External reference

USP39 stabilizes β-catenin by deubiquitination and suppressing E3 ligase TRIM26 pre-mRNA maturation to promote HCC progression

10.1038/s41419-023-05593-7 · 2023 · External reference

Deubiquitinating enzyme USP39 promotes the growth and metastasis of gastric cancer cells by modulating the degradation of RNA-binding protein RBM39

10.1016/j.jbc.2024.107751 · 2024 · External reference

The SR protein family of splicing factors: master regulators of gene expression

10.1042/bj20081501 · 2008 · External reference

Functional analysis of pre-mRNA splicing factor SF2/ASF structural domains

10.1002/j.1460-2075.1993.tb06160.x · 1993 · External reference

The splicing factor SRSF1 regulates apoptosis and proliferation to promote mammary epithelial cell transformation

10.1038/nsmb.2207 · 2012 · External reference

Nucleo-cytoplasmic shuttling of splicing factor SRSF1 is required for development and cilia function

10.7554/elife.65104 · 2021 · External reference

Cellular differentiation state modulates the mRNA export activity of SR proteins

10.1083/jcb.201610051 · 2017 · External reference

SR splicing factors promote cancer via multiple regulatory mechanisms

10.3390/genes13091659 · 2022 · External reference

USP39 promotes tumorigenesis by stabilizing and deubiquitinating SP1 protein in hepatocellular carcinoma

10.1016/j.cellsig.2021.110068 · 2021 · External reference

Impact of N-acetyltransferase 10 on macrophage activation and inflammation-induced cardiac dysfunction

10.1038/s41419-025-07796-6 · 2025 · External reference

SF2/ASF autoregulation involves multiple layers of post-transcriptional and translational control

10.1038/nsmb.1750 · 2010 · External reference

Splicing factor SF3b as a target of the antitumor natural product pladienolide

10.1038/nchembio.2007.16 · 2007 · External reference

RRM1 domain of the splicing oncoprotein SRSF1 is required for MEK1-MAPK-ERK activation and cellular transformation

10.1093/carcin/bgt247 · 2013 · External reference

Transcriptional activation by the human c-Myc oncoprotein in yeast requires interaction with Max

10.1038/359423a0 · 1992 · External reference

Binding of Myc proteins to canonical and noncanonical DNA sequences

1993 · External reference

Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

10.1126/science.2006410 · 1991 · External reference

Distinct DNA binding preferences for the c-Myc/Max and Max/Max dimers

10.1093/nar/21.23.5372 · 1993 · External reference

Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor network

10.1101/gad.1066903 · 2003 · External reference

Genomic targets of the human c-Myc protein

10.1101/gad.1067003 · 2003 · External reference

Transcriptional amplification in tumor cells with elevated c-Myc

10.1016/j.cell.2012.08.026 · 2012 · External reference

Oncogenic splicing factor SRSF1 is a critical transcriptional target of MYC

10.1016/j.celrep.2011.12.001 · 2012 · External reference

A novel genetic screen for snRNP assembly factors in yeast identifies a conserved protein, Sad1p, also required for pre-mRNA splicing

10.1128/mcb.19.3.2008 · 1999 · External reference

Cryo-EM structure of a pre-catalytic human spliceosome primed for activation

10.1016/j.cell.2017.07.011 · 2017 · External reference

Sad1 counteracts Brr2-mediated dissociation of U4/U6.U5 in tri-snRNP homeostasis

10.1128/mcb.00837-13 · 2014 · External reference

USP39 deubiquitinase is essential for KRAS oncogene-driven cancer

10.1074/jbc.m116.762757 · 2017 · External reference

The deubiquitinase USP9X suppresses pancreatic ductal adenocarcinoma

10.1038/nature11114 · 2012 · External reference

Roles of USP9X in cellular functions and tumorigenesis (Review)

10.3892/ol.2023.14093 · 2023 · External reference