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References from Diet-Induced Phospholipid Remodeling Dictates Ferroptosis Sensitivity and Tumorigenesis in the Pancreas. Local targets link to admitted publications; unresolved targets remain external evidence.
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Incidence of pancreatic cancer is dramatically increased by a high fat, high calorie diet in KrasG12D mice
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Lipocalin-2 promotes pancreatic ductal adenocarcinoma by regulating inflammation in the tumor microenvironment
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Endogenous hyperinsulinemia contributes to pancreatic cancer development
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Endocrine-Exocrine signaling drives obesity-associated pancreatic ductal adenocarcinoma
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Beta cell-derived cholecystokinin drives obesity-associated pancreatic adenocarcinoma development
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High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
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Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity
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High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity
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Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma
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The Kennedy pathway–de novo synthesis of phosphatidylethanolamine and phosphatidylcholine
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Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice
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The ratio of phosphatidylcholine to phosphatidylethanolamine influences membrane integrity and steatohepatitis
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10.1074/jbc.m404027200 · 2004 · External reference
Long-term fat intake and biomarkers
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Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
10.1038/nchembio.2238 · 2017 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
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A guideline on the molecular ecosystem regulating ferroptosis
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The cell biology of ferroptosis
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Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state
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Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury
10.1016/j.chembiol.2023.10.012 · 2024 · External reference
Oncogenic KRASG12D reprograms lipid metabolism by upregulating SLC25A1 to drive pancreatic tumorigenesis
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Hypoxic and Ras-transformed cells support growth by scavenging unsaturated fatty acids from lysophospholipids
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Survival of pancreatic cancer cells lacking KRAS function
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Cysteine depletion induces pancreatic tumor ferroptosis in mice
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Ferroptosis as a new tool for tumor suppression through lipid peroxidation
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Targeting FSP1 triggers ferroptosis in lung cancer
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On the mechanism of cytoprotection by ferrostatin-1 and liproxstatin-1 and the role of lipid peroxidation in ferroptotic cell death
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Integrated genomic characterization of pancreatic ductal adenocarcinoma
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Genomic analyses identify molecular subtypes of pancreatic cancer
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p53 in ferroptosis regulation: the new weapon for the old guardian
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Ferroptosis as a p53-mediated activity during tumour suppression
10.1038/nature14344 · 2015 · External reference
p53 suppresses metabolic stress-induced ferroptosis in cancer cells
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Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest
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Clonal dynamics following p53 loss of heterozygosity in Kras-driven cancers
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Mosaic analysis with double markers in mice
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Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
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NRF2 promotes tumor maintenance by modulating mRNA translation in pancreatic cancer
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Radiotherapy and immunotherapy promote tumoral lipid oxidation and ferroptosis via synergistic repression of SLC7A11
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Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking
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Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
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Multifaceted role for p53 in pancreatic cancer suppression
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α-Ketoglutarate links p53 to cell fate during tumour suppression
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A GPX1-OSBPL8 axis mediates noncanonical in vivo ferroptosis and cancer growth suppression
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Genetic background and sex control the outcome of high-fat diet feeding in mice
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The novel protein kinase C isoforms -delta and -epsilon modulate caerulein-induced zymogen activation in pancreatic acinar cells
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RASless MEFs as a tool to study RAS-dependent and RAS-independent functions
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Neonatal intake of Omega-3 fatty acids enhances lipid oxidation in adipocyte precursors
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SREBP1 regulates mitochondrial metabolism in oncogenic KRAS expressing NSCLC
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Precancerous neoplastic cells can move through the pancreatic ductal system
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