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References from Senescent-Like Neutrophils Shape Angiogenic Immunosuppressive Niches in Colorectal Cancer Liver Metastasis. Local targets link to admitted publications; unresolved targets remain external evidence.
Colorectal cancer
10.1016/s0140-6736(19)32319-0 · 2019 · External reference
A population-based study of the incidence, management and prognosis of hepatic metastases from colorectal cancer
10.1002/bjs.5278 · 2006 · External reference
Rates and patterns of recurrence following curative intent surgery for colorectal liver metastasis: an international multi-institutional analysis of 1669 patients
10.1097/sla.0b013e3181b4539b · 2009 · External reference
Cancer immunotherapy using checkpoint blockade
10.1126/science.aar4060 · 2018 · External reference
Liver metastasis restrains immunotherapy efficacy via macrophage-mediated T cell elimination
10.1038/s41591-020-1131-x · 2021 · External reference
The neutrophil
10.1016/j.immuni.2021.06.006 · 2021 · External reference
Neutrophil diversity and plasticity in tumour progression and therapy
10.1038/s41568-020-0281-y · 2020 · External reference
Neutrophils in the tumor microenvironment
10.1016/j.it.2015.11.008 · 2016 · External reference
Cathepsin C promotes breast cancer lung metastasis by modulating neutrophil infiltration and neutrophil extracellular trap formation
10.1016/j.ccell.2020.12.012 · 2021 · External reference
Deterministic reprogramming of neutrophils within tumors
10.1126/science.adf6493 · 2024 · External reference
Immunosuppressive CD10+ALPL+ neutrophils promote resistance to anti-PD-1 therapy in HCC by mediating irreversible exhaustion of T cells
10.1016/j.jhep.2023.08.024 · 2023 · External reference
CXCR1 and CXCR2 chemokine receptor agonists produced by tumors induce neutrophil extracellular traps that interfere with immune cytotoxicity
10.1016/j.immuni.2020.03.001 · 2020 · External reference
Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
10.1038/s41586-022-05400-x · 2022 · External reference
Interferon-stimulated neutrophils as a predictor of immunotherapy response
10.1016/j.ccell.2023.12.005 · 2024 · External reference
A neutrophil response linked to tumor control in immunotherapy
10.1016/j.cell.2023.02.032 · 2023 · External reference
T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants
10.1016/j.cell.2023.03.007 · 2023 · External reference
Neutrophil profiling illuminates anti-tumor antigen-presenting potency
10.1016/j.cell.2024.02.005 · 2024 · External reference
Spatiotemporal immune landscape of colorectal cancer liver metastasis at single-cell level
10.1158/2159-8290.cd-21-0316 · 2022 · External reference
Neutrophils in cancer: heterogeneous and multifaceted
10.1038/s41577-021-00571-6 · 2022 · External reference
Th17 cells secrete TWEAK to trigger epithelial-mesenchymal transition and promote colorectal cancer liver metastasis
10.1158/0008-5472.can-23-2123 · 2024 · External reference
Single-cell senescence identification reveals senescence heterogeneity, trajectory, and modulators
10.1016/j.cmet.2024.03.009 · 2024 · External reference
Mapping the cellular biogeography of human bone marrow niches using single-cell transcriptomics and proteomic imaging
10.1016/j.cell.2024.04.013 · 2024 · External reference
Neutrophil phenotypes and functions in cancer: a consensus statement
10.1084/jem.20220011 · 2022 · External reference
Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment
10.1136/gutjnl-2021-326070 · 2023 · External reference
Immunometabolism in the single-cell era
10.1016/j.cmet.2020.09.013 · 2020 · External reference
The immunometabolic ecosystem in cancer
10.1038/s41590-023-01675-y · 2023 · External reference
IFNα potentiates anti-PD-1 efficacy by remodeling glucose metabolism in the hepatocellular carcinoma microenvironment
10.1158/2159-8290.cd-21-1022 · 2022 · External reference
Apolipoprotein E induces pathogenic senescent-like myeloid cells in prostate cancer
10.1016/j.ccell.2023.02.004 · 2023 · External reference
Glycolytic neutrophils accrued in the spleen compromise anti-tumour T cell immunity in breast cancer
10.1038/s42255-023-00853-4 · 2023 · External reference
Transcription factor Bhlhe40 in immunity and autoimmunity
10.1016/j.it.2020.09.002 · 2020 · External reference
Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection
10.1084/jem.20171704 · 2018 · External reference
Bhlhe40 mediates tissue-specific control of macrophage proliferation in homeostasis and type 2 immunity
10.1038/s41590-019-0382-5 · 2019 · External reference
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer
10.1038/s41586-018-0694-x · 2018 · External reference
Cross-talk between myeloid and B cells shapes the distinct microenvironments of primary and secondary liver cancer
10.1158/0008-5472.can-23-0193 · 2023 · External reference
Tissue resident iNKT17 cells facilitate cancer cell extravasation in liver metastasis via interleukin-22
10.1016/j.immuni.2022.12.014 · 2023 · External reference
GIMAP5 deficiency reveals a mammalian ceramide-driven longevity assurance pathway
10.1038/s41590-023-01691-y · 2024 · External reference
ATAC-seq: a method for assaying chromatin accessibility genome-wide
10.1002/0471142727.mb2129s109 · 2015 · External reference
Fast gapped-read alignment with Bowtie 2
10.1038/nmeth.1923 · 2012 · External reference
Model-based analysis of ChIP-Seq (MACS)
10.1186/gb-2008-9-9-r137 · 2008 · External reference
ChIPseeker: an R/Bioconductor package for ChIP peak annotation, comparison and visualization
10.1093/bioinformatics/btv145 · 2015 · External reference
CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis
10.1016/j.ccell.2024.07.006 · 2024 · External reference
fastp: an ultra-fast all-in-one FASTQ preprocessor
10.1093/bioinformatics/bty560 · 2018 · External reference
DoubletFinder: doublet detection in single-cell RNA sequencing data using artificial nearest neighbors
10.1016/j.cels.2019.03.003 · 2019 · External reference
An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte-tumor cell crosstalk, local immunosuppression and tumor progression
10.1038/s41422-023-00831-1 · 2023 · External reference
SPOTlight: seeded NMF regression to deconvolute spatial transcriptomics spots with single-cell transcriptomes
10.1093/nar/gkab043 · 2021 · External reference
Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer
10.1016/j.cell.2020.03.048 · 2020 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
High-resolution single-cell atlas reveals diversity and plasticity of tissue-resident neutrophils in non-small cell lung cancer
10.1016/j.ccell.2022.10.008 · 2022 · External reference
Characterizing cancer metabolism from bulk and single-cell RNA-seq data using METAFlux
10.1038/s41467-023-40457-w · 2023 · External reference
MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma
10.1016/j.ccell.2023.05.015 · 2023 · External reference
Reversed graph embedding resolves complex single-cell trajectories
10.1038/nmeth.4402 · 2017 · External reference
Single-cell transcriptional diversity is a hallmark of developmental potential
10.1126/science.aax0249 · 2020 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
SCENIC: single-cell regulatory network inference and clustering
10.1038/nmeth.4463 · 2017 · External reference