Research graph
References from A Foundation Model of Cancer Genotype Enables Precise Predictions of Therapeutic Response. Local targets link to admitted publications; unresolved targets remain external evidence.
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Large-scale foundation model on single-cell transcriptomics
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Pretraining a foundation model for generalizable fluorescence microscopy-based image restoration
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A foundation model for generalizable disease detection from retinal images
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Robust and data-efficient generalization of self-supervised machine learning for diagnostic imaging
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Pretrained transformers applied to clinical studies improve predictions of treatment efficacy and associated biomarkers
10.1038/s41467-025-57181-2 · 2025 · External reference
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10.1158/2159-8290.cd-21-1547 · 2022 · External reference
The cancer genome atlas pan-cancer analysis project
10.1038/ng.2764 · 2013 · External reference
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10.1101/gr.239244.118 · 2018 · External reference
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10.1093/bioinformatics/btaa980 · 2021 · External reference
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10.1038/s41586-020-1943-3 · 2020 · External reference
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Emerging landscape of oncogenic signatures across human cancers
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Tumor aneuploidy correlates with markers of immune evasion and with reduced response to immunotherapy
10.1126/science.aaf8399 · 2017 · External reference
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10.1093/nar/gkab909 · 2022 · External reference
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10.1093/nar/gkac883 · 2023 · External reference
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10.1093/nar/gkx1013 · 2018 · External reference
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10.1093/database/baab010 · 2021 · External reference
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10.1093/nar/gkab962 · 2022 · External reference
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10.1126/science.adg7492 · 2023 · External reference
Genetic alterations during colorectal-tumor development
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Comprehensive molecular characterization of muscle-invasive bladder cancer
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Comprehensive molecular portraits of human breast tumours
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Comprehensive genomic characterization of squamous cell lung cancers
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TP53 mutations and survival in squamous-cell carcinoma of the head and neck
10.1056/nejmoa073770 · 2007 · External reference
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10.1038/nature21386 · 2017 · External reference
Comprehensive genomic characterization of head and neck squamous cell carcinomas
10.1038/nature14129 · 2015 · External reference
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Prognostic significance of p16INK4A and human papillomavirus in patients with oropharyngeal cancer treated on TROG 02.02 phase III trial
10.1200/jco.2010.29.2904 · 2010 · External reference
Integrative and comparative genomic analysis of HPV-positive and HPV-negative head and neck squamous cell carcinomas
10.1158/1078-0432.ccr-13-3310 · 2015 · External reference
Genomic correlates of response to immune checkpoint blockade in microsatellite-stable solid tumors
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Automated real-world data integration improves cancer outcome prediction
10.1038/s41586-024-08167-5 · 2024 · External reference
Pan-cancer analysis of advanced patient tumors reveals interactions between therapy and genomic landscapes
10.1038/s43018-020-0050-6 · 2020 · External reference
TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells
10.1038/nature25501 · 2018 · External reference
Multimodal integration of radiology, pathology and genomics for prediction of response to PD-(L)1 blockade in patients with non-small cell lung cancer
10.1038/s43018-022-00416-8 · 2022 · External reference
Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma
10.1038/s41591-019-0654-5 · 2019 · External reference
Genomic predictors of survival in patients with high-grade urothelial carcinoma of the bladder
10.1016/j.eururo.2014.06.050 · 2015 · External reference
Genomic mapping of metastatic organotropism in lung adenocarcinoma
10.1016/j.ccell.2023.03.018 · 2023 · External reference
Integrative clinical genomics of metastatic cancer
10.1038/nature23306 · 2017 · External reference
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10.1158/2159-8290.cd-12-0095 · 2012 · External reference
Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal
10.1126/scisignal.2004088 · 2013 · External reference
Analysis and visualization of longitudinal genomic and clinical data from the AACR Project GENIE Biopharma Collaborative in cBioPortal
10.1158/0008-5472.can-23-0816 · 2023 · External reference
Clinical, molecular, and immune correlates of the Immunotherapy Response Score in patients with advanced urothelial carcinoma under atezolizumab monotherapy: analysis of the phase II IMvigor210 trial
10.1016/j.esmoop.2023.101611 · 2023 · External reference
Tumor mutational load predicts survival after immunotherapy across multiple cancer types
10.1038/s41588-018-0312-8 · 2019 · External reference
PD-1 blockade in tumors with mismatch-repair deficiency
10.1056/nejmoa1500596 · 2015 · External reference
Results of a phase II open-label, non-randomized trial of cisplatin chemotherapy in patients with BRCA1-positive metastatic breast cancer
10.1186/bcr3231 · 2012 · External reference
Wnt/β-catenin signaling accelerates mouse lung tumorigenesis by imposing an embryonic distal progenitor phenotype on lung epithelium
10.1172/jci44871 · 2011 · External reference
Targeting CDK12 for cancer therapy: function, mechanism, and drug discovery
10.1158/0008-5472.can-20-2245 · 2021 · External reference
Clinical characteristics and outcomes of phase I cancer patients with CCNE1 amplification: MD Anderson experiences
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Distinct roles of VEGFA and ANGPT2 in lung adenocarcinoma and squamous cell carcinoma
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Comprehensive genomic and clinical analyses identify APOBEC mutational signatures as a brain metastasis risk factor in lung adenocarcinoma patients
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Single-chromosomal gains can function as metastasis suppressors and promoters in colon cancer
10.1016/j.devcel.2020.01.034 · 2020 · External reference
Cell-of-origin patterns dominate the molecular classification of 10,000 tumors from 33 types of cancer
10.1016/j.cell.2018.03.022 · 2018 · External reference
Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy
10.1016/j.ccr.2014.01.009 · 2014 · External reference
A prognostic gene expression signature in the molecular classification of chemotherapy-naïve urothelial cancer is predictive of clinical outcomes from neoadjuvant chemotherapy: a phase 2 trial of dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin with bevacizumab in urothelial cancer
10.1016/j.eururo.2015.08.034 · 2016 · External reference
Impact of molecular subtypes in muscle-invasive bladder cancer on predicting response and survival after neoadjuvant chemotherapy
10.1016/j.eururo.2017.03.030 · 2017 · External reference
Reshaping the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
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Chromatin remodelers are regulators of the tumor immune microenvironment
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Chromatin remodeling (SWI/SNF) complexes, cancer, and response to immunotherapy
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Chromatin-remodelling factor BRG1 selectively activates a subset of interferon-alpha-inducible genes
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Partial inactivation of the chromatin remodelers SMARCA2 and SMARCA4 in virus-infected cells by caspase-mediated cleavage
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Polycomb repressive complex 2 confers BRG1 dependency on the CIITA locus
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STK11 and KEAP1 mutations as prognostic biomarkers in an observational real-world lung adenocarcinoma cohort
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Emerging insights into STK11, KEAP1 and KRAS mutations: implications for immunotherapy in patients with advanced non-small cell lung cancer
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Integrated genomic characterization of pancreatic ductal adenocarcinoma
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The molecular taxonomy of primary prostate cancer
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Comprehensive and integrated genomic characterization of adult soft tissue sarcomas
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The international cancer genome consortium data portal
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Artificial intelligence-powered spatial analysis of tumor-infiltrating lymphocytes as complementary biomarker for immune checkpoint inhibition in non-small-cell lung cancer
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Prediction of immunotherapy response using mutations to cancer protein assemblies
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