Research graph
References from Asynchronous Evolution of Epithelium and Stroma Differentiates Precursor Lesions from Pancreatic Cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
Pancreatic adenocarcinoma pathology: changing “landscape”
10.3978/j.issn.2078-6891.2015.032 · 2015 · External reference
Pancreatic cancer: advances and challenges
10.1016/j.cell.2023.02.014 · 2023 · External reference
Presence of somatic mutations in most early-stage pancreatic intraepithelial neoplasia
10.1053/j.gastro.2011.12.042 · 2012 · External reference
3D genomic mapping reveals multifocality of human pancreatic precancers
10.1038/s41586-024-07359-3 · 2024 · External reference
Analysis of donor pancreata defines the transcriptomic signature and microenvironment of early neoplastic lesions
10.1158/2159-8290.cd-23-0013 · 2023 · External reference
The prevalence and clinicopathological characteristics of high-grade pancreatic intraepithelial neoplasia: autopsy study evaluating the entire pancreatic parenchyma
10.1097/mpa.0000000000000786 · 2017 · External reference
Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
10.1016/s1535-6108(03)00309-x · 2003 · External reference
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
10.1016/j.ccr.2005.04.023 · 2005 · External reference
Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice
10.1016/j.ccr.2007.01.012 · 2007 · External reference
Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
10.1172/jci59227 · 2012 · External reference
Single-nucleus and spatial transcriptome profiling of pancreatic cancer identifies multicellular dynamics associated with neoadjuvant treatment
10.1038/s41588-022-01134-8 · 2022 · External reference
Multimodal mapping of the tumor and peripheral blood immune landscape in human pancreatic cancer
10.1038/s43018-020-00121-4 · 2020 · External reference
PanIN and CAF transitions in pancreatic carcinogenesis revealed with spatial data integration
10.1016/j.cels.2024.07.001 · 2024 · External reference
Spatial mapping of transcriptomic plasticity in metastatic pancreatic cancer
10.1038/s41586-025-08927-x · 2025 · External reference
Ongoing replication stress tolerance and clonal T cell responses distinguish liver and lung recurrence and outcomes in pancreatic cancer
10.1038/s43018-024-00881-3 · 2025 · External reference
AI-powered Deep Visual Proteomics reveals critical molecular transitions in pancreatic cancer precursors
10.1158/2159-8290.cd-25-1119 · 2026 · External reference
KRT17high/CXCL8+ tumor cells display both classical and basal features and regulate myeloid infiltration in the pancreatic cancer microenvironment
10.1158/1078-0432.ccr-23-1421 · 2024 · External reference
Haplotype-aware analysis of somatic copy number variations from single-cell transcriptomes
10.1038/s41587-022-01468-y · 2023 · External reference
Integrated genomic characterization of pancreatic ductal adenocarcinoma
10.1016/j.ccell.2017.07.007 · 2017 · External reference
Robust decomposition of cell type mixtures in spatial transcriptomics
10.1038/s41587-021-00830-w · 2022 · External reference
Spatial transcriptomics at subspot resolution with BayesSpace
10.1038/s41587-021-00935-2 · 2021 · External reference
Benchmarking spatial clustering methods with spatially resolved transcriptomics data
10.1038/s41592-024-02215-8 · 2024 · External reference
Cancerization of the pancreatic ducts: demonstration of a common and under-recognized process using immunolabeling of paired duct lesions and invasive pancreatic ductal adenocarcinoma for p53 and Smad4 expression
10.1097/pas.0000000000001148 · 2018 · External reference
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma
10.1038/nrc2899 · 2010 · External reference
Virtual microdissection identifies distinct tumor- and stroma-specific subtypes of pancreatic ductal adenocarcinoma
10.1038/ng.3398 · 2015 · External reference
Characterization of cell fate probabilities in single-cell data with Palantir
10.1038/s41587-019-0068-4 · 2019 · External reference
Cell type and gene expression deconvolution with BayesPrism enables Bayesian integrative analysis across bulk and single-cell RNA sequencing in oncology
10.1038/s43018-022-00356-3 · 2022 · External reference
The emerging roles of human tissue kallikreins in cancer
10.1038/nrc1474 · 2004 · External reference
Remodelling of the tumour microenvironment by the kallikrein-related peptidases
10.1038/s41568-021-00436-z · 2022 · External reference
CD55 in cancer: complementing functions in a non-canonical manner
10.1016/j.canlet.2022.215935 · 2022 · External reference
GLUT-1 expression in pancreatic neoplasia: implications in pathogenesis, diagnosis, and prognosis
10.1097/mpa.0b013e318201c935 · 2011 · External reference
Trefoil factors and human gastric cancer (review)
10.3892/ijmm.12.1.3 · 2003 · External reference
Spatial transcriptomics of intraductal papillary mucinous neoplasms of the pancreas identifies NKX6-2 as a driver of gastric differentiation and indolent biological potential
10.1158/2159-8290.cd-22-1200 · 2023 · External reference
Gastrokines: stomach-specific proteins with putative homeostatic and tumor suppressor roles
10.1152/ajpgi.00374.2012 · 2013 · External reference
De novo expression of gastrokines in pancreatic precursor lesions impede the development of pancreatic cancer
10.1038/s41388-022-02182-4 · 2022 · External reference
A gene-environment-induced epigenetic program initiates tumorigenesis
10.1038/s41586-020-03147-x · 2021 · External reference
IL-33-activated ILC2s induce tertiary lymphoid structures in pancreatic cancer
10.1038/s41586-024-08426-5 · 2025 · External reference
Oncogenic KRAS-dependent stromal interleukin-33 directs the pancreatic microenvironment to promote tumor growth
10.1158/2159-8290.cd-24-0100 · 2024 · External reference
Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines
10.1136/jitc-2024-010579 · 2025 · External reference
Wnt7a activates canonical Wnt signaling, promotes bladder cancer cell invasion, and is suppressed by miR-370-3p
10.1074/jbc.ra118.001689 · 2018 · External reference
The Molecular Signatures Database (MSigDB) hallmark gene set collection
10.1016/j.cels.2015.12.004 · 2015 · External reference
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression
10.1016/j.ccr.2011.03.002 · 2011 · External reference
Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance
10.1158/0008-5472.can-13-1558-t · 2013 · External reference
Stat3/Socs3 activation by IL-6 transsignaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
10.1016/j.ccr.2011.03.009 · 2011 · External reference
Extrinsic KRAS signaling shapes the pancreatic microenvironment through fibroblast reprogramming
10.1016/j.jcmgh.2022.02.016 · 2022 · External reference
Fibroblast STAT3 activation drives organ-specific premetastatic niche formation
10.1158/0008-5472.can-25-3472 · 2026 · External reference
STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer
10.26508/lsa.202201460 · 2022 · External reference
B cells and tertiary lymphoid structures: friends or foes in cancer immunotherapy?
10.1158/1078-0432.ccr-21-1130 · 2022 · External reference
CCL19-producing fibroblasts promote tertiary lymphoid structure formation enhancing anti-tumor IgG response in colorectal cancer liver metastasis
10.1016/j.ccell.2024.07.006 · 2024 · External reference
Associations of immune cell homing gene signatures and infiltrates of lymphocyte subsets in human melanomas: discordance with CD163+ myeloid cell infiltrates
10.1186/s12967-021-03044-5 · 2021 · External reference
LIANA+ provides an all-in-one framework for cell-cell communication inference
10.1038/s41556-024-01469-w · 2024 · External reference
The paradoxical role of matrix metalloproteinase-11 in cancer
10.1016/j.biopha.2021.111899 · 2021 · External reference
Comprehensive analysis of matrix metalloproteinase and tissue inhibitor expression in pancreatic cancer: increased expression of matrix metalloproteinase-7 predicts poor survival
10.1158/1078-0432.ccr-1157-03 · 2004 · External reference
Stromelysin 3 is overexpressed in human pancreatic carcinoma and regulated by retinoic acid in pancreatic carcinoma cell lines
10.1136/gut.43.5.692 · 1998 · External reference
Periostin: a matricellular protein with multiple functions in cancer development and progression
10.3389/fonc.2018.00225 · 2018 · External reference
Periostin creates a tumor-supportive microenvironment in the pancreas by sustaining fibrogenic stellate cell activity
10.1053/j.gastro.2007.01.031 · 2007 · External reference
Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration
10.1161/01.res.0000154262.07264.12 · 2005 · External reference
Collagen type XI alpha 1 (COL11A1): a novel biomarker and a key player in cancer
10.3390/cancers13050935 · 2021 · External reference
Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway
10.1016/s1535-6108(04)00081-9 · 2004 · External reference
Pan-cancer analysis reveals IGFL2 as a potential target for cancer prognosis and immunotherapy
10.1038/s41598-023-27602-7 · 2023 · External reference
CTHRC1+ fibroblasts and SPP1+ macrophages synergistically contribute to pro-tumorigenic tumor microenvironment in pancreatic ductal adenocarcinoma
10.1038/s41598-024-68109-z · 2024 · External reference
Cancer-associated fibroblast-derived MMP11 promotes tumor progression in pancreatic cancer
10.1111/cas.16418 · 2025 · External reference
Insights into the distinct roles of MMP-11 in tumor biology and future therapeutics (Review)
10.3892/ijo.2016.3400 · 2016 · External reference
Stromelysin-3 gene expression in human cancer: an overview
1994 · External reference
Genomic relevance of FGF14 and associated genes on the prognosis of pancreatic cancer
10.1371/journal.pone.0252344 · 2021 · External reference
IGFL2-AS1-induced suppression of HIF-1α degradation promotes cell proliferation and invasion in colorectal cancer by upregulating CA9
10.1002/cam4.5562 · 2023 · External reference
KLF5-induced lncRNA IGFL2-AS1 promotes basal-like breast cancer cell growth and survival by upregulating the expression of IGFL1
10.1016/j.canlet.2021.04.016 · 2021 · External reference
LncRNA IGFL2-AS1 promotes the proliferation, migration, and invasion of colon cancer cells and is associated with patient prognosis
10.2147/cmar.s313775 · 2021 · External reference
Integrative single-cell and spatial transcriptomics analysis reveals ECM-remodeling cancer-associated fibroblast-derived POSTN as a key mediator in pancreatic ductal adenocarcinoma progression
10.7150/ijbs.108618 · 2025 · External reference
Periostin is associated with prognosis and immune cell infiltration in pancreatic adenocarcinoma based on integrated bioinformatics analysis
10.1002/cnr2.1990 · 2024 · External reference
Periostin: biology and function in cancer
10.1186/s12935-022-02714-8 · 2022 · External reference
GPX3 represses pancreatic cancer cell proliferation, migration and invasion, and improves their chemo-sensitivity by regulating the JNK/c-Jun signaling pathway
10.3892/etm.2024.12407 · 2024 · External reference
Extracellular glutathione peroxidase GPx3 and its role in cancer
10.3390/cancers12082197 · 2020 · External reference
Complement activation in tumor microenvironment after neoadjuvant therapy and its impact on pancreatic cancer outcomes
10.1038/s41698-025-00848-2 · 2025 · External reference
Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression
10.1016/j.ebiom.2021.103315 · 2021 · External reference
Pancreatic ductal adenocarcinoma with a high expression of alcohol dehydrogenase 1B is associated with less aggressive features and a favorable prognosis
2023 · External reference
Hypermethylation of EDNRB promoter contributes to the risk of colorectal cancer
10.1186/1746-1596-8-199 · 2013 · External reference
Differences in endothelin B receptor isoforms expression and function in breast cancer cells
10.7150/jca.41004 · 2020 · External reference
LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity
10.1038/s41586-022-05272-1 · 2022 · External reference
Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts
10.1158/2159-8290.cd-19-0094 · 2019 · External reference
MYC ecDNA promotes intratumour heterogeneity and plasticity in PDAC
10.1038/s41586-025-08721-9 · 2025 · External reference
Spatially resolved analysis of pancreatic cancer identifies therapy-associated remodeling of the tumor microenvironment
10.1038/s41588-024-01890-9 · 2024 · External reference
Cell simulation as cell segmentation
10.1038/s41592-025-02697-0 · 2025 · External reference
Wnt signaling pathway protein LEF1 in cancer, as a biomarker for prognosis and a target for treatment
2017 · External reference
Regulation of LEF-1/TCF transcription factors by Wnt and other signals
10.1016/s0955-0674(99)80031-3 · 1999 · External reference
Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
10.1126/science.1164368 · 2008 · External reference
Common activation of canonical Wnt signaling in pancreatic adenocarcinoma
10.1371/journal.pone.0001155 · 2007 · External reference
WNT signaling in the tumor microenvironment promotes immunosuppression in murine pancreatic cancer
10.1084/jem.20220503 · 2023 · External reference
Canonical Wnt signaling is required for pancreatic carcinogenesis
10.1158/0008-5472.can-12-4384 · 2013 · External reference
Inference and analysis of cell-cell communication using CellChat
10.1038/s41467-021-21246-9 · 2021 · External reference
Single-cell RNA sequencing in pancreatic cancer
10.1038/s41575-021-00471-z · 2021 · External reference
Spatially confined sub-tumor microenvironments in pancreatic cancer
10.1016/j.cell.2021.09.022 · 2021 · External reference
Netrin G1 promotes pancreatic tumorigenesis through cancer-associated fibroblast-driven nutritional support and immunosuppression
10.1158/2159-8290.cd-20-0775 · 2021 · External reference
Unsupervised removal of systematic background noise from droplet-based single-cell experiments using CellBender
10.1038/s41592-023-01943-7 · 2023 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2024 · External reference
SCANPY: large-scale single-cell gene expression data analysis
10.1186/s13059-017-1382-0 · 2018 · External reference
Scrublet: computational identification of cell doublets in single-cell transcriptomic data
10.1016/j.cels.2018.11.005 · 2019 · External reference
Deep generative modeling for single-cell transcriptomics
10.1038/s41592-018-0229-2 · 2018 · External reference
Clustering trees: a visualization for evaluating clusterings at multiple resolutions
10.1093/gigascience/giy083 · 2018 · External reference
SeuratExtend: streamlining single-cell RNA-seq analysis through an integrated and intuitive framework
10.1093/gigascience/giaf076 · 2025 · External reference
Differential abundance testing on single-cell data using k-nearest neighbor graphs
10.1038/s41587-021-01033-z · 2022 · External reference
Inferring histology-associated gene expression gradients in spatial transcriptomic studies
10.1038/s41467-024-50904-x · 2024 · External reference
Semla: a versatile toolkit for spatially resolved transcriptomics analysis and visualization
10.1093/bioinformatics/btad626 · 2023 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
10.1073/pnas.0506580102 · 2005 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
TCGAbiolinks: an R/Bioconductor package for integrative analysis of TCGA data
10.1093/nar/gkv1507 · 2016 · External reference
GSVA: gene set variation analysis for microarray and RNA-seq data
10.1186/1471-2105-14-7 · 2013 · External reference
Survival Genie, a web platform for survival analysis across pediatric and adult cancers
10.1038/s41598-022-06841-0 · 2022 · External reference
Fast, sensitive and accurate integration of single-cell data with Harmony
10.1038/s41592-019-0619-0 · 2019 · External reference
UCell: robust and scalable single-cell gene signature scoring
10.1016/j.csbj.2021.06.043 · 2021 · External reference
